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Protein

C-C motif chemokine 19

Gene

Ccl19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  1. CCR7 chemokine receptor binding Source: BHF-UCL
  2. chemokine activity Source: BHF-UCL
  3. chemokine receptor binding Source: UniProtKB

GO - Biological processi

  1. activation of JUN kinase activity Source: BHF-UCL
  2. cell maturation Source: BHF-UCL
  3. dendritic cell chemotaxis Source: BHF-UCL
  4. establishment of T cell polarity Source: BHF-UCL
  5. immune response Source: InterPro
  6. immunological synapse formation Source: BHF-UCL
  7. inflammatory response Source: UniProtKB-KW
  8. interleukin-12 secretion Source: BHF-UCL
  9. mature conventional dendritic cell differentiation Source: BHF-UCL
  10. myeloid dendritic cell chemotaxis Source: BHF-UCL
  11. negative regulation of leukocyte apoptotic process Source: BHF-UCL
  12. positive regulation of cell motility Source: BHF-UCL
  13. positive regulation of chemotaxis Source: BHF-UCL
  14. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  15. positive regulation of dendritic cell dendrite assembly Source: BHF-UCL
  16. positive regulation of endocytosis Source: BHF-UCL
  17. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  18. positive regulation of glycoprotein biosynthetic process Source: BHF-UCL
  19. positive regulation of GTPase activity Source: BHF-UCL
  20. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  21. positive regulation of interleukin-12 production Source: BHF-UCL
  22. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  23. positive regulation of JNK cascade Source: BHF-UCL
  24. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  25. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  26. positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
  27. positive regulation of protein kinase activity Source: BHF-UCL
  28. positive regulation of protein kinase B signaling Source: BHF-UCL
  29. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  30. positive regulation of T cell proliferation Source: BHF-UCL
  31. positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
  32. positive regulation of tumor necrosis factor production Source: BHF-UCL
  33. regulation of cell projection assembly Source: BHF-UCL
  34. release of sequestered calcium ion into cytosol Source: BHF-UCL
  35. response to nitric oxide Source: BHF-UCL
  36. response to prostaglandin E Source: BHF-UCL
  37. T cell costimulation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 19
Alternative name(s):
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name:
EBI1 ligand chemokine
Short name:
ELC
Small-inducible cytokine A19
Gene namesi
Name:Ccl19
Synonyms:Elc, Scya19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 4, Unplaced

Organism-specific databases

MGIiMGI:1346316. Ccl19.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 10883C-C motif chemokine 19PRO_0000005215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 59By similarity
Disulfide bondi34 ↔ 75By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO70460.

PTM databases

PhosphoSiteiO70460.

Expressioni

Tissue specificityi

Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.

Gene expression databases

BgeeiO70460.
CleanExiMM_CCL19.
ExpressionAtlasiO70460. baseline.
GenevestigatoriO70460.

Interactioni

Protein-protein interaction databases

DIPiDIP-5920N.
MINTiMINT-123893.
STRINGi10090.ENSMUSP00000103643.

Structurei

3D structure databases

ProteinModelPortaliO70460.
SMRiO70460. Positions 33-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39607.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO70460.
KOiK05512.
OMAiCCLATSE.
OrthoDBiEOG7X3QV0.
PhylomeDBiO70460.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRVTPLLA FSLLVLWTFP APTLGGANDA EDCCLSVTQR PIPGNIVKAF
60 70 80 90 100
RYLLNEDGCR VPAVVFTTLR GYQLCAPPDQ PWVDRIIRRL KKSSAKNKGN

STRRSPVS
Length:108
Mass (Da):11,911
Last modified:August 1, 1998 - v1
Checksum:i0E2BC86D728319A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059208 mRNA. Translation: AAC14661.1.
BC051472 mRNA. Translation: AAH51472.1.
CCDSiCCDS18080.1.
RefSeqiNP_036018.1. NM_011888.2.
XP_001472218.1. XM_001472168.5.
UniGeneiMm.426373.
Mm.459263.
Mm.6660.

Genome annotation databases

EnsembliENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005.
ENSMUST00000118540; ENSMUSP00000137353; ENSMUSG00000094661.
GeneIDi100039053.
24047.
KEGGimmu:100039053.
mmu:24047.
UCSCiuc008snx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059208 mRNA. Translation: AAC14661.1.
BC051472 mRNA. Translation: AAH51472.1.
CCDSiCCDS18080.1.
RefSeqiNP_036018.1. NM_011888.2.
XP_001472218.1. XM_001472168.5.
UniGeneiMm.426373.
Mm.459263.
Mm.6660.

3D structure databases

ProteinModelPortaliO70460.
SMRiO70460. Positions 33-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5920N.
MINTiMINT-123893.
STRINGi10090.ENSMUSP00000103643.

PTM databases

PhosphoSiteiO70460.

Proteomic databases

PRIDEiO70460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005.
ENSMUST00000118540; ENSMUSP00000137353; ENSMUSG00000094661.
GeneIDi100039053.
24047.
KEGGimmu:100039053.
mmu:24047.
UCSCiuc008snx.1. mouse.

Organism-specific databases

CTDi6363.
MGIiMGI:1346316. Ccl19.

Phylogenomic databases

eggNOGiNOG39607.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO70460.
KOiK05512.
OMAiCCLATSE.
OrthoDBiEOG7X3QV0.
PhylomeDBiO70460.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi303979.
PROiO70460.
SOURCEiSearch...

Gene expression databases

BgeeiO70460.
CleanExiMM_CCL19.
ExpressionAtlasiO70460. baseline.
GenevestigatoriO70460.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells."
    Ngo V.N., Tang H.L., Cyster J.G.
    J. Exp. Med. 188:181-191(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Lymphoid tissue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCCL19_MOUSE
AccessioniPrimary (citable) accession number: O70460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: April 29, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.