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Protein

Ankyrin-3

Gene

Ank3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg2+ levels, and thereby contributes to the regulation of renal Mg2+ reabsorption (By similarity).By similarity

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • cytoskeletal protein binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein binding, bridging Source: BHF-UCL
  • spectrin binding Source: BHF-UCL

GO - Biological processi

  • cellular response to magnesium ion Source: UniProtKB
  • magnesium ion homeostasis Source: UniProtKB
  • membrane assembly Source: BHF-UCL
  • negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
  • neuromuscular junction development Source: RGD
  • positive regulation of cation channel activity Source: BHF-UCL
  • positive regulation of cell communication by electrical coupling Source: RGD
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of homotypic cell-cell adhesion Source: RGD
  • positive regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • positive regulation of membrane potential Source: BHF-UCL
  • positive regulation of protein targeting to membrane Source: RGD
  • positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  • positive regulation of sodium ion transport Source: BHF-UCL
  • protein localization to plasma membrane Source: BHF-UCL
  • regulation of potassium ion transport Source: BHF-UCL
  • signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin-3
Short name:
ANK-3
Alternative name(s):
Ankyrin-G
Gene namesi
Name:Ank3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620157. Ank3.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projectionaxon
  • Cell membrane
  • Cell membranesarcolemma
  • Cell junctionsynapsepostsynaptic cell membrane
  • Lysosome By similarity

  • Note: In root dorsal ganglia, predominantly located in the axolemma of the axon proximal segments. Also associated with the plasma membrane in neuron cell bodies, although at a lower level than in the axon proximal segment. Isoform 1 is restricted to the axolemma of the axon proximal segment. Isoforms containing the muscle-specific 76 amino-acid insertion localize to the sarcolemma and on the postsynaptic membrane of neuromuscular junctions. Isoform 7 interacts with PLEC and FLNC through its muscle-specific C-terminal sequence.

GO - Cellular componenti

  • axon initial segment Source: BHF-UCL
  • cell surface Source: BHF-UCL
  • costamere Source: BHF-UCL
  • dendrite Source: RGD
  • intercalated disc Source: BHF-UCL
  • lysosome Source: UniProtKB-SubCell
  • neuromuscular junction Source: RGD
  • neuron projection Source: RGD
  • node of Ranvier Source: RGD
  • plasma membrane Source: BHF-UCL
  • postsynaptic membrane Source: RGD
  • sarcolemma Source: BHF-UCL
  • sarcoplasmic reticulum Source: RGD
  • spectrin-associated cytoskeleton Source: BHF-UCL
  • T-tubule Source: BHF-UCL
  • Z disc Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Lysosome, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004296321 – 2622Ankyrin-3Add BLAST2622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphoserineBy similarity1
Modified residuei631PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei921PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei930PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1
Modified residuei967PhosphoserineCombined sources1
Modified residuei1121PhosphoserineCombined sources1
Modified residuei1458PhosphoserineCombined sources1
Modified residuei1469PhosphoserineBy similarity1
Modified residuei1621PhosphoserineBy similarity1
Modified residuei1624PhosphoserineBy similarity1
Modified residuei1984PhosphoserineCombined sources1
Modified residuei2102PhosphoserineCombined sources1
Modified residuei2114PhosphoserineCombined sources1
Modified residuei2117PhosphoserineCombined sources1
Modified residuei2457PhosphoserineCombined sources1
Modified residuei2475PhosphoserineBy similarity1
Modified residuei2544PhosphoserineCombined sources1
Isoform 4 (identifier: O70511-4)
Modified residuei851PhosphoserineCombined sources1
Isoform 5 (identifier: O70511-5)
Modified residuei851PhosphoserineCombined sources1
Isoform 2 (identifier: O70511-2)
Modified residuei1679PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70511.

PTM databases

iPTMnetiO70511.
PhosphoSitePlusiO70511.
SwissPalmiO70511.

Expressioni

Tissue specificityi

Expressed at highest levels in brain and testis, followed by skin, kidney, liver and spleen. Isoforms 2, 3, 4, 5, 6 and 7 may be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level) (PubMed:11796721).3 Publications

Interactioni

Subunit structurei

May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG. Directly interacts with DMD and betaDAG1; this interaction does not interfere with DMD-binding and is required for DMD and betaDAG1 retention at costameres. Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 7 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). Interacts with PLEC and FLNC (PubMed:21223964). Interacts with KCNA1; this inhibits channel activity (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNCQ143152EBI-9663485,EBI-489954From a different organism.

