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Protein
Submitted name:

CD44 antigen

Gene

Cd44

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1474228. Degradation of the extracellular matrix.
R-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-216083. Integrin cell surface interactions.
R-RNO-2160916. Hyaluronan uptake and degradation.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
CD44 antigenImported
Submitted name:
CD44 antigen, isoform CRA_fImported
Submitted name:
Cd44 proteinImported
Submitted name:
Glycoprotein CD44sImported
Gene namesi
Name:Cd44Imported
ORF Names:rCG_26920Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2307. Cd44.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei272 – 293HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500877864722 – 364Sequence analysisAdd BLAST343

Expressioni

Gene expression databases

BgeeiENSRNOG00000006094.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009000.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 124LinkInterPro annotationAdd BLAST90

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOVERGENiHBG003850.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVWWHTAW GLLCLLQLSL AQQQIDLNIT CRYAGVFHVE KNGRYSISRT
60 70 80 90 100
EAADLCEAFN TTLPTMAQME LALSKGFETC RYGFIEGHVV IPRIHPNAIC
110 120 130 140 150
AANNTGVYIL LASNTSHYDT YCFNASAPLE EDCTSVTDLP NSFDGPVTIT
160 170 180 190 200
IVNRDGTRYS KKGEYRTHQE DIDASNIIDE DVSSGSTIEK STPEGYILHT
210 220 230 240 250
DLPTSQPTGD RDDAFFIGST LATSDGDSSM DPRGGFDTVT HGSELAGHSS
260 270 280 290 300
GNQDSGVTTT SGPARRPQIP EWLIILASLL ALALILAVCI AVNSRRRCGQ
310 320 330 340 350
KKKLVINSGN GTVEDRKPSE LNGEASKSQE MVHLVNKEPT ETPDQFMTAD
360
ETRNLQSVDM KIGV
Length:364
Mass (Da):39,725
Last modified:August 1, 1998 - v1
Checksum:iBA249776C4419AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109112 Genomic DNA. No translation available.
AF065147 mRNA. Translation: AAC17117.1.
BC061531 mRNA. Translation: AAH61531.1.
BC085703 mRNA. Translation: AAH85703.1.
BC107949 mRNA. Translation: AAI07950.1.
BC127485 mRNA. Translation: AAI27486.1.
CH473949 Genomic DNA. Translation: EDL79653.1.
RefSeqiXP_006234693.1. XM_006234631.3.
UniGeneiRn.1120.

Genome annotation databases

EnsembliENSRNOT00000009073; ENSRNOP00000009073; ENSRNOG00000006094.
GeneIDi25406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109112 Genomic DNA. No translation available.
AF065147 mRNA. Translation: AAC17117.1.
BC061531 mRNA. Translation: AAH61531.1.
BC085703 mRNA. Translation: AAH85703.1.
BC107949 mRNA. Translation: AAI07950.1.
BC127485 mRNA. Translation: AAI27486.1.
CH473949 Genomic DNA. Translation: EDL79653.1.
RefSeqiXP_006234693.1. XM_006234631.3.
UniGeneiRn.1120.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009073; ENSRNOP00000009073; ENSRNOG00000006094.
GeneIDi25406.

Organism-specific databases

CTDi960.
RGDi2307. Cd44.

Phylogenomic databases

eggNOGiENOG410IZCP. Eukaryota.
ENOG4111S6T. LUCA.
GeneTreeiENSGT00530000063822.
HOVERGENiHBG003850.

Enzyme and pathway databases

ReactomeiR-RNO-1474228. Degradation of the extracellular matrix.
R-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-216083. Integrin cell surface interactions.
R-RNO-2160916. Hyaluronan uptake and degradation.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-877300. Interferon gamma signaling.

Gene expression databases

BgeeiENSRNOG00000006094.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR001231. CD44_antigen.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR00658. CD44.
PR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO70509_RAT
AccessioniPrimary (citable) accession number: O70509
Secondary accession number(s): D4A7E6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.