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Protein

Ficolin-2

Gene

Fcn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi250CalciumBy similarity1
Metal bindingi252CalciumBy similarity1
Metal bindingi254Calcium; via carbonyl oxygenBy similarity1
Metal bindingi256Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-166662. Lectin pathway of complement activation.
R-MMU-166663. Initial triggering of complement.
R-MMU-2855086. Ficolins bind to repetitive carbohydrate structures on the target cell surface.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:Fcn2
Synonyms:Fcnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1341158. Fcnb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000914018 – 314Ficolin-2Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 127By similarity
Disulfide bondi106 ↔ 134By similarity
Disulfide bondi258 ↔ 271By similarity
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70497.
PRIDEiO70497.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026835.
CleanExiMM_FCNB.
ExpressionAtlasiO70497. baseline and differential.
GenevisibleiO70497. MM.

Interactioni

Subunit structurei

Homotrimer. Interacts with elastin. Interacts with MASP1 and MASP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028179.

Structurei

3D structure databases

ProteinModelPortaliO70497.
SMRiO70497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 96Collagen-likeAdd BLAST57
Domaini97 – 314Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Domaini

The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.By similarity

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiO70497.
KOiK10104.
OMAiWYADCHA.
OrthoDBiEOG091G03M1.
PhylomeDBiO70497.
TreeFamiTF329953.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGSAALFV LTLTVHAAGT CPELKVLDLE GYKQLTILQG CPGLPGAAGP
60 70 80 90 100
KGEAGAKGDR GESGLPGIPG KEGPTGPKGN QGEKGIRGEK GDSGPSQSCA
110 120 130 140 150
TGPRTCKELL TQGHFLTGWY TIYLPDCRPL TVLCDMDTDG GGWTVFQRRL
160 170 180 190 200
DGSVDFFRDW TSYKRGFGSQ LGEFWLGNDN IHALTTQGTS ELRVDLSDFE
210 220 230 240 250
GKHDFAKYSS FQIQGEAEKY KLILGNFLGG GAGDSLTPHN NRLFSTKDQD
260 270 280 290 300
NDGSTSSCAM GYHGAWWYSQ CHTSNLNGLY LRGPHKSYAN GVNWKSWRGY
310
NYSCKVSEMK VRLI
Length:314
Mass (Da):33,984
Last modified:December 12, 2006 - v2
Checksum:i6C1467BF0BE96E67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130L → M in AAC98781 (PubMed:9851834).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107220 mRNA. Translation: AAI07221.1.
BC107221 mRNA. Translation: AAI07222.1.
AF063217 mRNA. Translation: AAC98781.1.
CCDSiCCDS15832.1.
RefSeqiNP_034320.1. NM_010190.1.
UniGeneiMm.182935.

Genome annotation databases

EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835.
GeneIDi14134.
KEGGimmu:14134.
UCSCiuc008ixv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107220 mRNA. Translation: AAI07221.1.
BC107221 mRNA. Translation: AAI07222.1.
AF063217 mRNA. Translation: AAC98781.1.
CCDSiCCDS15832.1.
RefSeqiNP_034320.1. NM_010190.1.
UniGeneiMm.182935.

3D structure databases

ProteinModelPortaliO70497.
SMRiO70497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028179.

Proteomic databases

PaxDbiO70497.
PRIDEiO70497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835.
GeneIDi14134.
KEGGimmu:14134.
UCSCiuc008ixv.1. mouse.

Organism-specific databases

CTDi14134.
MGIiMGI:1341158. Fcnb.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiO70497.
KOiK10104.
OMAiWYADCHA.
OrthoDBiEOG091G03M1.
PhylomeDBiO70497.
TreeFamiTF329953.

Enzyme and pathway databases

ReactomeiR-MMU-166662. Lectin pathway of complement activation.
R-MMU-166663. Initial triggering of complement.
R-MMU-2855086. Ficolins bind to repetitive carbohydrate structures on the target cell surface.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO70497.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026835.
CleanExiMM_FCNB.
ExpressionAtlasiO70497. baseline and differential.
GenevisibleiO70497. MM.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCN2_MOUSE
AccessioniPrimary (citable) accession number: O70497
Secondary accession number(s): Q3KNL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 12, 2006
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.