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Protein

Monocarboxylate transporter 2

Gene

Slc16a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-433692. Proton-coupled monocarboxylate transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 2
Short name:
MCT 2
Alternative name(s):
Solute carrier family 16 member 7
Gene namesi
Name:Slc16a7
Synonyms:Mct2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1330284. Slc16a7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 60ExtracellularSequence analysisAdd BLAST23
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 90CytoplasmicSequence analysis9
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 116ExtracellularSequence analysis5
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 174ExtracellularSequence analysis4
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 245CytoplasmicSequence analysisAdd BLAST50
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 281ExtracellularSequence analysisAdd BLAST15
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 311CytoplasmicSequence analysis9
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 337ExtracellularSequence analysis5
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 372CytoplasmicSequence analysisAdd BLAST14
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 405ExtracellularSequence analysisAdd BLAST12
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 484CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113881 – 484Monocarboxylate transporter 2Add BLAST484

Proteomic databases

PaxDbiO70451.
PRIDEiO70451.

PTM databases

iPTMnetiO70451.
PhosphoSitePlusiO70451.

Expressioni

Tissue specificityi

Detected in testis and in spermatozoa (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000020102.
ExpressionAtlasiO70451. baseline and differential.
GenevisibleiO70451. MM.

Interactioni

Subunit structurei

Interacts with GRID2IP. Interacts with BSG.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065433.

Structurei

3D structure databases

ProteinModelPortaliO70451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVS. Eukaryota.
ENOG4111F0K. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO70451.
KOiK08184.
OMAiSSQIAWI.
OrthoDBiEOG091G05SW.
PhylomeDBiO70451.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF25. PTHR11360:SF25. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEPSAPLP QPLPPDGGWG WVVVCASFIS IGFSYAFPKA VTVFFKDIQE
60 70 80 90 100
IFNTTSSQIA WISSIMLAVM YAGGPISSVL VNNYGSRPVV IVGGLLCCIG
110 120 130 140 150
MILASYSNSV IELYLTVGFI GGLGLAFNLQ PALTIIGKYF YRRRPLANGC
160 170 180 190 200
AMAGSPVFLS TLAPFNQYLF NNYGWKGSFL ILGGIFLHSC VAGCLMRPVG
210 220 230 240 250
PSPNTKKSKS KVGSRHDSTL KKASKVSTAQ KVNRFLDFSL FMHRGFLIYL
260 270 280 290 300
SGNVILFLGI FAPIIFLAQY AKHIGVDDYN SAFLLSVMAF IDMFARPSVG
310 320 330 340 350
LIANTSLIRP RIQYLFSSAI IFTGICHLLC PLATTYSALV VYVVFFGLGF
360 370 380 390 400
GSISSLLFEC LMDIVGATRF SSAVGLTTIV ECCPVLFGPP LAGKLLDITG
410 420 430 440 450
EYKYLYIASG TVVLVSGTYL LIGNAINYRL LDKERKREKA KKKKSASHAS
460 470 480
REMEALNRSK QDEVTVKASN AHNPPSDRDK ESNI
Length:484
Mass (Da):52,604
Last modified:August 1, 1998 - v1
Checksum:iA23B62BCA4C5DF5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058054 mRNA. Translation: AAC13719.1.
AK076612 mRNA. Translation: BAC36415.1.
CCDSiCCDS24218.1.
RefSeqiNP_035521.1. NM_011391.1.
XP_006513469.1. XM_006513406.3.
XP_006513471.1. XM_006513408.3.
XP_006513472.1. XM_006513409.3.
XP_006513473.1. XM_006513410.3.
XP_006513474.1. XM_006513411.1.
XP_006513475.1. XM_006513412.3.
XP_006513476.1. XM_006513413.3.
XP_017169350.1. XM_017313861.1.
UniGeneiMm.29161.
Mm.455126.

Genome annotation databases

EnsembliENSMUST00000063318; ENSMUSP00000065433; ENSMUSG00000020102.
ENSMUST00000105257; ENSMUSP00000100892; ENSMUSG00000020102.
ENSMUST00000210780; ENSMUSP00000147560; ENSMUSG00000020102.
ENSMUST00000211781; ENSMUSP00000147968; ENSMUSG00000020102.
GeneIDi20503.
KEGGimmu:20503.
UCSCiuc007hgx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058054 mRNA. Translation: AAC13719.1.
AK076612 mRNA. Translation: BAC36415.1.
CCDSiCCDS24218.1.
RefSeqiNP_035521.1. NM_011391.1.
XP_006513469.1. XM_006513406.3.
XP_006513471.1. XM_006513408.3.
XP_006513472.1. XM_006513409.3.
XP_006513473.1. XM_006513410.3.
XP_006513474.1. XM_006513411.1.
XP_006513475.1. XM_006513412.3.
XP_006513476.1. XM_006513413.3.
XP_017169350.1. XM_017313861.1.
UniGeneiMm.29161.
Mm.455126.

3D structure databases

ProteinModelPortaliO70451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065433.

PTM databases

iPTMnetiO70451.
PhosphoSitePlusiO70451.

Proteomic databases

PaxDbiO70451.
PRIDEiO70451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063318; ENSMUSP00000065433; ENSMUSG00000020102.
ENSMUST00000105257; ENSMUSP00000100892; ENSMUSG00000020102.
ENSMUST00000210780; ENSMUSP00000147560; ENSMUSG00000020102.
ENSMUST00000211781; ENSMUSP00000147968; ENSMUSG00000020102.
GeneIDi20503.
KEGGimmu:20503.
UCSCiuc007hgx.1. mouse.

Organism-specific databases

CTDi9194.
MGIiMGI:1330284. Slc16a7.

Phylogenomic databases

eggNOGiENOG410IMVS. Eukaryota.
ENOG4111F0K. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO70451.
KOiK08184.
OMAiSSQIAWI.
OrthoDBiEOG091G05SW.
PhylomeDBiO70451.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiR-MMU-433692. Proton-coupled monocarboxylate transport.

Miscellaneous databases

PROiO70451.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020102.
ExpressionAtlasiO70451. baseline and differential.
GenevisibleiO70451. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR027178. MCT2.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF25. PTHR11360:SF25. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT2_MOUSE
AccessioniPrimary (citable) accession number: O70451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.