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Protein

Protein BTG4

Gene

Btg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Shows marked antiproliferative activity, being able to induce G1 arrest.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG4
Alternative name(s):
BTG family member 4
Protein PC3b
Gene namesi
Name:Btg4
Synonyms:Pc3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1860140. Btg4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Protein BTG4PRO_0000143811Add
BLAST

Proteomic databases

PaxDbiO70552.
PRIDEiO70552.

PTM databases

PhosphoSiteiO70552.

Expressioni

Tissue specificityi

Highly expressed in testis and in olfactory epithelium.

Gene expression databases

CleanExiMM_BTG4.
GenevisibleiO70552. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110074.

Structurei

3D structure databases

ProteinModelPortaliO70552.
SMRiO70552. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000234823.
HOVERGENiHBG004332.
InParanoidiO70552.
KOiK14443.
OMAiFQISCKK.
OrthoDBiEOG786H63.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033332. BTG4.
[Graphical view]
PANTHERiPTHR22978:SF5. PTHR22978:SF5. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDEIATAVF FVTRLVKKHE KLSTQQIETF ALKLMTILFE KYRGHWHPDC
60 70 80 90 100
PSKGQAFRCI RINNNENKDP VLERACAESN VNFFHLGLPK EMTIWVDPYE
110 120 130 140 150
VCCRYGEKKH PFTIASFKGR WENWELAQHV SCAVNRATGD CSSGTSSDEE
160 170 180 190 200
SCSREAQIIP KVNNPKSVYQ VENFKQSLQP WFCLPRRKHL ADGRGFLPGA
210 220 230 240 250
ACHPVPKSSK WCRPASRRVD RYHWVNAQLF SGQTAPGEPG EEALSSLKQK
Length:250
Mass (Da):28,613
Last modified:September 18, 2013 - v2
Checksum:i9C175309C017F7BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371I → V in CAA06384 (PubMed:10995567).Curated
Sequence conflicti158 – 1581I → V in CAA06384 (PubMed:10995567).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005120 mRNA. Translation: CAA06384.1.
AB050983 mRNA. Translation: BAB47554.2.
AK136041 mRNA. Translation: BAE22791.1.
AK136149 mRNA. Translation: BAE22846.1.
AK161379 mRNA. Translation: BAE36359.1.
AC119831 Genomic DNA. No translation available.
CCDSiCCDS40629.1.
RefSeqiNP_062366.2. NM_019493.3.
XP_006510561.1. XM_006510498.2.
XP_006510562.1. XM_006510499.2.
XP_006510563.1. XM_006510500.2.
XP_006510564.1. XM_006510501.2.
XP_006510565.1. XM_006510502.2.
UniGeneiMm.431317.

Genome annotation databases

EnsembliENSMUST00000114431; ENSMUSP00000110074; ENSMUSG00000032056.
GeneIDi56057.
KEGGimmu:56057.
UCSCiuc009pld.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005120 mRNA. Translation: CAA06384.1.
AB050983 mRNA. Translation: BAB47554.2.
AK136041 mRNA. Translation: BAE22791.1.
AK136149 mRNA. Translation: BAE22846.1.
AK161379 mRNA. Translation: BAE36359.1.
AC119831 Genomic DNA. No translation available.
CCDSiCCDS40629.1.
RefSeqiNP_062366.2. NM_019493.3.
XP_006510561.1. XM_006510498.2.
XP_006510562.1. XM_006510499.2.
XP_006510563.1. XM_006510500.2.
XP_006510564.1. XM_006510501.2.
XP_006510565.1. XM_006510502.2.
UniGeneiMm.431317.

3D structure databases

ProteinModelPortaliO70552.
SMRiO70552. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110074.

PTM databases

PhosphoSiteiO70552.

Proteomic databases

PaxDbiO70552.
PRIDEiO70552.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114431; ENSMUSP00000110074; ENSMUSG00000032056.
GeneIDi56057.
KEGGimmu:56057.
UCSCiuc009pld.1. mouse.

Organism-specific databases

CTDi54766.
MGIiMGI:1860140. Btg4.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000234823.
HOVERGENiHBG004332.
InParanoidiO70552.
KOiK14443.
OMAiFQISCKK.
OrthoDBiEOG786H63.
TreeFamiTF105272.

Miscellaneous databases

PROiO70552.
SOURCEiSearch...

Gene expression databases

CleanExiMM_BTG4.
GenevisibleiO70552. MM.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033332. BTG4.
[Graphical view]
PANTHERiPTHR22978:SF5. PTHR22978:SF5. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium."
    Buanne P., Corrente G., Micheli L., Palena A., Lavia P., Spadafora C., Lakshmana M.K., Rinaldi A., Banfi S., Quarto M., Bulfone A., Tirone F.
    Genomics 68:253-263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The initiate factors from mouse oocyte."
    Mano H.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiBTG4_MOUSE
AccessioniPrimary (citable) accession number: O70552
Secondary accession number(s): Q925T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 18, 2013
Last modified: July 6, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.