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O70458

- OSMR_MOUSE

UniProt

O70458 - OSMR_MOUSE

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Protein
Oncostatin-M-specific receptor subunit beta
Gene
Osmr, Osmrb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events By similarity.

GO - Molecular functioni

  1. oncostatin-M receptor activity Source: MGI

GO - Biological processi

  1. cell surface receptor signaling pathway Source: MGI
  2. oncostatin-M-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M-specific receptor subunit beta
Alternative name(s):
Interleukin-31 receptor subunit beta
Short name:
IL-31 receptor subunit beta
Short name:
IL-31R subunit beta
Short name:
IL-31R-beta
Short name:
IL-31RB
Gene namesi
Name:Osmr
Synonyms:Osmrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1330819. Osmr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 737714Extracellular Reviewed prediction
Add
BLAST
Transmembranei738 – 75821Helical; Reviewed prediction
Add
BLAST
Topological domaini759 – 971213Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 971948Oncostatin-M-specific receptor subunit beta
PRO_0000259760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi242 ↔ 252 By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi377 – 3771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi541 – 5411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi577 – 5771N-linked (GlcNAc...)1 Publication
Glycosylationi689 – 6891N-linked (GlcNAc...)1 Publication
Glycosylationi722 – 7221N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70458.
PRIDEiO70458.

PTM databases

PhosphoSiteiO70458.

Expressioni

Tissue specificityi

Widely expressed. Expressed at highest levels in the lung, heart, thymus and spleen.2 Publications

Gene expression databases

ArrayExpressiO70458.
BgeeiO70458.
CleanExiMM_OSMR.
GenevestigatoriO70458.

Interactioni

Subunit structurei

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.2 Publications

Protein-protein interaction databases

IntActiO70458. 1 interaction.
MINTiMINT-4105360.

Structurei

3D structure databases

ProteinModelPortaliO70458.
SMRiO70458. Positions 30-419.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini332 – 42594Fibronectin type-III 1
Add
BLAST
Domaini427 – 52397Fibronectin type-III 2
Add
BLAST
Domaini524 – 62097Fibronectin type-III 3
Add
BLAST
Domaini622 – 733112Fibronectin type-III 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi412 – 4165WSXWS motif By similarity
Motifi767 – 7759Box 1 motif By similarity

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding By similarity.
The box 1 motif is required for JAK interaction and/or activation By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43445.
GeneTreeiENSGT00550000074436.
HOVERGENiHBG082088.
InParanoidiO70458.
KOiK05057.
PhylomeDBiO70458.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O70458-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAFSVVLHPA FLLAVLSLRA SRSEVLEEPL PLTPEIHKVS FQLKLQEVNL    50
EWTVPALTHE ELNMIFQIEI SRLNISNTIW VENYSTTVKR EEAVRWNWTS 100
DIPLECVKHF IRIRALVDDT KSLPQSSWGN WSSWKEVNAK VSVEPDKSLI 150
FPKDKVLEEG SNVTICLMYG QNVYNVSCKL QDEPIHGEQL DSHVSLLKLN 200
NVVFLSDTGT NINCQATKGP KRIFGTVLFV SKVLEEPKNV SCETRDFKTL 250
DCSWEPGVDT TLTWRKQRFQ NYTLCESFSK RCEVSNYRNS YTWQITEGSQ 300
EMYNFTLTAE NQLRKRSVNI NFNLTHRVHP KAPQDVTLKI IGATKANMTW 350
KVHSHGNNYT LLCQVKLQYG EVIHEHNVSV HMSANYLFSD LDPDTKYKAF 400
VRCASANHFW KWSDWTQKEF STPETAPSQA LDVWRQVWSE NGRRIVTLFW 450
KPLLKSQANG KIISYNIVVE NEAKPTESEH YCVWAPALST NLSLDLQPYK 500
IRITTNNSMG ASPESLMVLS NDSGHEEVKE KTIKGIKDAF NISWEPVSGD 550
TMGYVVDWCA HSQDQRCDLQ WKNLGPNTTS TTITSDDFKP GVRYNFRIFE 600
RSVEHKARLV EKQRGYTQEL APLVNPKVEI PYSTPNSFVL RWPDYDSDFQ 650
AGFIKGYLVY VKSKEMQCNQ PWERTLLPDN SVLCKYDING SETKTLTVEN 700
LQPESLYEFF VTPYTSAGPG PNETFTKVTT PDARSHMLLQ IILPMTLCVL 750
LSIIVCYWKS QWVKEKCYPD IPNPYKSSIL SLIKSKKNPH LIMNVKDCIP 800
DVLEVINKAE GSKTQCVGSG KLHIEDVPTK PPIVPTEKDS SGPVPCIFFE 850
NFTYDQSAFD SGSHGLIPGP LKDTAHQLGL LAPPNKFQNV LKNDYMKPLV 900
ESPTEETSLI YVSQLASPMC GDKDTLATEP PVPVHGSEYK RQMVVPGSLA 950
SPSLKEDNSL TSTVLLGQGE Q 971
Length:971
Mass (Da):110,229
Last modified:August 1, 1998 - v1
Checksum:iBECAA85BBD47C1E7
GO
Isoform 2 (identifier: O70458-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     527-527: Missing.

