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Protein

Monocarboxylate transporter 3

Gene

Slc16a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 3
Short name:
MCT 3
Alternative name(s):
Solute carrier family 16 member 8
Gene namesi
Name:Slc16a8
Synonyms:Mct3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69282. Slc16a8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence analysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST
Topological domaini36 – 5823ExtracellularSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Topological domaini80 – 856CytoplasmicSequence analysis
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Topological domaini107 – 1159ExtracellularSequence analysis
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Topological domaini137 – 14711CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 1724ExtracellularSequence analysis
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Topological domaini194 – 23037CytoplasmicSequence analysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Topological domaini252 – 2576ExtracellularSequence analysis
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Topological domaini279 – 29315CytoplasmicSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST
Topological domaini315 – 3184ExtracellularSequence analysis
Transmembranei319 – 33921HelicalSequence analysisAdd
BLAST
Topological domaini340 – 35213CytoplasmicSequence analysisAdd
BLAST
Transmembranei353 – 37321HelicalSequence analysisAdd
BLAST
Topological domaini374 – 38613ExtracellularSequence analysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence analysisAdd
BLAST
Topological domaini408 – 49285CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • basal plasma membrane Source: RGD
  • integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Monocarboxylate transporter 3PRO_0000211392Add
BLAST

Proteomic databases

PaxDbiO70461.

PTM databases

PhosphoSiteiO70461.

Expressioni

Tissue specificityi

Retinal pigment epithelium. Restricted to the basolateral membrane.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016248.

Structurei

3D structure databases

ProteinModelPortaliO70461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO70461.
PhylomeDBiO70461.

Family and domain databases

InterProiIPR004743. MCT.
IPR030759. MCT3.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF26. PTHR11360:SF26. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGGPRRGA GPPDGGWGWV VLGACFVITG FAYGFPKAVS VFFRELKRDF
60 70 80 90 100
GAGYSDTAWV SSIMLAMLYG TGPLSSILVT RFGCRPVMLA GGLLASAGMI
110 120 130 140 150
LASFASRLLE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA
160 170 180 190 200
AGSPVFLSTL SPLGQLLGER FGWRGGFLLF GGLLLHCCAC GAVMRPPPGP
210 220 230 240 250
QPRPDPAPPG GRARHRQLLD LAVCTDRTFM VYMVTKFLMA LGLFVPAILL
260 270 280 290 300
VNYAKDAGVP DAEAAFLLSI VGFVDIVARP ACGALAGLGR LRPHVPYLFS
310 320 330 340 350
LALLANGLTD LISARARSYG TLVAFCIAFG LSYGMVGALQ FEVLMATVGA
360 370 380 390 400
PRFPSALGLV LLVEAVAVLI GPPSAGRLVD ALKNYEIIFY LAGSEVALAG
410 420 430 440 450
VFMAVTTYCC LRCSKNISSG RSAEGGASDP EDVEAERDSE PMPASTEEPG
460 470 480 490
SLEALEVLSP RAGSPEQEPE EEAVPELDHE SIGGHEARGQ KA
Length:492
Mass (Da):51,590
Last modified:August 1, 1998 - v1
Checksum:i5CCC44DC38B35FA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059258 mRNA. Translation: AAC18120.1.
UniGeneiRn.14526.
Rn.232572.

Genome annotation databases

UCSCiRGD:69282. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059258 mRNA. Translation: AAC18120.1.
UniGeneiRn.14526.
Rn.232572.

3D structure databases

ProteinModelPortaliO70461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016248.

PTM databases

PhosphoSiteiO70461.

Proteomic databases

PaxDbiO70461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:69282. rat.

Organism-specific databases

RGDi69282. Slc16a8.

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO70461.
PhylomeDBiO70461.

Miscellaneous databases

NextBioi13948108.
PROiO70461.

Family and domain databases

InterProiIPR004743. MCT.
IPR030759. MCT3.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF26. PTHR11360:SF26. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE."
    Philp N.J., Yoon H., Grollman E.F.
    Am. J. Physiol. 274:R1824-R1828(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Retina.

Entry informationi

Entry nameiMOT3_RAT
AccessioniPrimary (citable) accession number: O70461
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.