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O70531

- S26A2_RAT

UniProt

O70531 - S26A2_RAT

Protein

Sulfate transporter

Gene

Slc26a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Sulfate transporter. May play a role in endochondral bone formation.

    GO - Molecular functioni

    1. secondary active sulfate transmembrane transporter activity Source: InterPro
    2. sulfate transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. ossification Source: RGD
    2. sulfate transmembrane transport Source: GOC
    3. sulfate transport Source: RGD

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfate transporter
    Alternative name(s):
    Diastrophic dysplasia protein homolog
    Solute carrier family 26 member 2
    Gene namesi
    Name:Slc26a2
    Synonyms:Dtdst
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi620622. Slc26a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Sulfate transporterPRO_0000080160Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO70531.
    PRIDEiO70531.

    Expressioni

    Tissue specificityi

    Cartilage and intestine.

    Gene expression databases

    GenevestigatoriO70531.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024374.

    Structurei

    3D structure databases

    ProteinModelPortaliO70531.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 111111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 1364ExtracellularSequence Analysis
    Topological domaini158 – 1592CytoplasmicSequence Analysis
    Topological domaini181 – 21838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 2412CytoplasmicSequence Analysis
    Topological domaini263 – 29634ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 32811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini350 – 37728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini399 – 42022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini442 – 45413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini476 – 52348CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini545 – 64399ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini665 – 73975CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini568 – 719152STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    GeneTreeiENSGT00750000117294.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    InParanoidiO70531.
    KOiK14701.
    OMAiKKTCSCT.
    OrthoDBiEOG76T9QT.
    PhylomeDBiO70531.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O70531-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSENKEQHN LSPRDLPEEA YGFPPELPLG AQRGSSTDLR QFEPSDRRRA    50
    FRRIHMELHE KPDTNIRQLV MRKLQKSCQC NATKIRNRIF DFFPVLRWLP 100
    KYDLKKNILG DMMSGLIVGI LLVPQSIAYS LLAGQEPIYG LYTSFFASII 150
    YFLFGTSRHI SVGIFGILCL MIGEVVDREL HKACPDIDTT SSSIAMFSNG 200
    CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ VGFVSVYLSD 250
    ALLSGFVTGA SFTILTSQAK YLLGLSLPRS NGVGSVITTW IHIFRNIHKT 300
    NICDLITSLL CLLVLVPTKE LNEYFKSKLP APIPTELIVV VAATLASHFG 350
    KLNENYNSSI AGQIPTGFMP PQAPDWSLIP NVAVDAIAIS IIGFAITVSL 400
    SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCITTSAAL AKTLVKESTG 450
    CQTQLSAIVT SLVLLLVLLL IAPLFYSLQK CVLGVITIVN LRGALLKFRD 500
    LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF CVILRTQMPK 550
    ISLLGLEEES EIFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY 600
    KKTLNPVLVK AAWKKAAKRK LKEETVTFHG DPDEVSMQLS HDPLELHTVV 650
    IDCSAIQFLD TAGIHTLKEV RRDYEAIGIQ VLLAQCNPSV RDSLAKGEYC 700
    KKEEENLLFY SLSEAVAFAE ESQKEKGVCV VNGLSLSGD 739
    Length:739
    Mass (Da):82,028
    Last modified:August 1, 1998 - v1
    Checksum:i0C539F66D478C8DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82883 mRNA. Translation: BAA25987.1.
    RefSeqiNP_476468.1. NM_057127.1.
    XP_006254846.1. XM_006254784.1.
    XP_006254847.1. XM_006254785.1.
    XP_006254848.1. XM_006254786.1.
    XP_006254849.1. XM_006254787.1.
    XP_006254850.1. XM_006254788.1.
    UniGeneiRn.14549.

    Genome annotation databases

    EnsembliENSRNOT00000024374; ENSRNOP00000024374; ENSRNOG00000018082.
    GeneIDi117267.
    KEGGirno:117267.
    UCSCiRGD:620622. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82883 mRNA. Translation: BAA25987.1 .
    RefSeqi NP_476468.1. NM_057127.1.
    XP_006254846.1. XM_006254784.1.
    XP_006254847.1. XM_006254785.1.
    XP_006254848.1. XM_006254786.1.
    XP_006254849.1. XM_006254787.1.
    XP_006254850.1. XM_006254788.1.
    UniGenei Rn.14549.

    3D structure databases

    ProteinModelPortali O70531.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024374.

    Proteomic databases

    PaxDbi O70531.
    PRIDEi O70531.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000024374 ; ENSRNOP00000024374 ; ENSRNOG00000018082 .
    GeneIDi 117267.
    KEGGi rno:117267.
    UCSCi RGD:620622. rat.

    Organism-specific databases

    CTDi 1836.
    RGDi 620622. Slc26a2.

    Phylogenomic databases

    eggNOGi COG0659.
    GeneTreei ENSGT00750000117294.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    InParanoidi O70531.
    KOi K14701.
    OMAi KKTCSCT.
    OrthoDBi EOG76T9QT.
    PhylomeDBi O70531.
    TreeFami TF313784.

    Miscellaneous databases

    NextBioi 620161.
    PROi O70531.

    Gene expression databases

    Genevestigatori O70531.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans."
      Satoh H., Susaki M., Shukunami C., Iyama K., Negoro T., Hiraki Y.
      J. Biol. Chem. 273:12307-12315(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Osteosarcoma.

    Entry informationi

    Entry nameiS26A2_RAT
    AccessioniPrimary (citable) accession number: O70531
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3