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Protein

Telethonin

Gene

Tcap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Telethonin
Alternative name(s):
Titin cap protein
Gene namesi
Name:Tcap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1330233. Tcap.

Subcellular locationi

GO - Cellular componenti

  • I band Source: BHF-UCL
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167TelethoninPRO_0000072484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70548.
PRIDEiO70548.

PTM databases

iPTMnetiO70548.
PhosphoSiteiO70548.

Expressioni

Gene expression databases

BgeeiO70548.
CleanExiMM_TCAP.
ExpressionAtlasiO70548. baseline and differential.
GenevisibleiO70548. MM.

Interactioni

Subunit structurei

Interacts with MYOZ1, MYOZ2 and MYOZ3. Interacts with CSRP3. Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN) molecules. Interacts with ANKRD2; the interaction is direct (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008021.

Structurei

3D structure databases

ProteinModelPortaliO70548.
SMRiO70548. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IIUD. Eukaryota.
ENOG4111SDJ. LUCA.
HOGENOMiHOG000237275.
HOVERGENiHBG004497.
InParanoidiO70548.
KOiK19879.
OMAiTYHRQGQ.
OrthoDBiEOG76MK9Q.
PhylomeDBiO70548.
TreeFamiTF333228.

Family and domain databases

Gene3Di2.20.160.10. 1 hit.
InterProiIPR015667. Telethonin.
IPR023111. Titin-like_domain.
[Graphical view]
PANTHERiPTHR15143. PTHR15143. 1 hit.
PfamiPF09470. Telethonin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSELSCQV SEENQERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET
60 70 80 90 100
YHRQGQCQAV VQRSPWLVMR LGILGRGLQE YQLPYQRVLP LPIFTPTKVG
110 120 130 140 150
ASKEEREETP IQLRELLALE TALGGQCVER QDVAEITKQL PPVVPVSKPG
160
PLRRTLSRSM SQEAQRG
Length:167
Mass (Da):19,078
Last modified:August 1, 1998 - v1
Checksum:i2CB1F6F5415B4DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223854 mRNA. Translation: CAA11585.1.
Y15845 mRNA. Translation: CAB38077.1.
BC027631 mRNA. Translation: AAH27631.1.
CCDSiCCDS25346.1.
RefSeqiNP_035670.2. NM_011540.2.
UniGeneiMm.10762.

Genome annotation databases

EnsembliENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877.
GeneIDi21393.
KEGGimmu:21393.
UCSCiuc007lgf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223854 mRNA. Translation: CAA11585.1.
Y15845 mRNA. Translation: CAB38077.1.
BC027631 mRNA. Translation: AAH27631.1.
CCDSiCCDS25346.1.
RefSeqiNP_035670.2. NM_011540.2.
UniGeneiMm.10762.

3D structure databases

ProteinModelPortaliO70548.
SMRiO70548. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008021.

PTM databases

iPTMnetiO70548.
PhosphoSiteiO70548.

Proteomic databases

PaxDbiO70548.
PRIDEiO70548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877.
GeneIDi21393.
KEGGimmu:21393.
UCSCiuc007lgf.1. mouse.

Organism-specific databases

CTDi8557.
MGIiMGI:1330233. Tcap.

Phylogenomic databases

eggNOGiENOG410IIUD. Eukaryota.
ENOG4111SDJ. LUCA.
HOGENOMiHOG000237275.
HOVERGENiHBG004497.
InParanoidiO70548.
KOiK19879.
OMAiTYHRQGQ.
OrthoDBiEOG76MK9Q.
PhylomeDBiO70548.
TreeFamiTF333228.

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSiTcap. mouse.
NextBioi300652.
PROiO70548.
SOURCEiSearch...

Gene expression databases

BgeeiO70548.
CleanExiMM_TCAP.
ExpressionAtlasiO70548. baseline and differential.
GenevisibleiO70548. MM.

Family and domain databases

Gene3Di2.20.160.10. 1 hit.
InterProiIPR015667. Telethonin.
IPR023111. Titin-like_domain.
[Graphical view]
PANTHERiPTHR15143. PTHR15143. 1 hit.
PfamiPF09470. Telethonin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Skeletal muscle transcripts characterization in Homo sapiens and Mus musculus."
    Ievolella C., Formentin E., Valle G., Lanfranchi G.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Diaphragm.
  2. "The titin cap protein - a novel protein essential for sarcomere formation."
    Kolmerer B.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiTELT_MOUSE
AccessioniPrimary (citable) accession number: O70548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.