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O70548

- TELT_MOUSE

UniProt

O70548 - TELT_MOUSE

Protein

Telethonin

Gene

Tcap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: BHF-UCL
    2. structural constituent of muscle Source: Ensembl

    GO - Biological processi

    1. adult heart development Source: BHF-UCL
    2. cardiac muscle contraction Source: Ensembl
    3. cardiac muscle fiber development Source: Ensembl
    4. cardiac muscle hypertrophy in response to stress Source: Ensembl
    5. cardiac muscle tissue morphogenesis Source: Ensembl
    6. cardiac myofibril assembly Source: Ensembl
    7. detection of muscle stretch Source: Ensembl
    8. otic vesicle formation Source: BHF-UCL
    9. sarcomere organization Source: MGI
    10. sarcomerogenesis Source: Ensembl
    11. skeletal muscle contraction Source: Ensembl
    12. skeletal muscle myosin thick filament assembly Source: Ensembl
    13. skeletal muscle thin filament assembly Source: Ensembl
    14. somitogenesis Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Telethonin
    Alternative name(s):
    Titin cap protein
    Gene namesi
    Name:Tcap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1330233. Tcap.

    Subcellular locationi

    GO - Cellular componenti

    1. I band Source: BHF-UCL
    2. Z disc Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167TelethoninPRO_0000072484Add
    BLAST

    Proteomic databases

    PRIDEiO70548.

    PTM databases

    PhosphoSiteiO70548.

    Expressioni

    Gene expression databases

    ArrayExpressiO70548.
    BgeeiO70548.
    CleanExiMM_TCAP.
    GenevestigatoriO70548.

    Interactioni

    Subunit structurei

    Interacts with MYOZ1, MYOZ2 and MYOZ3. Interacts with CSRP3. Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN) molecules. Interacts with ANKRD2; the interaction is direct By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO70548.
    SMRiO70548. Positions 1-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG43340.
    HOGENOMiHOG000237275.
    HOVERGENiHBG004497.
    InParanoidiO70548.
    OMAiSPWLVMR.
    OrthoDBiEOG76MK9Q.
    PhylomeDBiO70548.
    TreeFamiTF333228.

    Family and domain databases

    Gene3Di2.20.160.10. 1 hit.
    InterProiIPR015667. Telethonin.
    IPR023111. Titin-like_domain.
    [Graphical view]
    PANTHERiPTHR15143. PTHR15143. 1 hit.
    PfamiPF09470. Telethonin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O70548-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSELSCQV SEENQERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET    50
    YHRQGQCQAV VQRSPWLVMR LGILGRGLQE YQLPYQRVLP LPIFTPTKVG 100
    ASKEEREETP IQLRELLALE TALGGQCVER QDVAEITKQL PPVVPVSKPG 150
    PLRRTLSRSM SQEAQRG 167
    Length:167
    Mass (Da):19,078
    Last modified:August 1, 1998 - v1
    Checksum:i2CB1F6F5415B4DC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223854 mRNA. Translation: CAA11585.1.
    Y15845 mRNA. Translation: CAB38077.1.
    BC027631 mRNA. Translation: AAH27631.1.
    CCDSiCCDS25346.1.
    RefSeqiNP_035670.2. NM_011540.2.
    UniGeneiMm.10762.

    Genome annotation databases

    EnsembliENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877.
    GeneIDi21393.
    KEGGimmu:21393.
    UCSCiuc007lgf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223854 mRNA. Translation: CAA11585.1 .
    Y15845 mRNA. Translation: CAB38077.1 .
    BC027631 mRNA. Translation: AAH27631.1 .
    CCDSi CCDS25346.1.
    RefSeqi NP_035670.2. NM_011540.2.
    UniGenei Mm.10762.

    3D structure databases

    ProteinModelPortali O70548.
    SMRi O70548. Positions 1-89.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O70548.

    Proteomic databases

    PRIDEi O70548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000008021 ; ENSMUSP00000008021 ; ENSMUSG00000007877 .
    GeneIDi 21393.
    KEGGi mmu:21393.
    UCSCi uc007lgf.1. mouse.

    Organism-specific databases

    CTDi 8557.
    MGIi MGI:1330233. Tcap.

    Phylogenomic databases

    eggNOGi NOG43340.
    HOGENOMi HOG000237275.
    HOVERGENi HBG004497.
    InParanoidi O70548.
    OMAi SPWLVMR.
    OrthoDBi EOG76MK9Q.
    PhylomeDBi O70548.
    TreeFami TF333228.

    Miscellaneous databases

    ChiTaRSi TCAP. mouse.
    NextBioi 300652.
    PROi O70548.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70548.
    Bgeei O70548.
    CleanExi MM_TCAP.
    Genevestigatori O70548.

    Family and domain databases

    Gene3Di 2.20.160.10. 1 hit.
    InterProi IPR015667. Telethonin.
    IPR023111. Titin-like_domain.
    [Graphical view ]
    PANTHERi PTHR15143. PTHR15143. 1 hit.
    Pfami PF09470. Telethonin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Skeletal muscle transcripts characterization in Homo sapiens and Mus musculus."
      Ievolella C., Formentin E., Valle G., Lanfranchi G.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Diaphragm.
    2. "The titin cap protein - a novel protein essential for sarcomere formation."
      Kolmerer B.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiTELT_MOUSE
    AccessioniPrimary (citable) accession number: O70548
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3