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Protein

Leukemia inhibitory factor receptor

Gene

Lifr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).By similarity

GO - Molecular functioni

  • cytokine binding Source: RGD
  • leukemia inhibitory factor receptor activity Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • negative regulation of muscle cell apoptotic process Source: RGD
  • neuron projection morphogenesis Source: RGD
  • organ regeneration Source: RGD
  • response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia inhibitory factor receptor
Short name:
LIF receptor
Short name:
LIF-R
Alternative name(s):
CD_antigen: CD118
Gene namesi
Name:Lifr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621431. Lifr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini44 – 829786ExtracellularSequence analysisAdd
BLAST
Transmembranei830 – 85021HelicalSequence analysisAdd
BLAST
Topological domaini851 – 1093243CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4343Sequence analysisAdd
BLAST
Chaini44 – 10931050Leukemia inhibitory factor receptorPRO_0000228095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 64By similarity
Disulfide bondi81 ↔ 89By similarity
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi209 ↔ 266By similarity
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi337 ↔ 347By similarity
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence analysis
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence analysis
Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi462 ↔ 507By similarity
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence analysis
Glycosylationi648 – 6481N-linked (GlcNAc...)Sequence analysis
Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence analysis
Glycosylationi676 – 6761N-linked (GlcNAc...)Sequence analysis
Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence analysis
Glycosylationi783 – 7831N-linked (GlcNAc...)Sequence analysis
Modified residuei923 – 9231PhosphoserineBy similarity
Modified residuei1040 – 10401PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO70535.
PRIDEiO70535.

PTM databases

PhosphoSiteiO70535.

Interactioni

Subunit structurei

Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity).By similarity

GO - Molecular functioni

  • cytokine binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016036.

Structurei

3D structure databases

ProteinModelPortaliO70535.
SMRiO70535. Positions 51-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12783Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini331 – 42898Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini431 – 530100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini534 – 62592Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini623 – 71593Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini720 – 829110Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi515 – 5195WSXWS motif
Motifi865 – 8739Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF1V. Eukaryota.
ENOG410ZMDF. LUCA.
HOGENOMiHOG000113324.
HOVERGENiHBG006266.
InParanoidiO70535.
KOiK05058.
PhylomeDBiO70535.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAFSWWRQP SWMADNKRGR MTPSLPWLLS ALTLLHLMMH VNGLKRGVQQ
60 70 80 90 100
DLKCTTNNMR VWDCSWPAPL GVSPGTVKDI CIKDRPHSCH RLETTNVKIP
110 120 130 140 150
ALSPGDHEVT INYQNGFQSK FTLNEKDVSL VPDTPEILSL SADFSTSTLQ
160 170 180 190 200
LKWNDKGSAL PYPSNATWEV KVLQNPRTEP VALVSLNTVL SGKDKGHHWN
210 220 230 240 250
WTSELPLQCA THSVSIRWHI DYPRFSGYKE WSEWSPLKNI SWTRNTETNV
260 270 280 290 300
FPQDKVVLAG SNMTICCIST TKVLSGQIGN TFRPLIHLYG ETVAINILNI
310 320 330 340 350
PVSENSGSNV IFSTVDDVYG TVVFAGYPPD VPQKLSCETH DLKEIICSWN
360 370 380 390 400
PGRITGLVGP RNTEYTLFES ISGKSAVFHR FEELANETYW LTLKMAPDQE
410 420 430 440 450
IHNFTLTARN PLGQTESAIV INATERVALH VPISLKVKDV NSTVVTLSWY
460 470 480 490 500
LPGNFTKINL VCQIEICKAN SKKEVRNVTM RGAEDSTYHV AVDKLNPYTI
510 520 530 540 550
YTFRVRCSSE TFWKWSKWSN EKRYLTTEAT PSKGPDTWRE WSSDGKNLII
560 570 580 590 600
YWKPLPINEA NGKILSYNVS CSSSEETQSL SEILDPQHKA EIKVNKNDYI
610 620 630 640 650
ISVVARNSAG SSPPSKIASM EIPNDDITVE QAVGIGNRIF LSWQHNPNMT
660 670 680 690 700
CDYVIKWCNS SWSEPCLLDW IKVPSNSTGT VIESDQFQPG VRYNFYLYGC
710 720 730 740 750
TNQGYQLLRS TIGYIEELAP IVAPNFTVED TSADSILVKW DDIPVEELRG
760 770 780 790 800
FLRGYLFYFQ KGERDTPKTR SLETSHSDIK LKNITDISQK TLRIADLQGK
810 820 830 840 850
TSYHLVLRAY THGGLGPEKS MFVVTKENSV GLIIAILIPV AVAVIVGVVT
860 870 880 890 900
SILCYRKREW IKETFYPDIP NPENCKALQF QKSVCEGSNA LKTLEMNPCT
910 920 930 940 950
PNHVEVLESR SIPPKIEDTE ITSPVSERPG ESSETDPENQ AAVSYCPPII
960 970 980 990 1000
EEEITNPAAD EAGGASQVVY IDVQSMYQPQ AKAEDEQDTD PVMVAGYKPQ
1010 1020 1030 1040 1050
MRLPINPTAE DTTAEDEADK TAGYRPQANV NTWNLVSPDS PRSTDSNSEV
1060 1070 1080 1090
VSFGSPCSIN SRQFLIPPKD EDSPKSNGGG WSFTNFFQNK PND
Length:1,093
Mass (Da):122,394
Last modified:August 1, 1998 - v1
Checksum:i08D43DEAF8F5E3F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86345 mRNA. Translation: BAA25907.1.
RefSeqiNP_112310.1. NM_031048.1.
UniGeneiRn.14529.

Genome annotation databases

GeneIDi81680.
KEGGirno:81680.
UCSCiRGD:621431. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86345 mRNA. Translation: BAA25907.1.
RefSeqiNP_112310.1. NM_031048.1.
UniGeneiRn.14529.

3D structure databases

ProteinModelPortaliO70535.
SMRiO70535. Positions 51-530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016036.

PTM databases

PhosphoSiteiO70535.

Proteomic databases

PaxDbiO70535.
PRIDEiO70535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81680.
KEGGirno:81680.
UCSCiRGD:621431. rat.

Organism-specific databases

CTDi3977.
RGDi621431. Lifr.

Phylogenomic databases

eggNOGiENOG410IF1V. Eukaryota.
ENOG410ZMDF. LUCA.
HOGENOMiHOG000113324.
HOVERGENiHBG006266.
InParanoidiO70535.
KOiK05058.
PhylomeDBiO70535.

Miscellaneous databases

PROiO70535.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIFR_RAT
AccessioniPrimary (citable) accession number: O70535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.