O70548 (TELT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Telethonin

Alternative name(s):
Titin cap protein

Gene names

Name:

Tcap

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk By similarity.
Subunit structure	Interacts with MYOZ1 and MYOZ3. Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN) molecules By similarity.
Subcellular location	Cytoplasm › myofibril › sarcomere.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult heart development Inferred from expression pattern PubMed 9817758. Source: BHF-UCL cardiac muscle contraction Inferred from electronic annotation. Source: Compara cardiac muscle fiber development Inferred from electronic annotation. Source: Compara cardiac muscle hypertrophy in response to stress Inferred from electronic annotation. Source: Compara cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara cardiac myofibril assembly Inferred from electronic annotation. Source: Compara detection of muscle stretch Inferred from electronic annotation. Source: Compara otic vesicle formation Inferred from expression pattern PubMed 9817758. Source: BHF-UCL sarcomere organization Inferred from sequence alignment PubMed 9817758. Source: MGI sarcomerogenesis Inferred from electronic annotation. Source: Compara skeletal muscle contraction Inferred from electronic annotation. Source: Compara skeletal muscle myosin thick filament assembly Inferred from electronic annotation. Source: Compara skeletal muscle thin filament assembly Inferred from electronic annotation. Source: Compara somitogenesis Inferred from expression pattern PubMed 9817758. Source: BHF-UCL
Cellular_component	Z disc Inferred from direct assay PubMed 9817758. Source: BHF-UCL
Molecular_function	structural constituent of muscle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Telethonin		PRO_0000072484

Sequences

	Sequence		Length	Mass (Da)
	O70548 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 2CB1F6F5415B4DC1	FASTA	167	19,078
	10 20 30 40 50 60 MATSELSCQV SEENQERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHRQGQCQAV 70 80 90 100 110 120 VQRSPWLVMR LGILGRGLQE YQLPYQRVLP LPIFTPTKVG ASKEEREETP IQLRELLALE 130 140 150 160 TALGGQCVER QDVAEITKQL PPVVPVSKPG PLRRTLSRSM SQEAQRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Skeletal muscle transcripts characterization in Homo sapiens and Mus musculus." Ievolella C., Formentin E., Valle G., Lanfranchi G. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Diaphragm.
[2]	"The titin cap protein - a novel protein essential for sarcomere formation." Kolmerer B. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223854 mRNA. Translation: CAA11585.1. Y15845 mRNA. Translation: CAB38077.1. BC027631 mRNA. Translation: AAH27631.1.
IPI	IPI00119331.
RefSeq	NP_035670.2. NM_011540.2.
UniGene	Mm.10762.
3D structure databases
ProteinModelPortal	O70548.
SMR	O70548. Positions 1-89.
ModBase	Search...
PTM databases
PhosphoSite	O70548.
Proteomic databases
PRIDE	O70548.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877.
GeneID	21393.
KEGG	mmu:21393.
Organism-specific databases
CTD	8557.
MGI	MGI:1330233. Tcap.
Phylogenomic databases
eggNOG	NOG43340.
HOGENOM	HOG000237275.
HOVERGEN	HBG004497.
InParanoid	O70548.
OMA	RSMSQEA.
OrthoDB	EOG4V6ZHW.
Gene expression databases
ArrayExpress	O70548.
Bgee	O70548.
CleanEx	MM_TCAP.
Genevestigator	O70548.
GermOnline	ENSMUSG00000007877. Mus musculus.
Family and domain databases
Gene3D	2.20.160.10. 1 hit.
InterPro	IPR015667. Telethonin. IPR023111. Titin-like_domain. [Graphical view]
PANTHER	PTHR15143. PTHR15143. 1 hit.
Pfam	PF09470. Telethonin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TCAP. mouse.
NextBio	300652.
SOURCE	Search...

Entry information

Entry name

TELT_MOUSE

Accession

Primary (citable) accession number: O70548

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program