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Protein
Submitted name:

Calpain Rt88

Gene

Capn3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109PROSITE-ProRule annotation1
Active sitei314PROSITE-ProRule annotation1
Active sitei338PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi641 – 652PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi671 – 682PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain Rt88Imported
Gene namesi
Name:Capn3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2269. Capn3.

Subcellular locationi

Structurei

3D structure databases

ProteinModelPortaliO70482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 397Calpain catalyticInterPro annotationAdd BLAST348
Domaini585 – 619EF-handInterPro annotationAdd BLAST35
Domaini628 – 654EF-handInterPro annotationAdd BLAST27
Domaini658 – 693EF-handInterPro annotationAdd BLAST36
Domaini723 – 757EF-handInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOVERGENiHBG012645.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

O70482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLLPGFFC DRVIRERDRR NGEGTVSQPL KFEGQDFVVL KQRCLAQKCL
60 70 80 90 100
FEDRVFPAGT QALGSHELSQ KAKMKAITWK RPKEICENPR FIIGGANRTD
110 120 130 140 150
ICQGDLGDCW FLAAIACLTL NERLLFRVIP HDQSFTENYA GIFHFQFWRY
160 170 180 190 200
GDWVDVVIDD CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK
210 220 230 240 250
GGNTTEAMED FTGGVTEFFE IKDAPSDMYK IMRKAIERGS LMGCSIDDGT
260 270 280 290 300
NMTYGTSPSG LNMGELIARM VRNMDNSLLR DSDLDPRASD DRPSRTIVPV
310 320 330 340 350
QYETRMACGL VKGHAYSVTG LEEALFKGEK VKLVRLRNPW GQVEWNGSWS
360 370 380 390 400
DGWKDWSFVD KDEKARLQHQ VTEDGEFWMS YDDFVYHFTK LEICNLTADA
410 420 430 440 450
LESDKLQTWT VSVNEGRWVR GCSAGGCRNF PDTFWTNPQY RLKLLEEDDD
460 470 480 490 500
PDDSEVICSF LVALMQKNRR KDRKLGANLF TIGFAIYEVP KEMHGNKQHL
510 520 530 540 550
QKDFFLYNAS KARSKTYINM REVSQRFRLP PSEYVIVPST YEPHQEGEFI
560 570 580 590 600
LRVFSEKRNL SEEAENTISV DRPVPRPGHT DQESEEQQQF RNIFRQIAGD
610 620 630 640 650
DMEICADELK NVLNTVVNKH KDLKTQGFTL ESCRSMIALM DTDGSGRLNL
660 670 680 690 700
QEFHHLWKKI KAWQKIFKHY DTDHSGTINS YEMRNAVNDA GFHLNSQLYD
710 720 730 740 750
IITMRYADKH MNIDFDSFIC CFVRLEGMFR AFHAFDKDGD GIIKLNVLEW

LQLTMYA
Length:757
Mass (Da):87,541
Last modified:May 1, 1999 - v2
Checksum:i892156FF1F125438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061726 mRNA. Translation: AAC23592.2.
RefSeqiXP_006234791.1. XM_006234729.3.
UniGeneiRn.9726.

Genome annotation databases

GeneIDi29155.

Similar proteinsi

Entry informationi

Entry nameiO70482_RAT
AccessioniPrimary (citable) accession number: O70482
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation