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Protein

C-C motif chemokine 19

Gene

Ccl19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: MGI
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: MGI
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 19
Alternative name(s):
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name:
EBI1 ligand chemokine
Short name:
ELC
Small-inducible cytokine A19
Gene namesi
Name:Ccl19
Synonyms:Elc, Scya19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346316. Ccl19.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • extracellular space Source: GO_Central
  • intracellular Source: GOC

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000521526 – 108C-C motif chemokine 19Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 59By similarity
Disulfide bondi34 ↔ 75By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70460.
PRIDEiO70460.

PTM databases

iPTMnetiO70460.
PhosphoSitePlusiO70460.

Expressioni

Tissue specificityi

Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.

Gene expression databases

BgeeiENSMUSG00000071005.
CleanExiMM_CCL19.
ExpressionAtlasiO70460. baseline and differential.
GenevisibleiO70460. MM.

Interactioni

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: MGI
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: MGI
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-5920N.
MINTiMINT-123893.
STRINGi10090.ENSMUSP00000137353.

Structurei

3D structure databases

ProteinModelPortaliO70460.
SMRiO70460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4UG. Eukaryota.
ENOG410ZG6G. LUCA.
GeneTreeiENSGT00730000111353.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiO70460.
KOiK05512.
OMAiCINTEAF.
OrthoDBiEOG091G10B5.
PhylomeDBiO70460.
TreeFamiTF334888.

Family and domain databases

CDDicd01119. Chemokine_CC_DCCL. 1 hit.
InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR034133. Chemokine_CC_DCCL.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRVTPLLA FSLLVLWTFP APTLGGANDA EDCCLSVTQR PIPGNIVKAF
60 70 80 90 100
RYLLNEDGCR VPAVVFTTLR GYQLCAPPDQ PWVDRIIRRL KKSSAKNKGN

STRRSPVS
Length:108
Mass (Da):11,911
Last modified:August 1, 1998 - v1
Checksum:i0E2BC86D728319A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059208 mRNA. Translation: AAC14661.1.
BC051472 mRNA. Translation: AAH51472.1.
CCDSiCCDS18080.1.
RefSeqiNP_036018.1. NM_011888.2.
XP_001472218.1. XM_001472168.6.
UniGeneiMm.426373.
Mm.459263.
Mm.6660.

Genome annotation databases

EnsembliENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005.
ENSMUST00000118540; ENSMUSP00000137353; ENSMUSG00000094661.
GeneIDi100039053.
24047.
KEGGimmu:100039053.
mmu:24047.
UCSCiuc008snx.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCCL19_MOUSE
AccessioniPrimary (citable) accession number: O70460
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: June 7, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families