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O70477 (PKNX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein PKNOX1
Alternative name(s):
PBX/knotted homeobox 1
Gene names
Name:Pknox1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the TALE/MEIS homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAC15990.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell differentiation

Inferred from mutant phenotype PubMed 16314502. Source: MGI

angiogenesis

Inferred from mutant phenotype PubMed 16847320. Source: MGI

camera-type eye development

Inferred from mutant phenotype PubMed 16847320. Source: MGI

erythrocyte differentiation

Inferred from mutant phenotype PubMed 16847320. Source: MGI

hemopoiesis

Inferred from mutant phenotype PubMed 17904118. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10381567. Source: MGI

positive regulation of transcription, DNA-templated

Traceable author statement PubMed 17875925. Source: BHF-UCL

regulation of transcription from RNA polymerase II promoter

Traceable author statement PubMed 17875925. Source: BHF-UCL

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10373562. Source: GOC

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15087118. Source: MGI

nucleus

Inferred from direct assay PubMed 15087118PubMed 16847320PubMed 17049510. Source: MGI

transcription factor complex

Inferred from direct assay PubMed 10373562PubMed 10381567PubMed 14764653PubMed 17049510PubMed 9405651. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 10381567PubMed 14764653PubMed 9405651. Source: MGI

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 10373562. Source: MGI

protein binding

Inferred from physical interaction PubMed 10373562PubMed 10381567PubMed 14764653. Source: MGI

protein heterodimerization activity

Inferred from physical interaction PubMed 9405651. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 17875925. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Homeobox protein PKNOX1
PRO_0000049249

Regions

DNA binding259 – 32163Homeobox; TALE-type

Experimental info

Sequence conflict2511I → T in AAC15990. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O70477 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: AC549642781DFCA0

FASTA43647,539
        10         20         30         40         50         60 
MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSDPDAEGV SPPPIESQTP MDADKQAIYR 

        70         80         90        100        110        120 
HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKDGKPFFCE DPETDNLMVK 

       130        140        150        160        170        180 
AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI 

       190        200        210        220        230        240 
TGTLSPQGIV VPASALQQGN VTMATVAGGT VYQPVTVVTP QGQVVTQALS PGTIRIQNSQ 

       250        260        270        280        290        300 
LQLQLNQDLS ILHQEDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN 

       310        320        330        340        350        360 
LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKPAQNR PVQRFWPDSL ASGVAQATPS 

       370        380        390        400        410        420 
ELAMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM AGQSEDESVD STEDEGGALA 

       430 
PTHISGLVLE NSDSLQ 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of the mouse Pknox1 homeobox gene."
Nakamura T., Yamazaki Y.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF061270 mRNA. Translation: AAC15990.1. Different initiation.
AK131788 mRNA. Translation: BAE20805.1.
AK134000 mRNA. Translation: BAE21975.1.
BC052701 mRNA. Translation: AAH52701.1.
CCDSCCDS28608.1.
RefSeqNP_057879.2. NM_016670.3.
XP_006523917.1. XM_006523854.1.
XP_006523918.1. XM_006523855.1.
UniGeneMm.259295.

3D structure databases

ProteinModelPortalO70477.
SMRO70477. Positions 258-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202211. 11 interactions.
STRING10090.ENSMUSP00000094966.

PTM databases

PhosphoSiteO70477.

Proteomic databases

PaxDbO70477.
PRIDEO70477.

Protocols and materials databases

DNASU18771.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097352; ENSMUSP00000094966; ENSMUSG00000006705.
ENSMUST00000175806; ENSMUSP00000134852; ENSMUSG00000006705.
ENSMUST00000176701; ENSMUSP00000135804; ENSMUSG00000006705.
GeneID18771.
KEGGmmu:18771.
UCSCuc008bvh.2. mouse.

Organism-specific databases

CTD5316.
MGIMGI:1201409. Pknox1.

Phylogenomic databases

eggNOGNOG277861.
GeneTreeENSGT00550000074260.
HOGENOMHOG000253922.
HOVERGENHBG055193.
InParanoidQ7TT01.
OMACSEPDVE.
OrthoDBEOG71CFNK.
TreeFamTF318093.

Gene expression databases

BgeeO70477.
CleanExMM_PKNOX1.
GenevestigatorO70477.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295001.
PROO70477.
SOURCESearch...

Entry information

Entry namePKNX1_MOUSE
AccessionPrimary (citable) accession number: O70477
Secondary accession number(s): Q7TT01
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot