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O70458

- OSMR_MOUSE

UniProt

O70458 - OSMR_MOUSE

Protein

Oncostatin-M-specific receptor subunit beta

Gene

Osmr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events By similarity.By similarity

    GO - Molecular functioni

    1. oncostatin-M receptor activity Source: MGI

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: MGI
    2. oncostatin-M-mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oncostatin-M-specific receptor subunit beta
    Alternative name(s):
    Interleukin-31 receptor subunit beta
    Short name:
    IL-31 receptor subunit beta
    Short name:
    IL-31R subunit beta
    Short name:
    IL-31R-beta
    Short name:
    IL-31RB
    Gene namesi
    Name:Osmr
    Synonyms:Osmrb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1330819. Osmr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 971948Oncostatin-M-specific receptor subunit betaPRO_0000259760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi242 ↔ 252By similarity
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi541 – 5411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi577 – 5771N-linked (GlcNAc...)1 Publication
    Glycosylationi689 – 6891N-linked (GlcNAc...)1 Publication
    Glycosylationi722 – 7221N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO70458.
    PRIDEiO70458.

    PTM databases

    PhosphoSiteiO70458.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at highest levels in the lung, heart, thymus and spleen.2 Publications

    Gene expression databases

    ArrayExpressiO70458.
    BgeeiO70458.
    CleanExiMM_OSMR.
    GenevestigatoriO70458.

    Interactioni

    Subunit structurei

    Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.2 Publications

    Protein-protein interaction databases

    DIPiDIP-5787N.
    IntActiO70458. 1 interaction.
    MINTiMINT-4105360.

    Structurei

    3D structure databases

    ProteinModelPortaliO70458.
    SMRiO70458. Positions 30-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 737714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini759 – 971213CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei738 – 75821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini332 – 42594Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini427 – 52397Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini524 – 62097Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini622 – 733112Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi412 – 4165WSXWS motifBy similarity
    Motifi767 – 7759Box 1 motifBy similarity

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
    The box 1 motif is required for JAK interaction and/or activation.By similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43445.
    GeneTreeiENSGT00550000074436.
    HOVERGENiHBG082088.
    InParanoidiO70458.
    KOiK05057.
    PhylomeDBiO70458.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 4 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O70458-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFSVVLHPA FLLAVLSLRA SRSEVLEEPL PLTPEIHKVS FQLKLQEVNL    50
    EWTVPALTHE ELNMIFQIEI SRLNISNTIW VENYSTTVKR EEAVRWNWTS 100
    DIPLECVKHF IRIRALVDDT KSLPQSSWGN WSSWKEVNAK VSVEPDKSLI 150
    FPKDKVLEEG SNVTICLMYG QNVYNVSCKL QDEPIHGEQL DSHVSLLKLN 200
    NVVFLSDTGT NINCQATKGP KRIFGTVLFV SKVLEEPKNV SCETRDFKTL 250
    DCSWEPGVDT TLTWRKQRFQ NYTLCESFSK RCEVSNYRNS YTWQITEGSQ 300
    EMYNFTLTAE NQLRKRSVNI NFNLTHRVHP KAPQDVTLKI IGATKANMTW 350
    KVHSHGNNYT LLCQVKLQYG EVIHEHNVSV HMSANYLFSD LDPDTKYKAF 400
    VRCASANHFW KWSDWTQKEF STPETAPSQA LDVWRQVWSE NGRRIVTLFW 450
    KPLLKSQANG KIISYNIVVE NEAKPTESEH YCVWAPALST NLSLDLQPYK 500
    IRITTNNSMG ASPESLMVLS NDSGHEEVKE KTIKGIKDAF NISWEPVSGD 550
    TMGYVVDWCA HSQDQRCDLQ WKNLGPNTTS TTITSDDFKP GVRYNFRIFE 600
    RSVEHKARLV EKQRGYTQEL APLVNPKVEI PYSTPNSFVL RWPDYDSDFQ 650
    AGFIKGYLVY VKSKEMQCNQ PWERTLLPDN SVLCKYDING SETKTLTVEN 700
    LQPESLYEFF VTPYTSAGPG PNETFTKVTT PDARSHMLLQ IILPMTLCVL 750
    LSIIVCYWKS QWVKEKCYPD IPNPYKSSIL SLIKSKKNPH LIMNVKDCIP 800
    DVLEVINKAE GSKTQCVGSG KLHIEDVPTK PPIVPTEKDS SGPVPCIFFE 850
    NFTYDQSAFD SGSHGLIPGP LKDTAHQLGL LAPPNKFQNV LKNDYMKPLV 900
    ESPTEETSLI YVSQLASPMC GDKDTLATEP PVPVHGSEYK RQMVVPGSLA 950
    SPSLKEDNSL TSTVLLGQGE Q 971
    Length:971
    Mass (Da):110,229
    Last modified:August 1, 1998 - v1
    Checksum:iBECAA85BBD47C1E7
    GO
    Isoform 2 (identifier: O70458-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         527-527: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:970
    Mass (Da):110,100
    Checksum:iCAD54A091AD24A82
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti505 – 5051T → A in BAA33725. (PubMed:9920829)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei527 – 5271Missing in isoform 2. 1 PublicationVSP_021530

