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O70497

- FCN2_MOUSE

UniProt

O70497 - FCN2_MOUSE

Protein

Ficolin-2

Gene

Fcn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin By similarity.By similarity

    GO - Molecular functioni

    1. carbohydrate derivative binding Source: MGI
    2. sialic acid binding Source: MGI

    GO - Biological processi

    1. complement activation, lectin pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Complement activation lectin pathway, Immunity, Innate immunity

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ficolin-2
    Alternative name(s):
    Collagen/fibrinogen domain-containing protein 2
    Ficolin-B
    Ficolin-beta
    L-ficolin
    Gene namesi
    Name:Fcn2
    Synonyms:Fcnb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1341158. Fcnb.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 314297Ficolin-2PRO_0000009140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO70497.

    Expressioni

    Gene expression databases

    BgeeiO70497.
    CleanExiMM_FCNB.
    GenevestigatoriO70497.

    Interactioni

    Subunit structurei

    Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO70497.
    SMRiO70497. Positions 98-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 9657Collagen-likeAdd
    BLAST
    Domaini97 – 314218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.

    Sequence similaritiesi

    Belongs to the ficolin lectin family.Curated
    Contains 1 collagen-like domain.Curated
    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG249945.
    GeneTreeiENSGT00750000117251.
    HOGENOMiHOG000037127.
    HOVERGENiHBG001644.
    InParanoidiO70497.
    KOiK10104.
    OMAiNFFSTKD.
    OrthoDBiEOG7X9G60.
    PhylomeDBiO70497.
    TreeFamiTF329953.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR008160. Collagen.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PfamiPF01391. Collagen. 1 hit.
    PF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70497-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALGSAALFV LTLTVHAAGT CPELKVLDLE GYKQLTILQG CPGLPGAAGP    50
    KGEAGAKGDR GESGLPGIPG KEGPTGPKGN QGEKGIRGEK GDSGPSQSCA 100
    TGPRTCKELL TQGHFLTGWY TIYLPDCRPL TVLCDMDTDG GGWTVFQRRL 150
    DGSVDFFRDW TSYKRGFGSQ LGEFWLGNDN IHALTTQGTS ELRVDLSDFE 200
    GKHDFAKYSS FQIQGEAEKY KLILGNFLGG GAGDSLTPHN NRLFSTKDQD 250
    NDGSTSSCAM GYHGAWWYSQ CHTSNLNGLY LRGPHKSYAN GVNWKSWRGY 300
    NYSCKVSEMK VRLI 314
    Length:314
    Mass (Da):33,984
    Last modified:December 12, 2006 - v2
    Checksum:i6C1467BF0BE96E67
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301L → M in AAC98781. (PubMed:9851834)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107220 mRNA. Translation: AAI07221.1.
    BC107221 mRNA. Translation: AAI07222.1.
    AF063217 mRNA. Translation: AAC98781.1.
    CCDSiCCDS15832.1.
    RefSeqiNP_034320.1. NM_010190.1.
    UniGeneiMm.182935.

    Genome annotation databases

    EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835.
    GeneIDi14134.
    KEGGimmu:14134.
    UCSCiuc008ixv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC107220 mRNA. Translation: AAI07221.1 .
    BC107221 mRNA. Translation: AAI07222.1 .
    AF063217 mRNA. Translation: AAC98781.1 .
    CCDSi CCDS15832.1.
    RefSeqi NP_034320.1. NM_010190.1.
    UniGenei Mm.182935.

    3D structure databases

    ProteinModelPortali O70497.
    SMRi O70497. Positions 98-312.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O70497.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028179 ; ENSMUSP00000028179 ; ENSMUSG00000026835 .
    GeneIDi 14134.
    KEGGi mmu:14134.
    UCSCi uc008ixv.1. mouse.

    Organism-specific databases

    CTDi 14134.
    MGIi MGI:1341158. Fcnb.

    Phylogenomic databases

    eggNOGi NOG249945.
    GeneTreei ENSGT00750000117251.
    HOGENOMi HOG000037127.
    HOVERGENi HBG001644.
    InParanoidi O70497.
    KOi K10104.
    OMAi NFFSTKD.
    OrthoDBi EOG7X9G60.
    PhylomeDBi O70497.
    TreeFami TF329953.

    Miscellaneous databases

    NextBioi 285244.
    PROi O70497.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70497.
    CleanExi MM_FCNB.
    Genevestigatori O70497.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR008160. Collagen.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    Pfami PF01391. Collagen. 1 hit.
    PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Oligomeric structure and tissue distribution of ficolins from mouse, pig and human."
      Ohashi T., Erickson H.P.
      Arch. Biochem. Biophys. 360:223-232(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-308.
      Strain: C57BL/6.
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiFCN2_MOUSE
    AccessioniPrimary (citable) accession number: O70497
    Secondary accession number(s): Q3KNL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3