Reviewed, UniProtKB/Swiss-Prot O70453 (HMOX3_RAT)

Names and origin

Protein names

Recommended name:
    Heme oxygenase 3
      Short name=HO-3
    EC=1.14.99.3

Gene names

Name:

Hmox3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase 3 could be implicated in some heme-dependent regulatory role in the cell.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Microsome. Endoplasmic reticulum.
Tissue specificity	Found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis.
Sequence similarities	Belongs to the heme oxygenase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Heme oxygenase 3		PRO_0000209695
Regions
	Repeat	238 – 243	6	HRM 1
	Repeat	255 – 260	6	HRM 2

Sequences

	Sequence		Length	Mass (Da)
	O70453-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 6600235CE8485829	FASTA	290	32,592
	10 20 30 40 50 60 MSSEVETAEA VDESEKNSMA SEKENHSKIA DFSDLLKEGT KEADDRAENT QFVKDFLKGN 70 80 90 100 110 120 IKKELFKLAT TALSYSAPEE EMDSLTKDME YFFGENWEEK VKCSEAAQTY VDQIHYVGQN 130 140 150 160 170 180 EPEHLVAHTY STYMGGNLSG DQVLKKETQP VPFTREGTQF YLFEHVDNAK QFKLFYCARL 190 200 210 220 230 240 NALDLNLKTK ERIVEEATKA FEYNMQIFSE LDQAGSIPVR ETLKNGLSIL DGKGGVCKCP 250 260 270 280 290 FNAAQPDKGT LGGSNCPFQM SMALLRKPNL QLILVASMAL VAGLLAWYYM

References

[1]	"Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3." McCoubrey W.K. Jr., Huang T.J., Maines M.D. Eur. J. Biochem. 247:725-732(1997) [PubMed: 9266719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF058787 mRNA. Translation: AAC14142.1.
IPI	IPI00198589.
RefSeq	NP_001070904.1.
UniGene	Rn.133155
3D structure databases
HSSP	HSSP built from PDB template 1IVJ based on UniProtKB P06762.
ModBase	Search...
Genome annotation databases
GeneID	365909.
KEGG	rno:365909.
Organism-specific databases
RGD	1565339. LOC365909.
Phylogenomic databases
HOVERGEN	O70453.
Enzyme and pathway databases
BRENDA	1.14.99.3. 248.
Family and domain databases
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PANTHER	PTHR10720. Haem_Oase. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	688338.

Entry information

Entry name

HMOX3_RAT

Accession

Primary (citable) accession number: O70453

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)