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O70453

- HMOX3_RAT

UniProt

O70453 - HMOX3_RAT

Protein

Putative heme oxygenase 3

Gene

Hmox3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase 3 could be implicated in some heme-dependent regulatory role in the cell.

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    GO - Molecular functioni

    1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme oxidation Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative heme oxygenase 3 (EC:1.14.99.3)
    Short name:
    HO-3
    Gene namesi
    Name:Hmox3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1565339. Hmox3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Putative heme oxygenase 3PRO_0000209695Add
    BLAST

    Proteomic databases

    PRIDEiO70453.

    Expressioni

    Tissue specificityi

    Found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis.

    Gene expression databases

    GenevestigatoriO70453.

    Structurei

    3D structure databases

    ProteinModelPortaliO70453.
    SMRiO70453. Positions 29-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati238 – 2436HRM 1
    Repeati255 – 2606HRM 2

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG005982.
    PhylomeDBiO70453.

    Family and domain databases

    Gene3Di1.20.910.10. 2 hits.
    InterProiIPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view]
    PANTHERiPTHR10720. PTHR10720. 1 hit.
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000343. Haem_Oase. 1 hit.
    SUPFAMiSSF48613. SSF48613. 1 hit.
    PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O70453-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEVETAEA VDESEKNSMA SEKENHSKIA DFSDLLKEGT KEADDRAENT    50
    QFVKDFLKGN IKKELFKLAT TALSYSAPEE EMDSLTKDME YFFGENWEEK 100
    VKCSEAAQTY VDQIHYVGQN EPEHLVAHTY STYMGGNLSG DQVLKKETQP 150
    VPFTREGTQF YLFEHVDNAK QFKLFYCARL NALDLNLKTK ERIVEEATKA 200
    FEYNMQIFSE LDQAGSIPVR ETLKNGLSIL DGKGGVCKCP FNAAQPDKGT 250
    LGGSNCPFQM SMALLRKPNL QLILVASMAL VAGLLAWYYM 290
    Length:290
    Mass (Da):32,592
    Last modified:August 1, 1998 - v1
    Checksum:i6600235CE8485829
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058787 mRNA. Translation: AAC14142.1.
    UniGeneiRn.133155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058787 mRNA. Translation: AAC14142.1 .
    UniGenei Rn.133155.

    3D structure databases

    ProteinModelPortali O70453.
    SMRi O70453. Positions 29-222.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O70453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 1565339. Hmox3.

    Phylogenomic databases

    HOVERGENi HBG005982.
    PhylomeDBi O70453.

    Miscellaneous databases

    NextBioi 13948106.

    Gene expression databases

    Genevestigatori O70453.

    Family and domain databases

    Gene3Di 1.20.910.10. 2 hits.
    InterProi IPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view ]
    PANTHERi PTHR10720. PTHR10720. 1 hit.
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000343. Haem_Oase. 1 hit.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3."
      McCoubrey W.K. Jr., Huang T.J., Maines M.D.
      Eur. J. Biochem. 247:725-732(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene."
      Hayashi S., Omata Y., Sakamoto H., Higashimoto Y., Hara T., Sagara Y., Noguchi M.
      Gene 336:241-250(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS A PSEUDOGENE.

    Entry informationi

    Entry nameiHMOX3_RAT
    AccessioniPrimary (citable) accession number: O70453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. Encoded by a single-exon gene, absent in other mammals, including mouse, and not supported by EST data. Expression could not be detected at the mRNA level in a genomic DNA-free liver library, nor at the protein level in kidney (PubMed:15246535).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3