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O70422 (TF2H4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor IIH subunit 4
Alternative name(s):
Basic transcription factor 2 52 kDa subunit
Short name=BTF2 p52
General transcription factor IIH polypeptide 4
TFIIH basal transcription factor complex p52 subunit
Gene names
Name:Gtf2h4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

Subunit structure

One of the six subunits forming the core-TFIIH basal transcription factor.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the TFB2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463General transcription factor IIH subunit 4
PRO_0000119254

Sequences

Sequence LengthMass (Da)Tools
O70422 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: DBAA15CB388C5AFC

FASTA46352,224
        10         20         30         40         50         60 
MEITPARGGL NRAHLQCRNL QEFLGGLSPG VLDRLYGHPA TCLAVFRELP SLAKNWVMRM 

        70         80         90        100        110        120 
LFLEQPLPQA AVALWVKKEF SKAQEESTGL LSGLRIWHTQ LLPGGLQGLI LNPVFRQNLR 

       130        140        150        160        170        180 
IALLGGGKAW SDDTSQLGPD KHARDVPSLD KYAEERWEVV LHFMVGSPSA AVSQDLAQLL 

       190        200        210        220        230        240 
SQAGLMKSTE PGEPPCITSA GFQFLLLDTP AQLWYFMLQY LQTAQSRGMD LVEILSFLFQ 

       250        260        270        280        290        300 
LSFSTLGKDY SVEGMSDSLL NFLQHLREFG LVFQRKRKSR RYYPTRLAIN LSSGVSGAGG 

       310        320        330        340        350        360 
TVHQPGFIVV ETNYRLYAYT ESELQIALIA LFSEMLYRFP NMVVAQVTRE SVQQAIASGI 

       370        380        390        400        410        420 
TAQQIIHFLR TRAHPVMLKQ NPVLPPTITD QIRLWELERD RLRFTEGVLY NQFLSQVDFE 

       430        440        450        460 
LLLAHARELG VLVFENSAKR LMVVTPAGHS DVKRFWKRQK HSS 

« Hide

References

« Hide 'large scale' references
[1]"The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H-2 complex: cloning and sequence polymorphism."
Lanning D., Lafuse W.P.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: T-cell lymphoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF054823 mRNA. Translation: AAC08594.1.
BC012638 mRNA. Translation: AAH12638.1.
CCDSCCDS28702.1.
RefSeqNP_034494.1. NM_010364.3.
XP_006523731.1. XM_006523668.1.
XP_006523732.1. XM_006523669.1.
XP_006536584.1. XM_006536521.1.
XP_006537317.1. XM_006537254.1.
UniGeneMm.10182.

3D structure databases

ProteinModelPortalO70422.
SMRO70422. Positions 383-458.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO70422. 2 interactions.
MINTMINT-4137470.

PTM databases

PhosphoSiteO70422.

Proteomic databases

PaxDbO70422.
PRIDEO70422.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001565; ENSMUSP00000001565; ENSMUSG00000001524.
ENSMUST00000160734; ENSMUSP00000124335; ENSMUSG00000001524.
GeneID14885.
KEGGmmu:14885.
UCSCuc008cig.1. mouse.

Organism-specific databases

CTD2968.
MGIMGI:1338799. Gtf2h4.

Phylogenomic databases

eggNOGCOG5144.
HOGENOMHOG000170529.
HOVERGENHBG054205.
InParanoidO70422.
KOK03144.
OMAPHAQLWE.
OrthoDBEOG71VSST.
PhylomeDBO70422.
TreeFamTF300879.

Gene expression databases

ArrayExpressO70422.
BgeeO70422.
CleanExMM_GTF2H4.
GenevestigatorO70422.

Family and domain databases

InterProIPR004598. TFIIH_p52/Tfb2.
[Graphical view]
PANTHERPTHR13152. PTHR13152. 1 hit.
PfamPF03849. Tfb2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00625. tfb2. 1 hit.
ProtoNetSearch...

Other

NextBio287167.
PROO70422.
SOURCESearch...

Entry information

Entry nameTF2H4_MOUSE
AccessionPrimary (citable) accession number: O70422
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot