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O70531

- S26A2_RAT

UniProt

O70531 - S26A2_RAT

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Protein

Sulfate transporter

Gene

Slc26a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sulfate transporter. May play a role in endochondral bone formation.

GO - Molecular functioni

  1. secondary active sulfate transmembrane transporter activity Source: InterPro
  2. sulfate transmembrane transporter activity Source: RGD

GO - Biological processi

  1. ossification Source: RGD
  2. sulfate transmembrane transport Source: GOC
  3. sulfate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_237370. Multifunctional anion exchangers.
REACT_253521. Transport and synthesis of PAPS.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein homolog
Solute carrier family 26 member 2
Gene namesi
Name:Slc26a2
Synonyms:Dtdst
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi620622. Slc26a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 111111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Topological domaini133 – 1364ExtracellularSequence Analysis
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 1592CytoplasmicSequence Analysis
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 21838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 2412CytoplasmicSequence Analysis
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Topological domaini263 – 29634ExtracellularSequence AnalysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence AnalysisAdd
BLAST
Topological domaini318 – 32811CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence AnalysisAdd
BLAST
Topological domaini350 – 37728ExtracellularSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Topological domaini399 – 42022CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST
Topological domaini442 – 45413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Topological domaini476 – 52348CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 64399ExtracellularSequence AnalysisAdd
BLAST
Transmembranei644 – 66421HelicalSequence AnalysisAdd
BLAST
Topological domaini665 – 73975CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Sulfate transporterPRO_0000080160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineBy similarity
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO70531.
PRIDEiO70531.

Expressioni

Tissue specificityi

Cartilage and intestine.

Gene expression databases

GenevestigatoriO70531.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024374.

Structurei

3D structure databases

ProteinModelPortaliO70531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini568 – 719152STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiO70531.
KOiK14701.
OMAiKKTCSCT.
OrthoDBiEOG76T9QT.
PhylomeDBiO70531.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70531-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSENKEQHN LSPRDLPEEA YGFPPELPLG AQRGSSTDLR QFEPSDRRRA
60 70 80 90 100
FRRIHMELHE KPDTNIRQLV MRKLQKSCQC NATKIRNRIF DFFPVLRWLP
110 120 130 140 150
KYDLKKNILG DMMSGLIVGI LLVPQSIAYS LLAGQEPIYG LYTSFFASII
160 170 180 190 200
YFLFGTSRHI SVGIFGILCL MIGEVVDREL HKACPDIDTT SSSIAMFSNG
210 220 230 240 250
CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ VGFVSVYLSD
260 270 280 290 300
ALLSGFVTGA SFTILTSQAK YLLGLSLPRS NGVGSVITTW IHIFRNIHKT
310 320 330 340 350
NICDLITSLL CLLVLVPTKE LNEYFKSKLP APIPTELIVV VAATLASHFG
360 370 380 390 400
KLNENYNSSI AGQIPTGFMP PQAPDWSLIP NVAVDAIAIS IIGFAITVSL
410 420 430 440 450
SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCITTSAAL AKTLVKESTG
460 470 480 490 500
CQTQLSAIVT SLVLLLVLLL IAPLFYSLQK CVLGVITIVN LRGALLKFRD
510 520 530 540 550
LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF CVILRTQMPK
560 570 580 590 600
ISLLGLEEES EIFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY
610 620 630 640 650
KKTLNPVLVK AAWKKAAKRK LKEETVTFHG DPDEVSMQLS HDPLELHTVV
660 670 680 690 700
IDCSAIQFLD TAGIHTLKEV RRDYEAIGIQ VLLAQCNPSV RDSLAKGEYC
710 720 730
KKEEENLLFY SLSEAVAFAE ESQKEKGVCV VNGLSLSGD
Length:739
Mass (Da):82,028
Last modified:August 1, 1998 - v1
Checksum:i0C539F66D478C8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82883 mRNA. Translation: BAA25987.1.
RefSeqiNP_476468.1. NM_057127.1.
XP_006254846.1. XM_006254784.2.
XP_006254847.1. XM_006254785.2.
XP_006254848.1. XM_006254786.2.
XP_006254849.1. XM_006254787.2.
XP_006254850.1. XM_006254788.2.
UniGeneiRn.14549.

Genome annotation databases

EnsembliENSRNOT00000024374; ENSRNOP00000024374; ENSRNOG00000018082.
GeneIDi117267.
KEGGirno:117267.
UCSCiRGD:620622. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82883 mRNA. Translation: BAA25987.1 .
RefSeqi NP_476468.1. NM_057127.1.
XP_006254846.1. XM_006254784.2.
XP_006254847.1. XM_006254785.2.
XP_006254848.1. XM_006254786.2.
XP_006254849.1. XM_006254787.2.
XP_006254850.1. XM_006254788.2.
UniGenei Rn.14549.

3D structure databases

ProteinModelPortali O70531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024374.

Proteomic databases

PaxDbi O70531.
PRIDEi O70531.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024374 ; ENSRNOP00000024374 ; ENSRNOG00000018082 .
GeneIDi 117267.
KEGGi rno:117267.
UCSCi RGD:620622. rat.

Organism-specific databases

CTDi 1836.
RGDi 620622. Slc26a2.

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00760000119026.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi O70531.
KOi K14701.
OMAi KKTCSCT.
OrthoDBi EOG76T9QT.
PhylomeDBi O70531.
TreeFami TF313784.

Enzyme and pathway databases

Reactomei REACT_237370. Multifunctional anion exchangers.
REACT_253521. Transport and synthesis of PAPS.

Miscellaneous databases

NextBioi 620161.
PROi O70531.

Gene expression databases

Genevestigatori O70531.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans."
    Satoh H., Susaki M., Shukunami C., Iyama K., Negoro T., Hiraki Y.
    J. Biol. Chem. 273:12307-12315(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Osteosarcoma.

Entry informationi

Entry nameiS26A2_RAT
AccessioniPrimary (citable) accession number: O70531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3