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O70570

- PIGR_MOUSE

UniProt

O70570 - PIGR_MOUSE

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Protein

Polymeric immunoglobulin receptor

Gene

Pigr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment By similarity.By similarity

GO - Molecular functioni

  1. polymeric immunoglobulin receptor activity Source: Ensembl

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: Ensembl
  2. epidermal growth factor receptor signaling pathway Source: Ensembl
  3. immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Source: Ensembl
  4. receptor clustering Source: Ensembl
  5. retina homeostasis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Cleaved into the following chain:
Gene namesi
Name:Pigr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:103080. Pigr.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 771753Polymeric immunoglobulin receptorPRO_0000014902Add
BLAST
Chaini19 – 611593Secretory componentPRO_0000014903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi257 ↔ 324PROSITE-ProRule annotation
Disulfide bondi370 ↔ 440PROSITE-ProRule annotation
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi484 ↔ 546PROSITE-ProRule annotation
Modified residuei689 – 6891Phosphoserine1 Publication
Modified residuei742 – 7421Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO70570.
PaxDbiO70570.
PRIDEiO70570.

PTM databases

PhosphoSiteiO70570.

Expressioni

Gene expression databases

BgeeiO70570.
CleanExiMM_PIGR.
ExpressionAtlasiO70570. baseline and differential.
GenevestigatoriO70570.

Interactioni

Protein-protein interaction databases

BioGridi202157. 1 interaction.
MINTiMINT-1865977.
STRINGi10090.ENSMUSP00000027675.

Structurei

Secondary structure

1
771
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316
Beta strandi36 – 416
Helixi46 – 505
Beta strandi53 – 586
Beta strandi64 – 696
Turni70 – 723
Helixi76 – 783
Turni79 – 813
Beta strandi82 – 876
Helixi88 – 903
Beta strandi92 – 976
Helixi102 – 1043
Beta strandi106 – 1127
Beta strandi119 – 12810
Beta strandi138 – 1436
Beta strandi148 – 1536
Helixi156 – 1583
Beta strandi163 – 1686
Beta strandi173 – 1786
Turni185 – 1906
Beta strandi191 – 1944
Beta strandi202 – 2076
Helixi212 – 2143
Beta strandi216 – 2249
Helixi225 – 2273
Beta strandi229 – 23810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NOBX-ray1.51A20-133[»]
4NOFX-ray1.65A/B133-245[»]
ProteinModelPortaliO70570.
SMRiO70570. Positions 20-241, 247-326, 358-447.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 645627ExtracellularSequence AnalysisAdd
BLAST
Topological domaini669 – 771103CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei646 – 66823HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 120100Ig-like V-type 1Add
BLAST
Domaini135 – 237103Ig-like V-type 2Add
BLAST
Domaini245 – 351107Ig-like V-type 3Add
BLAST
Domaini352 – 457106Ig-like V-type 4Add
BLAST
Domaini463 – 563101Ig-like V-type 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46873.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiO70570.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG7PCJG8.
PhylomeDBiO70570.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70570-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLYLFTLLV TVFSGVSTKS PIFGPQEVSS IEGDSVSITC YYPDTSVNRH
60 70 80 90 100
TRKYWCRQGA SGMCTTLISS NGYLSKEYSG RANLINFPEN NTFVINIEQL
110 120 130 140 150
TQDDTGSYKC GLGTSNRGLS FDVSLEVSQV PELPSDTHVY TKDIGRNVTI
160 170 180 190 200
ECPFKRENAP SKKSLCKKTN QSCELVIDST EKVNPSYIGR AKLFMKGTDL
210 220 230 240 250
TVFYVNISHL THNDAGLYIC QAGEGPSADK KNVDLQVLAP EPELLYKDLR
260 270 280 290 300
SSVTFECDLG REVANEAKYL CRMNKETCDV IINTLGKRDP DFEGRILITP
310 320 330 340 350
KDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPIQT WQLFVNEEST
360 370 380 390 400
IPNRRSVVKG VTGGSVAIAC PYNPKESSSL KYWCRWEGDG NGHCPVLVGT
410 420 430 440 450
QAQVQEEYEG RLALFDQPGN GTYTVILNQL TTEDAGFYWC LTNGDSRWRT
460 470 480 490 500
TIELQVAEAT REPNLEVTPQ NATAVLGETF TVSCHYPCKF YSQEKYWCKW
510 520 530 540 550
SNKGCHILPS HDEGARQSSV SCDQSSQLVS MTLNPVSKED EGWYWCGVKQ
560 570 580 590 600
GQTYGETTAI YIAVEERTRG SSHVNPTDAN ARAKVALEEE VVDSSISEKE
610 620 630 640 650
NKAIPNPGPF ANEREIQNVG DQAQENRASG DAGSADGQSR SSSSKVLFST
660 670 680 690 700
LVPLGLVLAV GAIAVWVARV RHRKNVDRMS ISSYRTDISM ADFKNSRDLG
710 720 730 740 750
GNDNMGASPD TQQTVIEGKD EIVTTTECTA EPEESKKAKR SSKEEADMAY
760 770
SAFLLQSSTI AAQVHDGPQE A
Length:771
Mass (Da):84,999
Last modified:August 1, 1998 - v1
Checksum:i78C81302EC710730
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591A → V in AAA67440. (PubMed:7836758)Curated
Sequence conflicti396 – 3961V → A in AAA67440. (PubMed:7836758)Curated
Sequence conflicti620 – 6201G → R in AAA67440. (PubMed:7836758)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06431 mRNA. Translation: AAA67440.1.
U83434
, U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA. Translation: AAC53585.1.
Y16524
, Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA. Translation: CAA76272.1.
CCDSiCCDS15260.1.
RefSeqiNP_035212.2. NM_011082.3.
UniGeneiMm.276414.

