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O70453

- HMOX3_RAT

UniProt

O70453 - HMOX3_RAT

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Protein

Putative heme oxygenase 3

Gene

Hmox3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini

Functioni

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase 3 could be implicated in some heme-dependent regulatory role in the cell.

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme oxidation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heme oxygenase 3 (EC:1.14.99.3)
Short name:
HO-3
Gene namesi
Name:Hmox3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1565339. Hmox3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Putative heme oxygenase 3PRO_0000209695Add
BLAST

Proteomic databases

PRIDEiO70453.

Expressioni

Tissue specificityi

Found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis.

Gene expression databases

GenevestigatoriO70453.

Structurei

3D structure databases

ProteinModelPortaliO70453.
SMRiO70453. Positions 29-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati238 – 2436HRM 1
Repeati255 – 2606HRM 2

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG005982.
InParanoidiO70453.
PhylomeDBiO70453.

Family and domain databases

Gene3Di1.20.910.10. 2 hits.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70453-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEVETAEA VDESEKNSMA SEKENHSKIA DFSDLLKEGT KEADDRAENT
60 70 80 90 100
QFVKDFLKGN IKKELFKLAT TALSYSAPEE EMDSLTKDME YFFGENWEEK
110 120 130 140 150
VKCSEAAQTY VDQIHYVGQN EPEHLVAHTY STYMGGNLSG DQVLKKETQP
160 170 180 190 200
VPFTREGTQF YLFEHVDNAK QFKLFYCARL NALDLNLKTK ERIVEEATKA
210 220 230 240 250
FEYNMQIFSE LDQAGSIPVR ETLKNGLSIL DGKGGVCKCP FNAAQPDKGT
260 270 280 290
LGGSNCPFQM SMALLRKPNL QLILVASMAL VAGLLAWYYM
Length:290
Mass (Da):32,592
Last modified:August 1, 1998 - v1
Checksum:i6600235CE8485829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058787 mRNA. Translation: AAC14142.1.
UniGeneiRn.133155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058787 mRNA. Translation: AAC14142.1 .
UniGenei Rn.133155.

3D structure databases

ProteinModelPortali O70453.
SMRi O70453. Positions 29-222.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O70453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 1565339. Hmox3.

Phylogenomic databases

HOVERGENi HBG005982.
InParanoidi O70453.
PhylomeDBi O70453.

Miscellaneous databases

NextBioi 13948106.

Gene expression databases

Genevestigatori O70453.

Family and domain databases

Gene3Di 1.20.910.10. 2 hits.
InterProi IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view ]
PANTHERi PTHR10720. PTHR10720. 1 hit.
Pfami PF01126. Heme_oxygenase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000343. Haem_Oase. 1 hit.
SUPFAMi SSF48613. SSF48613. 1 hit.
PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3."
    McCoubrey W.K. Jr., Huang T.J., Maines M.D.
    Eur. J. Biochem. 247:725-732(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene."
    Hayashi S., Omata Y., Sakamoto H., Higashimoto Y., Hara T., Sagara Y., Noguchi M.
    Gene 336:241-250(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS A PSEUDOGENE.

Entry informationi

Entry nameiHMOX3_RAT
AccessioniPrimary (citable) accession number: O70453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. Encoded by a single-exon gene, absent in other mammals, including mouse, and not supported by EST data. Expression could not be detected at the mRNA level in a genomic DNA-free liver library, nor at the protein level in kidney (PubMed:15246535).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3