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O70460 (CCL19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 19
Alternative name(s):
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name=EBI1 ligand chemokine
Short name=ELC
Small-inducible cytokine A19
Gene names
Name:Ccl19
Synonyms:Elc, Scya19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Subcellular location

Secreted.

Tissue specificity

Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

activation of JUN kinase activity

Inferred from direct assay PubMed 16027136. Source: BHF-UCL

cell maturation

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

dendritic cell chemotaxis

Inferred from direct assay PubMed 12200351PubMed 16027136. Source: BHF-UCL

establishment of T cell polarity

Inferred from sequence or structural similarity. Source: BHF-UCL

immune response

Inferred from electronic annotation. Source: InterPro

immunological synapse formation

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

interleukin-12 secretion

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

mature dendritic cell differentiation

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

myeloid dendritic cell chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of leukocyte apoptotic process

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of Cdc42 GTPase activity

Inferred from direct assay PubMed 12609829. Source: BHF-UCL

positive regulation of ERK1 and ERK2 cascade

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of JNK cascade

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of NF-kappaB import into nucleus

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of Ras GTPase activity

Inferred from direct assay PubMed 12609829. Source: BHF-UCL

positive regulation of T cell proliferation

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

positive regulation of T-helper 1 cell differentiation

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

positive regulation of cell motility

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of chemotaxis

Inferred from direct assay PubMed 9507024. Source: BHF-UCL

positive regulation of dendritic cell antigen processing and presentation

Inferred from mutant phenotype PubMed 15845453. Source: BHF-UCL

positive regulation of dendritic cell dendrite assembly

Inferred from direct assay PubMed 12200351. Source: BHF-UCL

positive regulation of endocytosis

Inferred from direct assay PubMed 16027136. Source: BHF-UCL

positive regulation of glycoprotein biosynthetic process

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

positive regulation of interleukin-1 beta secretion

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

positive regulation of neutrophil chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of protein kinase B signaling

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of protein kinase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of receptor-mediated endocytosis

Inferred from direct assay PubMed 12609829. Source: BHF-UCL

positive regulation of tumor necrosis factor production

Inferred from direct assay PubMed 15845453. Source: BHF-UCL

regulation of cell projection assembly

Inferred from direct assay PubMed 12200351. Source: BHF-UCL

release of sequestered calcium ion into cytosol

Inferred from sequence or structural similarity. Source: BHF-UCL

response to nitric oxide

Inferred from sequence or structural similarity. Source: BHF-UCL

response to prostaglandin E

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionCCR7 chemokine receptor binding

Inferred from physical interaction PubMed 9507024. Source: BHF-UCL

chemokine activity

Inferred from direct assay PubMed 12200351. Source: BHF-UCL

chemokine receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 10883C-C motif chemokine 19
PRO_0000005215

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 59 By similarity
Disulfide bond34 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
O70460 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 0E2BC86D728319A7

FASTA10811,911
        10         20         30         40         50         60 
MAPRVTPLLA FSLLVLWTFP APTLGGANDA EDCCLSVTQR PIPGNIVKAF RYLLNEDGCR 

        70         80         90        100 
VPAVVFTTLR GYQLCAPPDQ PWVDRIIRRL KKSSAKNKGN STRRSPVS 

« Hide

References

« Hide 'large scale' references
[1]"Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells."
Ngo V.N., Tang H.L., Cyster J.G.
J. Exp. Med. 188:181-191(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Lymphoid tissue.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF059208 mRNA. Translation: AAC14661.1.
BC051472 mRNA. Translation: AAH51472.1.
RefSeqNP_036018.1. NM_011888.2.
XP_001472218.1. XM_001472168.4.
UniGeneMm.426373.
Mm.459263.
Mm.6660.

3D structure databases

ProteinModelPortalO70460.
SMRO70460. Positions 33-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5920N.
MINTMINT-123893.
STRING10090.ENSMUSP00000103643.

PTM databases

PhosphoSiteO70460.

Proteomic databases

PRIDEO70460.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005.
ENSMUST00000118540; ENSMUSP00000137353; ENSMUSG00000094661.
GeneID100039053.
24047.
KEGGmmu:100039053.
mmu:24047.
UCSCuc008snx.1. mouse.

Organism-specific databases

CTD6363.
MGIMGI:1346316. Ccl19.

Phylogenomic databases

eggNOGNOG39607.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidO70460.
KOK05512.
OMACCLRTSE.
OrthoDBEOG7X3QV0.
PhylomeDBO70460.
TreeFamTF334888.

Gene expression databases

BgeeO70460.
CleanExMM_CCL19.
GenevestigatorO70460.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio303979.
PROO70460.
SOURCESearch...

Entry information

Entry nameCCL19_MOUSE
AccessionPrimary (citable) accession number: O70460
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot