SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O70443

- GNAZ_MOUSE

UniProt

O70443 - GNAZ_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Guanine nucleotide-binding protein G(z) subunit alpha
Gene
Gnaz
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Magnesium By similarity
Metal bindingi182 – 1821Magnesium By similarity
Binding sitei327 – 3271GTP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478GTP By similarity
Nucleotide bindingi176 – 1827GTP By similarity
Nucleotide bindingi201 – 2055GTP By similarity
Nucleotide bindingi270 – 2734GTP By similarity

GO - Molecular functioni

  1. G-protein beta/gamma-subunit complex binding Source: RefGenome
  2. G-protein coupled serotonin receptor binding Source: RefGenome
  3. GTP binding Source: UniProtKB-KW
  4. GTPase activity Source: RefGenome
  5. guanyl-nucleotide exchange factor activity Source: RefGenome
  6. metal ion binding Source: UniProtKB-KW
  7. signal transducer activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
  4. regulation of GTPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205726. G-protein activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(z) subunit alpha
Alternative name(s):
G(x) alpha chain
Gz-alpha
Gene namesi
Name:Gnaz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:95780. Gnaz.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extrinsic component of cytoplasmic side of plasma membrane Source: RefGenome
  3. heterotrimeric G-protein complex Source: RefGenome
  4. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed Inferred
Chaini2 – 355354Guanine nucleotide-binding protein G(z) subunit alpha
PRO_0000203697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Lipidationi3 – 31S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

MaxQBiO70443.
PaxDbiO70443.
PRIDEiO70443.

PTM databases

PhosphoSiteiO70443.

Expressioni

Gene expression databases

ArrayExpressiO70443.
BgeeiO70443.
GenevestigatoriO70443.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein-protein interaction databases

IntActiO70443. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO70443.
SMRiO70443. Positions 6-349.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG282619.
HOGENOMiHOG000038730.
HOVERGENiHBG063184.
InParanoidiO70443.
KOiK04535.
OMAiDYKGQNT.
OrthoDBiEOG72C50B.
PhylomeDBiO70443.
TreeFamiTF300673.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70443-1 [UniParc]FASTAAdd to Basket

« Hide

MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV    50
KQMKIIHSGG FNLDACKEYK PLIIYNAIDS LTRIIRALAA LKIDFHNPDR 100
AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FGRSSEYHLE 150
DNAAYYLNDL ERIAAPDYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV 200
DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL 250
FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLSVCFPE YKGQNTYEEA 300
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK 350
YIGLC 355
Length:355
Mass (Da):40,850
Last modified:January 23, 2007 - v4
Checksum:i24590AE5B1FE5D50
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101K → R in AAC37651. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC014702 mRNA. Translation: AAH14702.1.
AF056973 Genomic DNA. Translation: AAC13569.1.
AF056972 mRNA. Translation: AAC13568.1.
L17074 mRNA. Translation: AAC37651.1.
CCDSiCCDS23922.1.
RefSeqiNP_034441.1. NM_010311.3.
XP_006513298.1. XM_006513235.1.
XP_006513299.1. XM_006513236.1.
XP_006513300.1. XM_006513237.1.
UniGeneiMm.32595.
Mm.393508.

Genome annotation databases

EnsembliENSMUST00000037813; ENSMUSP00000036087; ENSMUSG00000040009.
ENSMUST00000159991; ENSMUSP00000124639; ENSMUSG00000040009.
GeneIDi14687.
KEGGimmu:14687.
UCSCiuc007fpt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC014702 mRNA. Translation: AAH14702.1 .
AF056973 Genomic DNA. Translation: AAC13569.1 .
AF056972 mRNA. Translation: AAC13568.1 .
L17074 mRNA. Translation: AAC37651.1 .
CCDSi CCDS23922.1.
RefSeqi NP_034441.1. NM_010311.3.
XP_006513298.1. XM_006513235.1.
XP_006513299.1. XM_006513236.1.
XP_006513300.1. XM_006513237.1.
UniGenei Mm.32595.
Mm.393508.

3D structure databases

ProteinModelPortali O70443.
SMRi O70443. Positions 6-349.
ModBasei Search...

Protein-protein interaction databases

IntActi O70443. 1 interaction.

PTM databases

PhosphoSitei O70443.

Proteomic databases

MaxQBi O70443.
PaxDbi O70443.
PRIDEi O70443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037813 ; ENSMUSP00000036087 ; ENSMUSG00000040009 .
ENSMUST00000159991 ; ENSMUSP00000124639 ; ENSMUSG00000040009 .
GeneIDi 14687.
KEGGi mmu:14687.
UCSCi uc007fpt.1. mouse.

Organism-specific databases

CTDi 2781.
MGIi MGI:95780. Gnaz.

Phylogenomic databases

eggNOGi NOG282619.
HOGENOMi HOG000038730.
HOVERGENi HBG063184.
InParanoidi O70443.
KOi K04535.
OMAi DYKGQNT.
OrthoDBi EOG72C50B.
PhylomeDBi O70443.
TreeFami TF300673.

Enzyme and pathway databases

Reactomei REACT_205726. G-protein activation.

Miscellaneous databases

NextBioi 286627.
PROi O70443.
SOURCEi Search...

Gene expression databases

ArrayExpressi O70443.
Bgeei O70443.
Genevestigatori O70443.

Family and domain databases

Gene3Di 1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10218. PTHR10218. 1 hit.
Pfami PF00503. G-alpha. 1 hit.
[Graphical view ]
PRINTSi PR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTi SM00275. G_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  2. "Partial genomic sequence of the mouse GTP binding protein Gz alpha."
    Matthaei K.I., Mellick A.M., Hendry I.A.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-353.
    Strain: C57BL/6.
  3. "Expression of cone transducin, Gz alpha, and other G-protein alpha-subunit messenger ribonucleic acids in pancreatic islets."
    Zigman J.M., Westermark G.T., LaMendola J., Steiner D.F.
    Endocrinology 135:31-37(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-267.
    Strain: BALB/c.
    Tissue: Pancreatic islet.

Entry informationi

Entry nameiGNAZ_MOUSE
AccessioniPrimary (citable) accession number: O70443
Secondary accession number(s): O70442, Q61637, Q91WM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi