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Protein

General transcription factor IIH subunit 4

Gene

Gtf2h4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_279019. Dual incision reaction in TC-NER.
REACT_282911. RNA Polymerase II Pre-transcription Events.
REACT_283211. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_289837. RNA Polymerase I Transcription Termination.
REACT_296099. RNA Polymerase I Promoter Escape.
REACT_296420. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_296832. Dual incision reaction in GG-NER.
REACT_302527. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_308057. Formation of the Early Elongation Complex.
REACT_314261. Formation of incision complex in GG-NER.
REACT_315215. RNA Polymerase II Transcription Elongation.
REACT_326102. Formation of RNA Pol II elongation complex.
REACT_329615. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_338828. mRNA Capping.
REACT_342690. RNA Polymerase II Transcription Initiation.
REACT_349121. RNA Polymerase II Promoter Escape.
REACT_350574. RNA Polymerase I Transcription Initiation.
REACT_354877. RNA Polymerase I Chain Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4
Alternative name(s):
Basic transcription factor 2 52 kDa subunit
Short name:
BTF2 p52
General transcription factor IIH polypeptide 4
TFIIH basal transcription factor complex p52 subunit
Gene namesi
Name:Gtf2h4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1338799. Gtf2h4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463General transcription factor IIH subunit 4PRO_0000119254Add
BLAST

Proteomic databases

MaxQBiO70422.
PaxDbiO70422.
PRIDEiO70422.

PTM databases

PhosphoSiteiO70422.

Expressioni

Gene expression databases

BgeeiO70422.
CleanExiMM_GTF2H4.
ExpressionAtlasiO70422. baseline and differential.
GenevisibleiO70422. MM.

Interactioni

Subunit structurei

One of the six subunits forming the core-TFIIH basal transcription factor.

Protein-protein interaction databases

IntActiO70422. 2 interactions.
MINTiMINT-4137470.
STRINGi10090.ENSMUSP00000001565.

Structurei

3D structure databases

ProteinModelPortaliO70422.
SMRiO70422. Positions 383-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.Curated

Phylogenomic databases

eggNOGiCOG5144.
GeneTreeiENSGT00390000014159.
HOGENOMiHOG000170529.
HOVERGENiHBG054205.
InParanoidiO70422.
KOiK03144.
OMAiRFTYTEG.
OrthoDBiEOG71VSST.
PhylomeDBiO70422.
TreeFamiTF300879.

Family and domain databases

InterProiIPR004598. TFIIH_p52/Tfb2.
[Graphical view]
PANTHERiPTHR13152. PTHR13152. 1 hit.
PfamiPF03849. Tfb2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00625. tfb2. 1 hit.

Sequencei

Sequence statusi: Complete.

O70422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITPARGGL NRAHLQCRNL QEFLGGLSPG VLDRLYGHPA TCLAVFRELP
60 70 80 90 100
SLAKNWVMRM LFLEQPLPQA AVALWVKKEF SKAQEESTGL LSGLRIWHTQ
110 120 130 140 150
LLPGGLQGLI LNPVFRQNLR IALLGGGKAW SDDTSQLGPD KHARDVPSLD
160 170 180 190 200
KYAEERWEVV LHFMVGSPSA AVSQDLAQLL SQAGLMKSTE PGEPPCITSA
210 220 230 240 250
GFQFLLLDTP AQLWYFMLQY LQTAQSRGMD LVEILSFLFQ LSFSTLGKDY
260 270 280 290 300
SVEGMSDSLL NFLQHLREFG LVFQRKRKSR RYYPTRLAIN LSSGVSGAGG
310 320 330 340 350
TVHQPGFIVV ETNYRLYAYT ESELQIALIA LFSEMLYRFP NMVVAQVTRE
360 370 380 390 400
SVQQAIASGI TAQQIIHFLR TRAHPVMLKQ NPVLPPTITD QIRLWELERD
410 420 430 440 450
RLRFTEGVLY NQFLSQVDFE LLLAHARELG VLVFENSAKR LMVVTPAGHS
460
DVKRFWKRQK HSS
Length:463
Mass (Da):52,224
Last modified:August 1, 1998 - v1
Checksum:iDBAA15CB388C5AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054823 mRNA. Translation: AAC08594.1.
BC012638 mRNA. Translation: AAH12638.1.
CCDSiCCDS28702.1.
RefSeqiNP_034494.1. NM_010364.4.
XP_006523731.1. XM_006523668.2.
XP_006523732.1. XM_006523669.2.
UniGeneiMm.10182.

