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O70453 (HMOX3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative heme oxygenase 3

Short name=HO-3
EC=1.14.99.3
Gene names
Name:Hmox3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase 3 could be implicated in some heme-dependent regulatory role in the cell.

Catalytic activity

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Tissue specificity

Found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis.

Sequence similarities

Belongs to the heme oxygenase family.

Contains 2 HRM (heme regulatory motif) repeats.

Caution

Could be the product of a pseudogene. Encoded by a single-exon gene, absent in other mammals, including mouse, and not supported by EST data. Expression could not be detected at the mRNA level in a genomic DNA-free liver library, nor at the protein level in kidney (Ref.2).

Ontologies

Keywords
   DomainRepeat
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheme oxidation

Inferred from electronic annotation. Source: InterPro

   Molecular_functionheme oxygenase (decyclizing) activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Putative heme oxygenase 3
PRO_0000209695

Regions

Repeat238 – 2436HRM 1
Repeat255 – 2606HRM 2

Sequences

Sequence LengthMass (Da)Tools
O70453 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 6600235CE8485829

FASTA29032,592
        10         20         30         40         50         60 
MSSEVETAEA VDESEKNSMA SEKENHSKIA DFSDLLKEGT KEADDRAENT QFVKDFLKGN 

        70         80         90        100        110        120 
IKKELFKLAT TALSYSAPEE EMDSLTKDME YFFGENWEEK VKCSEAAQTY VDQIHYVGQN 

       130        140        150        160        170        180 
EPEHLVAHTY STYMGGNLSG DQVLKKETQP VPFTREGTQF YLFEHVDNAK QFKLFYCARL 

       190        200        210        220        230        240 
NALDLNLKTK ERIVEEATKA FEYNMQIFSE LDQAGSIPVR ETLKNGLSIL DGKGGVCKCP 

       250        260        270        280        290 
FNAAQPDKGT LGGSNCPFQM SMALLRKPNL QLILVASMAL VAGLLAWYYM 

« Hide

References

[1]"Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3."
McCoubrey W.K. Jr., Huang T.J., Maines M.D.
Eur. J. Biochem. 247:725-732(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene."
Hayashi S., Omata Y., Sakamoto H., Higashimoto Y., Hara T., Sagara Y., Noguchi M.
Gene 336:241-250(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A PSEUDOGENE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF058787 mRNA. Translation: AAC14142.1.
UniGeneRn.133155.

3D structure databases

ProteinModelPortalO70453.
SMRO70453. Positions 29-222.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO70453.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD1565339. Hmox3.

Phylogenomic databases

HOVERGENHBG005982.
PhylomeDBO70453.

Gene expression databases

GenevestigatorO70453.

Family and domain databases

Gene3D1.20.910.10. 2 hits.
InterProIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERPTHR10720. PTHR10720. 1 hit.
PfamPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFPIRSF000343. Haem_Oase. 1 hit.
SUPFAMSSF48613. SSF48613. 1 hit.
PROSITEPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13948106.

Entry information

Entry nameHMOX3_RAT
AccessionPrimary (citable) accession number: O70453
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families