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • cytoskeletal protein binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein binding, bridging Source: BHF-UCL
  • spectrin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi262995. 3 interactors.
DIPiDIP-60342N.
IntActiO70511. 5 interactors.
STRINGi10116.ENSRNOP00000043687.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 102ANK 1Add BLAST30
Repeati106 – 135ANK 2Add BLAST30
Repeati139 – 168ANK 3Add BLAST30
Repeati172 – 201ANK 4Add BLAST30
Repeati203 – 230ANK 5Add BLAST28
Repeati242 – 271ANK 6Add BLAST30
Repeati275 – 304ANK 7Add BLAST30
Repeati308 – 337ANK 8Add BLAST30
Repeati341 – 370ANK 9Add BLAST30
Repeati374 – 403ANK 10Add BLAST30
Repeati407 – 436ANK 11Add BLAST30
Repeati440 – 469ANK 12Add BLAST30
Repeati473 – 502ANK 13Add BLAST30
Repeati506 – 535ANK 14Add BLAST30
Repeati539 – 568ANK 15Add BLAST30
Repeati572 – 601ANK 16Add BLAST30
Repeati605 – 634ANK 17Add BLAST30
Repeati638 – 667ANK 18Add BLAST30
Repeati671 – 700ANK 19Add BLAST30
Repeati704 – 733ANK 20Add BLAST30
Repeati737 – 766ANK 21Add BLAST30
Repeati770 – 799ANK 22Add BLAST30
Repeati803 – 832ANK 23Add BLAST30
Domaini990 – 1097ZU5 1PROSITE-ProRule annotationAdd BLAST108
Domaini1147 – 1266ZU5 2PROSITE-ProRule annotationAdd BLAST120
Domaini2336 – 2420DeathPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Contains 23 ANK repeats.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation
Contains 2 ZU5 domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000012873.
HOVERGENiHBG024337.
KOiK10380.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 6 hits.
PF13606. Ank_3. 1 hit.
PF00531. Death. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 22 hits.
SM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O70511-1) [UniParc]FASTAAdd to basket
Also known as: AnkG270

