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O70548 (TELT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Telethonin
Alternative name(s):
Titin cap protein
Gene names
Name:Tcap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk By similarity.

Subunit structure

Interacts with MYOZ1, MYOZ2 and MYOZ3. Interacts with CSRP3. Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN) molecules. Interacts with ANKRD2; the interaction is direct By similarity.

Subcellular location

Cytoplasmmyofibrilsarcomere.

Ontologies

Keywords
   Cellular componentCytoplasm
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult heart development

Inferred from expression pattern PubMed 9817758. Source: BHF-UCL

cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

cardiac muscle fiber development

Inferred from electronic annotation. Source: Ensembl

cardiac muscle hypertrophy in response to stress

Inferred from electronic annotation. Source: Ensembl

cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

cardiac myofibril assembly

Inferred from electronic annotation. Source: Ensembl

detection of muscle stretch

Inferred from electronic annotation. Source: Ensembl

otic vesicle formation

Inferred from expression pattern PubMed 9817758. Source: BHF-UCL

sarcomere organization

Inferred from sequence alignment PubMed 9817758. Source: MGI

sarcomerogenesis

Inferred from electronic annotation. Source: Ensembl

skeletal muscle contraction

Inferred from electronic annotation. Source: Ensembl

skeletal muscle myosin thick filament assembly

Inferred from electronic annotation. Source: Ensembl

skeletal muscle thin filament assembly

Inferred from electronic annotation. Source: Ensembl

somitogenesis

Inferred from expression pattern PubMed 9817758. Source: BHF-UCL

   Cellular_componentI band

Inferred from direct assay PubMed 9817758. Source: BHF-UCL

Z disc

Inferred from direct assay PubMed 9817758. Source: BHF-UCL

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 12507422. Source: BHF-UCL

structural constituent of muscle

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Telethonin
PRO_0000072484

Sequences

Sequence LengthMass (Da)Tools
O70548 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 2CB1F6F5415B4DC1

FASTA16719,078
        10         20         30         40         50         60 
MATSELSCQV SEENQERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHRQGQCQAV 

        70         80         90        100        110        120 
VQRSPWLVMR LGILGRGLQE YQLPYQRVLP LPIFTPTKVG ASKEEREETP IQLRELLALE 

       130        140        150        160 
TALGGQCVER QDVAEITKQL PPVVPVSKPG PLRRTLSRSM SQEAQRG 

« Hide

References

« Hide 'large scale' references
[1]"Skeletal muscle transcripts characterization in Homo sapiens and Mus musculus."
Ievolella C., Formentin E., Valle G., Lanfranchi G.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Diaphragm.
[2]"The titin cap protein - a novel protein essential for sarcomere formation."
Kolmerer B.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ223854 mRNA. Translation: CAA11585.1.
Y15845 mRNA. Translation: CAB38077.1.
BC027631 mRNA. Translation: AAH27631.1.
CCDSCCDS25346.1.
RefSeqNP_035670.2. NM_011540.2.
UniGeneMm.10762.

3D structure databases

ProteinModelPortalO70548.
SMRO70548. Positions 1-89.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO70548.

Proteomic databases

PRIDEO70548.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877.
GeneID21393.
KEGGmmu:21393.
UCSCuc007lgf.1. mouse.

Organism-specific databases

CTD8557.
MGIMGI:1330233. Tcap.

Phylogenomic databases

eggNOGNOG43340.
HOGENOMHOG000237275.
HOVERGENHBG004497.
InParanoidO70548.
OMASPWLVMR.
OrthoDBEOG76MK9Q.
PhylomeDBO70548.
TreeFamTF333228.

Gene expression databases

ArrayExpressO70548.
BgeeO70548.
CleanExMM_TCAP.
GenevestigatorO70548.

Family and domain databases

Gene3D2.20.160.10. 1 hit.
InterProIPR015667. Telethonin.
IPR023111. Titin-like_domain.
[Graphical view]
PANTHERPTHR15143. PTHR15143. 1 hit.
PfamPF09470. Telethonin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTCAP. mouse.
NextBio300652.
PROO70548.
SOURCESearch...

Entry information

Entry nameTELT_MOUSE
AccessionPrimary (citable) accession number: O70548
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot