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O70537 (CP3AV_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A31

EC=1.14.14.1
Alternative name(s):
CYPIIIA31
Cytochrome P450 SH3A-1
Gene names
Name:CYP3A31
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Expressed constitutively in liver.

Induction

Induced by phenobarbital and repressed by 3-methylcholanthrene or dexamethasone.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Cytochrome P450 3A31
PRO_0000051811

Sites

Metal binding4401Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O70537 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D6C32CEEAB056589

FASTA50157,772
        10         20         30         40         50         60 
MDLTSVLSLE TWVLLAISLV LLYRLGTHKY DIFKKQGIPG PKPLPFLGNV LNYYKGIWTF 

        70         80         90        100        110        120 
DIECHKKYGK IWGLFEGQRP LFTVTDTEMI KNVLVKECYS IFTNRRDFGP VGIMSKAVSI 

       130        140        150        160        170        180 
SKDEEWKRIR ALLSPTFTSG KLKEMFPIIE QYGDILVKFL RREAEKGNPV TTKEVFGAYS 

       190        200        210        220        230        240 
MDVITSTAFG VSVDSLNNPK DLLWKGRKLL RFDFFDPLFL SVVLFPFLIP IYEKLNVSMF 

       250        260        270        280        290        300 
PKDSISFFRK FVDKTKENRL DYNQKHRVDF LQLMMNSHDN SKDSHKALSD MEIIAQSIIF 

       310        320        330        340        350        360 
IFAGYDTTSS TLSFALYLLA THPDVQKKLQ EEIDIALPNK ARPSYDKVME MEYLDMVLNE 

       370        380        390        400        410        420 
TLRLYPIGSR LERVCKQDVE MDGVFVPKGS IVMVPVFALH YDPQYWPEPE KFRPERFSKE 

       430        440        450        460        470        480 
NKGSIDPYIF LPFGNGPRNC IGMRFALMNM KLALTKVLQN FSLQPCKETQ IPMKLSRKAM 

       490        500 
LQPEKPIILK VVPRDAIITG A 

« Hide

References

[1]"cDNA cloning and expression of a novel CYP3A from the Syrian hamster, CYP3A31."
Alabouch S., Kurose K., Tohkin M., Bani M.-H., Fukuhara M., Nagata K., Yamazoe Y.
Biochim. Biophys. Acta 1397:9-13(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86951 mRNA. Translation: BAA25811.1.
RefSeqNP_001268529.1. NM_001281600.1.

3D structure databases

ProteinModelPortalO70537.
SMRO70537. Positions 28-496.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101836914.

Phylogenomic databases

HOVERGENHBG108567.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AV_MESAU
AccessionPrimary (citable) accession number: O70537
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: December 11, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families