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O70422

- TF2H4_MOUSE

UniProt

O70422 - TF2H4_MOUSE

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Protein

General transcription factor IIH subunit 4

Gene

Gtf2h4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

GO - Molecular functioni

  1. ATP-dependent DNA helicase activity Source: InterPro
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: Ensembl

GO - Biological processi

  1. nucleotide-excision repair Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_203462. Formation of the Early Elongation Complex.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4
Alternative name(s):
Basic transcription factor 2 52 kDa subunit
Short name:
BTF2 p52
General transcription factor IIH polypeptide 4
TFIIH basal transcription factor complex p52 subunit
Gene namesi
Name:Gtf2h4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1338799. Gtf2h4.

Subcellular locationi

GO - Cellular componenti

  1. core TFIIH complex Source: InterPro
  2. holo TFIIH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463General transcription factor IIH subunit 4PRO_0000119254Add
BLAST

Proteomic databases

MaxQBiO70422.
PaxDbiO70422.
PRIDEiO70422.

PTM databases

PhosphoSiteiO70422.

Expressioni

Gene expression databases

BgeeiO70422.
CleanExiMM_GTF2H4.
ExpressionAtlasiO70422. baseline and differential.
GenevestigatoriO70422.

Interactioni

Subunit structurei

One of the six subunits forming the core-TFIIH basal transcription factor.

Protein-protein interaction databases

IntActiO70422. 2 interactions.
MINTiMINT-4137470.

Structurei

3D structure databases

ProteinModelPortaliO70422.
SMRiO70422. Positions 383-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.Curated

Phylogenomic databases

eggNOGiCOG5144.
HOGENOMiHOG000170529.
HOVERGENiHBG054205.
InParanoidiO70422.
KOiK03144.
OMAiPHAQLWE.
OrthoDBiEOG71VSST.
PhylomeDBiO70422.
TreeFamiTF300879.

Family and domain databases

InterProiIPR004598. TFIIH_p52/Tfb2.
[Graphical view]
PANTHERiPTHR13152. PTHR13152. 1 hit.
PfamiPF03849. Tfb2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00625. tfb2. 1 hit.

Sequencei

Sequence statusi: Complete.

O70422-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEITPARGGL NRAHLQCRNL QEFLGGLSPG VLDRLYGHPA TCLAVFRELP
60 70 80 90 100
SLAKNWVMRM LFLEQPLPQA AVALWVKKEF SKAQEESTGL LSGLRIWHTQ
110 120 130 140 150
LLPGGLQGLI LNPVFRQNLR IALLGGGKAW SDDTSQLGPD KHARDVPSLD
160 170 180 190 200
KYAEERWEVV LHFMVGSPSA AVSQDLAQLL SQAGLMKSTE PGEPPCITSA
210 220 230 240 250
GFQFLLLDTP AQLWYFMLQY LQTAQSRGMD LVEILSFLFQ LSFSTLGKDY
260 270 280 290 300
SVEGMSDSLL NFLQHLREFG LVFQRKRKSR RYYPTRLAIN LSSGVSGAGG
310 320 330 340 350
TVHQPGFIVV ETNYRLYAYT ESELQIALIA LFSEMLYRFP NMVVAQVTRE
360 370 380 390 400
SVQQAIASGI TAQQIIHFLR TRAHPVMLKQ NPVLPPTITD QIRLWELERD
410 420 430 440 450
RLRFTEGVLY NQFLSQVDFE LLLAHARELG VLVFENSAKR LMVVTPAGHS
460
DVKRFWKRQK HSS
Length:463
Mass (Da):52,224
Last modified:August 1, 1998 - v1
Checksum:iDBAA15CB388C5AFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054823 mRNA. Translation: AAC08594.1.
BC012638 mRNA. Translation: AAH12638.1.
CCDSiCCDS28702.1.
RefSeqiNP_034494.1. NM_010364.3.
XP_006523731.1. XM_006523668.1.
XP_006523732.1. XM_006523669.1.
XP_006536584.1. XM_006536521.1.
XP_006537317.1. XM_006537254.1.
UniGeneiMm.10182.

Genome annotation databases

EnsembliENSMUST00000001565; ENSMUSP00000001565; ENSMUSG00000001524.
ENSMUST00000160734; ENSMUSP00000124335; ENSMUSG00000001524.
GeneIDi14885.
KEGGimmu:14885.
UCSCiuc008cig.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054823 mRNA. Translation: AAC08594.1 .
BC012638 mRNA. Translation: AAH12638.1 .
CCDSi CCDS28702.1.
RefSeqi NP_034494.1. NM_010364.3.
XP_006523731.1. XM_006523668.1.
XP_006523732.1. XM_006523669.1.
XP_006536584.1. XM_006536521.1.
XP_006537317.1. XM_006537254.1.
UniGenei Mm.10182.

3D structure databases

ProteinModelPortali O70422.
SMRi O70422. Positions 383-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O70422. 2 interactions.
MINTi MINT-4137470.

PTM databases

PhosphoSitei O70422.

Proteomic databases

MaxQBi O70422.
PaxDbi O70422.
PRIDEi O70422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001565 ; ENSMUSP00000001565 ; ENSMUSG00000001524 .
ENSMUST00000160734 ; ENSMUSP00000124335 ; ENSMUSG00000001524 .
GeneIDi 14885.
KEGGi mmu:14885.
UCSCi uc008cig.1. mouse.

Organism-specific databases

CTDi 2968.
MGIi MGI:1338799. Gtf2h4.

Phylogenomic databases

eggNOGi COG5144.
HOGENOMi HOG000170529.
HOVERGENi HBG054205.
InParanoidi O70422.
KOi K03144.
OMAi PHAQLWE.
OrthoDBi EOG71VSST.
PhylomeDBi O70422.
TreeFami TF300879.

Enzyme and pathway databases

Reactomei REACT_203462. Formation of the Early Elongation Complex.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

NextBioi 287167.
PROi O70422.
SOURCEi Search...

Gene expression databases

Bgeei O70422.
CleanExi MM_GTF2H4.
ExpressionAtlasi O70422. baseline and differential.
Genevestigatori O70422.

Family and domain databases

InterProi IPR004598. TFIIH_p52/Tfb2.
[Graphical view ]
PANTHERi PTHR13152. PTHR13152. 1 hit.
Pfami PF03849. Tfb2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00625. tfb2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H-2 complex: cloning and sequence polymorphism."
    Lanning D., Lafuse W.P.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: T-cell lymphoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiTF2H4_MOUSE
AccessioniPrimary (citable) accession number: O70422
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3