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O70521

- RGS19_RAT

UniProt

O70521 - RGS19_RAT

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Protein

Regulator of G-protein signaling 19

Gene

Rgs19

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

  1. G-protein alpha-subunit binding Source: RGD
  2. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 19
Short name:
RGS19
Alternative name(s):
G-alpha-interacting protein
Short name:
GAIP
Gene namesi
Name:Rgs19
Synonyms:Gaip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi629471. Rgs19.

Subcellular locationi

Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. brush border Source: RGD
  2. clathrin-coated vesicle Source: RGD
  3. cytoplasm Source: RGD
  4. Golgi membrane Source: RGD
  5. membrane Source: RGD
  6. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi24 – 241S → A: 50% reduction of phosphorylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Regulator of G-protein signaling 19PRO_0000204231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Phosphoserine; by CK21 Publication
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei151 – 1511Phosphoserine; by MAPK1 and MAPK3By similarity

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
Phosphorylated, mainly on serine residues.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

PTM databases

PhosphoSiteiO70521.

Expressioni

Gene expression databases

GenevestigatoriO70521.

Interactioni

Subunit structurei

Interacts with GIPC PDZ domain.

Protein-protein interaction databases

BioGridi248744. 1 interaction.
MINTiMINT-191738.
STRINGi10116.ENSRNOP00000022451.

Structurei

3D structure databases

ProteinModelPortaliO70521.
SMRiO70521. Positions 79-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 206117RGSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 21610Interaction with GIPC

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 4911Poly-CysAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258376.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiO70521.
KOiK16449.
OMAiFDKLMHS.
OrthoDBiEOG7SN8DQ.
PhylomeDBiO70521.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70521 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS
60 70 80 90 100
WNQERQRAWQ VSRESKLQPL PSCEVCTPPS PEEVQSWAQS FDKLMHSPTG
110 120 130 140 150
RSVFRAFLRT EYSEENMLFW LACEELKTEA DRHVVDEKAR LIYEDYVSIL
160 170 180 190 200
SPKEVSLDSR VREGINRKMQ EPSPHTFDDA QLQIYTLMHR DSYPRFLTSP
210
TYRSLLLQGA PQSSEA
Length:216
Mass (Da):24,738
Last modified:August 1, 1998 - v1
Checksum:i554C479D4DD89238
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF068136 mRNA. Translation: AAC19130.1.
BC088141 mRNA. Translation: AAH88141.1.
RefSeqiNP_067693.1. NM_021661.2.
UniGeneiRn.88166.

Genome annotation databases

EnsembliENSRNOT00000022451; ENSRNOP00000022451; ENSRNOG00000016547.
GeneIDi59293.
KEGGirno:59293.
UCSCiRGD:629471. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF068136 mRNA. Translation: AAC19130.1 .
BC088141 mRNA. Translation: AAH88141.1 .
RefSeqi NP_067693.1. NM_021661.2.
UniGenei Rn.88166.

3D structure databases

ProteinModelPortali O70521.
SMRi O70521. Positions 79-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248744. 1 interaction.
MINTi MINT-191738.
STRINGi 10116.ENSRNOP00000022451.

PTM databases

PhosphoSitei O70521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022451 ; ENSRNOP00000022451 ; ENSRNOG00000016547 .
GeneIDi 59293.
KEGGi rno:59293.
UCSCi RGD:629471. rat.

Organism-specific databases

CTDi 10287.
RGDi 629471. Rgs19.

Phylogenomic databases

eggNOGi NOG258376.
GeneTreei ENSGT00760000118903.
HOGENOMi HOG000233513.
HOVERGENi HBG013233.
InParanoidi O70521.
KOi K16449.
OMAi FDKLMHS.
OrthoDBi EOG7SN8DQ.
PhylomeDBi O70521.

Miscellaneous databases

NextBioi 611813.
PROi O70521.

Gene expression databases

Genevestigatori O70521.

Family and domain databases

Gene3Di 1.10.196.10. 1 hit.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles."
    de Vries L., Elenko E., McCaffery J.M., Fischer T., Hubler L., McQuistan T., Watson N., Farquhar M.G.
    Mol. Biol. Cell 9:1123-1134(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles."
    Fischer T., Elenko E., Wan L., Thomas G., Farquhar M.G.
    Proc. Natl. Acad. Sci. U.S.A. 97:4040-4045(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-24, MUTAGENESIS OF SER-24.

Entry informationi

Entry nameiRGS19_RAT
AccessioniPrimary (citable) accession number: O70521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3