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Protein

Sorting nexin-12

Gene

Snx12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711Phosphatidylinositol 3-phosphateBy similarity
Binding sitei73 – 731Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei96 – 961Phosphatidylinositol 3-phosphateBy similarity
Binding sitei118 – 1181Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-12
Alternative name(s):
SDP8 protein
Gene namesi
Name:Snx12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919331. Snx12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 165164Sorting nexin-12PRO_0000213859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei23 – 231PhosphotyrosineBy similarity
Modified residuei73 – 731PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70493.
MaxQBiO70493.
PaxDbiO70493.
PeptideAtlasiO70493.
PRIDEiO70493.

2D gel databases

REPRODUCTION-2DPAGEO70493.

PTM databases

iPTMnetiO70493.
PhosphoSiteiO70493.

Expressioni

Gene expression databases

CleanExiMM_SNX12.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207759. 1 interaction.
STRINGi10090.ENSMUSP00000119102.

Structurei

3D structure databases

ProteinModelPortaliO70493.
SMRiO70493. Positions 28-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 151124PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
HOVERGENiHBG055338.
InParanoidiO70493.
KOiK17918.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY
60 70 80 90 100
EVRMRTNLPI FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR
110 120 130 140 150
HPFRGDEGIF EESFIEERRQ GLEQFINKIA GHPLAQNERC LHMFLQEEAI
160
DRNYVAGKVL GEKDC
Length:165
Mass (Da):19,116
Last modified:August 1, 1998 - v1
Checksum:iAB80CFE513B0D08A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011H → QL in BAB27499 (PubMed:16141072).Curated
Sequence conflicti156 – 1561A → P in BAB27499 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062484 mRNA. Translation: AAC16019.1.
AK011257 mRNA. Translation: BAB27499.1.
RefSeqiNP_061363.2. NM_018875.2.
UniGeneiMm.206949.

Genome annotation databases

GeneIDi55988.
KEGGimmu:55988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062484 mRNA. Translation: AAC16019.1.
AK011257 mRNA. Translation: BAB27499.1.
RefSeqiNP_061363.2. NM_018875.2.
UniGeneiMm.206949.

3D structure databases

ProteinModelPortaliO70493.
SMRiO70493. Positions 28-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207759. 1 interaction.
STRINGi10090.ENSMUSP00000119102.

PTM databases

iPTMnetiO70493.
PhosphoSiteiO70493.

2D gel databases

REPRODUCTION-2DPAGEO70493.

Proteomic databases

EPDiO70493.
MaxQBiO70493.
PaxDbiO70493.
PeptideAtlasiO70493.
PRIDEiO70493.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi55988.
KEGGimmu:55988.

Organism-specific databases

CTDi29934.
MGIiMGI:1919331. Snx12.

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
HOVERGENiHBG055338.
InParanoidiO70493.
KOiK17918.

Miscellaneous databases

PROiO70493.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SNX12.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX12_MOUSE
AccessioniPrimary (citable) accession number: O70493
Secondary accession number(s): Q9D0N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.