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Protein

Galectin-3-binding protein

Gene

Lgals3bp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Cyp-C-associated protein
Short name:
CyCAP
Lectin galactoside-binding soluble 3-binding protein
Mac-2-binding protein
Short name:
MAC2BP
Short name:
Mac-2 BP
Protein 90K
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620837 Lgals3bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000035703719 – 574Galectin-3-binding proteinAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 113PROSITE-ProRule annotation
Disulfide bondi62 ↔ 123PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi93 ↔ 103PROSITE-ProRule annotation
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70513
PRIDEiO70513

Expressioni

Tissue specificityi

Detected in thyroid (at protein level).1 Publication

Inductioni

Up-regulated by virus infection, double-stranded DNA, IFNG and insulin. Down-regulated by hydrocortisone.2 Publications

Gene expression databases

BgeeiENSRNOG00000003217
GenevisibleiO70513 RN

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity). The unglycosylated form interacts with PDE4DIP; this interaction, which is PDE4DIP isoform-specific, may connect a pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity).By similarity

Protein-protein interaction databases

IntActiO70513, 1 interactor
STRINGi10116.ENSRNOP00000004320

Structurei

3D structure databases

ProteinModelPortaliO70513
SMRiO70513
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 124SRCRPROSITE-ProRule annotationAdd BLAST101
Domaini153 – 221BTBPROSITE-ProRule annotationAdd BLAST69
Domaini260 – 360BACKAdd BLAST101

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY2Y Eukaryota
ENOG410YBYF LUCA
GeneTreeiENSGT00530000063814
HOGENOMiHOG000113318
HOVERGENiHBG052323
InParanoidiO70513
KOiK17300
OMAiQHPSFLF
OrthoDBiEOG091G0MFZ
PhylomeDBiO70513
TreeFamiTF331368

Family and domain databases

Gene3Di3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00202 SR, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF56487 SSF56487, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70513-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLWLLSVF LLVPGTQGAK DGDMRLVNGA SASEGRVEIF YRGRWGTVCD
60 70 80 90 100
NLWNLLDAHV VCRALGYENA TQALSRAAFG PGKGPIMLDE VECTGNESSL
110 120 130 140 150
ANCSSLGWMV SHCGHEKDAG VVCSNDSRGI HILDLSGELP DALGQIFDSQ
160 170 180 190 200
QDCDLFIQVT GQGHGDLSLC AHTLILRTNP EAQALWQVVG SSVIMRVDAE
210 220 230 240 250
CMPVVRDFLR YFYSRRIEVS MSSVKCLHKL ASAYGATELQ GYCGRLFVTL
260 270 280 290 300
LPQDPTFHTP LELYEYAQAT GDSVLEDLCV QFLAWNFEPL TQAEAWLSVP
310 320 330 340 350
NALIQALLPK SELAVSSELD LLKAVDQWST ATGASHGDVE RLVEQIRFPM
360 370 380 390 400
MLPQELFELQ FNLSLYQGHQ ALFQRKTMEA LEFHTVPLKV LAKYRSLNLT
410 420 430 440 450
EDVYKPRLYT SSTWSSLLMA GAWSTQSYKY RQFYTYNYGS QSRYSSYQNF
460 470 480 490 500
QTPQHPSFLF KDKLISWSAT YLPTIQSCWN YGFSCTSDEL PVLGLTTSSY
510 520 530 540 550
SDPTIGYENK ALILCGGYSV VDVTTFIGSK APIPGTQETN SSKTPSLFPC
560 570
ASGAFSSFRV VIRPFYLTNS TDTE
Length:574
Mass (Da):63,742
Last modified:December 16, 2008 - v2
Checksum:i9F0F2F0B828ABD24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32A → P in AAS58489 (PubMed:15231701).Curated1
Sequence conflicti48V → L in AAS58489 (PubMed:15231701).Curated1
Sequence conflicti61V → F in AAS58489 (PubMed:15231701).Curated1
Sequence conflicti68E → D in AAS58489 (PubMed:15231701).Curated1
Sequence conflicti72Q → P in AAS58489 (PubMed:15231701).Curated1
Sequence conflicti75 – 77SRA → NRV in AAS58489 (PubMed:15231701).Curated3
Sequence conflicti142A → S in AAS58489 (PubMed:15231701).Curated1
Sequence conflicti295A → S in AAS58489 (PubMed:15231701).Curated1
Sequence conflicti560V → E in AAC17177 (PubMed:12650929).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065438 mRNA Translation: AAC17177.1
AY552591 mRNA Translation: AAS58489.1
CH473948 Genomic DNA Translation: EDM06756.1
BC081724 mRNA Translation: AAH81724.1
RefSeqiNP_620796.1, NM_139096.1
UniGeneiRn.3251

Genome annotation databases

EnsembliENSRNOT00000004320; ENSRNOP00000004320; ENSRNOG00000003217
GeneIDi245955
KEGGirno:245955
UCSCiRGD:620837 rat

Similar proteinsi

Entry informationi

Entry nameiLG3BP_RAT
AccessioniPrimary (citable) accession number: O70513
Secondary accession number(s): Q66HR4, Q6Q8R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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