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHAASQLKK NRDLEINAEE ETEKKKKHRK RSRDRKKKSD ANASYLRAAR
60 70 80 90 100
AGHLEKALDY IKNGVDVNIC NQNGLNALHL ASKEGHVEVV SELLQREANV
110 120 130 140 150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
160 170 180 190 200
NHLEVVRFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
210 220 230 240 250
VRLPALHIAA RKDDTKAAAL LLQNDTNADI ESKMVVNRAT ESGFTPLHIA
260 270 280 290 300
AHYGNINVAT LLLNRAAAVD FTARNDITPL HVASKRGNAN MVKLLLDRGA
310 320 330 340 350
KIDAKTRDGL TPLHCGARSG HEQVVEMLLD RAAPILSKTK NGLSPLHMAT
360 370 380 390 400
QGDHLNCVQL LLQHNVPVDD VTNDYLTALH VAAHCGHYKV AKVLLDKKAN
410 420 430 440 450
PNAKALNGFT PLHIACKKNR IRVMELLLKH GASIQAVTES GLTPIHVAAF
460 470 480 490 500
MGHVNIVSQL MHHGASPNTT NVRGETALHM AARSGQAEVV RYLVQDGAQV
510 520 530 540 550
EAKAKDDQTP LHISARLGKA DIVQQLLQQG ASPNAATTSG YTPLHLSARE
560 570 580 590 600
GHEDVAAFLL DHGASLSITT KKGFTPLHVA AKYGKLEVAS LLLQKSASPD
610 620 630 640 650
AAGKSGLTPL HVAAHYDNQK VALLLLDQGA SPHAAAKNGY TPLHIAAKKN
660 670 680 690 700
QMDIATSLLE YGADANAVTR QGIASVHLAA QEGHVDMVSL LLSRNANVNL
710 720 730 740 750
SNKSGLTPLH LAAQEDRVNV AEVLVNQGAH VDAQTKMGYT PLHVGCHYGN
760 770 780 790 800
IKIVNFLLQH SAKVNAKTKN GYTPLHQAAQ QGHTHIINVL LQNNASPNEL
810 820 830 840 850
TVNGNTALAI ARRLGYISVV DTLKVVTEEI MTTTTITEKH KMNVPETMNE
860 870 880 890 900
VLDMSDDEVG KASAPEKLSD GEYISDGEEG EDAITGDTDK YLGPQDLKEL
910 920 930 940 950
GDDSLPAEGY VGFSLGARSA SLRSFSSDRS YTLNRSSYAR DSMMIEELLV
960 970 980 990 1000
PSKEQHLPFT REFDSDSLRH YSWAADTLDN VNLVSSPVHS GFLVSFMVDA
1010 1020 1030 1040 1050
RGGSMRGSRH HGMRIIIPPR KCTAPTRITC RLVKRHKLAN PPPMVEGEGL
1060 1070 1080 1090 1100
ASRLVEMGPA GAQFLGPVIV EIPHFGSMRG KERELIVLRS ENGETWKEHQ
1110 1120 1130 1140 1150
FDSKNEDLSE LLNGMDEELD SPEELGTKRI CRIITKDFPQ YFAVVSRIKQ
1160 1170 1180 1190 1200
ESNQIGPEGG ILSSTTVPLV QASFPEGALT KRIRVGLQAQ PVPEETVKKI
1210 1220 1230 1240 1250
LGNKATFSPI VTVEPRRRKF HKPITMTIPV PPPSGEGVSN GYKGDTTPSL
1260 1270 1280 1290 1300
RLLCSITGGT SPAQWEDITG TTPLTFIKDC VSFTTNVSAR FWLADCHQVL
1310 1320 1330 1340 1350
ETVGLASQLY RELICVPYMA KFVVFAKTND PVESSLRCFC MTDDRVDKTL
1360 1370 1380 1390 1400
EQQENFEEVA RSKDIEVLEG KPIYVDCYGN LAPLTKGGQQ LVFNFYSFKE
1410 1420 1430 1440 1450
NRLPFSIKVR DTSQEPCGRL SFLKEPKTTK GLPQTAVCNL NITLPAHKKA
1460 1470 1480 1490 1500
EKADRRQSFT SLALRKRYSY LTEPSMKTVE RSSGTARSLP TTYSHKPFFS
1510 1520 1530 1540 1550
TRPYQSWTTT PITVPGPAKS GSLSSSPSNT PSASPLKSIW SVSTPSPIKS
1560 1570 1580 1590 1600
TLGASTTSSV KSISDVASPI RSFRTISSPI RTVASPSPYN TQVASGTLGR
1610 1620 1630 1640 1650
VPTITEATPI KGVAPNSTLS SRTSPVTTAG SLLEKSSITM TPPASPKANI
1660 1670 1680 1690 1700
TMYSSSLPFK SIITSAAPLI SSPLKSVVSP TKSAADVIST AKAAMASTLS
1710 1720 1730 1740 1750
SPLKQMSGHA EVALVNGSVS PLKYPSSSAL INGCKATATL QDKISTATNA
1760 1770 1780 1790 1800
VSSVVSAAPD TVEKALSTTT AMPFSPLRSY VSAAAPSAFQ SLRAPSASAL
1810 1820 1830 1840 1850
YNSLGPSVGV TTSSVTSSII TVPVYSVGNV LAEPALKKLP DSNSLTKSAA
1860 1870 1880 1890 1900
ALLSPIKTLT TETRPQPHFN RTSSPVKSSL FLASSALKPS VPSSLSSSQE
1910 1920 1930 1940 1950
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ TDLPREGRID DEEPFKIVEK
1960 1970 1980 1990 2000
VKEDLVKVSE ILKKDVCVES KGPPKSPKSD KGHSPEDDWT EFSSEEIREA
2010 2020 2030 2040 2050
RQAAASHAPS LPERVHGKAN LTRVIDYLTN DIGSSSLTNL KYKFEEAKKE
2060 2070 2080 2090 2100
GEERQKRILK PAMALQEHKL KMPPASMRPS TSEKELCKMA DSFFGTDAIL
2110 2120 2130 2140 2150
ESPDDFSQHD QDKSPLSDSG FETRSEKTPS APQSAESTGP KPLFHEVPIP
2160 2170 2180 2190 2200
PVITETRTEV VHVIRSYEPS TGEIPQSQPE DPVSPKPPPT FMELEPKPTA
2210 2220 2230 2240 2250
LSIKEKVKAF QMKASSEEED HSRVLSKGMR VKEETHITTT TRMVYHSPPG
2260 2270 2280 2290 2300
SECASERIEE TMSVHDIMKA FQSGRDPSKE LAGLFEHKSA MSPDVAKSAA
2310 2320 2330 2340 2350
ETSAQHAEKD NQMKPKLERI IEVHIEKGPQ SPCERTDIRM AIVADHLGLS
2360 2370 2380 2390 2400
WTELARELNF SVDEINQIRV ENPNSLISQS FMLLKKWVTR DGKNATTDAL
2410 2420 2430 2440 2450
TSVLTKINRI DIVTLLEGPI FDYGNISGTR SFADENNVFH DPVDGWQNET
2460 2470 2480 2490 2500
PSGSLESPAQ ARRITGGLLD RLDDSSDQVR DPITSYLTGE AGKFEANGNH
2510 2520 2530 2540 2550
AEVIPEAKAK AYFPESQNDI GKQSIKENLK PKTHGCGRAE EPVSPLTAYQ
2560 2570 2580 2590 2600
KSLEETSKLV IEDAPKPCVP VGMKKMTRTP ADGKARLNLQ EEEGSARSEP
2610 2620
KQGEGYKVKT KKEIRNVEKK AH
Length:2,622
Mass (Da):284,443
Last modified:July 9, 2014 - v3
Checksum:iA17F304D792333F5
GO
Isoform 2 (identifier: O70511-2) [UniParc]FASTAAdd to basket
Also known as: AnkG217

