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Protein

Small proline-rich protein 2E

Gene

Sprr2e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: GO_Central
  • response to estradiol Source: MGI
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2E
Gene namesi
Name:Sprr2e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1330346. Sprr2e.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Small proline-rich protein 2EPRO_0000150017Add
BLAST

Proteomic databases

PaxDbiO70556.
PRIDEiO70556.

Expressioni

Tissue specificityi

Expressed in uterus.1 Publication

Developmental stagei

During early pregnancy, uterine expression is markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3 dpc onwards.1 Publication

Inductioni

Up-regulated by estrogen in the uterus of ovariectomized animals, with strongly increased expression detected in luminal epithelial cells at 6 and 12 hours after hormone injection.1 Publication

Gene expression databases

CleanExiMM_SPRR2E.

Structurei

3D structure databases

ProteinModelPortaliO70556.
SMRiO70556. Positions 3-73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati30 – 3892
Repeati39 – 4793

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 47273 X 9 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiPECPEPC.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPP KKCPEPCPHP QCPEPCPPPK CPEPCPEPCP
60 70
PPSYQQKCPP VQPPPPCQQK CPPKSK
Length:76
Mass (Da):8,406
Last modified:August 1, 1998 - v1
Checksum:iE2DDEEFE5E6C1B49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005563 Genomic DNA. Translation: CAA06592.1.
AY158989 mRNA. Translation: AAN86826.1.
CCDSiCCDS57225.1.
RefSeqiNP_035601.1. NM_011471.2.
UniGeneiMm.261596.

Genome annotation databases

EnsembliENSMUST00000068399; ENSMUSP00000064652; ENSMUSG00000055030.
GeneIDi20759.
KEGGimmu:20759.
UCSCiuc008qdt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005563 Genomic DNA. Translation: CAA06592.1.
AY158989 mRNA. Translation: AAN86826.1.
CCDSiCCDS57225.1.
RefSeqiNP_035601.1. NM_011471.2.
UniGeneiMm.261596.

3D structure databases

ProteinModelPortaliO70556.
SMRiO70556. Positions 3-73.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO70556.
PRIDEiO70556.

Protocols and materials databases

DNASUi20759.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068399; ENSMUSP00000064652; ENSMUSG00000055030.
GeneIDi20759.
KEGGimmu:20759.
UCSCiuc008qdt.1. mouse.

Organism-specific databases

CTDi6704.
MGIiMGI:1330346. Sprr2e.

Phylogenomic databases

OMAiPECPEPC.

Miscellaneous databases

PROiO70556.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SPRR2E.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues."
    Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M., Kartasova T.
    Genomics 55:28-42(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "Mouse Sprr locus: a tandem array of coordinately regulated genes."
    Patel S., Kartasova T., Segre J.A.
    Mamm. Genome 14:140-148(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus."
    Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H., Kang B.M., Kim M.K.
    Mol. Cells 17:477-484(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Entry informationi

Entry nameiSPR2E_MOUSE
AccessioniPrimary (citable) accession number: O70556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.