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Protein

Polymeric immunoglobulin receptor

Gene

Pigr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Cleaved into the following chain:
Gene namesi
Name:Pigr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103080. Pigr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 645ExtracellularSequence analysisAdd BLAST627
Transmembranei646 – 668HelicalSequence analysisAdd BLAST23
Topological domaini669 – 771CytoplasmicSequence analysisAdd BLAST103

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001490219 – 771Polymeric immunoglobulin receptorAdd BLAST753
ChainiPRO_000001490319 – 611Secretory componentAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation
Glycosylationi170N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi257 ↔ 324PROSITE-ProRule annotation
Disulfide bondi370 ↔ 440PROSITE-ProRule annotation
Glycosylationi420N-linked (GlcNAc...)Sequence analysis1
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi484 ↔ 546PROSITE-ProRule annotation
Modified residuei680PhosphoserineBy similarity1
Modified residuei689PhosphoserineCombined sources1
Modified residuei696PhosphoserineBy similarity1
Modified residuei742PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO70570.
PaxDbiO70570.
PeptideAtlasiO70570.
PRIDEiO70570.

PTM databases

iPTMnetiO70570.
PhosphoSitePlusiO70570.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026417.
CleanExiMM_PIGR.
ExpressionAtlasiO70570. baseline and differential.
GenevisibleiO70570. MM.

Interactioni

Protein-protein interaction databases

BioGridi202157. 1 interactor.
MINTiMINT-1865977.
STRINGi10090.ENSMUSP00000027675.

Structurei

Secondary structure

1771
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 31Combined sources6
Beta strandi36 – 41Combined sources6
Helixi46 – 50Combined sources5
Beta strandi53 – 58Combined sources6
Beta strandi64 – 69Combined sources6
Turni70 – 72Combined sources3
Helixi76 – 78Combined sources3
Turni79 – 81Combined sources3
Beta strandi82 – 87Combined sources6
Helixi88 – 90Combined sources3
Beta strandi92 – 97Combined sources6
Helixi102 – 104Combined sources3
Beta strandi106 – 112Combined sources7
Beta strandi119 – 128Combined sources10
Beta strandi138 – 143Combined sources6
Beta strandi148 – 153Combined sources6
Helixi156 – 158Combined sources3
Beta strandi163 – 168Combined sources6
Beta strandi173 – 178Combined sources6
Turni185 – 190Combined sources6
Beta strandi191 – 194Combined sources4
Beta strandi202 – 207Combined sources6
Helixi212 – 214Combined sources3
Beta strandi216 – 224Combined sources9
Helixi225 – 227Combined sources3
Beta strandi229 – 238Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NOBX-ray1.51A20-133[»]
4NOFX-ray1.65A/B133-245[»]
ProteinModelPortaliO70570.
SMRiO70570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 120Ig-like V-type 1Add BLAST100
Domaini135 – 237Ig-like V-type 2Add BLAST103
Domaini245 – 351Ig-like V-type 3Add BLAST107
Domaini352 – 457Ig-like V-type 4Add BLAST106
Domaini463 – 563Ig-like V-type 5Add BLAST101

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiO70570.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG091G03V3.
PhylomeDBiO70570.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLYLFTLLV TVFSGVSTKS PIFGPQEVSS IEGDSVSITC YYPDTSVNRH
60 70 80 90 100
TRKYWCRQGA SGMCTTLISS NGYLSKEYSG RANLINFPEN NTFVINIEQL
110 120 130 140 150
TQDDTGSYKC GLGTSNRGLS FDVSLEVSQV PELPSDTHVY TKDIGRNVTI
160 170 180 190 200
ECPFKRENAP SKKSLCKKTN QSCELVIDST EKVNPSYIGR AKLFMKGTDL
210 220 230 240 250
TVFYVNISHL THNDAGLYIC QAGEGPSADK KNVDLQVLAP EPELLYKDLR
260 270 280 290 300
SSVTFECDLG REVANEAKYL CRMNKETCDV IINTLGKRDP DFEGRILITP
310 320 330 340 350
KDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPIQT WQLFVNEEST
360 370 380 390 400
IPNRRSVVKG VTGGSVAIAC PYNPKESSSL KYWCRWEGDG NGHCPVLVGT
410 420 430 440 450
QAQVQEEYEG RLALFDQPGN GTYTVILNQL TTEDAGFYWC LTNGDSRWRT
460 470 480 490 500
TIELQVAEAT REPNLEVTPQ NATAVLGETF TVSCHYPCKF YSQEKYWCKW
510 520 530 540 550
SNKGCHILPS HDEGARQSSV SCDQSSQLVS MTLNPVSKED EGWYWCGVKQ
560 570 580 590 600
GQTYGETTAI YIAVEERTRG SSHVNPTDAN ARAKVALEEE VVDSSISEKE
610 620 630 640 650
NKAIPNPGPF ANEREIQNVG DQAQENRASG DAGSADGQSR SSSSKVLFST
660 670 680 690 700
LVPLGLVLAV GAIAVWVARV RHRKNVDRMS ISSYRTDISM ADFKNSRDLG
710 720 730 740 750
GNDNMGASPD TQQTVIEGKD EIVTTTECTA EPEESKKAKR SSKEEADMAY
760 770
SAFLLQSSTI AAQVHDGPQE A
Length:771
Mass (Da):84,999
Last modified:August 1, 1998 - v1
Checksum:i78C81302EC710730
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159A → V in AAA67440 (PubMed:7836758).Curated1
Sequence conflicti396V → A in AAA67440 (PubMed:7836758).Curated1
Sequence conflicti620G → R in AAA67440 (PubMed:7836758).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06431 mRNA. Translation: AAA67440.1.
U83434
, U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA. Translation: AAC53585.1.
Y16524
, Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA. Translation: CAA76272.1.
CCDSiCCDS15260.1.
RefSeqiNP_035212.2. NM_011082.3.
UniGeneiMm.276414.

Genome annotation databases

EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417.
GeneIDi18703.
KEGGimmu:18703.
UCSCiuc011wrk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06431 mRNA. Translation: AAA67440.1.
U83434
, U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA. Translation: AAC53585.1.
Y16524
, Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA. Translation: CAA76272.1.
CCDSiCCDS15260.1.
RefSeqiNP_035212.2. NM_011082.3.
UniGeneiMm.276414.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NOBX-ray1.51A20-133[»]
4NOFX-ray1.65A/B133-245[»]
ProteinModelPortaliO70570.
SMRiO70570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202157. 1 interactor.
MINTiMINT-1865977.
STRINGi10090.ENSMUSP00000027675.

PTM databases

iPTMnetiO70570.
PhosphoSitePlusiO70570.

Proteomic databases

MaxQBiO70570.
PaxDbiO70570.
PeptideAtlasiO70570.
PRIDEiO70570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417.
GeneIDi18703.
KEGGimmu:18703.
UCSCiuc011wrk.1. mouse.

Organism-specific databases

CTDi5284.
MGIiMGI:103080. Pigr.

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
GeneTreeiENSGT00530000063436.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiO70570.
KOiK13073.
OMAiYWCGVKQ.
OrthoDBiEOG091G03V3.
PhylomeDBiO70570.
TreeFamiTF334441.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiPigr. mouse.
PROiO70570.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026417.
CleanExiMM_PIGR.
ExpressionAtlasiO70570. baseline and differential.
GenevisibleiO70570. MM.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGR_MOUSE
AccessioniPrimary (citable) accession number: O70570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.