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O70521

- RGS19_RAT

UniProt

O70521 - RGS19_RAT

Protein

Regulator of G-protein signaling 19

Gene

Rgs19

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein By similarity.By similarity

    GO - Molecular functioni

    1. G-protein alpha-subunit binding Source: RGD
    2. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 19
    Short name:
    RGS19
    Alternative name(s):
    G-alpha-interacting protein
    Short name:
    GAIP
    Gene namesi
    Name:Rgs19
    Synonyms:Gaip
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi629471. Rgs19.

    Subcellular locationi

    Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. brush border Source: RGD
    2. clathrin-coated vesicle Source: RGD
    3. cytoplasm Source: RGD
    4. Golgi membrane Source: RGD
    5. membrane Source: RGD
    6. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi24 – 241S → A: 50% reduction of phosphorylation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Regulator of G-protein signaling 19PRO_0000204231Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Phosphoserine; by CK21 Publication
    Modified residuei97 – 971PhosphoserineBy similarity
    Modified residuei151 – 1511Phosphoserine; by MAPK1 and MAPK3By similarity

    Post-translational modificationi

    Fatty acylated. Heavily palmitoylated in the cysteine string motif By similarity.By similarity
    Phosphorylated, mainly on serine residues.1 Publication

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    PTM databases

    PhosphoSiteiO70521.

    Expressioni

    Gene expression databases

    GenevestigatoriO70521.

    Interactioni

    Subunit structurei

    Interacts with GIPC PDZ domain.

    Protein-protein interaction databases

    BioGridi248744. 1 interaction.
    MINTiMINT-191738.
    STRINGi10116.ENSRNOP00000022451.

    Structurei

    3D structure databases

    ProteinModelPortaliO70521.
    SMRiO70521. Positions 79-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini90 – 206117RGSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni207 – 21610Interaction with GIPC

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi39 – 4911Poly-CysAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258376.
    GeneTreeiENSGT00750000117371.
    HOGENOMiHOG000233513.
    HOVERGENiHBG013233.
    InParanoidiO70521.
    KOiK16449.
    OMAiFDKLMHS.
    OrthoDBiEOG7SN8DQ.
    PhylomeDBiO70521.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O70521-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS    50
    WNQERQRAWQ VSRESKLQPL PSCEVCTPPS PEEVQSWAQS FDKLMHSPTG 100
    RSVFRAFLRT EYSEENMLFW LACEELKTEA DRHVVDEKAR LIYEDYVSIL 150
    SPKEVSLDSR VREGINRKMQ EPSPHTFDDA QLQIYTLMHR DSYPRFLTSP 200
    TYRSLLLQGA PQSSEA 216
    Length:216
    Mass (Da):24,738
    Last modified:August 1, 1998 - v1
    Checksum:i554C479D4DD89238
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068136 mRNA. Translation: AAC19130.1.
    BC088141 mRNA. Translation: AAH88141.1.
    RefSeqiNP_067693.1. NM_021661.2.
    UniGeneiRn.88166.

    Genome annotation databases

    EnsembliENSRNOT00000022451; ENSRNOP00000022451; ENSRNOG00000016547.
    GeneIDi59293.
    KEGGirno:59293.
    UCSCiRGD:629471. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068136 mRNA. Translation: AAC19130.1 .
    BC088141 mRNA. Translation: AAH88141.1 .
    RefSeqi NP_067693.1. NM_021661.2.
    UniGenei Rn.88166.

    3D structure databases

    ProteinModelPortali O70521.
    SMRi O70521. Positions 79-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248744. 1 interaction.
    MINTi MINT-191738.
    STRINGi 10116.ENSRNOP00000022451.

    PTM databases

    PhosphoSitei O70521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022451 ; ENSRNOP00000022451 ; ENSRNOG00000016547 .
    GeneIDi 59293.
    KEGGi rno:59293.
    UCSCi RGD:629471. rat.

    Organism-specific databases

    CTDi 10287.
    RGDi 629471. Rgs19.

    Phylogenomic databases

    eggNOGi NOG258376.
    GeneTreei ENSGT00750000117371.
    HOGENOMi HOG000233513.
    HOVERGENi HBG013233.
    InParanoidi O70521.
    KOi K16449.
    OMAi FDKLMHS.
    OrthoDBi EOG7SN8DQ.
    PhylomeDBi O70521.

    Miscellaneous databases

    NextBioi 611813.
    PROi O70521.

    Gene expression databases

    Genevestigatori O70521.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles."
      de Vries L., Elenko E., McCaffery J.M., Fischer T., Hubler L., McQuistan T., Watson N., Farquhar M.G.
      Mol. Biol. Cell 9:1123-1134(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    3. "Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles."
      Fischer T., Elenko E., Wan L., Thomas G., Farquhar M.G.
      Proc. Natl. Acad. Sci. U.S.A. 97:4040-4045(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-24, MUTAGENESIS OF SER-24.

    Entry informationi

    Entry nameiRGS19_RAT
    AccessioniPrimary (citable) accession number: O70521
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3