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Protein

Regulator of G-protein signaling 19

Gene

Rgs19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD
  • GTPase activator activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 19
Short name:
RGS19
Alternative name(s):
G-alpha-interacting protein
Short name:
GAIP
Gene namesi
Name:Rgs19
Synonyms:Gaip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi629471. Rgs19.

Subcellular locationi

GO - Cellular componenti

  • brush border Source: RGD
  • clathrin-coated vesicle Source: RGD
  • cytoplasm Source: RGD
  • Golgi membrane Source: RGD
  • membrane Source: RGD
  • membrane raft Source: RGD
  • plasma membrane Source: GO_Central

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24S → A: 50% reduction of phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042311 – 216Regulator of G-protein signaling 19Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Phosphoserine; by CK21 Publication1
Modified residuei97PhosphoserineBy similarity1
Modified residuei151Phosphoserine; by MAPK1 and MAPK3By similarity1

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
Phosphorylated, mainly on serine residues.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO70521.
PRIDEiO70521.

PTM databases

iPTMnetiO70521.
PhosphoSitePlusiO70521.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016547.
GenevisibleiO70521. RN.

Interactioni

Subunit structurei

Interacts with GIPC PDZ domain.

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD

Protein-protein interaction databases

BioGridi248744. 1 interactor.
MINTiMINT-191738.
STRINGi10116.ENSRNOP00000022451.

Structurei

3D structure databases

ProteinModelPortaliO70521.
SMRiO70521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 206RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 216Interaction with GIPC10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 49Poly-CysAdd BLAST11

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiO70521.
KOiK16449.
OMAiGINKKMQ.
OrthoDBiEOG091G0BDG.
PhylomeDBiO70521.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiView protein in InterPro
IPR016137. RGS.
IPR024066. RGS_subdom1.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiView protein in PROSITE
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

O70521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS
60 70 80 90 100
WNQERQRAWQ VSRESKLQPL PSCEVCTPPS PEEVQSWAQS FDKLMHSPTG
110 120 130 140 150
RSVFRAFLRT EYSEENMLFW LACEELKTEA DRHVVDEKAR LIYEDYVSIL
160 170 180 190 200
SPKEVSLDSR VREGINRKMQ EPSPHTFDDA QLQIYTLMHR DSYPRFLTSP
210
TYRSLLLQGA PQSSEA
Length:216
Mass (Da):24,738
Last modified:August 1, 1998 - v1
Checksum:i554C479D4DD89238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068136 mRNA. Translation: AAC19130.1.
BC088141 mRNA. Translation: AAH88141.1.
RefSeqiNP_067693.1. NM_021661.2.
XP_006235863.2. XM_006235801.3.
UniGeneiRn.88166.

Genome annotation databases

EnsembliENSRNOT00000022451; ENSRNOP00000022451; ENSRNOG00000016547.
GeneIDi59293.
KEGGirno:59293.
UCSCiRGD:629471. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068136 mRNA. Translation: AAC19130.1.
BC088141 mRNA. Translation: AAH88141.1.
RefSeqiNP_067693.1. NM_021661.2.
XP_006235863.2. XM_006235801.3.
UniGeneiRn.88166.

3D structure databases

ProteinModelPortaliO70521.
SMRiO70521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248744. 1 interactor.
MINTiMINT-191738.
STRINGi10116.ENSRNOP00000022451.

PTM databases

iPTMnetiO70521.
PhosphoSitePlusiO70521.

Proteomic databases

PaxDbiO70521.
PRIDEiO70521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022451; ENSRNOP00000022451; ENSRNOG00000016547.
GeneIDi59293.
KEGGirno:59293.
UCSCiRGD:629471. rat.

Organism-specific databases

CTDi10287.
RGDi629471. Rgs19.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiO70521.
KOiK16449.
OMAiGINKKMQ.
OrthoDBiEOG091G0BDG.
PhylomeDBiO70521.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiO70521.

Gene expression databases

BgeeiENSRNOG00000016547.
GenevisibleiO70521. RN.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiView protein in InterPro
IPR016137. RGS.
IPR024066. RGS_subdom1.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiView protein in PROSITE
PS50132. RGS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRGS19_RAT
AccessioniPrimary (citable) accession number: O70521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: March 15, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.