Genome annotation databases

EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417.
GeneIDi18703.
KEGGimmu:18703.
UCSCiuc011wrk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06431 mRNA. Translation: AAA67440.1 .
U83434
, U83427 , U83428 , U83429 , U83430 , U83431 , U83432 , U83433 Genomic DNA. Translation: AAC53585.1 .
Y16524
, Y16525 , Y16526 , Y16527 , Y16528 , Y16529 , Y16530 , Y16531 , Y16532 Genomic DNA. Translation: CAA76272.1 .
CCDSi CCDS15260.1.
RefSeqi NP_035212.2. NM_011082.3.
UniGenei Mm.276414.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4NOB X-ray 1.51 A 20-133 [» ]
4NOF X-ray 1.65 A/B 133-245 [» ]
ProteinModelPortali O70570.
SMRi O70570. Positions 20-241, 247-326, 358-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202157. 1 interaction.
MINTi MINT-1865977.
STRINGi 10090.ENSMUSP00000027675.

PTM databases

PhosphoSitei O70570.

Proteomic databases

MaxQBi O70570.
PaxDbi O70570.
PRIDEi O70570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027675 ; ENSMUSP00000027675 ; ENSMUSG00000026417 .
GeneIDi 18703.
KEGGi mmu:18703.
UCSCi uc011wrk.1. mouse.

Organism-specific databases

CTDi 5284.
MGIi MGI:103080. Pigr.

Phylogenomic databases

eggNOGi NOG46873.
GeneTreei ENSGT00530000063436.
HOGENOMi HOG000115545.
HOVERGENi HBG008199.
InParanoidi O70570.
KOi K13073.
OMAi YWCGVKQ.
OrthoDBi EOG7PCJG8.
PhylomeDBi O70570.
TreeFami TF334441.

Miscellaneous databases

ChiTaRSi PIGR. mouse.
NextBioi 294755.
PROi O70570.
SOURCEi Search...

Gene expression databases

Bgeei O70570.
CleanExi MM_PIGR.
ExpressionAtlasi O70570. baseline and differential.
Genevestigatori O70570.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 5 hits.
[Graphical view ]
SMARTi SM00409. IG. 5 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species."
    Piskurich J.F., Blanchard M.H., Youngman K.R., France J.A., Kaetzel C.S.
    J. Immunol. 154:1735-1747(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "Genomic cloning and structural analysis of the murine polymeric receptor (pIgR) gene and promoter region."
    Martin M.G., Gutierrez E.M., Lam J.T., Li T.W.H., Wang J.
    Gene 201:189-197(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice."
    de Groot N., van Kuik-Romeijn P., Lee S.H., de Boer H.A.
    Transgenic Res. 8:125-135(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129.
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689 AND SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPIGR_MOUSE
AccessioniPrimary (citable) accession number: O70570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3