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O70460

- CCL19_MOUSE

UniProt

O70460 - CCL19_MOUSE

Protein

C-C motif chemokine 19

Gene

Ccl19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

    GO - Molecular functioni

    1. CCR7 chemokine receptor binding Source: BHF-UCL
    2. chemokine activity Source: BHF-UCL
    3. chemokine receptor binding Source: UniProtKB

    GO - Biological processi

    1. activation of JUN kinase activity Source: BHF-UCL
    2. cell maturation Source: BHF-UCL
    3. dendritic cell chemotaxis Source: BHF-UCL
    4. establishment of T cell polarity Source: BHF-UCL
    5. immune response Source: InterPro
    6. immunological synapse formation Source: BHF-UCL
    7. inflammatory response Source: UniProtKB-KW
    8. interleukin-12 secretion Source: BHF-UCL
    9. mature dendritic cell differentiation Source: BHF-UCL
    10. myeloid dendritic cell chemotaxis Source: BHF-UCL
    11. negative regulation of leukocyte apoptotic process Source: BHF-UCL
    12. positive regulation of Cdc42 GTPase activity Source: BHF-UCL
    13. positive regulation of cell motility Source: BHF-UCL
    14. positive regulation of chemotaxis Source: BHF-UCL
    15. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
    16. positive regulation of dendritic cell dendrite assembly Source: BHF-UCL
    17. positive regulation of endocytosis Source: BHF-UCL
    18. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    19. positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
    20. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
    21. positive regulation of interleukin-12 production Source: BHF-UCL
    22. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
    23. positive regulation of JNK cascade Source: BHF-UCL
    24. positive regulation of neutrophil chemotaxis Source: BHF-UCL
    25. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
    26. positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
    27. positive regulation of protein kinase activity Source: BHF-UCL
    28. positive regulation of protein kinase B signaling Source: BHF-UCL
    29. positive regulation of Ras GTPase activity Source: BHF-UCL
    30. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
    31. positive regulation of T cell proliferation Source: BHF-UCL
    32. positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
    33. positive regulation of tumor necrosis factor production Source: BHF-UCL
    34. regulation of cell projection assembly Source: BHF-UCL
    35. release of sequestered calcium ion into cytosol Source: BHF-UCL
    36. response to nitric oxide Source: BHF-UCL
    37. response to prostaglandin E Source: BHF-UCL
    38. T cell costimulation Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 19
    Alternative name(s):
    Epstein-Barr virus-induced molecule 1 ligand chemokine
    Short name:
    EBI1 ligand chemokine
    Short name:
    ELC
    Small-inducible cytokine A19
    Gene namesi
    Name:Ccl19
    Synonyms:Elc, Scya19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1346316. Ccl19.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 10883C-C motif chemokine 19PRO_0000005215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 59By similarity
    Disulfide bondi34 ↔ 75By similarity
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO70460.

    PTM databases

    PhosphoSiteiO70460.

    Expressioni

    Tissue specificityi

    Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.

    Gene expression databases

    BgeeiO70460.
    CleanExiMM_CCL19.
    GenevestigatoriO70460.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5920N.
    MINTiMINT-123893.
    STRINGi10090.ENSMUSP00000103643.

    Structurei

    3D structure databases

    ProteinModelPortaliO70460.
    SMRiO70460. Positions 33-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39607.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiO70460.
    KOiK05512.
    OMAiGCEIPAN.
    OrthoDBiEOG7X3QV0.
    PhylomeDBiO70460.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70460-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRVTPLLA FSLLVLWTFP APTLGGANDA EDCCLSVTQR PIPGNIVKAF    50
    RYLLNEDGCR VPAVVFTTLR GYQLCAPPDQ PWVDRIIRRL KKSSAKNKGN 100
    STRRSPVS 108
    Length:108
    Mass (Da):11,911
    Last modified:August 1, 1998 - v1
    Checksum:i0E2BC86D728319A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059208 mRNA. Translation: AAC14661.1.
    BC051472 mRNA. Translation: AAH51472.1.
    CCDSiCCDS18080.1.
    RefSeqiNP_036018.1. NM_011888.2.
    XP_001472218.1. XM_001472168.4.
    UniGeneiMm.426373.
    Mm.459263.
    Mm.6660.

    Genome annotation databases

    EnsembliENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005.
    ENSMUST00000118540; ENSMUSP00000137353; ENSMUSG00000094661.
    GeneIDi100039053.
    24047.
    KEGGimmu:100039053.
    mmu:24047.
    UCSCiuc008snx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059208 mRNA. Translation: AAC14661.1 .
    BC051472 mRNA. Translation: AAH51472.1 .
    CCDSi CCDS18080.1.
    RefSeqi NP_036018.1. NM_011888.2.
    XP_001472218.1. XM_001472168.4.
    UniGenei Mm.426373.
    Mm.459263.
    Mm.6660.

    3D structure databases

    ProteinModelPortali O70460.
    SMRi O70460. Positions 33-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5920N.
    MINTi MINT-123893.
    STRINGi 10090.ENSMUSP00000103643.

    PTM databases

    PhosphoSitei O70460.

    Proteomic databases

    PRIDEi O70460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102957 ; ENSMUSP00000100022 ; ENSMUSG00000071005 .
    ENSMUST00000118540 ; ENSMUSP00000137353 ; ENSMUSG00000094661 .
    GeneIDi 100039053.
    24047.
    KEGGi mmu:100039053.
    mmu:24047.
    UCSCi uc008snx.1. mouse.

    Organism-specific databases

    CTDi 6363.
    MGIi MGI:1346316. Ccl19.

    Phylogenomic databases

    eggNOGi NOG39607.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi O70460.
    KOi K05512.
    OMAi GCEIPAN.
    OrthoDBi EOG7X3QV0.
    PhylomeDBi O70460.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 303979.
    PROi O70460.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70460.
    CleanExi MM_CCL19.
    Genevestigatori O70460.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells."
      Ngo V.N., Tang H.L., Cyster J.G.
      J. Exp. Med. 188:181-191(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Lymphoid tissue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCCL19_MOUSE
    AccessioniPrimary (citable) accession number: O70460
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3