O70473 (AK1A1_CRIGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase [NADP+]
EC=1.1.1.2

Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1

Gene names

Name:	AKR1A1
Synonyms:	ALR

Organism

Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

Taxonomic identifier

10029 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

Protein attributes

Sequence length	228 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.
Catalytic activity	An alcohol + NADP+ = an aldehyde + NADPH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular function	alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›228	›228	Alcohol dehydrogenase [NADP+]		PRO_0000124616
Regions
	Nucleotide binding	196 – 228	33	NADP By similarity
Sites
	Active site	35	1	Proton donor By similarity
	Binding site	98	1	Substrate By similarity
	Site	65	1	Lowers pKa of active site Tyr By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	228	1

Sequences

	Sequence		Length	Mass (Da)
	O70473 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 90C5625FD810DA93	FASTA	228	25,450
	10 20 30 40 50 60 LIGLGTWKSN PGQVKAAIKY ALSVGYRHID CAAVYGNEIE IGEALKENVG PGKAVPREEL 70 80 90 100 110 120 FVTSKLWNTK HHPEDVEAAL RKTLADLQLE YLDLYLMHWP YAFERGDNPF PKNDDGTIRY 130 140 150 160 170 180 DSTHYKETWK ALEALVAKGL VKALGLSNFN SRQIDDILSV ASVRPAVLQV ECHPYLAQNE 190 200 210 220 LIAHCQARGL EVTAYSPLGS SDRAWRHPDE PVLLEEPVVL ALAEKHGR

References

[1]	"Partial sequence of Chinese hamster aldehyde reductase." Hyndman D.J., Flynn T.G. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF060820 mRNA. Translation: AAC15760.1.
3D structure databases
ProteinModelPortal	O70473.
SMR	O70473. Positions 1-228.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000020.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK1A1_CRIGR

Accession

Primary (citable) accession number: O70473

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program