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Protein

B2 bradykinin receptor

Gene

BDKRB2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
B2 bradykinin receptor
Short name:
B2R
Short name:
BK-2 receptor
Gene namesi
Name:BDKRB2
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5824Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 679CytoplasmicSequence analysis
Transmembranei68 – 9225Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini93 – 10513ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12722Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 14922CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17223Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini173 – 19523ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 22227Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini223 – 24119CytoplasmicSequence analysisAdd
BLAST
Transmembranei242 – 26625Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 28418ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30824Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 36456CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372B2 bradykinin receptorPRO_0000069189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 185PROSITE-ProRule annotation
Modified residuei130 – 1301PhosphotyrosineBy similarity
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence analysis
Modified residuei320 – 3201PhosphotyrosineBy similarity
Lipidationi324 – 3241S-palmitoyl cysteineBy similarity
Modified residuei339 – 3391PhosphoserineBy similarity
Modified residuei342 – 3421PhosphothreonineBy similarity
Modified residuei346 – 3461Phosphoserine; by GRK6By similarity
Modified residuei348 – 3481Phosphoserine; by GRK6By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Subunit structurei

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020477.

Chemistry

BindingDBiO70526.

Structurei

3D structure databases

ProteinModelPortaliO70526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INT3. Eukaryota.
ENOG41117RA. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiO70526.
OMAiENSMGTL.
OrthoDBiEOG7HHWSV.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNITSQVSA LNATLAQGNS CLDAEWWSWL NTIQAPFLWV LFVLAVLENI
60 70 80 90 100
FVLSVFFLHK SSCTVAEIYL GNLAVADLIL AFGLPFWAIT IANNFDWLFG
110 120 130 140 150
EVLCRMVNTM IQMNMYSSIC FLMLVSIDRY LALVKTMSMG RMRGVRWAKL
160 170 180 190 200
YSLVIWGCAL LLSSPMLVFR TMKDYRDEGH NVTACLIIYP SLTWQVFTNV
210 220 230 240 250
LLNLVGFLLP LSIITFCTVQ IMQVLRNNEM QKFKEIQTER RATVLVLAVL
260 270 280 290 300
LLFVVCWLPF QIGTFLDTLR LLGFLPGCWE HVIDLITQIS SYLAYSNSCL
310 320 330 340 350
NPLVYVIVGK RFRKKSREVY HGLCRSGGCV SEPAQSENSM GTLRTSISVD
360 370
RQIHKLQDWA RSSSEGTPPG LL
Length:372
Mass (Da):42,210
Last modified:August 1, 1998 - v1
Checksum:i8B736B50887DAE67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003243 mRNA. Translation: CAA06025.1.
RefSeqiNP_001166391.1. NM_001172920.1.

Genome annotation databases

EnsembliENSCPOT00000015571; ENSCPOP00000020477; ENSCPOG00000015420.
GeneIDi100135486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003243 mRNA. Translation: CAA06025.1.
RefSeqiNP_001166391.1. NM_001172920.1.

3D structure databases

ProteinModelPortaliO70526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020477.

Chemistry

BindingDBiO70526.
ChEMBLiCHEMBL4111.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000015571; ENSCPOP00000020477; ENSCPOG00000015420.
GeneIDi100135486.

Organism-specific databases

CTDi624.

Phylogenomic databases

eggNOGiENOG410INT3. Eukaryota.
ENOG41117RA. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiO70526.
OMAiENSMGTL.
OrthoDBiEOG7HHWSV.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing and functional expression of a guinea pig lung bradykinin B2 receptor."
    Farmer S.G., Powell S.J., Wilkins D.E., Graham A.
    Eur. J. Pharmacol. 346:291-298(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Lung.

Entry informationi

Entry nameiBKRB2_CAVPO
AccessioniPrimary (citable) accession number: O70526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: March 16, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.