Note: No experimental confirmation available.

Show »
Length:970
Mass (Da):110,100
Checksum:iCAD54A091AD24A82
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei527 – 5271Missing in isoform 2.
VSP_021530

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti505 – 5051T → A in BAA33725. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF058805 mRNA. Translation: AAC40122.1.
AB015978 mRNA. Translation: BAA33725.1.
CCDSiCCDS27368.1. [O70458-1]
RefSeqiNP_035149.2. NM_011019.3.
XP_006520038.1. XM_006519975.1.
UniGeneiMm.10760.

Genome annotation databases

EnsembliENSMUST00000176826; ENSMUSP00000135204; ENSMUSG00000022146.
GeneIDi18414.
KEGGimmu:18414.
UCSCiuc011zrc.1. mouse. [O70458-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF058805 mRNA. Translation: AAC40122.1 .
AB015978 mRNA. Translation: BAA33725.1 .
CCDSi CCDS27368.1. [O70458-1 ]
RefSeqi NP_035149.2. NM_011019.3.
XP_006520038.1. XM_006519975.1.
UniGenei Mm.10760.

3D structure databases

ProteinModelPortali O70458.
SMRi O70458. Positions 30-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O70458. 1 interaction.
MINTi MINT-4105360.

PTM databases

PhosphoSitei O70458.

Proteomic databases

PaxDbi O70458.
PRIDEi O70458.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000176826 ; ENSMUSP00000135204 ; ENSMUSG00000022146 .
GeneIDi 18414.
KEGGi mmu:18414.
UCSCi uc011zrc.1. mouse. [O70458-2 ]

Organism-specific databases

CTDi 9180.
MGIi MGI:1330819. Osmr.

Phylogenomic databases

eggNOGi NOG43445.
GeneTreei ENSGT00550000074436.
HOVERGENi HBG082088.
InParanoidi O70458.
KOi K05057.
PhylomeDBi O70458.

Miscellaneous databases

ChiTaRSi OSMR. mouse.
NextBioi 294044.
PROi O70458.
SOURCEi Search...

Gene expression databases

ArrayExpressi O70458.
Bgeei O70458.
CleanExi MM_OSMR.
Genevestigatori O70458.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a specific receptor for mouse oncostatin M."
    Lindberg R.A., Juan T.S.-C., Welcher A.A., Sun Y., Cupples R., Guthrie B., Fletcher F.A.
    Mol. Cell. Biol. 18:3357-3367(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, TISSUE SPECIFICITY.
  2. "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the OSM receptor beta subunit."
    Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A., Miyajima A.
    Blood 93:804-815(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBUNIT, TISSUE SPECIFICITY.
  3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-577; ASN-689 AND ASN-722.
    Tissue: Myoblast.

Entry informationi

Entry nameiOSMR_MOUSE
AccessioniPrimary (citable) accession number: O70458
Secondary accession number(s): O88821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi