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Protein

Fibroblast growth factor-binding protein 1

Gene

Fgfbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a carrier protein that releases fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhances the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity).By similarity

GO - Molecular functioni

  • fibroblast growth factor binding Source: UniProtKB

GO - Biological processi

  • mitophagy in response to mitochondrial depolarization Source: Ensembl
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of defense response to virus by host Source: Ensembl
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  • xenophagy Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-190377. FGFR2b ligand binding and activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor-binding protein 1
Short name:
FGF-BP
Short name:
FGF-BP1
Short name:
FGF-binding protein 1
Short name:
FGFBP-1
Gene namesi
Name:Fgfbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1096350. Fgfbp1.

Subcellular locationi

  • Secretedextracellular space By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity

  • Note: Extracellular and plasma membrane-associated.By similarity

GO - Cellular componenti

  • cell surface Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000024551321 – 251Fibroblast growth factor-binding protein 1Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 91By similarity
Disulfide bondi100 ↔ 133By similarity
Disulfide bondi109 ↔ 145By similarity
Glycosylationi175O-linked (GalNAc...)By similarity1
Disulfide bondi214 ↔ 251By similarity
Disulfide bondi231 ↔ 239By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70514.
PRIDEiO70514.

PTM databases

PhosphoSitePlusiO70514.

Expressioni

Tissue specificityi

Expressed in intestine, ovary, lung, placenta and normal and wounded skin.2 Publications

Developmental stagei

Expressed in digestive system, skin, hair follicles, the dental germ, respiratory tract, various glandular tissues, kidney, liver and certain areas of the central nervous system between 8 and 16 dpc (at protein level). Expressed. in embryo between 9 to 18 dpc. Expressed at 14 dpc in the epithelial cells and 18 dpc in basal epithelial cells of intestinal crypts. Expressed in mesenchymal and epidermal structures of the body wall at 9 dpc. Expressed in basal cells of the subepidermal layer of the skin at 12 dpc. Expressed in hair follicles at 14 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000048373.
CleanExiMM_FGFBP1.
GenevisibleiO70514. MM.

Interactioni

Subunit structurei

Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF7, FGF10, FGF22 and HSPG2 (By similarity). Interacts with FGF2.By similarity1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi199655. 4 interactors.
STRINGi10090.ENSMUSP00000056900.

Structurei

3D structure databases

ProteinModelPortaliO70514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 251Sufficient for interaction with FGF2 and FGF2-induced effectsBy similarityAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBN. Eukaryota.
ENOG4111SHY. LUCA.
GeneTreeiENSGT00730000111278.
HOGENOMiHOG000013097.
HOVERGENiHBG053095.
InParanoidiO70514.
OMAiLKVECTR.
OrthoDBiEOG091G0Q03.
PhylomeDBiO70514.
TreeFamiTF335877.

Family and domain databases

InterProiIPR010510. FGF1-bd.
[Graphical view]
PANTHERiPTHR15258. PTHR15258. 1 hit.
PfamiPF06473. FGF-BP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLHSLILLS FLLLATQAFS EKVRKRAKNA PHSTAEEGVE GSAPSLGKAQ
60 70 80 90 100
NKQRSRTSKS LTHGKFVTKD QATCRWAVTE EEQGISLKVQ CTQADQEFSC
110 120 130 140 150
VFAGDPTDCL KHDKDQIYWK QVARTLRKQK NICRNAKSVL KTRVCRKRFP
160 170 180 190 200
ESNLKLVNPN ARGNTKPRKE KAEVSAREHN KVQEAVSTEP NRVKEDITLN
210 220 230 240 250
PAATQTMAIR DPECLEDPDV LNQRKTALEF CGESWSSICT FFLNMLQATS

C
Length:251
Mass (Da):28,294
Last modified:August 1, 1998 - v1
Checksum:i3449252921A9E98C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135N → D in AAB05227 (PubMed:9178765).Curated1
Sequence conflicti193V → I in AAB05227 (PubMed:9178765).Curated1
Sequence conflicti208A → T in AAB05227 (PubMed:9178765).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49641 mRNA. Translation: AAB05227.1.
AF065441 mRNA. Translation: AAC17439.1.
AK146625 mRNA. Translation: BAE27314.1.
BC065774 mRNA. Translation: AAH65774.1.
CCDSiCCDS19268.1.
RefSeqiNP_001258545.1. NM_001271616.1.
NP_032035.2. NM_008009.4.
XP_006503774.1. XM_006503711.3.
XP_006503775.1. XM_006503712.3.
UniGeneiMm.46053.

Genome annotation databases

EnsembliENSMUST00000061299; ENSMUSP00000056900; ENSMUSG00000048373.
ENSMUST00000199481; ENSMUSP00000143011; ENSMUSG00000048373.
ENSMUST00000199894; ENSMUSP00000142520; ENSMUSG00000048373.
GeneIDi14181.
KEGGimmu:14181.
UCSCiuc008xid.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49641 mRNA. Translation: AAB05227.1.
AF065441 mRNA. Translation: AAC17439.1.
AK146625 mRNA. Translation: BAE27314.1.
BC065774 mRNA. Translation: AAH65774.1.
CCDSiCCDS19268.1.
RefSeqiNP_001258545.1. NM_001271616.1.
NP_032035.2. NM_008009.4.
XP_006503774.1. XM_006503711.3.
XP_006503775.1. XM_006503712.3.
UniGeneiMm.46053.

3D structure databases

ProteinModelPortaliO70514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199655. 4 interactors.
STRINGi10090.ENSMUSP00000056900.

PTM databases

PhosphoSitePlusiO70514.

Proteomic databases

PaxDbiO70514.
PRIDEiO70514.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061299; ENSMUSP00000056900; ENSMUSG00000048373.
ENSMUST00000199481; ENSMUSP00000143011; ENSMUSG00000048373.
ENSMUST00000199894; ENSMUSP00000142520; ENSMUSG00000048373.
GeneIDi14181.
KEGGimmu:14181.
UCSCiuc008xid.3. mouse.

Organism-specific databases

CTDi9982.
MGIiMGI:1096350. Fgfbp1.

Phylogenomic databases

eggNOGiENOG410IZBN. Eukaryota.
ENOG4111SHY. LUCA.
GeneTreeiENSGT00730000111278.
HOGENOMiHOG000013097.
HOVERGENiHBG053095.
InParanoidiO70514.
OMAiLKVECTR.
OrthoDBiEOG091G0Q03.
PhylomeDBiO70514.
TreeFamiTF335877.

Enzyme and pathway databases

ReactomeiR-MMU-190377. FGFR2b ligand binding and activation.

Miscellaneous databases

ChiTaRSiFgfbp1. mouse.
PROiO70514.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048373.
CleanExiMM_FGFBP1.
GenevisibleiO70514. MM.

Family and domain databases

InterProiIPR010510. FGF1-bd.
[Graphical view]
PANTHERiPTHR15258. PTHR15258. 1 hit.
PfamiPF06473. FGF-BP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGFP1_MOUSE
AccessioniPrimary (citable) accession number: O70514
Secondary accession number(s): Q62399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Expression is significantly up-regulated in skin papillomas and carcinomas.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.