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Protein

Guanine nucleotide-binding protein G(z) subunit alpha

Gene

Gnaz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47MagnesiumBy similarity1
Metal bindingi182MagnesiumBy similarity1
Binding sitei327GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi176 – 182GTPBy similarity7
Nucleotide bindingi201 – 205GTPBy similarity5
Nucleotide bindingi270 – 273GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-112043. PLC beta mediated events.
R-MMU-202040. G-protein activation.
R-MMU-418597. G alpha (z) signalling events.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(z) subunit alpha
Alternative name(s):
G(x) alpha chain
Gz-alpha
Gene namesi
Name:Gnaz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:95780. Gnaz.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: MGI
  • cytosol Source: Ensembl
  • dendrite Source: MGI
  • extracellular exosome Source: MGI
  • heterotrimeric G-protein complex Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00002036972 – 355Guanine nucleotide-binding protein G(z) subunit alphaAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiO70443.
PaxDbiO70443.
PeptideAtlasiO70443.
PRIDEiO70443.

PTM databases

iPTMnetiO70443.
PhosphoSitePlusiO70443.
SwissPalmiO70443.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040009.
ExpressionAtlasiO70443. baseline and differential.
GenevisibleiO70443. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

IntActiO70443. 1 interactor.
STRINGi10090.ENSMUSP00000036087.

Structurei

3D structure databases

ProteinModelPortaliO70443.
SMRiO70443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(i/o/t/z) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
HOVERGENiHBG063184.
InParanoidiO70443.
KOiK04535.
OMAiNIVETGK.
OrthoDBiEOG091G0VUT.
PhylomeDBiO70443.
TreeFamiTF300673.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV
60 70 80 90 100
KQMKIIHSGG FNLDACKEYK PLIIYNAIDS LTRIIRALAA LKIDFHNPDR
110 120 130 140 150
AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FGRSSEYHLE
160 170 180 190 200
DNAAYYLNDL ERIAAPDYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV
210 220 230 240 250
DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL
260 270 280 290 300
FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLSVCFPE YKGQNTYEEA
310 320 330 340 350
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK

YIGLC
Length:355
Mass (Da):40,850
Last modified:January 23, 2007 - v4
Checksum:i24590AE5B1FE5D50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210K → R in AAC37651 (PubMed:8013366).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014702 mRNA. Translation: AAH14702.1.
AF056973 Genomic DNA. Translation: AAC13569.1.
AF056972 mRNA. Translation: AAC13568.1.
L17074 mRNA. Translation: AAC37651.1.
CCDSiCCDS23922.1.
RefSeqiNP_034441.1. NM_010311.3.
XP_006513298.1. XM_006513235.3.
XP_006513299.1. XM_006513236.1.
XP_006513300.1. XM_006513237.2.
UniGeneiMm.32595.
Mm.393508.

Genome annotation databases

EnsembliENSMUST00000037813; ENSMUSP00000036087; ENSMUSG00000040009.
ENSMUST00000159991; ENSMUSP00000124639; ENSMUSG00000040009.
GeneIDi14687.
KEGGimmu:14687.
UCSCiuc007fpt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014702 mRNA. Translation: AAH14702.1.
AF056973 Genomic DNA. Translation: AAC13569.1.
AF056972 mRNA. Translation: AAC13568.1.
L17074 mRNA. Translation: AAC37651.1.
CCDSiCCDS23922.1.
RefSeqiNP_034441.1. NM_010311.3.
XP_006513298.1. XM_006513235.3.
XP_006513299.1. XM_006513236.1.
XP_006513300.1. XM_006513237.2.
UniGeneiMm.32595.
Mm.393508.

3D structure databases

ProteinModelPortaliO70443.
SMRiO70443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70443. 1 interactor.
STRINGi10090.ENSMUSP00000036087.

PTM databases

iPTMnetiO70443.
PhosphoSitePlusiO70443.
SwissPalmiO70443.

Proteomic databases

EPDiO70443.
PaxDbiO70443.
PeptideAtlasiO70443.
PRIDEiO70443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037813; ENSMUSP00000036087; ENSMUSG00000040009.
ENSMUST00000159991; ENSMUSP00000124639; ENSMUSG00000040009.
GeneIDi14687.
KEGGimmu:14687.
UCSCiuc007fpt.1. mouse.

Organism-specific databases

CTDi2781.
MGIiMGI:95780. Gnaz.

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
HOVERGENiHBG063184.
InParanoidiO70443.
KOiK04535.
OMAiNIVETGK.
OrthoDBiEOG091G0VUT.
PhylomeDBiO70443.
TreeFamiTF300673.

Enzyme and pathway databases

ReactomeiR-MMU-112043. PLC beta mediated events.
R-MMU-202040. G-protein activation.
R-MMU-418597. G alpha (z) signalling events.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiO70443.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040009.
ExpressionAtlasiO70443. baseline and differential.
GenevisibleiO70443. MM.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGNAZ_MOUSE
AccessioniPrimary (citable) accession number: O70443
Secondary accession number(s): O70442, Q61637, Q91WM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 153 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.