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O70497

- FCN2_MOUSE

UniProt

O70497 - FCN2_MOUSE

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Protein

Ficolin-2

Gene

Fcn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin By similarity.By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. carbohydrate derivative binding Source: MGI
  3. sialic acid binding Source: MGI

GO - Biological processi

  1. complement activation, lectin pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:Fcn2
Synonyms:Fcnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1341158. Fcnb.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 314297Ficolin-2PRO_0000009140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO70497.

Expressioni

Gene expression databases

BgeeiO70497.
CleanExiMM_FCNB.
ExpressionAtlasiO70497. baseline and differential.
GenevestigatoriO70497.

Interactioni

Subunit structurei

Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliO70497.
SMRiO70497. Positions 98-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9657Collagen-likeAdd
BLAST
Domaini97 – 314218Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Domaini

The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated
Contains 1 collagen-like domain.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG249945.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiO70497.
KOiK10104.
OMAiNFFSTKD.
OrthoDBiEOG7X9G60.
PhylomeDBiO70497.
TreeFamiTF329953.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70497-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGSAALFV LTLTVHAAGT CPELKVLDLE GYKQLTILQG CPGLPGAAGP
60 70 80 90 100
KGEAGAKGDR GESGLPGIPG KEGPTGPKGN QGEKGIRGEK GDSGPSQSCA
110 120 130 140 150
TGPRTCKELL TQGHFLTGWY TIYLPDCRPL TVLCDMDTDG GGWTVFQRRL
160 170 180 190 200
DGSVDFFRDW TSYKRGFGSQ LGEFWLGNDN IHALTTQGTS ELRVDLSDFE
210 220 230 240 250
GKHDFAKYSS FQIQGEAEKY KLILGNFLGG GAGDSLTPHN NRLFSTKDQD
260 270 280 290 300
NDGSTSSCAM GYHGAWWYSQ CHTSNLNGLY LRGPHKSYAN GVNWKSWRGY
310
NYSCKVSEMK VRLI
Length:314
Mass (Da):33,984
Last modified:December 12, 2006 - v2
Checksum:i6C1467BF0BE96E67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301L → M in AAC98781. (PubMed:9851834)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC107220 mRNA. Translation: AAI07221.1.
BC107221 mRNA. Translation: AAI07222.1.
AF063217 mRNA. Translation: AAC98781.1.
CCDSiCCDS15832.1.
RefSeqiNP_034320.1. NM_010190.1.
UniGeneiMm.182935.

Genome annotation databases

EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835.
GeneIDi14134.
KEGGimmu:14134.
UCSCiuc008ixv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC107220 mRNA. Translation: AAI07221.1 .
BC107221 mRNA. Translation: AAI07222.1 .
AF063217 mRNA. Translation: AAC98781.1 .
CCDSi CCDS15832.1.
RefSeqi NP_034320.1. NM_010190.1.
UniGenei Mm.182935.

3D structure databases

ProteinModelPortali O70497.
SMRi O70497. Positions 98-312.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O70497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028179 ; ENSMUSP00000028179 ; ENSMUSG00000026835 .
GeneIDi 14134.
KEGGi mmu:14134.
UCSCi uc008ixv.1. mouse.

Organism-specific databases

CTDi 14134.
MGIi MGI:1341158. Fcnb.

Phylogenomic databases

eggNOGi NOG249945.
GeneTreei ENSGT00760000118809.
HOGENOMi HOG000037127.
HOVERGENi HBG001644.
InParanoidi O70497.
KOi K10104.
OMAi NFFSTKD.
OrthoDBi EOG7X9G60.
PhylomeDBi O70497.
TreeFami TF329953.

Miscellaneous databases

NextBioi 285244.
PROi O70497.
SOURCEi Search...

Gene expression databases

Bgeei O70497.
CleanExi MM_FCNB.
ExpressionAtlasi O70497. baseline and differential.
Genevestigatori O70497.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
Pfami PF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Oligomeric structure and tissue distribution of ficolins from mouse, pig and human."
    Ohashi T., Erickson H.P.
    Arch. Biochem. Biophys. 360:223-232(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-308.
    Strain: C57BL/6.
    Tissue: Bone marrow.

Entry informationi

Entry nameiFCN2_MOUSE
AccessioniPrimary (citable) accession number: O70497
Secondary accession number(s): Q3KNL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3