Genome annotation databases

EnsembliENSMUST00000001565; ENSMUSP00000001565; ENSMUSG00000001524.
ENSMUST00000160734; ENSMUSP00000124335; ENSMUSG00000001524.
GeneIDi14885.
KEGGimmu:14885.
UCSCiuc008cig.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054823 mRNA. Translation: AAC08594.1.
BC012638 mRNA. Translation: AAH12638.1.
CCDSiCCDS28702.1.
RefSeqiNP_034494.1. NM_010364.4.
XP_006523731.1. XM_006523668.2.
XP_006523732.1. XM_006523669.2.
UniGeneiMm.10182.

3D structure databases

ProteinModelPortaliO70422.
SMRiO70422. Positions 383-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70422. 2 interactions.
MINTiMINT-4137470.
STRINGi10090.ENSMUSP00000001565.

PTM databases

PhosphoSiteiO70422.

Proteomic databases

MaxQBiO70422.
PaxDbiO70422.
PRIDEiO70422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001565; ENSMUSP00000001565; ENSMUSG00000001524.
ENSMUST00000160734; ENSMUSP00000124335; ENSMUSG00000001524.
GeneIDi14885.
KEGGimmu:14885.
UCSCiuc008cig.2. mouse.

Organism-specific databases

CTDi2968.
MGIiMGI:1338799. Gtf2h4.

Phylogenomic databases

eggNOGiCOG5144.
GeneTreeiENSGT00390000014159.
HOGENOMiHOG000170529.
HOVERGENiHBG054205.
InParanoidiO70422.
KOiK03144.
OMAiRFTYTEG.
OrthoDBiEOG71VSST.
PhylomeDBiO70422.
TreeFamiTF300879.

Enzyme and pathway databases

ReactomeiREACT_279019. Dual incision reaction in TC-NER.
REACT_282911. RNA Polymerase II Pre-transcription Events.
REACT_283211. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_289837. RNA Polymerase I Transcription Termination.
REACT_296099. RNA Polymerase I Promoter Escape.
REACT_296420. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_296832. Dual incision reaction in GG-NER.
REACT_302527. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_308057. Formation of the Early Elongation Complex.
REACT_314261. Formation of incision complex in GG-NER.
REACT_315215. RNA Polymerase II Transcription Elongation.
REACT_326102. Formation of RNA Pol II elongation complex.
REACT_329615. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_338828. mRNA Capping.
REACT_342690. RNA Polymerase II Transcription Initiation.
REACT_349121. RNA Polymerase II Promoter Escape.
REACT_350574. RNA Polymerase I Transcription Initiation.
REACT_354877. RNA Polymerase I Chain Elongation.

Miscellaneous databases

NextBioi287167.
PROiO70422.
SOURCEiSearch...

Gene expression databases

BgeeiO70422.
CleanExiMM_GTF2H4.
ExpressionAtlasiO70422. baseline and differential.
GenevisibleiO70422. MM.

Family and domain databases

InterProiIPR004598. TFIIH_p52/Tfb2.
[Graphical view]
PANTHERiPTHR13152. PTHR13152. 1 hit.
PfamiPF03849. Tfb2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00625. tfb2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H-2 complex: cloning and sequence polymorphism."
    Lanning D., Lafuse W.P.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: T-cell lymphoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiTF2H4_MOUSE
AccessioniPrimary (citable) accession number: O70422
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1998
Last modified: July 22, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.