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Protein

Synapsin-3

Gene

Syn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed.

GO - Molecular functioni

  • ATP binding Source: RGD
  • catalytic activity Source: InterPro

GO - Biological processi

  • neurotransmitter secretion Source: RGD
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-3
Alternative name(s):
Synapsin III
Gene namesi
Name:Syn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3799. Syn3.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • synaptic vesicle Source: UniProtKB
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830261 – 579Synapsin-3Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by PKA and CaMK1By similarity1
Modified residuei454PhosphoserineBy similarity1
Modified residuei461PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70441.
PRIDEiO70441.

PTM databases

iPTMnetiO70441.
PhosphoSitePlusiO70441.

Expressioni

Tissue specificityi

Expressed primarily in brain.

Gene expression databases

BgeeiENSRNOG00000026866.

Interactioni

Subunit structurei

Interacts with CAPON.1 Publication

Protein-protein interaction databases

DIPiDIP-358N.
MINTiMINT-232985.
STRINGi10116.ENSRNOP00000036740.

Structurei

3D structure databases

ProteinModelPortaliO70441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28AAdd BLAST28
Regioni28 – 90B; linkerAdd BLAST63
Regioni91 – 398C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni399 – 530J; Pro-rich linkerAdd BLAST132
Regioni531 – 579EAdd BLAST49

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiKOG3895. Eukaryota.
ENOG410XQH5. LUCA.
HOGENOMiHOG000231323.
HOVERGENiHBG016354.
InParanoidiO70441.
KOiK19941.
PhylomeDBiO70441.
TreeFamiTF319919.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA
60 70 80 90 100
SFSSPGSSLF SSFSSAMKQT PQAPTGLMEP PTPVTPVVQR PRILLVIDDA
110 120 130 140 150
HTDWSKYFHG KKVNGDIEIR VEQAEFSELN LAAYVTGGCM VDMQVVRNGT
160 170 180 190 200
KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV IGLQYGGLPA VNSLYSVYNF
210 220 230 240 250
CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP NFPVVIKLGH
260 270 280 290 300
AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN
310 320 330 340 350
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV
360 370 380 390 400
KAVHSKNGRD YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA
410 420 430 440 450
SVPSPLRPWG PQTKSAKSPG QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP
460 470 480 490 500
RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS PGSPQLSRAS GGSSPNQASK
510 520 530 540 550
PTASLSSHTR PPVQGRSTSQ QGEEPQKTAS PHPHLNKSQS LTNSLSTSDT
560 570
SHRGTPSEDE AKAETIRNLR KSFASLFSD
Length:579
Mass (Da):63,349
Last modified:August 1, 1998 - v1
Checksum:iEA69F25ED14A4722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056704 mRNA. Translation: AAC24521.1.
RefSeqiNP_058805.1. NM_017109.1.
UniGeneiRn.162920.

Genome annotation databases

GeneIDi29130.
KEGGirno:29130.
UCSCiRGD:3799. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056704 mRNA. Translation: AAC24521.1.
RefSeqiNP_058805.1. NM_017109.1.
UniGeneiRn.162920.

3D structure databases

ProteinModelPortaliO70441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-358N.
MINTiMINT-232985.
STRINGi10116.ENSRNOP00000036740.

PTM databases

iPTMnetiO70441.
PhosphoSitePlusiO70441.

Proteomic databases

PaxDbiO70441.
PRIDEiO70441.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29130.
KEGGirno:29130.
UCSCiRGD:3799. rat.

Organism-specific databases

CTDi8224.
RGDi3799. Syn3.

Phylogenomic databases

eggNOGiKOG3895. Eukaryota.
ENOG410XQH5. LUCA.
HOGENOMiHOG000231323.
HOVERGENiHBG016354.
InParanoidiO70441.
KOiK19941.
PhylomeDBiO70441.
TreeFamiTF319919.

Miscellaneous databases

PROiO70441.

Gene expression databases

BgeeiENSRNOG00000026866.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYN3_RAT
AccessioniPrimary (citable) accession number: O70441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Regulated by calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.