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Protein

Sulfate transporter

Gene

Slc26a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sulfate transporter. May play a role in endochondral bone formation.

GO - Molecular functioni

GO - Biological processi

  • bicarbonate transport Source: GO_Central
  • chloride transmembrane transport Source: GO_Central
  • ossification Source: RGD
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • sulfate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-174362. Transport and synthesis of PAPS.
R-RNO-427601. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein homolog
Solute carrier family 26 member 2
Gene namesi
Name:Slc26a2
Synonyms:Dtdst
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi620622. Slc26a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 111CytoplasmicSequence analysisAdd BLAST111
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 136ExtracellularSequence analysis4
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 159CytoplasmicSequence analysis2
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 218ExtracellularSequence analysisAdd BLAST38
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 241CytoplasmicSequence analysis2
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 296ExtracellularSequence analysisAdd BLAST34
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Topological domaini318 – 328CytoplasmicSequence analysisAdd BLAST11
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 377ExtracellularSequence analysisAdd BLAST28
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 420CytoplasmicSequence analysisAdd BLAST22
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 454ExtracellularSequence analysisAdd BLAST13
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 523CytoplasmicSequence analysisAdd BLAST48
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 643ExtracellularSequence analysisAdd BLAST99
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 739CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801601 – 739Sulfate transporterAdd BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO70531.
PRIDEiO70531.

Expressioni

Tissue specificityi

Cartilage and intestine.

Gene expression databases

BgeeiENSRNOG00000018082.
GenevisibleiO70531. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024374.

Structurei

3D structure databases

ProteinModelPortaliO70531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini568 – 719STASPROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiO70531.
KOiK14701.
OMAiDTVIWLV.
OrthoDBiEOG091G07RT.
PhylomeDBiO70531.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030280. SLC26A2.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PTHR11814:SF16. PTHR11814:SF16. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSENKEQHN LSPRDLPEEA YGFPPELPLG AQRGSSTDLR QFEPSDRRRA
60 70 80 90 100
FRRIHMELHE KPDTNIRQLV MRKLQKSCQC NATKIRNRIF DFFPVLRWLP
110 120 130 140 150
KYDLKKNILG DMMSGLIVGI LLVPQSIAYS LLAGQEPIYG LYTSFFASII
160 170 180 190 200
YFLFGTSRHI SVGIFGILCL MIGEVVDREL HKACPDIDTT SSSIAMFSNG
210 220 230 240 250
CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ VGFVSVYLSD
260 270 280 290 300
ALLSGFVTGA SFTILTSQAK YLLGLSLPRS NGVGSVITTW IHIFRNIHKT
310 320 330 340 350
NICDLITSLL CLLVLVPTKE LNEYFKSKLP APIPTELIVV VAATLASHFG
360 370 380 390 400
KLNENYNSSI AGQIPTGFMP PQAPDWSLIP NVAVDAIAIS IIGFAITVSL
410 420 430 440 450
SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCITTSAAL AKTLVKESTG
460 470 480 490 500
CQTQLSAIVT SLVLLLVLLL IAPLFYSLQK CVLGVITIVN LRGALLKFRD
510 520 530 540 550
LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF CVILRTQMPK
560 570 580 590 600
ISLLGLEEES EIFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY
610 620 630 640 650
KKTLNPVLVK AAWKKAAKRK LKEETVTFHG DPDEVSMQLS HDPLELHTVV
660 670 680 690 700
IDCSAIQFLD TAGIHTLKEV RRDYEAIGIQ VLLAQCNPSV RDSLAKGEYC
710 720 730
KKEEENLLFY SLSEAVAFAE ESQKEKGVCV VNGLSLSGD
Length:739
Mass (Da):82,028
Last modified:August 1, 1998 - v1
Checksum:i0C539F66D478C8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82883 mRNA. Translation: BAA25987.1.
RefSeqiNP_476468.1. NM_057127.1.
XP_006254849.1. XM_006254787.2.
XP_006254850.1. XM_006254788.2.
XP_017456324.1. XM_017600835.1.
UniGeneiRn.14549.

Genome annotation databases

EnsembliENSRNOT00000024374; ENSRNOP00000024374; ENSRNOG00000018082.
GeneIDi117267.
KEGGirno:117267.
UCSCiRGD:620622. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82883 mRNA. Translation: BAA25987.1.
RefSeqiNP_476468.1. NM_057127.1.
XP_006254849.1. XM_006254787.2.
XP_006254850.1. XM_006254788.2.
XP_017456324.1. XM_017600835.1.
UniGeneiRn.14549.

3D structure databases

ProteinModelPortaliO70531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024374.

Proteomic databases

PaxDbiO70531.
PRIDEiO70531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024374; ENSRNOP00000024374; ENSRNOG00000018082.
GeneIDi117267.
KEGGirno:117267.
UCSCiRGD:620622. rat.

Organism-specific databases

CTDi1836.
RGDi620622. Slc26a2.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiO70531.
KOiK14701.
OMAiDTVIWLV.
OrthoDBiEOG091G07RT.
PhylomeDBiO70531.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-RNO-174362. Transport and synthesis of PAPS.
R-RNO-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiO70531.

Gene expression databases

BgeeiENSRNOG00000018082.
GenevisibleiO70531. RN.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030280. SLC26A2.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PTHR11814:SF16. PTHR11814:SF16. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS26A2_RAT
AccessioniPrimary (citable) accession number: O70531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.