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Protein

Small proline-rich protein 2D

Gene

Sprr2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: UniProtKB
  • female gonad development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: GO_Central
  • response to estradiol Source: MGI
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2D
Gene namesi
Name:Sprr2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1330347. Sprr2d.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500161 – 85Small proline-rich protein 2DAdd BLAST85

Proteomic databases

PaxDbiO70555.
PRIDEiO70555.

PTM databases

PhosphoSitePlusiO70555.

Expressioni

Tissue specificityi

Expressed in uterus.1 Publication

Developmental stagei

During early pregnancy, uterine expression is markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3 dpc onwards.1 Publication

Inductioni

Up-regulated by estrogen in the uterus of ovariectomized animals, with strongly increased expression detected in luminal epithelial cells at 6 and 12 hours after hormone injection.1 Publication

Gene expression databases

BgeeiENSMUSG00000042212.
CleanExiMM_SPRR2D.
GenevisibleiO70555. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039821.

Structurei

3D structure databases

ProteinModelPortaliO70555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 2919
Repeati30 – 3829
Repeati39 – 4739
Repeati48 – 5649

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 564 X 9 AA approximate tandem repeatsAdd BLAST36

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00860000136350.
OMAiLKCPEPC.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPP KKCPEPCPPL KCPEPCPPPK CPEPCPPPKC
60 70 80
PEPCPEPCPP PSCQQKCPPA QPPPPCQQKC PPKSK
Length:85
Mass (Da):9,243
Last modified:August 1, 1998 - v1
Checksum:iA526EFF9428382A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005562 mRNA. Translation: CAA06591.1.
AY158988 mRNA. Translation: AAN86825.1.
AK008778 mRNA. Translation: BAC25232.1.
CCDSiCCDS38510.1.
RefSeqiNP_035600.1. NM_011470.2.
UniGeneiMm.87820.

Genome annotation databases

EnsembliENSMUST00000047477; ENSMUSP00000039821; ENSMUSG00000042212.
GeneIDi20758.
KEGGimmu:20758.
UCSCiuc008qds.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005562 mRNA. Translation: CAA06591.1.
AY158988 mRNA. Translation: AAN86825.1.
AK008778 mRNA. Translation: BAC25232.1.
CCDSiCCDS38510.1.
RefSeqiNP_035600.1. NM_011470.2.
UniGeneiMm.87820.

3D structure databases

ProteinModelPortaliO70555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039821.

PTM databases

PhosphoSitePlusiO70555.

Proteomic databases

PaxDbiO70555.
PRIDEiO70555.

Protocols and materials databases

DNASUi20758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047477; ENSMUSP00000039821; ENSMUSG00000042212.
GeneIDi20758.
KEGGimmu:20758.
UCSCiuc008qds.2. mouse.

Organism-specific databases

CTDi6703.
MGIiMGI:1330347. Sprr2d.

Phylogenomic databases

GeneTreeiENSGT00860000136350.
OMAiLKCPEPC.

Miscellaneous databases

ChiTaRSiSprr2d. mouse.
PROiO70555.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042212.
CleanExiMM_SPRR2D.
GenevisibleiO70555. MM.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPR2D_MOUSE
AccessioniPrimary (citable) accession number: O70555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.