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Protein

Small proline-rich protein 2D

Gene

Sprr2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: UniProtKB
  • female gonad development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: GO_Central
  • response to estradiol Source: MGI
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2D
Gene namesi
Name:Sprr2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1330347. Sprr2d.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Small proline-rich protein 2DPRO_0000150016Add
BLAST

Proteomic databases

PaxDbiO70555.
PRIDEiO70555.

Expressioni

Tissue specificityi

Expressed in uterus.1 Publication

Developmental stagei

During early pregnancy, uterine expression is markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3 dpc onwards.1 Publication

Inductioni

Up-regulated by estrogen in the uterus of ovariectomized animals, with strongly increased expression detected in luminal epithelial cells at 6 and 12 hours after hormone injection.1 Publication

Gene expression databases

BgeeiO70555.
CleanExiMM_SPRR2D.
GenevisibleiO70555. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039821.

Structurei

3D structure databases

ProteinModelPortaliO70555.
SMRiO70555. Positions 4-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati30 – 3892
Repeati39 – 4793
Repeati48 – 5694

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 56364 X 9 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiLKCPEPC.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPP KKCPEPCPPL KCPEPCPPPK CPEPCPPPKC
60 70 80
PEPCPEPCPP PSCQQKCPPA QPPPPCQQKC PPKSK
Length:85
Mass (Da):9,243
Last modified:August 1, 1998 - v1
Checksum:iA526EFF9428382A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005562 mRNA. Translation: CAA06591.1.
AY158988 mRNA. Translation: AAN86825.1.
AK008778 mRNA. Translation: BAC25232.1.
CCDSiCCDS38510.1.
RefSeqiNP_035600.1. NM_011470.2.
UniGeneiMm.87820.

Genome annotation databases

EnsembliENSMUST00000047477; ENSMUSP00000039821; ENSMUSG00000042212.
GeneIDi20758.
KEGGimmu:20758.
UCSCiuc008qds.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005562 mRNA. Translation: CAA06591.1.
AY158988 mRNA. Translation: AAN86825.1.
AK008778 mRNA. Translation: BAC25232.1.
CCDSiCCDS38510.1.
RefSeqiNP_035600.1. NM_011470.2.
UniGeneiMm.87820.

3D structure databases

ProteinModelPortaliO70555.
SMRiO70555. Positions 4-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039821.

Proteomic databases

PaxDbiO70555.
PRIDEiO70555.

Protocols and materials databases

DNASUi20758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047477; ENSMUSP00000039821; ENSMUSG00000042212.
GeneIDi20758.
KEGGimmu:20758.
UCSCiuc008qds.2. mouse.

Organism-specific databases

CTDi6703.
MGIiMGI:1330347. Sprr2d.

Phylogenomic databases

OMAiLKCPEPC.

Miscellaneous databases

ChiTaRSiSprr2d. mouse.
PROiO70555.
SOURCEiSearch...

Gene expression databases

BgeeiO70555.
CleanExiMM_SPRR2D.
GenevisibleiO70555. MM.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues."
    Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M., Kartasova T.
    Genomics 55:28-42(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "Mouse Sprr locus: a tandem array of coordinately regulated genes."
    Patel S., Kartasova T., Segre J.A.
    Mamm. Genome 14:140-148(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Stomach.
  4. "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus."
    Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H., Kang B.M., Kim M.K.
    Mol. Cells 17:477-484(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Entry informationi

Entry nameiSPR2D_MOUSE
AccessioniPrimary (citable) accession number: O70555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.