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Protein

Small proline-rich protein 2I

Gene

Sprr2i

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).By similarity

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2I
Gene namesi
Name:Sprr2i
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1330309. Sprr2i.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Small proline-rich protein 2IPRO_0000150021Add
BLAST

Proteomic databases

PaxDbiO70560.
PRIDEiO70560.

Expressioni

Tissue specificityi

Not expressed in uterus.1 Publication

Gene expression databases

BgeeiO70560.
CleanExiMM_SPRR2I.
GenevisibleiO70560. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043513.

Structurei

3D structure databases

ProteinModelPortaliO70560.
SMRiO70560. Positions 5-72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati30 – 3892
Repeati39 – 4793

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 47273 X 9 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiCTEKCTP.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPP KKCPEPCPPP QCPEPCPPPK CPEPCPESCP
60 70
PPSYQQKCPP VQPPPPCQQK CPPKSK
Length:76
Mass (Da):8,356
Last modified:August 1, 1998 - v1
Checksum:i29B04A7E5D5C2856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005567 Genomic DNA. Translation: CAA06596.1.
AY158993 mRNA. Translation: AAN86830.1.
CCDSiCCDS38511.1.
RefSeqiNP_035605.1. NM_011475.3.
UniGeneiMm.196439.

Genome annotation databases

EnsembliENSMUST00000047264; ENSMUSP00000043513; ENSMUSG00000042157.
GeneIDi20763.
KEGGimmu:20763.
UCSCiuc008qdy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005567 Genomic DNA. Translation: CAA06596.1.
AY158993 mRNA. Translation: AAN86830.1.
CCDSiCCDS38511.1.
RefSeqiNP_035605.1. NM_011475.3.
UniGeneiMm.196439.

3D structure databases

ProteinModelPortaliO70560.
SMRiO70560. Positions 5-72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043513.

Proteomic databases

PaxDbiO70560.
PRIDEiO70560.

Protocols and materials databases

DNASUi20763.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047264; ENSMUSP00000043513; ENSMUSG00000042157.
GeneIDi20763.
KEGGimmu:20763.
UCSCiuc008qdy.1. mouse.

Organism-specific databases

CTDi20763.
MGIiMGI:1330309. Sprr2i.

Phylogenomic databases

OMAiCTEKCTP.

Miscellaneous databases

NextBioi299458.
PROiO70560.
SOURCEiSearch...

Gene expression databases

BgeeiO70560.
CleanExiMM_SPRR2I.
GenevisibleiO70560. MM.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues."
    Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M., Kartasova T.
    Genomics 55:28-42(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. Kartasova T.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Mouse Sprr locus: a tandem array of coordinately regulated genes."
    Patel S., Kartasova T., Segre J.A.
    Mamm. Genome 14:140-148(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  4. "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus."
    Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H., Kang B.M., Kim M.K.
    Mol. Cells 17:477-484(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSPR2I_MOUSE
AccessioniPrimary (citable) accession number: O70560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.