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O70497 (FCN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene names
Name:Fcn2
Synonyms:Fcnb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin By similarity.

Subunit structure

Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2 By similarity.

Subcellular location

Secreted.

Domain

The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding.

Sequence similarities

Belongs to the ficolin lectin family.

Contains 1 collagen-like domain.

Contains 1 fibrinogen C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 314297Ficolin-2
PRO_0000009140

Regions

Domain40 – 9657Collagen-like
Domain97 – 314218Fibrinogen C-terminal

Amino acid modifications

Glycosylation3011N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1301L → M in AAC98781. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O70497 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: 6C1467BF0BE96E67

FASTA31433,984
        10         20         30         40         50         60 
MALGSAALFV LTLTVHAAGT CPELKVLDLE GYKQLTILQG CPGLPGAAGP KGEAGAKGDR 

        70         80         90        100        110        120 
GESGLPGIPG KEGPTGPKGN QGEKGIRGEK GDSGPSQSCA TGPRTCKELL TQGHFLTGWY 

       130        140        150        160        170        180 
TIYLPDCRPL TVLCDMDTDG GGWTVFQRRL DGSVDFFRDW TSYKRGFGSQ LGEFWLGNDN 

       190        200        210        220        230        240 
IHALTTQGTS ELRVDLSDFE GKHDFAKYSS FQIQGEAEKY KLILGNFLGG GAGDSLTPHN 

       250        260        270        280        290        300 
NRLFSTKDQD NDGSTSSCAM GYHGAWWYSQ CHTSNLNGLY LRGPHKSYAN GVNWKSWRGY 

       310 
NYSCKVSEMK VRLI 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Oligomeric structure and tissue distribution of ficolins from mouse, pig and human."
Ohashi T., Erickson H.P.
Arch. Biochem. Biophys. 360:223-232(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-308.
Strain: C57BL/6.
Tissue: Bone marrow.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC107220 mRNA. Translation: AAI07221.1.
BC107221 mRNA. Translation: AAI07222.1.
AF063217 mRNA. Translation: AAC98781.1.
CCDSCCDS15832.1.
RefSeqNP_034320.1. NM_010190.1.
UniGeneMm.182935.

3D structure databases

ProteinModelPortalO70497.
SMRO70497. Positions 98-312.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO70497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835.
GeneID14134.
KEGGmmu:14134.
UCSCuc008ixv.1. mouse.

Organism-specific databases

CTD14134.
MGIMGI:1341158. Fcnb.

Phylogenomic databases

eggNOGNOG249945.
GeneTreeENSGT00750000117251.
HOGENOMHOG000037127.
HOVERGENHBG001644.
InParanoidO70497.
KOK10104.
OMANFFSTKD.
OrthoDBEOG7X9G60.
PhylomeDBO70497.
TreeFamTF329953.

Gene expression databases

BgeeO70497.
CleanExMM_FCNB.
GenevestigatorO70497.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR008160. Collagen.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamPF01391. Collagen. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285244.
PROO70497.
SOURCESearch...

Entry information

Entry nameFCN2_MOUSE
AccessionPrimary (citable) accession number: O70497
Secondary accession number(s): Q3KNL6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot