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Protein

Stimulated by retinoic acid gene 6 protein

Gene

Stra6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.90.1.2. the vitamin a receptor/transporter (stra6) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Stimulated by retinoic acid gene 6 protein
Alternative name(s):
Retinoic acid-responsive protein
Gene namesi
Name:Stra6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107742. Stra6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050ExtracellularSequence analysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Topological domaini72 – 9726CytoplasmicSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Topological domaini119 – 16850ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Topological domaini190 – 20415CytoplasmicSequence analysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence analysisAdd
BLAST
Topological domaini226 – 29671ExtracellularSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Topological domaini318 – 3258CytoplasmicSequence analysis
Transmembranei326 – 34520HelicalSequence analysisAdd
BLAST
Topological domaini346 – 36217ExtracellularSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Topological domaini384 – 44057CytoplasmicSequence analysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence analysisAdd
BLAST
Topological domaini462 – 47514ExtracellularSequence analysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence analysisAdd
BLAST
Topological domaini497 – 51014CytoplasmicSequence analysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence analysisAdd
BLAST
Topological domaini532 – 670139ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Stimulated by retinoic acid gene 6 proteinPRO_0000311229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO70491.
PaxDbiO70491.
PRIDEiO70491.

PTM databases

iPTMnetiO70491.
PhosphoSiteiO70491.

Expressioni

Tissue specificityi

Widely expressed in the embryo. In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in the eye (retinal pigment epithelium), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta (at protein level). Also detected in kidney, spleen, and female genital tract; and at lower levels in heart and lung. Not detected in liver.1 Publication

Developmental stagei

During embryogenesis, strongly expressed in the periocular mesenchyme, in the developing eyes, in respiratory mesenchymes, and in respiratory and bronchial epithelium, as well as in the developing central nervous system and in different embryonic gut derivatives (the epithelium of the pharyngeal pouches, mesenchyme of the esophagus, stomach, intestine, and rectum). In Sertoli cells expression depends on the stage of the spermatogenic cycle. During early placentation, is expressed in the yolk sac membrane and the chorionic plate. Expression was no longer detected in the yolk sac membrane during mid-late gestation, but was found in the labyrinthine zone of the chorioallantoic placenta. Expressed during early dorsoventral limb patterning and during endochondral ossification.3 Publications

Inductioni

By retinoic acid. Synergistically up-regulated by Wnt1 and retinoids in mammary epithelial cells.4 Publications

Gene expression databases

BgeeiO70491.
CleanExiMM_STRA6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034880.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYH. Eukaryota.
ENOG410YGRH. LUCA.
HOGENOMiHOG000154441.
HOVERGENiHBG106311.
InParanoidiO70491.
OrthoDBiEOG7CRTPB.
PhylomeDBiO70491.
TreeFamiTF331851.

Family and domain databases

InterProiIPR026612. STRA6.
[Graphical view]
PANTHERiPTHR21444:SF16. PTHR21444:SF16. 1 hit.

Sequencei

Sequence statusi: Complete.

O70491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQASENGS QTSSGVTDDY SSWYIEEPLG AEEVQPEGVI PLCQLTAPPA
60 70 80 90 100
LLHACLASLS FLVLLLLALL VRRRRLWPRC GHRGLGLPSP VDFLAGDLSW
110 120 130 140 150
TVPAAVFVVL FSNLCLLLPD ENPLPFLNLT AASSPDGEME TSRGPWKLLA
160 170 180 190 200
LLYYPALYYP LAACASAGHQ AAFLLGTVLS WAHFGVQVWQ KAECPQDPKI
210 220 230 240 250
YKHYSLLASL PLLLGLGFLS LWYPVQLVQS LRHRTGAGSQ GLQTSYSEKY
260 270 280 290 300
LRTLLCPKKL DSCSHPASKR SLLSRAWAFS HHSIYTPQPG FRLPLKLVIS
310 320 330 340 350
ATLTGTATYQ VALLLLVSVV PTVQKVRAGI NTDVSYLLAG FGIVLSEDRQ
360 370 380 390 400
EVVELVKHHL WTVEACYISA LVLSCASTFL LLIRSLRTHR ANLQALHRGA
410 420 430 440 450
ALDLDPPLQS IHPSRQAIVS WMSFCAYQTA FSCLGLLVQQ VIFFLGTTSL
460 470 480 490 500
AFLVFVPLLH GRNLLLLRSL ESTWPFWLTV ALAVILQNIA ANWIFLRTHH
510 520 530 540 550
GYPELTNRRM LCVATFLLFP INMLVGAIMA VWRVLISSLY NTVHLGQMDL
560 570 580 590 600
SLLPQRAASL DPGYHTYQNF LRIEASQSHP GVIAFCALLL HAPSPQPRPP
610 620 630 640 650
LAPQDSLRPA EEEEGMQLLQ TKDLMAKGAG HKGSQSRARW GLAYTLLHNP
660 670
SLQAFRKAAL TSAKANGTQP
Length:670
Mass (Da):73,775
Last modified:August 1, 1998 - v1
Checksum:i6ACE69F3EE16A4F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2341R → P in AAH75657 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062476 mRNA. Translation: AAC16016.1.
BC075657 mRNA. Translation: AAH75657.1.
CCDSiCCDS23236.1.
RefSeqiNP_001155947.1. NM_001162475.1.
NP_001155948.1. NM_001162476.1.
NP_001155951.1. NM_001162479.1.
NP_033317.2. NM_009291.2.
XP_006511004.2. XM_006510941.2.
XP_006511006.1. XM_006510943.2.
XP_006511007.1. XM_006510944.2.
XP_006511008.1. XM_006510945.2.
XP_006511009.1. XM_006510946.2.
XP_011240997.1. XM_011242695.1.
UniGeneiMm.10801.

Genome annotation databases

GeneIDi20897.
KEGGimmu:20897.
UCSCiuc009pwi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062476 mRNA. Translation: AAC16016.1.
BC075657 mRNA. Translation: AAH75657.1.
CCDSiCCDS23236.1.
RefSeqiNP_001155947.1. NM_001162475.1.
NP_001155948.1. NM_001162476.1.
NP_001155951.1. NM_001162479.1.
NP_033317.2. NM_009291.2.
XP_006511004.2. XM_006510941.2.
XP_006511006.1. XM_006510943.2.
XP_006511007.1. XM_006510944.2.
XP_006511008.1. XM_006510945.2.
XP_006511009.1. XM_006510946.2.
XP_011240997.1. XM_011242695.1.
UniGeneiMm.10801.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034880.

Protein family/group databases

TCDBi2.A.90.1.2. the vitamin a receptor/transporter (stra6) family.

PTM databases

iPTMnetiO70491.
PhosphoSiteiO70491.

Proteomic databases

MaxQBiO70491.
PaxDbiO70491.
PRIDEiO70491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20897.
KEGGimmu:20897.
UCSCiuc009pwi.2. mouse.

Organism-specific databases

CTDi64220.
MGIiMGI:107742. Stra6.

Phylogenomic databases

eggNOGiENOG410IDYH. Eukaryota.
ENOG410YGRH. LUCA.
HOGENOMiHOG000154441.
HOVERGENiHBG106311.
InParanoidiO70491.
OrthoDBiEOG7CRTPB.
PhylomeDBiO70491.
TreeFamiTF331851.

Miscellaneous databases

PROiO70491.
SOURCEiSearch...

Gene expression databases

BgeeiO70491.
CleanExiMM_STRA6.

Family and domain databases

InterProiIPR026612. STRA6.
[Graphical view]
PANTHERiPTHR21444:SF16. PTHR21444:SF16. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein."
    Bouillet P., Sapin V., Chazaud C., Messaddeq N., Decimo D., Dolle P., Chambon P.
    Mech. Dev. 63:173-186(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. "Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types."
    Taneja R., Bouillet P., Boylan J.F., Gaub M.-P., Roy B., Gudas L.J., Chambon P.
    Proc. Natl. Acad. Sci. U.S.A. 92:7854-7858(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "Restricted expression of a novel retinoic acid responsive gene during limb bud dorsoventral patterning and endochondral ossification."
    Chazaud C., Bouillet P., Oulad-Abdelghani M., Dolle P.
    Dev. Genet. 19:66-73(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. "Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation."
    Sapin V., Bouillet P., Oulad-Abdelghani M., Dastugue B., Chambon P., Dolle P.
    Mech. Dev. 92:295-299(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. "Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid."
    Szeto W., Jiang W., Tice D.A., Rubinfeld B., Hollingshead P.G., Fong S.E., Dugger D.L., Pham T., Yansura D.G., Wong T.A., Grimaldi J.C., Corpuz R.T., Singh J.S., Frantz G.D., Devaux B., Crowley C.W., Schwall R.H., Eberhard D.A.
    , Rastelli L., Polakis P., Pennica D.
    Cancer Res. 61:4197-4205(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling."
    Tice D.A., Szeto W., Soloviev I., Rubinfeld B., Fong S.E., Dugger D.L., Winer J., Williams P.M., Wieand D., Smith V., Schwall R.H., Pennica D., Polakis P.
    J. Biol. Chem. 277:14329-14335(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiSTRA6_MOUSE
AccessioniPrimary (citable) accession number: O70491
Secondary accession number(s): Q6DIA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The retinoic acid-induced activation is impaired in retinoic acid receptor gamma-null F9 cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.