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Protein

Small proline-rich protein 2B

Gene

Sprr2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).By similarity

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • response to estradiol Source: MGI
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2B
Gene namesi
Name:Sprr2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1330352. Sprr2b.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Small proline-rich protein 2BPRO_0000150015Add
BLAST

Proteomic databases

PaxDbiO70554.
PRIDEiO70554.

Expressioni

Tissue specificityi

Expressed in uterus.1 Publication

Developmental stagei

Expression in uterus varies during the estrous cycle, with highest levels during proestrus and estrus stages and declining sharply from metestrus to diestrus. During early pregnancy, uterine expression is markedly increased at 1 dpc, declines rapidly at 2 dpc and is almost undetectable from 3 dpc to 6 dpc.1 Publication

Inductioni

Up-regulated by estrogen in the uterus of ovariectomized animals, with strongly increased expression detected in luminal epithelial cells at 6 and 12 hours after hormone injection.1 Publication

Gene expression databases

CleanExiMM_SPRR2B.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati30 – 3892
Repeati39 – 4793
Repeati48 – 5694
Repeati57 – 6595

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 65455 X 9 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYYQQQCKQ PCQPPPVCPP PKCPEPCPPP KCPEPCPPPV CCEPCPPPKC
60 70 80 90
PEPCPPPVCC EPCPPPVCCE PCPPQPWQPK CPPVQFPPCQ QKCPPKNK
Length:98
Mass (Da):10,735
Last modified:August 1, 1998 - v1
Checksum:i81FB0894FA6CDBCC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41Y → H in AAP57203 (Ref. 3) Curated
Sequence conflicti43 – 519Missing in AAP57203 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005560 Genomic DNA. Translation: CAA06589.1.
AY158987 mRNA. Translation: AAN86824.1.
AY298855 mRNA. Translation: AAP57203.1.
CCDSiCCDS38509.1.
UniGeneiMm.445310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005560 Genomic DNA. Translation: CAA06589.1.
AY158987 mRNA. Translation: AAN86824.1.
AY298855 mRNA. Translation: AAP57203.1.
CCDSiCCDS38509.1.
UniGeneiMm.445310.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO70554.
PRIDEiO70554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1330352. Sprr2b.

Miscellaneous databases

PROiO70554.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SPRR2B.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues."
    Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M., Kartasova T.
    Genomics 55:28-42(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "Mouse Sprr locus: a tandem array of coordinately regulated genes."
    Patel S., Kartasova T., Segre J.A.
    Mamm. Genome 14:140-148(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "Small proline rich proteins in the reproductive system of female mice."
    Tan Y., Sun X., Wang Y.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Uterus.
  4. "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus."
    Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H., Kang B.M., Kim M.K.
    Mol. Cells 17:477-484(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.

Entry informationi

Entry nameiSPR2B_MOUSE
AccessioniPrimary (citable) accession number: O70554
Secondary accession number(s): Q7TSB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.