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O70433

- FHL2_MOUSE

UniProt

O70433 - FHL2_MOUSE

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Protein

Four and a half LIM domains protein 2

Gene
Fhl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3125C4-type Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. transcription factor binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. atrial cardiac muscle cell development Source: BHF-UCL
  2. heart trabecula formation Source: BHF-UCL
  3. negative regulation of apoptotic process Source: UniProtKB
  4. negative regulation of transcription, DNA-templated Source: BHF-UCL
  5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. osteoblast differentiation Source: BHF-UCL
  7. regulation of transcription from RNA polymerase II promoter Source: MGI
  8. response to hormone Source: Ensembl
  9. transcription, DNA-templated Source: UniProtKB-KW
  10. ventricular cardiac muscle cell development Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 2
Short name:
FHL-2
Alternative name(s):
Skeletal muscle LIM-protein 3
Short name:
SLIM-3
Gene namesi
Name:Fhl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1338762. Fhl2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. focal adhesion Source: Ensembl
  3. M band Source: Ensembl
  4. nucleus Source: BHF-UCL
  5. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Four and a half LIM domains protein 2PRO_0000075738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei238 – 2381Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70433.
PaxDbiO70433.
PRIDEiO70433.

PTM databases

PhosphoSiteiO70433.

Expressioni

Tissue specificityi

Highly expressed in heart but also detectable in brain and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiO70433.
BgeeiO70433.
CleanExiMM_FHL2.
GenevestigatoriO70433.

Interactioni

Subunit structurei

Interacts with ZNF638 and TTN/titin. Interacts with E4F1. Interacts with GRB7. Interacts with SIRT1 and FOXO1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Plcg2Q8CIH53EBI-299379,EBI-617954

Protein-protein interaction databases

BioGridi199669. 7 interactions.
IntActiO70433. 6 interactions.
MINTiMINT-152324.

Structurei

3D structure databases

ProteinModelPortaliO70433.
SMRiO70433. Positions 1-159, 162-218, 225-279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9253LIM zinc-binding 1Add
BLAST
Domaini101 – 15353LIM zinc-binding 2Add
BLAST
Domaini162 – 21251LIM zinc-binding 3Add
BLAST
Domaini221 – 27555LIM zinc-binding 4Add
BLAST

Domaini

The third LIM zinc-binding mediates interaction with E4F1 By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3125C4-type Reviewed predictionAdd
BLAST

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG314122.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiO70433.
KOiK14380.
OMAiYCVACFE.
OrthoDBiEOG7P8P7M.
PhylomeDBiO70433.
TreeFamiTF321684.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70433-1 [UniParc]FASTAAdd to Basket

« Hide

MTERFDCHHC NESLYGKKYI LKEENPHCVA CFEELYANTC EECGTPIGCD    50
CKDLSYKDRH WHEGCFHCSR CGSSLVDKPF AAKEEQLLCT DCYSNEYSSK 100
CQECKKTIMP GTRKMEYKGS SWHETCFTCQ RCQQPIGTKS FIPKENQNFC 150
VPCYEKQYAL QCVQCKKPIT TGGVTYREQP WHKECFVCTA CKKQLSGQRF 200
TARDEFPYCL TCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN 250
CKKCSLSLVG RGFLTERDDI LCPDCGKDI 279
Length:279
Mass (Da):32,073
Last modified:August 1, 1998 - v1
Checksum:i6D8CBC4B4424BFF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055889 mRNA. Translation: AAC12770.1.
U77040 mRNA. Translation: AAB19211.2.
AF114381 mRNA. Translation: AAD53230.1.
AF153340 mRNA. Translation: AAD34170.1.
CCDSiCCDS14922.1.
RefSeqiNP_001276462.1. NM_001289533.1.
NP_034342.1. NM_010212.4.
UniGeneiMm.6799.

Genome annotation databases

EnsembliENSMUST00000008280; ENSMUSP00000008280; ENSMUSG00000008136.
GeneIDi14200.
KEGGimmu:14200.
UCSCiuc007avk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055889 mRNA. Translation: AAC12770.1 .
U77040 mRNA. Translation: AAB19211.2 .
AF114381 mRNA. Translation: AAD53230.1 .
AF153340 mRNA. Translation: AAD34170.1 .
CCDSi CCDS14922.1.
RefSeqi NP_001276462.1. NM_001289533.1.
NP_034342.1. NM_010212.4.
UniGenei Mm.6799.

3D structure databases

ProteinModelPortali O70433.
SMRi O70433. Positions 1-159, 162-218, 225-279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199669. 7 interactions.
IntActi O70433. 6 interactions.
MINTi MINT-152324.

PTM databases

PhosphoSitei O70433.

Proteomic databases

MaxQBi O70433.
PaxDbi O70433.
PRIDEi O70433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000008280 ; ENSMUSP00000008280 ; ENSMUSG00000008136 .
GeneIDi 14200.
KEGGi mmu:14200.
UCSCi uc007avk.1. mouse.

Organism-specific databases

CTDi 2274.
MGIi MGI:1338762. Fhl2.

Phylogenomic databases

eggNOGi NOG314122.
HOGENOMi HOG000231075.
HOVERGENi HBG074526.
InParanoidi O70433.
KOi K14380.
OMAi YCVACFE.
OrthoDBi EOG7P8P7M.
PhylomeDBi O70433.
TreeFami TF321684.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.

Miscellaneous databases

ChiTaRSi FHL2. mouse.
NextBioi 285434.
PROi O70433.
SOURCEi Search...

Gene expression databases

ArrayExpressi O70433.
Bgeei O70433.
CleanExi MM_FHL2.
Genevestigatori O70433.

Family and domain databases

Gene3Di 2.10.110.10. 5 hits.
InterProi IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 4 hits.
[Graphical view ]
SMARTi SM00132. LIM. 4 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cloning, sequencing and characterization of a mouse FHL2, which contains four and a half LIM domains."
    Chan K.K., Tsui S.K.W., Lee C.Y., Fung K.P., Waye M.M.Y.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle."
    Morgan M.J., Madgwick A.J.A.
    Biochem. Biophys. Res. Commun. 255:245-250(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system."
    Chu P.-H., Ruiz-Lozano P., Zhou Q., Cai C., Chen J.
    Mech. Dev. 95:259-265(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  4. "Isolation of the mouse homolog mDRAL from skeletal muscle derived myoblasts."
    Starzinski-Powitz A., Martin B., Eckerdt F.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.

Entry informationi

Entry nameiFHL2_MOUSE
AccessioniPrimary (citable) accession number: O70433
Secondary accession number(s): P97448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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