Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ficolin-2

Gene

Fcn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:Fcn2
Synonyms:Fcnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1341158. Fcnb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 314297Ficolin-2PRO_0000009140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO70497.

Expressioni

Gene expression databases

BgeeiO70497.
CleanExiMM_FCNB.
ExpressionAtlasiO70497. baseline and differential.
GenevestigatoriO70497.

Interactioni

Subunit structurei

Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO70497.
SMRiO70497. Positions 98-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9657Collagen-likeAdd
BLAST
Domaini97 – 314218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Domaini

The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG249945.
GeneTreeiENSGT00770000120463.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiO70497.
KOiK10104.
OMAiNFFSTKD.
OrthoDBiEOG7X9G60.
PhylomeDBiO70497.
TreeFamiTF329953.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGSAALFV LTLTVHAAGT CPELKVLDLE GYKQLTILQG CPGLPGAAGP
60 70 80 90 100
KGEAGAKGDR GESGLPGIPG KEGPTGPKGN QGEKGIRGEK GDSGPSQSCA
110 120 130 140 150
TGPRTCKELL TQGHFLTGWY TIYLPDCRPL TVLCDMDTDG GGWTVFQRRL
160 170 180 190 200
DGSVDFFRDW TSYKRGFGSQ LGEFWLGNDN IHALTTQGTS ELRVDLSDFE
210 220 230 240 250
GKHDFAKYSS FQIQGEAEKY KLILGNFLGG GAGDSLTPHN NRLFSTKDQD
260 270 280 290 300
NDGSTSSCAM GYHGAWWYSQ CHTSNLNGLY LRGPHKSYAN GVNWKSWRGY
310
NYSCKVSEMK VRLI
Length:314
Mass (Da):33,984
Last modified:December 12, 2006 - v2
Checksum:i6C1467BF0BE96E67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301L → M in AAC98781 (PubMed:9851834).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107220 mRNA. Translation: AAI07221.1.
BC107221 mRNA. Translation: AAI07222.1.
AF063217 mRNA. Translation: AAC98781.1.
CCDSiCCDS15832.1.
RefSeqiNP_034320.1. NM_010190.1.
UniGeneiMm.182935.

Genome annotation databases

EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835.
GeneIDi14134.
KEGGimmu:14134.
UCSCiuc008ixv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107220 mRNA. Translation: AAI07221.1.
BC107221 mRNA. Translation: AAI07222.1.
AF063217 mRNA. Translation: AAC98781.1.
CCDSiCCDS15832.1.
RefSeqiNP_034320.1. NM_010190.1.
UniGeneiMm.182935.

3D structure databases

ProteinModelPortaliO70497.
SMRiO70497. Positions 98-312.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO70497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835.
GeneIDi14134.
KEGGimmu:14134.
UCSCiuc008ixv.1. mouse.

Organism-specific databases

CTDi14134.
MGIiMGI:1341158. Fcnb.

Phylogenomic databases

eggNOGiNOG249945.
GeneTreeiENSGT00770000120463.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiO70497.
KOiK10104.
OMAiNFFSTKD.
OrthoDBiEOG7X9G60.
PhylomeDBiO70497.
TreeFamiTF329953.

Miscellaneous databases

NextBioi285244.
PROiO70497.
SOURCEiSearch...

Gene expression databases

BgeeiO70497.
CleanExiMM_FCNB.
ExpressionAtlasiO70497. baseline and differential.
GenevestigatoriO70497.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Oligomeric structure and tissue distribution of ficolins from mouse, pig and human."
    Ohashi T., Erickson H.P.
    Arch. Biochem. Biophys. 360:223-232(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-308.
    Strain: C57BL/6.
    Tissue: Bone marrow.

Entry informationi

Entry nameiFCN2_MOUSE
AccessioniPrimary (citable) accession number: O70497
Secondary accession number(s): Q3KNL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 12, 2006
Last modified: April 1, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.