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O70548

- TELT_MOUSE

UniProt

O70548 - TELT_MOUSE

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Protein

Telethonin

Gene

Tcap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity).By similarity

GO - Molecular functioni

  1. structural constituent of muscle Source: Ensembl

GO - Biological processi

  1. adult heart development Source: BHF-UCL
  2. cardiac muscle contraction Source: Ensembl
  3. cardiac muscle fiber development Source: Ensembl
  4. cardiac muscle hypertrophy in response to stress Source: Ensembl
  5. cardiac muscle tissue morphogenesis Source: Ensembl
  6. cardiac myofibril assembly Source: Ensembl
  7. detection of muscle stretch Source: Ensembl
  8. otic vesicle formation Source: BHF-UCL
  9. sarcomere organization Source: MGI
  10. sarcomerogenesis Source: Ensembl
  11. skeletal muscle contraction Source: Ensembl
  12. skeletal muscle myosin thick filament assembly Source: Ensembl
  13. skeletal muscle thin filament assembly Source: Ensembl
  14. somitogenesis Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_232053. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Telethonin
Alternative name(s):
Titin cap protein
Gene namesi
Name:Tcap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1330233. Tcap.

Subcellular locationi

GO - Cellular componenti

  1. I band Source: BHF-UCL
  2. Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167TelethoninPRO_0000072484Add
BLAST

Proteomic databases

PRIDEiO70548.

PTM databases

PhosphoSiteiO70548.

Expressioni

Gene expression databases

BgeeiO70548.
CleanExiMM_TCAP.
ExpressionAtlasiO70548. baseline and differential.
GenevestigatoriO70548.

Interactioni

Subunit structurei

Interacts with MYOZ1, MYOZ2 and MYOZ3. Interacts with CSRP3. Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN) molecules. Interacts with ANKRD2; the interaction is direct (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO70548.
SMRiO70548. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG43340.
HOGENOMiHOG000237275.
HOVERGENiHBG004497.
InParanoidiO70548.
OMAiSPWLVMR.
OrthoDBiEOG76MK9Q.
PhylomeDBiO70548.
TreeFamiTF333228.

Family and domain databases

Gene3Di2.20.160.10. 1 hit.
InterProiIPR015667. Telethonin.
IPR023111. Titin-like_domain.
[Graphical view]
PANTHERiPTHR15143. PTHR15143. 1 hit.
PfamiPF09470. Telethonin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70548-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSELSCQV SEENQERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET
60 70 80 90 100
YHRQGQCQAV VQRSPWLVMR LGILGRGLQE YQLPYQRVLP LPIFTPTKVG
110 120 130 140 150
ASKEEREETP IQLRELLALE TALGGQCVER QDVAEITKQL PPVVPVSKPG
160
PLRRTLSRSM SQEAQRG
Length:167
Mass (Da):19,078
Last modified:August 1, 1998 - v1
Checksum:i2CB1F6F5415B4DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223854 mRNA. Translation: CAA11585.1.
Y15845 mRNA. Translation: CAB38077.1.
BC027631 mRNA. Translation: AAH27631.1.
CCDSiCCDS25346.1.
RefSeqiNP_035670.2. NM_011540.2.
UniGeneiMm.10762.

Genome annotation databases

EnsembliENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877.
GeneIDi21393.
KEGGimmu:21393.
UCSCiuc007lgf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223854 mRNA. Translation: CAA11585.1 .
Y15845 mRNA. Translation: CAB38077.1 .
BC027631 mRNA. Translation: AAH27631.1 .
CCDSi CCDS25346.1.
RefSeqi NP_035670.2. NM_011540.2.
UniGenei Mm.10762.

3D structure databases

ProteinModelPortali O70548.
SMRi O70548. Positions 1-89.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O70548.

Proteomic databases

PRIDEi O70548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000008021 ; ENSMUSP00000008021 ; ENSMUSG00000007877 .
GeneIDi 21393.
KEGGi mmu:21393.
UCSCi uc007lgf.1. mouse.

Organism-specific databases

CTDi 8557.
MGIi MGI:1330233. Tcap.

Phylogenomic databases

eggNOGi NOG43340.
HOGENOMi HOG000237275.
HOVERGENi HBG004497.
InParanoidi O70548.
OMAi SPWLVMR.
OrthoDBi EOG76MK9Q.
PhylomeDBi O70548.
TreeFami TF333228.

Enzyme and pathway databases

Reactomei REACT_232053. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSi Tcap. mouse.
NextBioi 300652.
PROi O70548.
SOURCEi Search...

Gene expression databases

Bgeei O70548.
CleanExi MM_TCAP.
ExpressionAtlasi O70548. baseline and differential.
Genevestigatori O70548.

Family and domain databases

Gene3Di 2.20.160.10. 1 hit.
InterProi IPR015667. Telethonin.
IPR023111. Titin-like_domain.
[Graphical view ]
PANTHERi PTHR15143. PTHR15143. 1 hit.
Pfami PF09470. Telethonin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Skeletal muscle transcripts characterization in Homo sapiens and Mus musculus."
    Ievolella C., Formentin E., Valle G., Lanfranchi G.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Diaphragm.
  2. "The titin cap protein - a novel protein essential for sarcomere formation."
    Kolmerer B.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTELT_MOUSE
AccessioniPrimary (citable) accession number: O70548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3