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Protein

Monocarboxylate transporter 2

Gene

Slc16a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-433692. Proton-coupled monocarboxylate transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 2
Short name:
MCT 2
Alternative name(s):
Solute carrier family 16 member 7
Gene namesi
Name:Slc16a7
Synonyms:Mct2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1330284. Slc16a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 6023ExtracellularSequence analysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Topological domaini82 – 909CytoplasmicSequence analysis
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Topological domaini112 – 1165ExtracellularSequence analysis
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 14912CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 1744ExtracellularSequence analysis
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 24550CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 28115ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Topological domaini303 – 3119CytoplasmicSequence analysis
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Topological domaini333 – 3375ExtracellularSequence analysis
Transmembranei338 – 35821HelicalSequence analysisAdd
BLAST
Topological domaini359 – 37214CytoplasmicSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Topological domaini394 – 40512ExtracellularSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Topological domaini427 – 48458CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Monocarboxylate transporter 2PRO_0000211388Add
BLAST

Proteomic databases

PaxDbiO70451.
PRIDEiO70451.

PTM databases

iPTMnetiO70451.
PhosphoSiteiO70451.

Expressioni

Tissue specificityi

Detected in testis and in spermatozoa (at protein level).1 Publication

Gene expression databases

BgeeiO70451.
ExpressionAtlasiO70451. baseline and differential.
GenevisibleiO70451. MM.

Interactioni

Subunit structurei

Interacts with GRID2IP. Interacts with BSG.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065433.

Structurei

3D structure databases

ProteinModelPortaliO70451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVS. Eukaryota.
ENOG4111F0K. LUCA.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO70451.
KOiK08184.
OMAiSSQIAWI.
OrthoDBiEOG7W9RTN.
PhylomeDBiO70451.
TreeFamiTF313792.

Family and domain databases

InterProiIPR004743. MCT.
IPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF25. PTHR11360:SF25. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEPSAPLP QPLPPDGGWG WVVVCASFIS IGFSYAFPKA VTVFFKDIQE
60 70 80 90 100
IFNTTSSQIA WISSIMLAVM YAGGPISSVL VNNYGSRPVV IVGGLLCCIG
110 120 130 140 150
MILASYSNSV IELYLTVGFI GGLGLAFNLQ PALTIIGKYF YRRRPLANGC
160 170 180 190 200
AMAGSPVFLS TLAPFNQYLF NNYGWKGSFL ILGGIFLHSC VAGCLMRPVG
210 220 230 240 250
PSPNTKKSKS KVGSRHDSTL KKASKVSTAQ KVNRFLDFSL FMHRGFLIYL
260 270 280 290 300
SGNVILFLGI FAPIIFLAQY AKHIGVDDYN SAFLLSVMAF IDMFARPSVG
310 320 330 340 350
LIANTSLIRP RIQYLFSSAI IFTGICHLLC PLATTYSALV VYVVFFGLGF
360 370 380 390 400
GSISSLLFEC LMDIVGATRF SSAVGLTTIV ECCPVLFGPP LAGKLLDITG
410 420 430 440 450
EYKYLYIASG TVVLVSGTYL LIGNAINYRL LDKERKREKA KKKKSASHAS
460 470 480
REMEALNRSK QDEVTVKASN AHNPPSDRDK ESNI
Length:484
Mass (Da):52,604
Last modified:August 1, 1998 - v1
Checksum:iA23B62BCA4C5DF5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058054 mRNA. Translation: AAC13719.1.
AK076612 mRNA. Translation: BAC36415.1.
CCDSiCCDS24218.1.
RefSeqiNP_035521.1. NM_011391.1.
XP_006513469.1. XM_006513406.2.
XP_006513470.1. XM_006513407.2.
XP_006513471.1. XM_006513408.2.
XP_006513472.1. XM_006513409.2.
XP_006513473.1. XM_006513410.2.
XP_006513474.1. XM_006513411.1.
XP_006513475.1. XM_006513412.2.
XP_006513476.1. XM_006513413.2.
UniGeneiMm.29161.
Mm.455126.

Genome annotation databases

EnsembliENSMUST00000063318; ENSMUSP00000065433; ENSMUSG00000020102.
ENSMUST00000105257; ENSMUSP00000100892; ENSMUSG00000020102.
GeneIDi20503.
KEGGimmu:20503.
UCSCiuc007hgx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058054 mRNA. Translation: AAC13719.1.
AK076612 mRNA. Translation: BAC36415.1.
CCDSiCCDS24218.1.
RefSeqiNP_035521.1. NM_011391.1.
XP_006513469.1. XM_006513406.2.
XP_006513470.1. XM_006513407.2.
XP_006513471.1. XM_006513408.2.
XP_006513472.1. XM_006513409.2.
XP_006513473.1. XM_006513410.2.
XP_006513474.1. XM_006513411.1.
XP_006513475.1. XM_006513412.2.
XP_006513476.1. XM_006513413.2.
UniGeneiMm.29161.
Mm.455126.

3D structure databases

ProteinModelPortaliO70451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065433.

PTM databases

iPTMnetiO70451.
PhosphoSiteiO70451.

Proteomic databases

PaxDbiO70451.
PRIDEiO70451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063318; ENSMUSP00000065433; ENSMUSG00000020102.
ENSMUST00000105257; ENSMUSP00000100892; ENSMUSG00000020102.
GeneIDi20503.
KEGGimmu:20503.
UCSCiuc007hgx.1. mouse.

Organism-specific databases

CTDi9194.
MGIiMGI:1330284. Slc16a7.

Phylogenomic databases

eggNOGiENOG410IMVS. Eukaryota.
ENOG4111F0K. LUCA.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO70451.
KOiK08184.
OMAiSSQIAWI.
OrthoDBiEOG7W9RTN.
PhylomeDBiO70451.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiR-MMU-433692. Proton-coupled monocarboxylate transport.

Miscellaneous databases

PROiO70451.
SOURCEiSearch...

Gene expression databases

BgeeiO70451.
ExpressionAtlasiO70451. baseline and differential.
GenevisibleiO70451. MM.

Family and domain databases

InterProiIPR004743. MCT.
IPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF25. PTHR11360:SF25. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Monocarboxylate transporter expression in mouse brain."
    Koehler-Stec E.M., Simpson I.A., Vannucci S.J., Landschulz K.T., Landschulz W.H.
    Am. J. Physiol. 275:E516-E524(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The synaptic scaffolding protein Delphilin interacts with monocarboxylate transporter 2."
    Watanabe-Kaneko K., Sonoda T., Miyagi Y., Yamashita T., Okuda K., Kawamoto S.
    NeuroReport 18:489-493(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRID2IP.
  4. "Basigin interacts with both MCT1 and MCT2 in murine spermatozoa."
    Mannowetz N., Wandernoth P., Wennemuth G.
    J. Cell. Physiol. 227:2154-2162(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BSG, TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiMOT2_MOUSE
AccessioniPrimary (citable) accession number: O70451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.