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Protein

Protein BTG4

Gene

Btg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows marked antiproliferative activity, being able to induce G1 arrest.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG4
Alternative name(s):
BTG family member 4
Protein PC3b
Gene namesi
Name:Btg4
Synonyms:Pc3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1860140 Btg4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438111 – 250Protein BTG4Add BLAST250

Proteomic databases

PaxDbiO70552
PRIDEiO70552

PTM databases

PhosphoSitePlusiO70552

Expressioni

Tissue specificityi

Highly expressed in testis and in olfactory epithelium.

Gene expression databases

BgeeiENSMUSG00000032056
CleanExiMM_BTG4
ExpressionAtlasiO70552 baseline and differential
GenevisibleiO70552 MM

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-61987N
IntActiO70552, 4 interactors
STRINGi10090.ENSMUSP00000110074

Structurei

3D structure databases

ProteinModelPortaliO70552
SMRiO70552
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000234823
HOVERGENiHBG004332
InParanoidiO70552
KOiK14443
OMAiDRYHWVN
OrthoDBiEOG091G0U1P
TreeFamiTF105272

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033332 BTG4
PANTHERiPTHR22978:SF5 PTHR22978:SF5, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDEIATAVF FVTRLVKKHE KLSTQQIETF ALKLMTILFE KYRGHWHPDC
60 70 80 90 100
PSKGQAFRCI RINNNENKDP VLERACAESN VNFFHLGLPK EMTIWVDPYE
110 120 130 140 150
VCCRYGEKKH PFTIASFKGR WENWELAQHV SCAVNRATGD CSSGTSSDEE
160 170 180 190 200
SCSREAQIIP KVNNPKSVYQ VENFKQSLQP WFCLPRRKHL ADGRGFLPGA
210 220 230 240 250
ACHPVPKSSK WCRPASRRVD RYHWVNAQLF SGQTAPGEPG EEALSSLKQK
Length:250
Mass (Da):28,613
Last modified:September 18, 2013 - v2
Checksum:i9C175309C017F7BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37I → V in CAA06384 (PubMed:10995567).Curated1
Sequence conflicti158I → V in CAA06384 (PubMed:10995567).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005120 mRNA Translation: CAA06384.1
AB050983 mRNA Translation: BAB47554.2
AK136041 mRNA Translation: BAE22791.1
AK136149 mRNA Translation: BAE22846.1
AK161379 mRNA Translation: BAE36359.1
AC119831 Genomic DNA No translation available.
CCDSiCCDS40629.1
RefSeqiNP_062366.2, NM_019493.4
XP_006510562.1, XM_006510499.3
XP_006510563.1, XM_006510500.2
XP_006510564.1, XM_006510501.3
XP_006510565.1, XM_006510502.2
XP_017168979.1, XM_017313490.1
UniGeneiMm.431317

Genome annotation databases

EnsembliENSMUST00000114431; ENSMUSP00000110074; ENSMUSG00000032056
ENSMUST00000213680; ENSMUSP00000149181; ENSMUSG00000032056
GeneIDi56057
KEGGimmu:56057
UCSCiuc009pld.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBTG4_MOUSE
AccessioniPrimary (citable) accession number: O70552
Secondary accession number(s): Q925T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 18, 2013
Last modified: March 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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