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O70571 (PDK4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
EC=2.7.11.2
Alternative name(s):
Pyruvate dehydrogenase kinase isoform 4
Gene names
Name:Pdk4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism By similarity.

Catalytic activity

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the PDK/BCKDK protein kinase family.

Contains 1 histidine kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 412[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialPRO_0000023446

Regions

Domain138 – 368231Histidine kinase
Nucleotide binding254 – 2618ATP By similarity
Nucleotide binding312 – 3132ATP By similarity
Nucleotide binding329 – 3346ATP By similarity

Sites

Binding site2931ATP By similarity

Amino acid modifications

Modified residue1271Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
O70571 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 74815502E711054C

FASTA41246,596
        10         20         30         40         50         60 
MKAARFVMRS ASSLSSASLV PREVELFSRY SPSPLSMKQL LDFGSENACE RTSFAFLRQE 

        70         80         90        100        110        120 
LPVRLANILK EIDILPDRLV NTPSVQLVKS WYIQSLMDLV EFHEKSPEDQ KALSEFVDTL 

       130        140        150        160        170        180 
VKVRNRHHNV VPTMAQGILE YKDTCTVDPV TNQNLQYFLD RFYMNRISTR MLMNQHILIF 

       190        200        210        220        230        240 
SDSKTGNPSH IGSIDPNCDV VAVVQDAFEC AKMLCDQYYL TSPELNLTQV NGKFPGQPIH 

       250        260        270        280        290        300 
IVYVPSHLHH MLFELFKNAM RATVEHQENR PSLTPVEATV VLGKEDLTIK ISDRGGGVPL 

       310        320        330        340        350        360 
RITDRLFSYT YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLNL YSMSGYGTDA 

       370        380        390        400        410 
IIYLKALSSE SVEKLPVFNK SAFKHYQMSS EADDWCIPSR EPKNLAKEKL AV

« Hide

References

« Hide 'large scale' references
[1]"A novel gene in carnitine-deficient JVS mice."
Horiuchi M., Kobayashi K., Masuda M., Saheki T.
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H.
Tissue: Heart.
[2]"Promoter and partial structural region of Mus musculus pyruvate dehydrogenase kinase 4 (PDK4)."
Jeoung N.H., Bowker-Kinley M.M., Harris R.A.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ001418 mRNA. Translation: CAA04752.1.
AF239176 Genomic DNA. Translation: AAG44393.1.
BC026134 mRNA. Translation: AAH26134.1.
IPIIPI00119431.
RefSeqNP_038771.1. NM_013743.2.
UniGeneMm.235547.

3D structure databases

ProteinModelPortalO70571.
SMRO70571. Positions 20-386.
ModBaseSearch...

Protein-protein interaction databases

STRINGO70571.

Proteomic databases

PRIDEO70571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019721; ENSMUSP00000019721; ENSMUSG00000019577.
GeneID27273.
KEGGmmu:27273.

Organism-specific databases

CTD5166.
MGIMGI:1351481. Pdk4.

Phylogenomic databases

eggNOGroNOG14495.
HOGENOMHBG382024.
HOVERGENHBG000511.
InParanoidO70571.
OMAYFQGDLN.
OrthoDBEOG4G1MGF.
PhylomeDBO70571.

Gene expression databases

ArrayExpressO70571.
BgeeO70571.
CleanExMM_PDK4.
GenevestigatorO70571.
GermOnlineENSMUSG00000019577. Mus musculus.

Family and domain databases

InterProIPR003594. ATPase-like_ATP-bd.
IPR018955. BCDHK/PDK_N.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
G3DSA:1.20.140.20. BCDHK/PDK_N. 1 hit.
KOK00898.
PfamPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
SSF69012. BCDHK/PDK_N. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio305172.
SOURCESearch...

Entry information

Entry namePDK4_MOUSE
AccessionPrimary (citable) accession number: O70571
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: November 16, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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