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O70460

- CCL19_MOUSE

UniProt

O70460 - CCL19_MOUSE

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Protein

C-C motif chemokine 19

Gene
Ccl19, Elc, Scya19
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  1. CCR7 chemokine receptor binding Source: BHF-UCL
  2. chemokine activity Source: BHF-UCL
  3. chemokine receptor binding Source: UniProtKB

GO - Biological processi

  1. activation of JUN kinase activity Source: BHF-UCL
  2. cell maturation Source: BHF-UCL
  3. dendritic cell chemotaxis Source: BHF-UCL
  4. establishment of T cell polarity Source: BHF-UCL
  5. immune response Source: InterPro
  6. immunological synapse formation Source: BHF-UCL
  7. inflammatory response Source: UniProtKB-KW
  8. interleukin-12 secretion Source: BHF-UCL
  9. mature dendritic cell differentiation Source: BHF-UCL
  10. myeloid dendritic cell chemotaxis Source: BHF-UCL
  11. negative regulation of leukocyte apoptotic process Source: BHF-UCL
  12. positive regulation of Cdc42 GTPase activity Source: BHF-UCL
  13. positive regulation of cell motility Source: BHF-UCL
  14. positive regulation of chemotaxis Source: BHF-UCL
  15. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  16. positive regulation of dendritic cell dendrite assembly Source: BHF-UCL
  17. positive regulation of endocytosis Source: BHF-UCL
  18. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  19. positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
  20. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  21. positive regulation of interleukin-12 production Source: BHF-UCL
  22. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  23. positive regulation of JNK cascade Source: BHF-UCL
  24. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  25. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  26. positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
  27. positive regulation of protein kinase activity Source: BHF-UCL
  28. positive regulation of protein kinase B signaling Source: BHF-UCL
  29. positive regulation of Ras GTPase activity Source: BHF-UCL
  30. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  31. positive regulation of T cell proliferation Source: BHF-UCL
  32. positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
  33. positive regulation of tumor necrosis factor production Source: BHF-UCL
  34. regulation of cell projection assembly Source: BHF-UCL
  35. release of sequestered calcium ion into cytosol Source: BHF-UCL
  36. response to nitric oxide Source: BHF-UCL
  37. response to prostaglandin E Source: BHF-UCL
  38. T cell costimulation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 19
Alternative name(s):
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name:
EBI1 ligand chemokine
Short name:
ELC
Small-inducible cytokine A19
Gene namesi
Name:Ccl19
Synonyms:Elc, Scya19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1346316. Ccl19.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 10883C-C motif chemokine 19PRO_0000005215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 59 By similarity
Disulfide bondi34 ↔ 75 By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO70460.

PTM databases

PhosphoSiteiO70460.

Expressioni

Tissue specificityi

Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.

Gene expression databases

BgeeiO70460.
CleanExiMM_CCL19.
GenevestigatoriO70460.

Interactioni

Protein-protein interaction databases

DIPiDIP-5920N.
MINTiMINT-123893.
STRINGi10090.ENSMUSP00000103643.

Structurei

3D structure databases

ProteinModelPortaliO70460.
SMRiO70460. Positions 33-91.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39607.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO70460.
KOiK05512.
OMAiGCEIPAN.
OrthoDBiEOG7X3QV0.
PhylomeDBiO70460.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70460-1 [UniParc]FASTAAdd to Basket

« Hide

MAPRVTPLLA FSLLVLWTFP APTLGGANDA EDCCLSVTQR PIPGNIVKAF    50
RYLLNEDGCR VPAVVFTTLR GYQLCAPPDQ PWVDRIIRRL KKSSAKNKGN 100
STRRSPVS 108
Length:108
Mass (Da):11,911
Last modified:August 1, 1998 - v1
Checksum:i0E2BC86D728319A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF059208 mRNA. Translation: AAC14661.1.
BC051472 mRNA. Translation: AAH51472.1.
CCDSiCCDS18080.1.
RefSeqiNP_036018.1. NM_011888.2.
XP_001472218.1. XM_001472168.4.
UniGeneiMm.426373.
Mm.459263.
Mm.6660.

Genome annotation databases

EnsembliENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005.
ENSMUST00000118540; ENSMUSP00000137353; ENSMUSG00000094661.
GeneIDi100039053.
24047.
KEGGimmu:100039053.
mmu:24047.
UCSCiuc008snx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF059208 mRNA. Translation: AAC14661.1 .
BC051472 mRNA. Translation: AAH51472.1 .
CCDSi CCDS18080.1.
RefSeqi NP_036018.1. NM_011888.2.
XP_001472218.1. XM_001472168.4.
UniGenei Mm.426373.
Mm.459263.
Mm.6660.

3D structure databases

ProteinModelPortali O70460.
SMRi O70460. Positions 33-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5920N.
MINTi MINT-123893.
STRINGi 10090.ENSMUSP00000103643.

PTM databases

PhosphoSitei O70460.

Proteomic databases

PRIDEi O70460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102957 ; ENSMUSP00000100022 ; ENSMUSG00000071005 .
ENSMUST00000118540 ; ENSMUSP00000137353 ; ENSMUSG00000094661 .
GeneIDi 100039053.
24047.
KEGGi mmu:100039053.
mmu:24047.
UCSCi uc008snx.1. mouse.

Organism-specific databases

CTDi 6363.
MGIi MGI:1346316. Ccl19.

Phylogenomic databases

eggNOGi NOG39607.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi O70460.
KOi K05512.
OMAi GCEIPAN.
OrthoDBi EOG7X3QV0.
PhylomeDBi O70460.
TreeFami TF334888.

Miscellaneous databases

NextBioi 303979.
PROi O70460.
SOURCEi Search...

Gene expression databases

Bgeei O70460.
CleanExi MM_CCL19.
Genevestigatori O70460.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells."
    Ngo V.N., Tang H.L., Cyster J.G.
    J. Exp. Med. 188:181-191(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Lymphoid tissue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCCL19_MOUSE
AccessioniPrimary (citable) accession number: O70460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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