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O70537

- CP3AV_MESAU

UniProt

O70537 - CP3AV_MESAU

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Protein

Cytochrome P450 3A31

Gene

CYP3A31

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi440 – 4401Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A31 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA31
Cytochrome P450 SH3A-1
Gene namesi
Name:CYP3A31
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 3A31PRO_0000051811Add
BLAST

Expressioni

Tissue specificityi

Expressed constitutively in liver.

Inductioni

Induced by phenobarbital and repressed by 3-methylcholanthrene or dexamethasone.

Structurei

3D structure databases

ProteinModelPortaliO70537.
SMRiO70537. Positions 28-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70537-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLTSVLSLE TWVLLAISLV LLYRLGTHKY DIFKKQGIPG PKPLPFLGNV
60 70 80 90 100
LNYYKGIWTF DIECHKKYGK IWGLFEGQRP LFTVTDTEMI KNVLVKECYS
110 120 130 140 150
IFTNRRDFGP VGIMSKAVSI SKDEEWKRIR ALLSPTFTSG KLKEMFPIIE
160 170 180 190 200
QYGDILVKFL RREAEKGNPV TTKEVFGAYS MDVITSTAFG VSVDSLNNPK
210 220 230 240 250
DLLWKGRKLL RFDFFDPLFL SVVLFPFLIP IYEKLNVSMF PKDSISFFRK
260 270 280 290 300
FVDKTKENRL DYNQKHRVDF LQLMMNSHDN SKDSHKALSD MEIIAQSIIF
310 320 330 340 350
IFAGYDTTSS TLSFALYLLA THPDVQKKLQ EEIDIALPNK ARPSYDKVME
360 370 380 390 400
MEYLDMVLNE TLRLYPIGSR LERVCKQDVE MDGVFVPKGS IVMVPVFALH
410 420 430 440 450
YDPQYWPEPE KFRPERFSKE NKGSIDPYIF LPFGNGPRNC IGMRFALMNM
460 470 480 490 500
KLALTKVLQN FSLQPCKETQ IPMKLSRKAM LQPEKPIILK VVPRDAIITG

A
Length:501
Mass (Da):57,772
Last modified:August 1, 1998 - v1
Checksum:iD6C32CEEAB056589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86951 mRNA. Translation: BAA25811.1.
RefSeqiNP_001268529.1. NM_001281600.1.

Genome annotation databases

GeneIDi101836914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86951 mRNA. Translation: BAA25811.1 .
RefSeqi NP_001268529.1. NM_001281600.1.

3D structure databases

ProteinModelPortali O70537.
SMRi O70537. Positions 28-496.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101836914.

Phylogenomic databases

HOVERGENi HBG108567.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and expression of a novel CYP3A from the Syrian hamster, CYP3A31."
    Alabouch S., Kurose K., Tohkin M., Bani M.-H., Fukuhara M., Nagata K., Yamazoe Y.
    Biochim. Biophys. Acta 1397:9-13(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP3AV_MESAU
AccessioniPrimary (citable) accession number: O70537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3