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O70570

- PIGR_MOUSE

UniProt

O70570 - PIGR_MOUSE

Protein

Polymeric immunoglobulin receptor

Gene

Pigr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polymeric immunoglobulin receptor
    Short name:
    PIgR
    Short name:
    Poly-Ig receptor
    Cleaved into the following chain:
    Gene namesi
    Name:Pigr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:103080. Pigr.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell
    4. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 771753Polymeric immunoglobulin receptorPRO_0000014902Add
    BLAST
    Chaini19 – 611593Secretory componentPRO_0000014903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 220PROSITE-ProRule annotation
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi257 ↔ 324PROSITE-ProRule annotation
    Disulfide bondi370 ↔ 440PROSITE-ProRule annotation
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi484 ↔ 546PROSITE-ProRule annotation
    Modified residuei689 – 6891Phosphoserine1 Publication
    Modified residuei742 – 7421Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO70570.
    PaxDbiO70570.
    PRIDEiO70570.

    PTM databases

    PhosphoSiteiO70570.

    Expressioni

    Gene expression databases

    ArrayExpressiO70570.
    BgeeiO70570.
    CleanExiMM_PIGR.
    GenevestigatoriO70570.

    Interactioni

    Protein-protein interaction databases

    BioGridi202157. 1 interaction.
    MINTiMINT-1865977.
    STRINGi10090.ENSMUSP00000027675.

    Structurei

    Secondary structure

    1
    771
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 316
    Beta strandi36 – 416
    Helixi46 – 505
    Beta strandi53 – 586
    Beta strandi64 – 696
    Turni70 – 723
    Helixi76 – 783
    Turni79 – 813
    Beta strandi82 – 876
    Helixi88 – 903
    Beta strandi92 – 976
    Helixi102 – 1043
    Beta strandi106 – 1127
    Beta strandi119 – 12810
    Beta strandi138 – 1436
    Beta strandi148 – 1536
    Helixi156 – 1583
    Beta strandi163 – 1686
    Beta strandi173 – 1786
    Turni185 – 1906
    Beta strandi191 – 1944
    Beta strandi202 – 2076
    Helixi212 – 2143
    Beta strandi216 – 2249
    Helixi225 – 2273
    Beta strandi229 – 23810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4NOBX-ray1.51A20-133[»]
    4NOFX-ray1.65A/B133-245[»]
    ProteinModelPortaliO70570.
    SMRiO70570. Positions 20-241, 247-326, 358-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 645627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini669 – 771103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei646 – 66823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 120100Ig-like V-type 1Add
    BLAST
    Domaini135 – 237103Ig-like V-type 2Add
    BLAST
    Domaini245 – 351107Ig-like V-type 3Add
    BLAST
    Domaini352 – 457106Ig-like V-type 4Add
    BLAST
    Domaini463 – 563101Ig-like V-type 5Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46873.
    GeneTreeiENSGT00530000063436.
    HOGENOMiHOG000115545.
    HOVERGENiHBG008199.
    InParanoidiO70570.
    KOiK13073.
    OMAiYWCGVKQ.
    OrthoDBiEOG7PCJG8.
    PhylomeDBiO70570.
    TreeFamiTF334441.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 5 hits.
    [Graphical view]
    SMARTiSM00409. IG. 5 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70570-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLYLFTLLV TVFSGVSTKS PIFGPQEVSS IEGDSVSITC YYPDTSVNRH    50
    TRKYWCRQGA SGMCTTLISS NGYLSKEYSG RANLINFPEN NTFVINIEQL 100
    TQDDTGSYKC GLGTSNRGLS FDVSLEVSQV PELPSDTHVY TKDIGRNVTI 150
    ECPFKRENAP SKKSLCKKTN QSCELVIDST EKVNPSYIGR AKLFMKGTDL 200
    TVFYVNISHL THNDAGLYIC QAGEGPSADK KNVDLQVLAP EPELLYKDLR 250
    SSVTFECDLG REVANEAKYL CRMNKETCDV IINTLGKRDP DFEGRILITP 300
    KDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPIQT WQLFVNEEST 350
    IPNRRSVVKG VTGGSVAIAC PYNPKESSSL KYWCRWEGDG NGHCPVLVGT 400
    QAQVQEEYEG RLALFDQPGN GTYTVILNQL TTEDAGFYWC LTNGDSRWRT 450
    TIELQVAEAT REPNLEVTPQ NATAVLGETF TVSCHYPCKF YSQEKYWCKW 500
    SNKGCHILPS HDEGARQSSV SCDQSSQLVS MTLNPVSKED EGWYWCGVKQ 550
    GQTYGETTAI YIAVEERTRG SSHVNPTDAN ARAKVALEEE VVDSSISEKE 600
    NKAIPNPGPF ANEREIQNVG DQAQENRASG DAGSADGQSR SSSSKVLFST 650
    LVPLGLVLAV GAIAVWVARV RHRKNVDRMS ISSYRTDISM ADFKNSRDLG 700
    GNDNMGASPD TQQTVIEGKD EIVTTTECTA EPEESKKAKR SSKEEADMAY 750
    SAFLLQSSTI AAQVHDGPQE A 771
    Length:771
    Mass (Da):84,999
    Last modified:August 1, 1998 - v1
    Checksum:i78C81302EC710730
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591A → V in AAA67440. (PubMed:7836758)Curated
    Sequence conflicti396 – 3961V → A in AAA67440. (PubMed:7836758)Curated
    Sequence conflicti620 – 6201G → R in AAA67440. (PubMed:7836758)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06431 mRNA. Translation: AAA67440.1.
    U83434
    , U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA. Translation: AAC53585.1.
    Y16524
    , Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA. Translation: CAA76272.1.
    CCDSiCCDS15260.1.
    RefSeqiNP_035212.2. NM_011082.3.
    UniGeneiMm.276414.

