ID   AK1A1_CRIGR             Reviewed;         228 AA.
AC   O70473;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 41.
DE   RecName: Full=Alcohol dehydrogenase [NADP+];
DE            EC=1.1.1.2;
DE   AltName: Full=Aldehyde reductase;
DE   AltName: Full=Aldo-keto reductase family 1 member A1;
DE   Flags: Fragment;
GN   Name=AKR1A1; Synonyms=ALR;
OS   Cricetulus griseus (Chinese hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hyndman D.J., Flynn T.G.;
RT   "Partial sequence of Chinese hamster aldehyde reductase.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of a variety of
CC       aldehydes to their corresponding alcohols (By similarity).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NADP(+) = an aldehyde + NADPH.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family.
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DR   EMBL; AF060820; AAC15760.1; -; mRNA.
DR   HSSP; P14550; 2ALR.
DR   SMR; O70473; 1-228.
DR   HOVERGEN; O70473; -.
DR   BRENDA; 1.1.1.2; 18.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001395; Aldo/ket_red.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   Gene3D; G3DSA:3.20.20.100; Aldo/ket_red; 1.
DR   PANTHER; PTHR11732; Aldo/ket_red; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   ProDom; PD000288; Aldo/ket_red; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase.
FT   CHAIN        <1   >228       Alcohol dehydrogenase [NADP+].
FT                                /FTId=PRO_0000124616.
FT   NP_BIND     196    228       NADP (By similarity).
FT   ACT_SITE     35     35       Proton donor (By similarity).
FT   BINDING      98     98       Substrate (By similarity).
FT   SITE         65     65       Lowers pKa of active site Tyr (By
FT                                similarity).
FT   NON_TER       1      1
FT   NON_TER     228    228
SQ   SEQUENCE   228 AA;  25450 MW;  90C5625FD810DA93 CRC64;
     LIGLGTWKSN PGQVKAAIKY ALSVGYRHID CAAVYGNEIE IGEALKENVG PGKAVPREEL
     FVTSKLWNTK HHPEDVEAAL RKTLADLQLE YLDLYLMHWP YAFERGDNPF PKNDDGTIRY
     DSTHYKETWK ALEALVAKGL VKALGLSNFN SRQIDDILSV ASVRPAVLQV ECHPYLAQNE
     LIAHCQARGL EVTAYSPLGS SDRAWRHPDE PVLLEEPVVL ALAEKHGR
//