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Protein

Polymeric immunoglobulin receptor

Gene

Pigr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).By similarity

GO - Molecular functioni

  1. polymeric immunoglobulin receptor activity Source: MGI

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of bitter taste Source: MGI
  2. epidermal growth factor receptor signaling pathway Source: MGI
  3. Fc receptor signaling pathway Source: MGI
  4. immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Source: MGI
  5. receptor clustering Source: MGI
  6. retina homeostasis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Cleaved into the following chain:
Gene namesi
Name:Pigr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:103080. Pigr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 645627ExtracellularSequence AnalysisAdd
BLAST
Transmembranei646 – 66823HelicalSequence AnalysisAdd
BLAST
Topological domaini669 – 771103CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
  5. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 771753Polymeric immunoglobulin receptorPRO_0000014902Add
BLAST
Chaini19 – 611593Secretory componentPRO_0000014903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi257 ↔ 324PROSITE-ProRule annotation
Disulfide bondi370 ↔ 440PROSITE-ProRule annotation
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi484 ↔ 546PROSITE-ProRule annotation
Modified residuei689 – 6891Phosphoserine1 Publication
Modified residuei742 – 7421Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO70570.
PaxDbiO70570.
PRIDEiO70570.

PTM databases

PhosphoSiteiO70570.

Expressioni

Gene expression databases

BgeeiO70570.
CleanExiMM_PIGR.
ExpressionAtlasiO70570. baseline and differential.
GenevestigatoriO70570.

Interactioni

Protein-protein interaction databases

BioGridi202157. 1 interaction.
MINTiMINT-1865977.
STRINGi10090.ENSMUSP00000027675.

Structurei

Secondary structure

1
771
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Beta strandi36 – 416Combined sources
Helixi46 – 505Combined sources
Beta strandi53 – 586Combined sources
Beta strandi64 – 696Combined sources
Turni70 – 723Combined sources
Helixi76 – 783Combined sources
Turni79 – 813Combined sources
Beta strandi82 – 876Combined sources
Helixi88 – 903Combined sources
Beta strandi92 – 976Combined sources
Helixi102 – 1043Combined sources
Beta strandi106 – 1127Combined sources
Beta strandi119 – 12810Combined sources
Beta strandi138 – 1436Combined sources
Beta strandi148 – 1536Combined sources
Helixi156 – 1583Combined sources
Beta strandi163 – 1686Combined sources
Beta strandi173 – 1786Combined sources
Turni185 – 1906Combined sources
Beta strandi191 – 1944Combined sources
Beta strandi202 – 2076Combined sources
Helixi212 – 2143Combined sources
Beta strandi216 – 2249Combined sources
Helixi225 – 2273Combined sources
Beta strandi229 – 23810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NOBX-ray1.51A20-133[»]
4NOFX-ray1.65A/B133-245[»]
ProteinModelPortaliO70570.
SMRiO70570. Positions 20-241, 247-326, 358-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 120100Ig-like V-type 1Add
BLAST
Domaini135 – 237103Ig-like V-type 2Add
BLAST
Domaini245 – 351107Ig-like V-type 3Add
BLAST
Domaini352 – 457106Ig-like V-type 4Add
BLAST
Domaini463 – 563101Ig-like V-type 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46873.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiO70570.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG7PCJG8.
PhylomeDBiO70570.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70570-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLYLFTLLV TVFSGVSTKS PIFGPQEVSS IEGDSVSITC YYPDTSVNRH
60 70 80 90 100
TRKYWCRQGA SGMCTTLISS NGYLSKEYSG RANLINFPEN NTFVINIEQL
110 120 130 140 150
TQDDTGSYKC GLGTSNRGLS FDVSLEVSQV PELPSDTHVY TKDIGRNVTI
160 170 180 190 200
ECPFKRENAP SKKSLCKKTN QSCELVIDST EKVNPSYIGR AKLFMKGTDL
210 220 230 240 250
TVFYVNISHL THNDAGLYIC QAGEGPSADK KNVDLQVLAP EPELLYKDLR
260 270 280 290 300
SSVTFECDLG REVANEAKYL CRMNKETCDV IINTLGKRDP DFEGRILITP
310 320 330 340 350
KDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPIQT WQLFVNEEST
360 370 380 390 400
IPNRRSVVKG VTGGSVAIAC PYNPKESSSL KYWCRWEGDG NGHCPVLVGT
410 420 430 440 450
QAQVQEEYEG RLALFDQPGN GTYTVILNQL TTEDAGFYWC LTNGDSRWRT
460 470 480 490 500
TIELQVAEAT REPNLEVTPQ NATAVLGETF TVSCHYPCKF YSQEKYWCKW
510 520 530 540 550
SNKGCHILPS HDEGARQSSV SCDQSSQLVS MTLNPVSKED EGWYWCGVKQ
560 570 580 590 600
GQTYGETTAI YIAVEERTRG SSHVNPTDAN ARAKVALEEE VVDSSISEKE
610 620 630 640 650
NKAIPNPGPF ANEREIQNVG DQAQENRASG DAGSADGQSR SSSSKVLFST
660 670 680 690 700
LVPLGLVLAV GAIAVWVARV RHRKNVDRMS ISSYRTDISM ADFKNSRDLG
710 720 730 740 750
GNDNMGASPD TQQTVIEGKD EIVTTTECTA EPEESKKAKR SSKEEADMAY
760 770
SAFLLQSSTI AAQVHDGPQE A
Length:771
Mass (Da):84,999
Last modified:August 1, 1998 - v1
Checksum:i78C81302EC710730
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591A → V in AAA67440. (PubMed:7836758)Curated
Sequence conflicti396 – 3961V → A in AAA67440. (PubMed:7836758)Curated
Sequence conflicti620 – 6201G → R in AAA67440. (PubMed:7836758)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06431 mRNA. Translation: AAA67440.1.
U83434
, U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA. Translation: AAC53585.1.
Y16524
, Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA. Translation: CAA76272.1.
CCDSiCCDS15260.1.
RefSeqiNP_035212.2. NM_011082.3.
UniGeneiMm.276414.

Genome annotation databases

EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417.
GeneIDi18703.
KEGGimmu:18703.
UCSCiuc011wrk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06431 mRNA. Translation: AAA67440.1.
U83434
, U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA. Translation: AAC53585.1.
Y16524
, Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA. Translation: CAA76272.1.
CCDSiCCDS15260.1.
RefSeqiNP_035212.2. NM_011082.3.
UniGeneiMm.276414.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NOBX-ray1.51A20-133[»]
4NOFX-ray1.65A/B133-245[»]
ProteinModelPortaliO70570.
SMRiO70570. Positions 20-241, 247-326, 358-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202157. 1 interaction.
MINTiMINT-1865977.
STRINGi10090.ENSMUSP00000027675.

PTM databases

PhosphoSiteiO70570.

Proteomic databases

MaxQBiO70570.
PaxDbiO70570.
PRIDEiO70570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417.
GeneIDi18703.
KEGGimmu:18703.
UCSCiuc011wrk.1. mouse.

Organism-specific databases

CTDi5284.
MGIiMGI:103080. Pigr.

Phylogenomic databases

eggNOGiNOG46873.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiO70570.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG7PCJG8.
PhylomeDBiO70570.
TreeFamiTF334441.

Miscellaneous databases

ChiTaRSiPigr. mouse.
NextBioi294755.
PROiO70570.
SOURCEiSearch...

Gene expression databases

BgeeiO70570.
CleanExiMM_PIGR.
ExpressionAtlasiO70570. baseline and differential.
GenevestigatoriO70570.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species."
    Piskurich J.F., Blanchard M.H., Youngman K.R., France J.A., Kaetzel C.S.
    J. Immunol. 154:1735-1747(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "Genomic cloning and structural analysis of the murine polymeric receptor (pIgR) gene and promoter region."
    Martin M.G., Gutierrez E.M., Lam J.T., Li T.W.H., Wang J.
    Gene 201:189-197(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice."
    de Groot N., van Kuik-Romeijn P., Lee S.H., de Boer H.A.
    Transgenic Res. 8:125-135(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129.
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689 AND SER-742, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPIGR_MOUSE
AccessioniPrimary (citable) accession number: O70570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 4, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.