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Protein

Galectin-3-binding protein

Gene

Lgals3bp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3-binding protein
Alternative name(s):
Cyp-C-associated protein
Short name:
CyCAP
Lectin galactoside-binding soluble 3-binding protein
Mac-2-binding protein
Short name:
MAC2BP
Short name:
Mac-2 BP
Protein 90K
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620837. Lgals3bp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 574556Galectin-3-binding proteinPRO_0000357037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 113PROSITE-ProRule annotation
Disulfide bondi62 ↔ 123PROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi93 ↔ 103PROSITE-ProRule annotation
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence analysis
Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70513.
PRIDEiO70513.

Expressioni

Tissue specificityi

Detected in thyroid (at protein level).1 Publication

Inductioni

Up-regulated by virus infection, double-stranded DNA, IFNG and insulin. Down-regulated by hydrocortisone.2 Publications

Gene expression databases

BgeeiENSRNOG00000003217.
GenevisibleiO70513. RN.

Interactioni

Subunit structurei

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity).By similarity

Protein-protein interaction databases

IntActiO70513. 1 interaction.
STRINGi10116.ENSRNOP00000004320.

Structurei

3D structure databases

ProteinModelPortaliO70513.
SMRiO70513. Positions 21-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 124101SRCRPROSITE-ProRule annotationAdd
BLAST
Domaini153 – 22169BTBPROSITE-ProRule annotationAdd
BLAST
Domaini260 – 360101BACKAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiO70513.
KOiK17300.
OMAiQHPSFLF.
OrthoDBiEOG091G0MFZ.
PhylomeDBiO70513.
TreeFamiTF331368.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70513-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLWLLSVF LLVPGTQGAK DGDMRLVNGA SASEGRVEIF YRGRWGTVCD
60 70 80 90 100
NLWNLLDAHV VCRALGYENA TQALSRAAFG PGKGPIMLDE VECTGNESSL
110 120 130 140 150
ANCSSLGWMV SHCGHEKDAG VVCSNDSRGI HILDLSGELP DALGQIFDSQ
160 170 180 190 200
QDCDLFIQVT GQGHGDLSLC AHTLILRTNP EAQALWQVVG SSVIMRVDAE
210 220 230 240 250
CMPVVRDFLR YFYSRRIEVS MSSVKCLHKL ASAYGATELQ GYCGRLFVTL
260 270 280 290 300
LPQDPTFHTP LELYEYAQAT GDSVLEDLCV QFLAWNFEPL TQAEAWLSVP
310 320 330 340 350
NALIQALLPK SELAVSSELD LLKAVDQWST ATGASHGDVE RLVEQIRFPM
360 370 380 390 400
MLPQELFELQ FNLSLYQGHQ ALFQRKTMEA LEFHTVPLKV LAKYRSLNLT
410 420 430 440 450
EDVYKPRLYT SSTWSSLLMA GAWSTQSYKY RQFYTYNYGS QSRYSSYQNF
460 470 480 490 500
QTPQHPSFLF KDKLISWSAT YLPTIQSCWN YGFSCTSDEL PVLGLTTSSY
510 520 530 540 550
SDPTIGYENK ALILCGGYSV VDVTTFIGSK APIPGTQETN SSKTPSLFPC
560 570
ASGAFSSFRV VIRPFYLTNS TDTE
Length:574
Mass (Da):63,742
Last modified:December 16, 2008 - v2
Checksum:i9F0F2F0B828ABD24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321A → P in AAS58489 (PubMed:15231701).Curated
Sequence conflicti48 – 481V → L in AAS58489 (PubMed:15231701).Curated
Sequence conflicti61 – 611V → F in AAS58489 (PubMed:15231701).Curated
Sequence conflicti68 – 681E → D in AAS58489 (PubMed:15231701).Curated
Sequence conflicti72 – 721Q → P in AAS58489 (PubMed:15231701).Curated
Sequence conflicti75 – 773SRA → NRV in AAS58489 (PubMed:15231701).Curated
Sequence conflicti142 – 1421A → S in AAS58489 (PubMed:15231701).Curated
Sequence conflicti295 – 2951A → S in AAS58489 (PubMed:15231701).Curated
Sequence conflicti560 – 5601V → E in AAC17177 (PubMed:12650929).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065438 mRNA. Translation: AAC17177.1.
AY552591 mRNA. Translation: AAS58489.1.
CH473948 Genomic DNA. Translation: EDM06756.1.
BC081724 mRNA. Translation: AAH81724.1.
RefSeqiNP_620796.1. NM_139096.1.
UniGeneiRn.3251.

Genome annotation databases

EnsembliENSRNOT00000004320; ENSRNOP00000004320; ENSRNOG00000003217.
GeneIDi245955.
KEGGirno:245955.
UCSCiRGD:620837. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065438 mRNA. Translation: AAC17177.1.
AY552591 mRNA. Translation: AAS58489.1.
CH473948 Genomic DNA. Translation: EDM06756.1.
BC081724 mRNA. Translation: AAH81724.1.
RefSeqiNP_620796.1. NM_139096.1.
UniGeneiRn.3251.

3D structure databases

ProteinModelPortaliO70513.
SMRiO70513. Positions 21-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70513. 1 interaction.
STRINGi10116.ENSRNOP00000004320.

Proteomic databases

PaxDbiO70513.
PRIDEiO70513.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004320; ENSRNOP00000004320; ENSRNOG00000003217.
GeneIDi245955.
KEGGirno:245955.
UCSCiRGD:620837. rat.

Organism-specific databases

CTDi3959.
RGDi620837. Lgals3bp.

Phylogenomic databases

eggNOGiENOG410IY2Y. Eukaryota.
ENOG410YBYF. LUCA.
GeneTreeiENSGT00530000063814.
HOGENOMiHOG000113318.
HOVERGENiHBG052323.
InParanoidiO70513.
KOiK17300.
OMAiQHPSFLF.
OrthoDBiEOG091G0MFZ.
PhylomeDBiO70513.
TreeFamiTF331368.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Miscellaneous databases

PROiO70513.

Gene expression databases

BgeeiENSRNOG00000003217.
GenevisibleiO70513. RN.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF56487. SSF56487. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLG3BP_RAT
AccessioniPrimary (citable) accession number: O70513
Secondary accession number(s): Q66HR4, Q6Q8R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.