O70473 (AK1A1_CRIGR) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 51.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alcohol dehydrogenase [NADP+] EC=1.1.1.2 Alternative name(s): Aldehyde reductase Aldo-keto reductase family 1 member A1 | ||||
| Gene names |
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| Organism | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) | ||||
| Taxonomic identifier | 10029 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus |
Protein attributes
| Sequence length | 228 AA. |
| Sequence status | Fragment. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity. |
| Catalytic activity | An alcohol + NADP+ = an aldehyde + NADPH. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the aldo/keto reductase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Molecular function | alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – ›228 | ›228 | Alcohol dehydrogenase [NADP+] | PRO_0000124616 | |||||
Regions | |||||||||
| Nucleotide binding | 196 – 228 | 33 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 35 | 1 | Proton donor By similarity | ||||||
| Binding site | 98 | 1 | Substrate By similarity | ||||||
| Site | 65 | 1 | Lowers pKa of active site Tyr By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 1 | 1 | |||||||
| Non-terminal residue | 228 | 1 | |||||||
Sequences
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References
| [1] | "Partial sequence of Chinese hamster aldehyde reductase." Hyndman D.J., Flynn T.G. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF060820 mRNA. Translation: AAC15760.1. |
3D structure databases | |
| ProteinModelPortal | O70473. |
| SMR | O70473. Positions 1-228. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG000020. |
Family and domain databases | |
| InterPro | IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view] |
| Gene3D | G3DSA:3.20.20.100. Aldo/ket_red. 1 hit. |
| PANTHER | PTHR11732. Aldo/ket_red. 1 hit. |
| Pfam | PF00248. Aldo_ket_red. 1 hit. [Graphical view] |
| PIRSF | PIRSF000097. AKR. 1 hit. |
| PRINTS | PR00069. ALDKETRDTASE. |
| SUPFAM | SSF51430. Aldo/ket_red. 1 hit. |
| PROSITE | PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AK1A1_CRIGR | ||||||||
| Accession | Primary (citable) accession number: O70473 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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