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRK → MSEEAKEKTAKPAHRKRKG
     234-241: Missing.
     858-878: Missing.
     922-927: LRSFSS → PKISS
     1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
     2601-2601: K → KDLRHSESDS...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1888 to Val-1963 is encoded by a muscle-specific exon.Combined sources
Show »
Length:1,984
Mass (Da):216,577
Checksum:i45C2EEA326E36AD5
GO
Isoform 3 (identifier: O70511-3) [UniParc]FASTAAdd to basket
Also known as: AnkG197

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRK → MSEEAKEKTAKPAHRKRKG
     234-241: Missing.
     858-878: Missing.
     922-927: LRSFSS → PKISS
     1466-2328: Missing.
     2601-2601: K → KQVKSPGEAF...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1710 to Val-1785 is encoded by a muscle-specific exon.
Show »
Length:1,806
Mass (Da):197,423
Checksum:i6197309048CD689A
GO
Isoform 4 (identifier: O70511-4) [UniParc]FASTAAdd to basket
Also known as: Ank130

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
     2601-2601: K → KVKSPGEAFT...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1077 to Val-1152 is encoded by a muscle-specific exon.Combined sources
Show »
Length:1,173
Mass (Da):129,941
Checksum:i9E0602541FE4FE65
GO
Isoform 5 (identifier: O70511-5) [UniParc]FASTAAdd to basket
Also known as: AnkG128

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
     2601-2601: K → KDLRHSESDS...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1060 to Val-1135 is encoded by a muscle-specific exon.Combined sources
Show »
Length:1,156
Mass (Da):128,067
Checksum:i043E3872865D1117
GO
Isoform 6 (identifier: O70511-6) [UniParc]FASTAAdd to basket
Also known as: AnkG109

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2328: Missing.
     2601-2601: K → KVKSPGEAFT...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-881 to Val-956 is encoded by a muscle-specific exon.
Show »
Length:977
Mass (Da):108,785
Checksum:i02844AE344A6561D
GO
Isoform 7 (identifier: O70511-7) [UniParc]FASTAAdd to basket
Also known as: AnkG107