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058805 mRNA. Translation: AAC40122.1.
    AB015978 mRNA. Translation: BAA33725.1.
    CCDSiCCDS27368.1. [O70458-1]
    RefSeqiNP_035149.2. NM_011019.3.
    XP_006520038.1. XM_006519975.1.
    UniGeneiMm.10760.

    Genome annotation databases

    EnsembliENSMUST00000176826; ENSMUSP00000135204; ENSMUSG00000022146.
    GeneIDi18414.
    KEGGimmu:18414.
    UCSCiuc011zrc.1. mouse. [O70458-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058805 mRNA. Translation: AAC40122.1 .
    AB015978 mRNA. Translation: BAA33725.1 .
    CCDSi CCDS27368.1. [O70458-1 ]
    RefSeqi NP_035149.2. NM_011019.3.
    XP_006520038.1. XM_006519975.1.
    UniGenei Mm.10760.

    3D structure databases

    ProteinModelPortali O70458.
    SMRi O70458. Positions 30-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5787N.
    IntActi O70458. 1 interaction.
    MINTi MINT-4105360.

    PTM databases

    PhosphoSitei O70458.

    Proteomic databases

    PaxDbi O70458.
    PRIDEi O70458.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000176826 ; ENSMUSP00000135204 ; ENSMUSG00000022146 .
    GeneIDi 18414.
    KEGGi mmu:18414.
    UCSCi uc011zrc.1. mouse. [O70458-2 ]

    Organism-specific databases

    CTDi 9180.
    MGIi MGI:1330819. Osmr.

    Phylogenomic databases

    eggNOGi NOG43445.
    GeneTreei ENSGT00550000074436.
    HOVERGENi HBG082088.
    InParanoidi O70458.
    KOi K05057.
    PhylomeDBi O70458.

    Miscellaneous databases

    ChiTaRSi OSMR. mouse.
    NextBioi 294044.
    PROi O70458.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70458.
    Bgeei O70458.
    CleanExi MM_OSMR.
    Genevestigatori O70458.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 4 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a specific receptor for mouse oncostatin M."
      Lindberg R.A., Juan T.S.-C., Welcher A.A., Sun Y., Cupples R., Guthrie B., Fletcher F.A.
      Mol. Cell. Biol. 18:3357-3367(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, TISSUE SPECIFICITY.
    2. "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the OSM receptor beta subunit."
      Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A., Miyajima A.
      Blood 93:804-815(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBUNIT, TISSUE SPECIFICITY.
    3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-577; ASN-689 AND ASN-722.
      Tissue: Myoblast.

    Entry informationi

    Entry nameiOSMR_MOUSE
    AccessioniPrimary (citable) accession number: O70458
    Secondary accession number(s): O88821
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2006
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3