Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative heme oxygenase 3

Gene

Hmox3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase 3 could be implicated in some heme-dependent regulatory role in the cell.

Caution

Could be the product of a pseudogene. Encoded by a single-exon gene, absent in other mammals, including mouse, and not supported by EST data. Expression could not be detected at the mRNA level in a genomic DNA-free liver library, nor at the protein level in kidney (PubMed:15246535).1 Publication

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heme oxygenase 3 (EC:1.14.14.18By similarity)
Short name:
HO-3
Gene namesi
Name:Hmox3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1565339 Hmox3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002096951 – 290Putative heme oxygenase 3Add BLAST290

Proteomic databases

PRIDEiO70453

Expressioni

Tissue specificityi

Found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis.

Structurei

3D structure databases

ProteinModelPortaliO70453
SMRiO70453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati238 – 243HRM 16
Repeati255 – 260HRM 26

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG005982
InParanoidiO70453
PhylomeDBiO70453

Family and domain databases

CDDicd00232 HemeO, 1 hit
Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR002051 Haem_Oase
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR018207 Haem_oxygenase_CS
PANTHERiPTHR10720 PTHR10720, 1 hit
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
SUPFAMiSSF48613 SSF48613, 1 hit
PROSITEiView protein in PROSITE
PS00593 HEME_OXYGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

O70453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEVETAEA VDESEKNSMA SEKENHSKIA DFSDLLKEGT KEADDRAENT
60 70 80 90 100
QFVKDFLKGN IKKELFKLAT TALSYSAPEE EMDSLTKDME YFFGENWEEK
110 120 130 140 150
VKCSEAAQTY VDQIHYVGQN EPEHLVAHTY STYMGGNLSG DQVLKKETQP
160 170 180 190 200
VPFTREGTQF YLFEHVDNAK QFKLFYCARL NALDLNLKTK ERIVEEATKA
210 220 230 240 250
FEYNMQIFSE LDQAGSIPVR ETLKNGLSIL DGKGGVCKCP FNAAQPDKGT
260 270 280 290
LGGSNCPFQM SMALLRKPNL QLILVASMAL VAGLLAWYYM
Length:290
Mass (Da):32,592
Last modified:August 1, 1998 - v1
Checksum:i6600235CE8485829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058787 mRNA Translation: AAC14142.1
UniGeneiRn.133155

Entry informationi

Entry nameiHMOX3_RAT
AccessioniPrimary (citable) accession number: O70453
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health