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Protein

B2 bradykinin receptor

Gene

BDKRB2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
B2 bradykinin receptor
Short name:
B2R
Short name:
BK-2 receptor
Gene namesi
Name:BDKRB2
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 58Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini59 – 67CytoplasmicSequence analysis9
Transmembranei68 – 92Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini93 – 105ExtracellularSequence analysisAdd BLAST13
Transmembranei106 – 127Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini128 – 149CytoplasmicSequence analysisAdd BLAST22
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 195ExtracellularSequence analysisAdd BLAST23
Transmembranei196 – 222Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini223 – 241CytoplasmicSequence analysisAdd BLAST19
Transmembranei242 – 266Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini267 – 284ExtracellularSequence analysisAdd BLAST18
Transmembranei285 – 308Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini309 – 364CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691891 – 372B2 bradykinin receptorAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 185PROSITE-ProRule annotation
Modified residuei130PhosphotyrosineBy similarity1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Modified residuei320PhosphotyrosineBy similarity1
Lipidationi324S-palmitoyl cysteineBy similarity1
Modified residuei339PhosphoserineBy similarity1
Modified residuei342PhosphothreonineBy similarity1
Modified residuei346Phosphoserine; by GRK6By similarity1
Modified residuei348Phosphoserine; by GRK6By similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Subunit structurei

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020477.

Chemistry databases

BindingDBiO70526.

Structurei

3D structure databases

ProteinModelPortaliO70526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INT3. Eukaryota.
ENOG41117RA. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiO70526.
OMAiENSMGTL.
OrthoDBiEOG091G0AAK.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNITSQVSA LNATLAQGNS CLDAEWWSWL NTIQAPFLWV LFVLAVLENI
60 70 80 90 100
FVLSVFFLHK SSCTVAEIYL GNLAVADLIL AFGLPFWAIT IANNFDWLFG
110 120 130 140 150
EVLCRMVNTM IQMNMYSSIC FLMLVSIDRY LALVKTMSMG RMRGVRWAKL
160 170 180 190 200
YSLVIWGCAL LLSSPMLVFR TMKDYRDEGH NVTACLIIYP SLTWQVFTNV
210 220 230 240 250
LLNLVGFLLP LSIITFCTVQ IMQVLRNNEM QKFKEIQTER RATVLVLAVL
260 270 280 290 300
LLFVVCWLPF QIGTFLDTLR LLGFLPGCWE HVIDLITQIS SYLAYSNSCL
310 320 330 340 350
NPLVYVIVGK RFRKKSREVY HGLCRSGGCV SEPAQSENSM GTLRTSISVD
360 370
RQIHKLQDWA RSSSEGTPPG LL
Length:372
Mass (Da):42,210
Last modified:August 1, 1998 - v1
Checksum:i8B736B50887DAE67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003243 mRNA. Translation: CAA06025.1.
RefSeqiNP_001166391.1. NM_001172920.1.

Genome annotation databases

EnsembliENSCPOT00000015571; ENSCPOP00000020477; ENSCPOG00000015420.
GeneIDi100135486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003243 mRNA. Translation: CAA06025.1.
RefSeqiNP_001166391.1. NM_001172920.1.

3D structure databases

ProteinModelPortaliO70526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020477.

Chemistry databases

BindingDBiO70526.
ChEMBLiCHEMBL4111.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000015571; ENSCPOP00000020477; ENSCPOG00000015420.
GeneIDi100135486.

Organism-specific databases

CTDi624.

Phylogenomic databases

eggNOGiENOG410INT3. Eukaryota.
ENOG41117RA. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiO70526.
OMAiENSMGTL.
OrthoDBiEOG091G0AAK.
TreeFamiTF330024.

Miscellaneous databases

PROiO70526.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBKRB2_CAVPO
AccessioniPrimary (citable) accession number: O70526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.