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O70531

- S26A2_RAT

UniProt

O70531 - S26A2_RAT

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Protein
Sulfate transporter
Gene
Slc26a2, Dtdst
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sulfate transporter. May play a role in endochondral bone formation.

GO - Molecular functioni

  1. secondary active sulfate transmembrane transporter activity Source: InterPro
  2. sulfate transmembrane transporter activity Source: RGD

GO - Biological processi

  1. ossification Source: RGD
  2. sulfate transmembrane transport Source: GOC
  3. sulfate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein homolog
Solute carrier family 26 member 2
Gene namesi
Name:Slc26a2
Synonyms:Dtdst
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi620622. Slc26a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 111111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Topological domaini133 – 1364Extracellular Reviewed prediction
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 1592Cytoplasmic Reviewed prediction
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 21838Extracellular Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Reviewed prediction
Add
BLAST
Topological domaini240 – 2412Cytoplasmic Reviewed prediction
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Topological domaini263 – 29634Extracellular Reviewed prediction
Add
BLAST
Transmembranei297 – 31721Helical; Reviewed prediction
Add
BLAST
Topological domaini318 – 32811Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei329 – 34921Helical; Reviewed prediction
Add
BLAST
Topological domaini350 – 37728Extracellular Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Topological domaini399 – 42022Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei421 – 44121Helical; Reviewed prediction
Add
BLAST
Topological domaini442 – 45413Extracellular Reviewed prediction
Add
BLAST
Transmembranei455 – 47521Helical; Reviewed prediction
Add
BLAST
Topological domaini476 – 52348Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei524 – 54421Helical; Reviewed prediction
Add
BLAST
Topological domaini545 – 64399Extracellular Reviewed prediction
Add
BLAST
Transmembranei644 – 66421Helical; Reviewed prediction
Add
BLAST
Topological domaini665 – 73975Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Sulfate transporter
PRO_0000080160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine By similarity
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO70531.
PRIDEiO70531.

Expressioni

Tissue specificityi

Cartilage and intestine.

Gene expression databases

GenevestigatoriO70531.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024374.

Structurei

3D structure databases

ProteinModelPortaliO70531.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini568 – 719152STAS
Add
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00750000117294.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiO70531.
KOiK14701.
OMAiKKTCSCT.
OrthoDBiEOG76T9QT.
PhylomeDBiO70531.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70531-1 [UniParc]FASTAAdd to Basket

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MSSENKEQHN LSPRDLPEEA YGFPPELPLG AQRGSSTDLR QFEPSDRRRA    50
FRRIHMELHE KPDTNIRQLV MRKLQKSCQC NATKIRNRIF DFFPVLRWLP 100
KYDLKKNILG DMMSGLIVGI LLVPQSIAYS LLAGQEPIYG LYTSFFASII 150
YFLFGTSRHI SVGIFGILCL MIGEVVDREL HKACPDIDTT SSSIAMFSNG 200
CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ VGFVSVYLSD 250
ALLSGFVTGA SFTILTSQAK YLLGLSLPRS NGVGSVITTW IHIFRNIHKT 300
NICDLITSLL CLLVLVPTKE LNEYFKSKLP APIPTELIVV VAATLASHFG 350
KLNENYNSSI AGQIPTGFMP PQAPDWSLIP NVAVDAIAIS IIGFAITVSL 400
SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCITTSAAL AKTLVKESTG 450
CQTQLSAIVT SLVLLLVLLL IAPLFYSLQK CVLGVITIVN LRGALLKFRD 500
LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF CVILRTQMPK 550
ISLLGLEEES EIFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY 600
KKTLNPVLVK AAWKKAAKRK LKEETVTFHG DPDEVSMQLS HDPLELHTVV 650
IDCSAIQFLD TAGIHTLKEV RRDYEAIGIQ VLLAQCNPSV RDSLAKGEYC 700
KKEEENLLFY SLSEAVAFAE ESQKEKGVCV VNGLSLSGD 739
Length:739
Mass (Da):82,028
Last modified:August 1, 1998 - v1
Checksum:i0C539F66D478C8DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D82883 mRNA. Translation: BAA25987.1.
RefSeqiNP_476468.1. NM_057127.1.
XP_006254846.1. XM_006254784.1.
XP_006254847.1. XM_006254785.1.
XP_006254848.1. XM_006254786.1.
XP_006254849.1. XM_006254787.1.
XP_006254850.1. XM_006254788.1.
UniGeneiRn.14549.

Genome annotation databases

EnsembliENSRNOT00000024374; ENSRNOP00000024374; ENSRNOG00000018082.
GeneIDi117267.
KEGGirno:117267.
UCSCiRGD:620622. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D82883 mRNA. Translation: BAA25987.1 .
RefSeqi NP_476468.1. NM_057127.1.
XP_006254846.1. XM_006254784.1.
XP_006254847.1. XM_006254785.1.
XP_006254848.1. XM_006254786.1.
XP_006254849.1. XM_006254787.1.
XP_006254850.1. XM_006254788.1.
UniGenei Rn.14549.

3D structure databases

ProteinModelPortali O70531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024374.

Proteomic databases

PaxDbi O70531.
PRIDEi O70531.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000024374 ; ENSRNOP00000024374 ; ENSRNOG00000018082 .
GeneIDi 117267.
KEGGi rno:117267.
UCSCi RGD:620622. rat.

Organism-specific databases

CTDi 1836.
RGDi 620622. Slc26a2.

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00750000117294.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi O70531.
KOi K14701.
OMAi KKTCSCT.
OrthoDBi EOG76T9QT.
PhylomeDBi O70531.
TreeFami TF313784.

Miscellaneous databases

NextBioi 620161.
PROi O70531.

Gene expression databases

Genevestigatori O70531.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans."
    Satoh H., Susaki M., Shukunami C., Iyama K., Negoro T., Hiraki Y.
    J. Biol. Chem. 273:12307-12315(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Osteosarcoma.

Entry informationi

Entry nameiS26A2_RAT
AccessioniPrimary (citable) accession number: O70531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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