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O70477

- PKNX1_MOUSE

UniProt

O70477 - PKNX1_MOUSE

Protein

Homeobox protein PKNOX1

Gene

Pknox1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi259 – 32163Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. protein heterodimerization activity Source: MGI
    4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    5. sequence-specific DNA binding Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. camera-type eye development Source: MGI
    3. erythrocyte differentiation Source: MGI
    4. hemopoiesis Source: MGI
    5. positive regulation of transcription, DNA-templated Source: BHF-UCL
    6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    7. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    8. T cell differentiation Source: MGI
    9. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein PKNOX1
    Alternative name(s):
    PBX/knotted homeobox 1
    Gene namesi
    Name:Pknox1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1201409. Pknox1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Homeobox protein PKNOX1PRO_0000049249Add
    BLAST

    Proteomic databases

    PaxDbiO70477.
    PRIDEiO70477.

    PTM databases

    PhosphoSiteiO70477.

    Expressioni

    Gene expression databases

    BgeeiO70477.
    CleanExiMM_PKNOX1.
    GenevestigatoriO70477.

    Interactioni

    Protein-protein interaction databases

    BioGridi202211. 11 interactions.
    STRINGi10090.ENSMUSP00000094966.

    Structurei

    3D structure databases

    ProteinModelPortaliO70477.
    SMRiO70477. Positions 258-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TALE/MEIS homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG277861.
    GeneTreeiENSGT00550000074260.
    HOGENOMiHOG000253922.
    HOVERGENiHBG055193.
    InParanoidiQ7TT01.
    OMAiCSEPDVE.
    OrthoDBiEOG71CFNK.
    TreeFamiTF318093.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O70477-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSDPDAEGV SPPPIESQTP    50
    MDADKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ 100
    EKDGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL 150
    KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTLSPQGIV VPASALQQGN 200
    VTMATVAGGT VYQPVTVVTP QGQVVTQALS PGTIRIQNSQ LQLQLNQDLS 250
    ILHQEDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN 300
    LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKPAQNR PVQRFWPDSL 350
    ASGVAQATPS ELAMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM 400
    AGQSEDESVD STEDEGGALA PTHISGLVLE NSDSLQ 436
    Length:436
    Mass (Da):47,539
    Last modified:July 27, 2011 - v3
    Checksum:iAC549642781DFCA0
    GO

    Sequence cautioni

    The sequence AAC15990.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti251 – 2511I → T in AAC15990. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061270 mRNA. Translation: AAC15990.1. Different initiation.
    AK131788 mRNA. Translation: BAE20805.1.
    AK134000 mRNA. Translation: BAE21975.1.
    BC052701 mRNA. Translation: AAH52701.1.
    CCDSiCCDS28608.1.
    RefSeqiNP_057879.2. NM_016670.3.
    XP_006523917.1. XM_006523854.1.
    XP_006523918.1. XM_006523855.1.
    UniGeneiMm.259295.

    Genome annotation databases

    EnsembliENSMUST00000097352; ENSMUSP00000094966; ENSMUSG00000006705.
    ENSMUST00000175806; ENSMUSP00000134852; ENSMUSG00000006705.
    ENSMUST00000176701; ENSMUSP00000135804; ENSMUSG00000006705.
    GeneIDi18771.
    KEGGimmu:18771.
    UCSCiuc008bvh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061270 mRNA. Translation: AAC15990.1 . Different initiation.
    AK131788 mRNA. Translation: BAE20805.1 .
    AK134000 mRNA. Translation: BAE21975.1 .
    BC052701 mRNA. Translation: AAH52701.1 .
    CCDSi CCDS28608.1.
    RefSeqi NP_057879.2. NM_016670.3.
    XP_006523917.1. XM_006523854.1.
    XP_006523918.1. XM_006523855.1.
    UniGenei Mm.259295.

    3D structure databases

    ProteinModelPortali O70477.
    SMRi O70477. Positions 258-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202211. 11 interactions.
    STRINGi 10090.ENSMUSP00000094966.

    PTM databases

    PhosphoSitei O70477.

    Proteomic databases

    PaxDbi O70477.
    PRIDEi O70477.

    Protocols and materials databases

    DNASUi 18771.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097352 ; ENSMUSP00000094966 ; ENSMUSG00000006705 .
    ENSMUST00000175806 ; ENSMUSP00000134852 ; ENSMUSG00000006705 .
    ENSMUST00000176701 ; ENSMUSP00000135804 ; ENSMUSG00000006705 .
    GeneIDi 18771.
    KEGGi mmu:18771.
    UCSCi uc008bvh.2. mouse.

    Organism-specific databases

    CTDi 5316.
    MGIi MGI:1201409. Pknox1.

    Phylogenomic databases

    eggNOGi NOG277861.
    GeneTreei ENSGT00550000074260.
    HOGENOMi HOG000253922.
    HOVERGENi HBG055193.
    InParanoidi Q7TT01.
    OMAi CSEPDVE.
    OrthoDBi EOG71CFNK.
    TreeFami TF318093.

    Miscellaneous databases

    NextBioi 295001.
    PROi O70477.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70477.
    CleanExi MM_PKNOX1.
    Genevestigatori O70477.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the mouse Pknox1 homeobox gene."
      Nakamura T., Yamazaki Y.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPKNX1_MOUSE
    AccessioniPrimary (citable) accession number: O70477
    Secondary accession number(s): Q7TT01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3