    Genome annotation databases

    EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417.
    GeneIDi18703.
    KEGGimmu:18703.
    UCSCiuc011wrk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06431 mRNA. Translation: AAA67440.1 .
    U83434
    , U83427 , U83428 , U83429 , U83430 , U83431 , U83432 , U83433 Genomic DNA. Translation: AAC53585.1 .
    Y16524
    , Y16525 , Y16526 , Y16527 , Y16528 , Y16529 , Y16530 , Y16531 , Y16532 Genomic DNA. Translation: CAA76272.1 .
    CCDSi CCDS15260.1.
    RefSeqi NP_035212.2. NM_011082.3.
    UniGenei Mm.276414.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4NOB X-ray 1.51 A 20-133 [» ]
    4NOF X-ray 1.65 A/B 133-245 [» ]
    ProteinModelPortali O70570.
    SMRi O70570. Positions 20-241, 247-326, 358-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202157. 1 interaction.
    MINTi MINT-1865977.
    STRINGi 10090.ENSMUSP00000027675.

    PTM databases

    PhosphoSitei O70570.

    Proteomic databases

    MaxQBi O70570.
    PaxDbi O70570.
    PRIDEi O70570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027675 ; ENSMUSP00000027675 ; ENSMUSG00000026417 .
    GeneIDi 18703.
    KEGGi mmu:18703.
    UCSCi uc011wrk.1. mouse.

    Organism-specific databases

    CTDi 5284.
    MGIi MGI:103080. Pigr.

    Phylogenomic databases

    eggNOGi NOG46873.
    GeneTreei ENSGT00530000063436.
    HOGENOMi HOG000115545.
    HOVERGENi HBG008199.
    InParanoidi O70570.
    KOi K13073.
    OMAi YWCGVKQ.
    OrthoDBi EOG7PCJG8.
    PhylomeDBi O70570.
    TreeFami TF334441.

    Miscellaneous databases

    ChiTaRSi PIGR. mouse.
    NextBioi 294755.
    PROi O70570.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70570.
    Bgeei O70570.
    CleanExi MM_PIGR.
    Genevestigatori O70570.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 5 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 5 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species."
      Piskurich J.F., Blanchard M.H., Youngman K.R., France J.A., Kaetzel C.S.
      J. Immunol. 154:1735-1747(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "Genomic cloning and structural analysis of the murine polymeric receptor (pIgR) gene and promoter region."
      Martin M.G., Gutierrez E.M., Lam J.T., Li T.W.H., Wang J.
      Gene 201:189-197(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice."
      de Groot N., van Kuik-Romeijn P., Lee S.H., de Boer H.A.
      Transgenic Res. 8:125-135(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129.
      Tissue: Liver.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689 AND SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiPIGR_MOUSE
    AccessioniPrimary (citable) accession number: O70570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3