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Protein

Syntaxin-7

Gene

Stx7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-7
Gene namesi
Name:Stx7
Synonyms:Syn7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1858210. Stx7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 238CytoplasmicSequence analysisAdd BLAST237
Transmembranei239 – 259Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini260 – 261VesicularSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102142 – 261Syntaxin-7Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei4PhosphothreonineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei75PhosphoserineBy similarity1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70439.
MaxQBiO70439.
PaxDbiO70439.
PeptideAtlasiO70439.
PRIDEiO70439.
TopDownProteomicsiO70439.

PTM databases

iPTMnetiO70439.
PhosphoSitePlusiO70439.
SwissPalmiO70439.

Expressioni

Gene expression databases

CleanExiMM_STX7.

Interactioni

Subunit structurei

Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A (By similarity). Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiO70439. 6 interactors.
MINTiMINT-1870254.
STRINGi10090.ENSMUSP00000020174.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi170 – 226Combined sources57

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90B169-228[»]
ProteinModelPortaliO70439.
SMRiO70439.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO70439.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 227t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 68Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiO70439.
PhylomeDBiO70439.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTPGIGGD SAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ
60 70 80 90 100
LLQQKQQYTN QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS
110 120 130 140 150
LTNFQKAQRQ AAEREKEFVA RVRASSRVSG GFPEDSSKEK NLVSWESQTQ
160 170 180 190 200
PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG
210 220 230 240 250
DMIDSIEANV ESAEVHVQQA NQQLSRAADY QRKSRKTLCI IIFILVVRIV
260
IICLIVWGLK G
Length:261
Mass (Da):29,821
Last modified:January 23, 2007 - v3
Checksum:i62F4E4B33F247ADB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056323 mRNA. Translation: AAC15971.1.
CCDSiCCDS23749.1.
UniGeneiMm.248042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056323 mRNA. Translation: AAC15971.1.
CCDSiCCDS23749.1.
UniGeneiMm.248042.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90B169-228[»]
ProteinModelPortaliO70439.
SMRiO70439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70439. 6 interactors.
MINTiMINT-1870254.
STRINGi10090.ENSMUSP00000020174.

PTM databases

iPTMnetiO70439.
PhosphoSitePlusiO70439.
SwissPalmiO70439.

Proteomic databases

EPDiO70439.
MaxQBiO70439.
PaxDbiO70439.
PeptideAtlasiO70439.
PRIDEiO70439.
TopDownProteomicsiO70439.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1858210. Stx7.

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiO70439.
PhylomeDBiO70439.

Miscellaneous databases

ChiTaRSiStx7. mouse.
EvolutionaryTraceiO70439.
PROiO70439.
SOURCEiSearch...

Gene expression databases

CleanExiMM_STX7.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX7_MOUSE
AccessioniPrimary (citable) accession number: O70439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.