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2328: Missing.
     2601-2601: K → KDLRHSESDS...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-864 to Val-939 is encoded by a muscle-specific exon.
Show »
Length:960
Mass (Da):106,911
Checksum:iF850EF67D120878A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246P → S in AAC78143 (PubMed:9744885).Curated1
Sequence conflicti635A → S in CAH19223 (PubMed:15953600).Curated1
Sequence conflicti635A → S in CAH19224 (PubMed:15953600).Curated1
Sequence conflicti667A → P in AAC78143 (PubMed:9744885).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0550041 – 880MAHAA…DGEEG → MALPHS in isoform 4, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST880
Alternative sequenceiVSP_0550051 – 36MAHAA…SRDRK → MSEEAKEKTAKPAHRKRKG in isoform 2 and isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_055006234 – 241Missing in isoform 2 and isoform 3. 1 Publication8
Alternative sequenceiVSP_055007858 – 878Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_055008922 – 927LRSFSS → PKISS in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications6
Alternative sequenceiVSP_0550091466 – 2444KRYSY…HDPVD → PQSPCERTDIRMAIVADHLG LSWTELARELNFSVDEINQI RVENPNSLISQSFMLLKKWV TRDGKNATTDALTSVLTKIN RIDIVTLLEGPIFDYGNISG TRSFADENNVFHDPVDGHPS FQVELETPMGLYCTPPTPFQ QDDHFSDNSSIESPFRTPSR LSDGLMPSQGSIEHPAGGPP VVTAEDTSLEDSKMDDSVTV TETADPLDVDESQLKDLCQS ECAHCWASVPGVPSGGPQAE PLRAQTRKVGVSSEQQEKGD SGPEEEMADDKVRSLFEDIQ LEEVEAEEMTEDEGQAILNR VPRAELAMSSLA in isoform 2, isoform 4 and isoform 5. 1 PublicationAdd BLAST979
Alternative sequenceiVSP_0550101466 – 2328Missing in isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST863
Alternative sequenceiVSP_0550112601K → KDLRHSESDSSSEEERRVTT RVIRRRVIIKGEEAKTIPGE SVTEEQFTDEEGNLITRKIT RKVIRRIGPQERKQDDV in isoform 2, isoform 5 and isoform 7. 2 Publications1
Alternative sequenceiVSP_0550122601K → KQVKSPGEAFTRMTACCYKD LRHSESDSSSEEERRVTTRV IRRRVIIKGEEAKTIPGESV TEEQFTDEEGNLITRKITRK VIRRIGPQERKQDDV in isoform 3. 1 Publication1
Alternative sequenceiVSP_0550132601K → KVKSPGEAFTRMTACCYKDL RHSESDSSSEEERRVTTRVI RRRVIIKGEEAKTIPGESVT EEQFTDEEGNLITRKITRKV IRRIGPQERKQDDV in isoform 4 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102552 mRNA. Translation: AAC78143.1.
AJ428573 mRNA. Translation: CAD21705.1.
AJ812019 mRNA. Translation: CAH19219.1.
AJ812021 mRNA. Translation: CAH19221.1.
AJ812022 mRNA. Translation: CAH19222.1.
AJ812023 mRNA. Translation: CAH19223.1.
AJ812024 mRNA. Translation: CAH19224.1.
RefSeqiNP_001029156.1. NM_001033984.1. [O70511-1]
NP_113993.1. NM_031805.1. [O70511-2]
UniGeneiRn.211093.
Rn.212410.

Genome annotation databases

GeneIDi361833.
KEGGirno:361833.
UCSCiRGD:620157. rat.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102552 mRNA. Translation: AAC78143.1.
AJ428573 mRNA. Translation: CAD21705.1.
AJ812019 mRNA. Translation: CAH19219.1.
AJ812021 mRNA. Translation: CAH19221.1.
AJ812022 mRNA. Translation: CAH19222.1.
AJ812023 mRNA. Translation: CAH19223.1.
AJ812024 mRNA. Translation: CAH19224.1.
RefSeqiNP_001029156.1. NM_001033984.1. [O70511-1]
NP_113993.1. NM_031805.1. [O70511-2]
UniGeneiRn.211093.
Rn.212410.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262995. 3 interactors.
DIPiDIP-60342N.
IntActiO70511. 5 interactors.
STRINGi10116.ENSRNOP00000043687.

PTM databases

iPTMnetiO70511.
PhosphoSitePlusiO70511.
SwissPalmiO70511.

Proteomic databases

PaxDbiO70511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361833.
KEGGirno:361833.
UCSCiRGD:620157. rat.

Organism-specific databases

CTDi288.
RGDi620157. Ank3.

Phylogenomic databases

eggNOGiKOG4177. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000012873.
HOVERGENiHBG024337.
KOiK10380.

Miscellaneous databases

PROiO70511.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 6 hits.
PF13606. Ank_3. 1 hit.
PF00531. Death. 1 hit.
PF00791. ZU5. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 22 hits.
SM00005. DEATH. 1 hit.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
PS50017. DEATH_DOMAIN. 1 hit.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANK3_RAT
AccessioniPrimary (citable) accession number: O70511
Secondary accession number(s): Q574D7
, Q574D8, Q574D9, Q574E0, Q574E2, Q8VDA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 30, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.