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O70458 (OSMR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oncostatin-M-specific receptor subunit beta
Alternative name(s):
Interleukin-31 receptor subunit beta
Short name=IL-31 receptor subunit beta
Short name=IL-31R subunit beta
Short name=IL-31R-beta
Short name=IL-31RB
Gene names
Name:Osmr
Synonyms:Osmrb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length971 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events By similarity.

Subunit structure

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor. Ref.1 Ref.2

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Widely expressed. Expressed at highest levels in the lung, heart, thymus and spleen. Ref.1 Ref.2

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding By similarity.

The box 1 motif is required for JAK interaction and/or activation By similarity.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Contains 4 fibronectin type-III domains.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to plasma membrane

Traceable author statement Ref.1. Source: MGI

   Molecular_functiononcostatin-M receptor activity

Inferred from direct assay Ref.2. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O70458-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O70458-2)

The sequence of this isoform differs from the canonical sequence as follows:
     527-527: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 971948Oncostatin-M-specific receptor subunit beta
PRO_0000259760

Regions

Topological domain24 – 737714Extracellular Potential
Transmembrane738 – 75821Helical; Potential
Topological domain759 – 971213Cytoplasmic Potential
Domain330 – 42293Fibronectin type-III 1
Domain424 – 52097Fibronectin type-III 2
Domain521 – 61797Fibronectin type-III 3
Domain619 – 729111Fibronectin type-III 4
Motif412 – 4165WSXWS motif By similarity
Motif767 – 7759Box 1 motif By similarity

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation3041N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Glycosylation5411N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Ref.3
Glycosylation6891N-linked (GlcNAc...) Ref.3
Glycosylation7221N-linked (GlcNAc...) Ref.3
Disulfide bond242 ↔ 252 By similarity

Natural variations

Alternative sequence5271Missing in isoform 2.
VSP_021530

Experimental info

Sequence conflict5051T → A in BAA33725. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: BECAA85BBD47C1E7

FASTA971110,229
        10         20         30         40         50         60 
MAFSVVLHPA FLLAVLSLRA SRSEVLEEPL PLTPEIHKVS FQLKLQEVNL EWTVPALTHE 

        70         80         90        100        110        120 
ELNMIFQIEI SRLNISNTIW VENYSTTVKR EEAVRWNWTS DIPLECVKHF IRIRALVDDT 

       130        140        150        160        170        180 
KSLPQSSWGN WSSWKEVNAK VSVEPDKSLI FPKDKVLEEG SNVTICLMYG QNVYNVSCKL 

       190        200        210        220        230        240 
QDEPIHGEQL DSHVSLLKLN NVVFLSDTGT NINCQATKGP KRIFGTVLFV SKVLEEPKNV 

       250        260        270        280        290        300 
SCETRDFKTL DCSWEPGVDT TLTWRKQRFQ NYTLCESFSK RCEVSNYRNS YTWQITEGSQ 

       310        320        330        340        350        360 
EMYNFTLTAE NQLRKRSVNI NFNLTHRVHP KAPQDVTLKI IGATKANMTW KVHSHGNNYT 

       370        380        390        400        410        420 
LLCQVKLQYG EVIHEHNVSV HMSANYLFSD LDPDTKYKAF VRCASANHFW KWSDWTQKEF 

       430        440        450        460        470        480 
STPETAPSQA LDVWRQVWSE NGRRIVTLFW KPLLKSQANG KIISYNIVVE NEAKPTESEH 

       490        500        510        520        530        540 
YCVWAPALST NLSLDLQPYK IRITTNNSMG ASPESLMVLS NDSGHEEVKE KTIKGIKDAF 

       550        560        570        580        590        600 
NISWEPVSGD TMGYVVDWCA HSQDQRCDLQ WKNLGPNTTS TTITSDDFKP GVRYNFRIFE 

       610        620        630        640        650        660 
RSVEHKARLV EKQRGYTQEL APLVNPKVEI PYSTPNSFVL RWPDYDSDFQ AGFIKGYLVY 

       670        680        690        700        710        720 
VKSKEMQCNQ PWERTLLPDN SVLCKYDING SETKTLTVEN LQPESLYEFF VTPYTSAGPG 

       730        740        750        760        770        780 
PNETFTKVTT PDARSHMLLQ IILPMTLCVL LSIIVCYWKS QWVKEKCYPD IPNPYKSSIL 

       790        800        810        820        830        840 
SLIKSKKNPH LIMNVKDCIP DVLEVINKAE GSKTQCVGSG KLHIEDVPTK PPIVPTEKDS 

       850        860        870        880        890        900 
SGPVPCIFFE NFTYDQSAFD SGSHGLIPGP LKDTAHQLGL LAPPNKFQNV LKNDYMKPLV 

       910        920        930        940        950        960 
ESPTEETSLI YVSQLASPMC GDKDTLATEP PVPVHGSEYK RQMVVPGSLA SPSLKEDNSL 

       970 
TSTVLLGQGE Q

« Hide

Isoform 2 [UniParc].

Checksum: CAD54A091AD24A82
Show »

FASTA970110,100

References

« Hide 'large scale' references
[1]"Cloning and characterization of a specific receptor for mouse oncostatin M."
Lindberg R.A., Juan T.S.-C., Welcher A.A., Sun Y., Cupples R., Guthrie B., Fletcher F.A.
Mol. Cell. Biol. 18:3357-3367(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, TISSUE SPECIFICITY.
[2]"Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the OSM receptor beta subunit."
Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A., Miyajima A.
Blood 93:804-815(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBUNIT, TISSUE SPECIFICITY.
[3]"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-577; ASN-689 AND ASN-722, MASS SPECTROMETRY.
Tissue: Myoblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF058805 mRNA. Translation: AAC40122.1.
AB015978 mRNA. Translation: BAA33725.1.
IPIIPI00118291.
IPI00808355.
RefSeqNP_035149.2. NM_011019.3.
UniGeneMm.10760.

3D structure databases

ProteinModelPortalO70458.
SMRO70458. Positions 30-419, 697-731.
ModBaseSearch...

PTM databases

PhosphoSiteO70458.

Proteomic databases

PaxDbO70458.
PRIDEO70458.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000176826; ENSMUSP00000135204; ENSMUSG00000022146.
GeneID18414.
KEGGmmu:18414.
UCSCuc007vdt.2. mouse.
uc011zrc.1. mouse.

Organism-specific databases

CTD9180.
MGIMGI:1330819. Osmr.

Phylogenomic databases

eggNOGNOG43445.
GeneTreeENSGT00550000074436.
HOVERGENHBG082088.
InParanoidO70458.
KOK05057.
OrthoDBEOG4FBHS4.

Gene expression databases

ArrayExpressO70458.
BgeeO70458.
CleanExMM_OSMR.
GenevestigatorO70458.
GermOnlineENSMUSG00000022146. Mus musculus.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 2 hits.
[Graphical view]
SMARTSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 5 hits.
PROSITEPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOSMR. mouse.
NextBio294044.
SOURCESearch...

Entry information

Entry nameOSMR_MOUSE
AccessionPrimary (citable) accession number: O70458
Secondary accession number(s): O88821
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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