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O70570 (PIGR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polymeric immunoglobulin receptor

Short name=PIgR
Short name=Poly-Ig receptor

Cleaved into the following chain:

  1. Secretory component
Gene names
Name:Pigr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length771 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Secretory component: Secreted.

Sequence similarities

Contains 5 Ig-like V-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 771753Polymeric immunoglobulin receptor
PRO_0000014902
Chain19 – 611593Secretory component
PRO_0000014903

Regions

Topological domain19 – 645627Extracellular Potential
Transmembrane646 – 66823Helical; Potential
Topological domain669 – 771103Cytoplasmic Potential
Domain21 – 120100Ig-like V-type 1
Domain135 – 237103Ig-like V-type 2
Domain245 – 351107Ig-like V-type 3
Domain352 – 457106Ig-like V-type 4
Domain463 – 563101Ig-like V-type 5

Amino acid modifications

Modified residue6891Phosphoserine Ref.4
Modified residue7421Phosphoserine Ref.4
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation4201N-linked (GlcNAc...) Potential
Glycosylation4711N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 110 Potential
Disulfide bond152 ↔ 220 Potential
Disulfide bond257 ↔ 324 Potential
Disulfide bond370 ↔ 440 Potential
Disulfide bond484 ↔ 546 Potential

Experimental info

Sequence conflict1591A → V in AAA67440. Ref.1
Sequence conflict3961V → A in AAA67440. Ref.1
Sequence conflict6201G → R in AAA67440. Ref.1

Secondary structure

............................................... 771
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O70570 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 78C81302EC710730

FASTA77184,999
        10         20         30         40         50         60 
MRLYLFTLLV TVFSGVSTKS PIFGPQEVSS IEGDSVSITC YYPDTSVNRH TRKYWCRQGA 

        70         80         90        100        110        120 
SGMCTTLISS NGYLSKEYSG RANLINFPEN NTFVINIEQL TQDDTGSYKC GLGTSNRGLS 

       130        140        150        160        170        180 
FDVSLEVSQV PELPSDTHVY TKDIGRNVTI ECPFKRENAP SKKSLCKKTN QSCELVIDST 

       190        200        210        220        230        240 
EKVNPSYIGR AKLFMKGTDL TVFYVNISHL THNDAGLYIC QAGEGPSADK KNVDLQVLAP 

       250        260        270        280        290        300 
EPELLYKDLR SSVTFECDLG REVANEAKYL CRMNKETCDV IINTLGKRDP DFEGRILITP 

       310        320        330        340        350        360 
KDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPIQT WQLFVNEEST IPNRRSVVKG 

       370        380        390        400        410        420 
VTGGSVAIAC PYNPKESSSL KYWCRWEGDG NGHCPVLVGT QAQVQEEYEG RLALFDQPGN 

       430        440        450        460        470        480 
GTYTVILNQL TTEDAGFYWC LTNGDSRWRT TIELQVAEAT REPNLEVTPQ NATAVLGETF 

       490        500        510        520        530        540 
TVSCHYPCKF YSQEKYWCKW SNKGCHILPS HDEGARQSSV SCDQSSQLVS MTLNPVSKED 

       550        560        570        580        590        600 
EGWYWCGVKQ GQTYGETTAI YIAVEERTRG SSHVNPTDAN ARAKVALEEE VVDSSISEKE 

       610        620        630        640        650        660 
NKAIPNPGPF ANEREIQNVG DQAQENRASG DAGSADGQSR SSSSKVLFST LVPLGLVLAV 

       670        680        690        700        710        720 
GAIAVWVARV RHRKNVDRMS ISSYRTDISM ADFKNSRDLG GNDNMGASPD TQQTVIEGKD 

       730        740        750        760        770 
EIVTTTECTA EPEESKKAKR SSKEEADMAY SAFLLQSSTI AAQVHDGPQE A 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species."
Piskurich J.F., Blanchard M.H., Youngman K.R., France J.A., Kaetzel C.S.
J. Immunol. 154:1735-1747(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
[2]"Genomic cloning and structural analysis of the murine polymeric receptor (pIgR) gene and promoter region."
Martin M.G., Gutierrez E.M., Lam J.T., Li T.W.H., Wang J.
Gene 201:189-197(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice."
de Groot N., van Kuik-Romeijn P., Lee S.H., de Boer H.A.
Transgenic Res. 8:125-135(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129.
Tissue: Liver.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689 AND SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06431 mRNA. Translation: AAA67440.1.
U83434 expand/collapse EMBL AC list , U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA. Translation: AAC53585.1.
Y16524 expand/collapse EMBL AC list , Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA. Translation: CAA76272.1.
CCDSCCDS15260.1.
RefSeqNP_035212.2. NM_011082.3.
UniGeneMm.276414.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4NOBX-ray1.51A20-133[»]
4NOFX-ray1.65A/B133-245[»]
ProteinModelPortalO70570.
SMRO70570. Positions 20-241, 247-326, 358-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202157. 1 interaction.
MINTMINT-1865977.
STRING10090.ENSMUSP00000027675.

PTM databases

PhosphoSiteO70570.

Proteomic databases

MaxQBO70570.
PaxDbO70570.
PRIDEO70570.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417.
GeneID18703.
KEGGmmu:18703.
UCSCuc011wrk.1. mouse.

Organism-specific databases

CTD5284.
MGIMGI:103080. Pigr.

Phylogenomic databases

eggNOGNOG46873.
GeneTreeENSGT00530000063436.
HOGENOMHOG000115545.
HOVERGENHBG008199.
InParanoidO70570.
KOK13073.
OMAYWCGVKQ.
OrthoDBEOG7PCJG8.
PhylomeDBO70570.
TreeFamTF334441.

Gene expression databases

ArrayExpressO70570.
BgeeO70570.
CleanExMM_PIGR.
GenevestigatorO70570.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 5 hits.
[Graphical view]
SMARTSM00409. IG. 5 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPIGR. mouse.
NextBio294755.
PROO70570.
SOURCESearch...

Entry information

Entry namePIGR_MOUSE
AccessionPrimary (citable) accession number: O70570
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot