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Protein

Homeobox protein PKNOX1

Gene

Pknox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi259 – 32163Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  • sequence-specific DNA binding Source: BHF-UCL

GO - Biological processi

  • angiogenesis Source: MGI
  • camera-type eye development Source: MGI
  • erythrocyte differentiation Source: MGI
  • hemopoiesis Source: MGI
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • T cell differentiation Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein PKNOX1
Alternative name(s):
PBX/knotted homeobox 1
Gene namesi
Name:Pknox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1201409. Pknox1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Homeobox protein PKNOX1PRO_0000049249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70477.
PaxDbiO70477.
PRIDEiO70477.

PTM databases

PhosphoSiteiO70477.

Expressioni

Gene expression databases

BgeeiO70477.
CleanExiMM_PKNOX1.
GenevisibleiO70477. MM.

Interactioni

Protein-protein interaction databases

BioGridi202211. 11 interactions.
STRINGi10090.ENSMUSP00000094966.

Structurei

3D structure databases

ProteinModelPortaliO70477.
SMRiO70477. Positions 258-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG277861.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253922.
HOVERGENiHBG055193.
InParanoidiO70477.
OMAiCSEPDVE.
OrthoDBiEOG71CFNK.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSDPDAEGV SPPPIESQTP
60 70 80 90 100
MDADKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ
110 120 130 140 150
EKDGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL
160 170 180 190 200
KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTLSPQGIV VPASALQQGN
210 220 230 240 250
VTMATVAGGT VYQPVTVVTP QGQVVTQALS PGTIRIQNSQ LQLQLNQDLS
260 270 280 290 300
ILHQEDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN
310 320 330 340 350
LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKPAQNR PVQRFWPDSL
360 370 380 390 400
ASGVAQATPS ELAMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM
410 420 430
AGQSEDESVD STEDEGGALA PTHISGLVLE NSDSLQ
Length:436
Mass (Da):47,539
Last modified:July 27, 2011 - v3
Checksum:iAC549642781DFCA0
GO

Sequence cautioni

The sequence AAC15990.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511I → T in AAC15990 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061270 mRNA. Translation: AAC15990.1. Different initiation.
AK131788 mRNA. Translation: BAE20805.1.
AK134000 mRNA. Translation: BAE21975.1.
BC052701 mRNA. Translation: AAH52701.1.
CCDSiCCDS28608.1.
RefSeqiNP_057879.2. NM_016670.3.
XP_006523917.1. XM_006523854.1.
XP_006523918.1. XM_006523855.1.
UniGeneiMm.259295.

Genome annotation databases

EnsembliENSMUST00000097352; ENSMUSP00000094966; ENSMUSG00000006705.
ENSMUST00000175806; ENSMUSP00000134852; ENSMUSG00000006705.
ENSMUST00000176701; ENSMUSP00000135804; ENSMUSG00000006705.
GeneIDi18771.
KEGGimmu:18771.
UCSCiuc008bvh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061270 mRNA. Translation: AAC15990.1. Different initiation.
AK131788 mRNA. Translation: BAE20805.1.
AK134000 mRNA. Translation: BAE21975.1.
BC052701 mRNA. Translation: AAH52701.1.
CCDSiCCDS28608.1.
RefSeqiNP_057879.2. NM_016670.3.
XP_006523917.1. XM_006523854.1.
XP_006523918.1. XM_006523855.1.
UniGeneiMm.259295.

3D structure databases

ProteinModelPortaliO70477.
SMRiO70477. Positions 258-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202211. 11 interactions.
STRINGi10090.ENSMUSP00000094966.

PTM databases

PhosphoSiteiO70477.

Proteomic databases

MaxQBiO70477.
PaxDbiO70477.
PRIDEiO70477.

Protocols and materials databases

DNASUi18771.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097352; ENSMUSP00000094966; ENSMUSG00000006705.
ENSMUST00000175806; ENSMUSP00000134852; ENSMUSG00000006705.
ENSMUST00000176701; ENSMUSP00000135804; ENSMUSG00000006705.
GeneIDi18771.
KEGGimmu:18771.
UCSCiuc008bvh.2. mouse.

Organism-specific databases

CTDi5316.
MGIiMGI:1201409. Pknox1.

Phylogenomic databases

eggNOGiNOG277861.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253922.
HOVERGENiHBG055193.
InParanoidiO70477.
OMAiCSEPDVE.
OrthoDBiEOG71CFNK.
TreeFamiTF318093.

Miscellaneous databases

ChiTaRSiPknox1. mouse.
NextBioi295001.
PROiO70477.
SOURCEiSearch...

Gene expression databases

BgeeiO70477.
CleanExiMM_PKNOX1.
GenevisibleiO70477. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the mouse Pknox1 homeobox gene."
    Nakamura T., Yamazaki Y.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPKNX1_MOUSE
AccessioniPrimary (citable) accession number: O70477
Secondary accession number(s): Q7TT01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.