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O70537

- CP3AV_MESAU

UniProt

O70537 - CP3AV_MESAU

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Protein
Cytochrome P450 3A31
Gene
CYP3A31
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi440 – 4401Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A31 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA31
    Cytochrome P450 SH3A-1
    Gene namesi
    Name:CYP3A31
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cytochrome P450 3A31
    PRO_0000051811Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed constitutively in liver.

    Inductioni

    Induced by phenobarbital and repressed by 3-methylcholanthrene or dexamethasone.

    Structurei

    3D structure databases

    ProteinModelPortaliO70537.
    SMRiO70537. Positions 28-496.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG108567.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O70537-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLTSVLSLE TWVLLAISLV LLYRLGTHKY DIFKKQGIPG PKPLPFLGNV    50
    LNYYKGIWTF DIECHKKYGK IWGLFEGQRP LFTVTDTEMI KNVLVKECYS 100
    IFTNRRDFGP VGIMSKAVSI SKDEEWKRIR ALLSPTFTSG KLKEMFPIIE 150
    QYGDILVKFL RREAEKGNPV TTKEVFGAYS MDVITSTAFG VSVDSLNNPK 200
    DLLWKGRKLL RFDFFDPLFL SVVLFPFLIP IYEKLNVSMF PKDSISFFRK 250
    FVDKTKENRL DYNQKHRVDF LQLMMNSHDN SKDSHKALSD MEIIAQSIIF 300
    IFAGYDTTSS TLSFALYLLA THPDVQKKLQ EEIDIALPNK ARPSYDKVME 350
    MEYLDMVLNE TLRLYPIGSR LERVCKQDVE MDGVFVPKGS IVMVPVFALH 400
    YDPQYWPEPE KFRPERFSKE NKGSIDPYIF LPFGNGPRNC IGMRFALMNM 450
    KLALTKVLQN FSLQPCKETQ IPMKLSRKAM LQPEKPIILK VVPRDAIITG 500
    A 501
    Length:501
    Mass (Da):57,772
    Last modified:August 1, 1998 - v1
    Checksum:iD6C32CEEAB056589
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86951 mRNA. Translation: BAA25811.1.
    RefSeqiNP_001268529.1. NM_001281600.1.

    Genome annotation databases

    GeneIDi101836914.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86951 mRNA. Translation: BAA25811.1 .
    RefSeqi NP_001268529.1. NM_001281600.1.

    3D structure databases

    ProteinModelPortali O70537.
    SMRi O70537. Positions 28-496.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101836914.

    Phylogenomic databases

    HOVERGENi HBG108567.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and expression of a novel CYP3A from the Syrian hamster, CYP3A31."
      Alabouch S., Kurose K., Tohkin M., Bani M.-H., Fukuhara M., Nagata K., Yamazoe Y.
      Biochim. Biophys. Acta 1397:9-13(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AV_MESAU
    AccessioniPrimary (citable) accession number: O70537
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: December 11, 2013
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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