Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O70531 (S26A2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein homolog
Solute carrier family 26 member 2
Gene names
Name:Slc26a2
Synonyms:Dtdst
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sulfate transporter. May play a role in endochondral bone formation.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Cartilage and intestine.

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Sulfate transporter
PRO_0000080160

Regions

Topological domain1 – 111111Cytoplasmic Potential
Transmembrane112 – 13221Helical; Potential
Topological domain133 – 1364Extracellular Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 1592Cytoplasmic Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 21838Extracellular Potential
Transmembrane219 – 23921Helical; Potential
Topological domain240 – 2412Cytoplasmic Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 29634Extracellular Potential
Transmembrane297 – 31721Helical; Potential
Topological domain318 – 32811Cytoplasmic Potential
Transmembrane329 – 34921Helical; Potential
Topological domain350 – 37728Extracellular Potential
Transmembrane378 – 39821Helical; Potential
Topological domain399 – 42022Cytoplasmic Potential
Transmembrane421 – 44121Helical; Potential
Topological domain442 – 45413Extracellular Potential
Transmembrane455 – 47521Helical; Potential
Topological domain476 – 52348Cytoplasmic Potential
Transmembrane524 – 54421Helical; Potential
Topological domain545 – 64399Extracellular Potential
Transmembrane644 – 66421Helical; Potential
Topological domain665 – 73975Cytoplasmic Potential
Domain568 – 719152STAS

Amino acid modifications

Modified residue121Phosphoserine By similarity
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation3571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O70531 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 0C539F66D478C8DA

FASTA73982,028
        10         20         30         40         50         60 
MSSENKEQHN LSPRDLPEEA YGFPPELPLG AQRGSSTDLR QFEPSDRRRA FRRIHMELHE 

        70         80         90        100        110        120 
KPDTNIRQLV MRKLQKSCQC NATKIRNRIF DFFPVLRWLP KYDLKKNILG DMMSGLIVGI 

       130        140        150        160        170        180 
LLVPQSIAYS LLAGQEPIYG LYTSFFASII YFLFGTSRHI SVGIFGILCL MIGEVVDREL 

       190        200        210        220        230        240 
HKACPDIDTT SSSIAMFSNG CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ 

       250        260        270        280        290        300 
VGFVSVYLSD ALLSGFVTGA SFTILTSQAK YLLGLSLPRS NGVGSVITTW IHIFRNIHKT 

       310        320        330        340        350        360 
NICDLITSLL CLLVLVPTKE LNEYFKSKLP APIPTELIVV VAATLASHFG KLNENYNSSI 

       370        380        390        400        410        420 
AGQIPTGFMP PQAPDWSLIP NVAVDAIAIS IIGFAITVSL SEMFAKKHGY TVKANQEMYA 

       430        440        450        460        470        480 
IGFCNIIPSF FHCITTSAAL AKTLVKESTG CQTQLSAIVT SLVLLLVLLL IAPLFYSLQK 

       490        500        510        520        530        540 
CVLGVITIVN LRGALLKFRD LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF 

       550        560        570        580        590        600 
CVILRTQMPK ISLLGLEEES EIFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY 

       610        620        630        640        650        660 
KKTLNPVLVK AAWKKAAKRK LKEETVTFHG DPDEVSMQLS HDPLELHTVV IDCSAIQFLD 

       670        680        690        700        710        720 
TAGIHTLKEV RRDYEAIGIQ VLLAQCNPSV RDSLAKGEYC KKEEENLLFY SLSEAVAFAE 

       730 
ESQKEKGVCV VNGLSLSGD 

« Hide

References

[1]"Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans."
Satoh H., Susaki M., Shukunami C., Iyama K., Negoro T., Hiraki Y.
J. Biol. Chem. 273:12307-12315(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Osteosarcoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D82883 mRNA. Translation: BAA25987.1.
RefSeqNP_476468.1. NM_057127.1.
XP_006254846.1. XM_006254784.1.
XP_006254847.1. XM_006254785.1.
XP_006254848.1. XM_006254786.1.
XP_006254849.1. XM_006254787.1.
XP_006254850.1. XM_006254788.1.
UniGeneRn.14549.

3D structure databases

ProteinModelPortalO70531.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000024374.

Proteomic databases

PaxDbO70531.
PRIDEO70531.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024374; ENSRNOP00000024374; ENSRNOG00000018082.
GeneID117267.
KEGGrno:117267.
UCSCRGD:620622. rat.

Organism-specific databases

CTD1836.
RGD620622. Slc26a2.

Phylogenomic databases

eggNOGCOG0659.
GeneTreeENSGT00750000117294.
HOGENOMHOG000006546.
HOVERGENHBG000639.
InParanoidO70531.
KOK14701.
OMAKKTCSCT.
OrthoDBEOG76T9QT.
PhylomeDBO70531.
TreeFamTF313784.

Gene expression databases

GenevestigatorO70531.

Family and domain databases

Gene3D3.30.750.24. 2 hits.
InterProIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 2 hits.
TIGRFAMsTIGR00815. sulP. 1 hit.
PROSITEPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620161.
PROO70531.

Entry information

Entry nameS26A2_RAT
AccessionPrimary (citable) accession number: O70531
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families