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Protein

C-C motif chemokine 19

Gene

Ccl19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: MGI
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: MGI
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 19
Alternative name(s):
Epstein-Barr virus-induced molecule 1 ligand chemokine
Short name:
EBI1 ligand chemokine
Short name:
ELC
Small-inducible cytokine A19
Gene namesi
Name:Ccl19
Synonyms:Elc, Scya19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346316 Ccl19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000521526 – 108C-C motif chemokine 19Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 59By similarity
Disulfide bondi34 ↔ 75By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70460
PRIDEiO70460

PTM databases

iPTMnetiO70460
PhosphoSitePlusiO70460

Expressioni

Tissue specificityi

Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.

Gene expression databases

BgeeiENSMUSG00000071005
CleanExiMM_CCL19
ExpressionAtlasiO70460 baseline and differential
GenevisibleiO70460 MM

Interactioni

GO - Molecular functioni

  • CCR10 chemokine receptor binding Source: MGI
  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: MGI
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-5920N
STRINGi10090.ENSMUSP00000137353

Structurei

3D structure databases

ProteinModelPortaliO70460
SMRiO70460
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4UG Eukaryota
ENOG410ZG6G LUCA
GeneTreeiENSGT00730000111353
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO70460
KOiK05512
OMAiCINTEAF
OrthoDBiEOG091G10B5
PhylomeDBiO70460
TreeFamiTF334888

Family and domain databases

CDDicd01119 Chemokine_CC_DCCL, 1 hit
InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR034133 Chemokine_CC_DCCL
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRVTPLLA FSLLVLWTFP APTLGGANDA EDCCLSVTQR PIPGNIVKAF
60 70 80 90 100
RYLLNEDGCR VPAVVFTTLR GYQLCAPPDQ PWVDRIIRRL KKSSAKNKGN

STRRSPVS
Length:108
Mass (Da):11,911
Last modified:August 1, 1998 - v1
Checksum:i0E2BC86D728319A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059208 mRNA Translation: AAC14661.1
BC051472 mRNA Translation: AAH51472.1
CCDSiCCDS18080.1
RefSeqiNP_036018.1, NM_011888.2
XP_001472218.1, XM_001472168.6
UniGeneiMm.426373
Mm.459263
Mm.6660

Genome annotation databases

EnsembliENSMUST00000102957; ENSMUSP00000100022; ENSMUSG00000071005
ENSMUST00000118540; ENSMUSP00000137353; ENSMUSG00000094661
GeneIDi100039053
24047
KEGGimmu:100039053
mmu:24047
UCSCiuc008snx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCL19_MOUSE
AccessioniPrimary (citable) accession number: O70460
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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