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O70422

- TF2H4_MOUSE

UniProt

O70422 - TF2H4_MOUSE

Protein

General transcription factor IIH subunit 4

Gene

Gtf2h4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

    GO - Molecular functioni

    1. ATP-dependent DNA helicase activity Source: InterPro
    2. RNA polymerase II carboxy-terminal domain kinase activity Source: Ensembl

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. nucleotide-excision repair Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_203462. Formation of the Early Elongation Complex.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIH subunit 4
    Alternative name(s):
    Basic transcription factor 2 52 kDa subunit
    Short name:
    BTF2 p52
    General transcription factor IIH polypeptide 4
    TFIIH basal transcription factor complex p52 subunit
    Gene namesi
    Name:Gtf2h4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1338799. Gtf2h4.

    Subcellular locationi

    GO - Cellular componenti

    1. core TFIIH complex Source: InterPro
    2. holo TFIIH complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463General transcription factor IIH subunit 4PRO_0000119254Add
    BLAST

    Proteomic databases

    PaxDbiO70422.
    PRIDEiO70422.

    PTM databases

    PhosphoSiteiO70422.

    Expressioni

    Gene expression databases

    ArrayExpressiO70422.
    BgeeiO70422.
    CleanExiMM_GTF2H4.
    GenevestigatoriO70422.

    Interactioni

    Subunit structurei

    One of the six subunits forming the core-TFIIH basal transcription factor.

    Protein-protein interaction databases

    IntActiO70422. 2 interactions.
    MINTiMINT-4137470.

    Structurei

    3D structure databases

    ProteinModelPortaliO70422.
    SMRiO70422. Positions 383-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TFB2 family.Curated

    Phylogenomic databases

    eggNOGiCOG5144.
    HOGENOMiHOG000170529.
    HOVERGENiHBG054205.
    InParanoidiO70422.
    KOiK03144.
    OMAiPHAQLWE.
    OrthoDBiEOG71VSST.
    PhylomeDBiO70422.
    TreeFamiTF300879.

    Family and domain databases

    InterProiIPR004598. TFIIH_p52/Tfb2.
    [Graphical view]
    PANTHERiPTHR13152. PTHR13152. 1 hit.
    PfamiPF03849. Tfb2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00625. tfb2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O70422-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEITPARGGL NRAHLQCRNL QEFLGGLSPG VLDRLYGHPA TCLAVFRELP    50
    SLAKNWVMRM LFLEQPLPQA AVALWVKKEF SKAQEESTGL LSGLRIWHTQ 100
    LLPGGLQGLI LNPVFRQNLR IALLGGGKAW SDDTSQLGPD KHARDVPSLD 150
    KYAEERWEVV LHFMVGSPSA AVSQDLAQLL SQAGLMKSTE PGEPPCITSA 200
    GFQFLLLDTP AQLWYFMLQY LQTAQSRGMD LVEILSFLFQ LSFSTLGKDY 250
    SVEGMSDSLL NFLQHLREFG LVFQRKRKSR RYYPTRLAIN LSSGVSGAGG 300
    TVHQPGFIVV ETNYRLYAYT ESELQIALIA LFSEMLYRFP NMVVAQVTRE 350
    SVQQAIASGI TAQQIIHFLR TRAHPVMLKQ NPVLPPTITD QIRLWELERD 400
    RLRFTEGVLY NQFLSQVDFE LLLAHARELG VLVFENSAKR LMVVTPAGHS 450
    DVKRFWKRQK HSS 463
    Length:463
    Mass (Da):52,224
    Last modified:August 1, 1998 - v1
    Checksum:iDBAA15CB388C5AFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054823 mRNA. Translation: AAC08594.1.
    BC012638 mRNA. Translation: AAH12638.1.
    CCDSiCCDS28702.1.
    RefSeqiNP_034494.1. NM_010364.3.
    XP_006523731.1. XM_006523668.1.
    XP_006523732.1. XM_006523669.1.
    XP_006536584.1. XM_006536521.1.
    XP_006537317.1. XM_006537254.1.
    UniGeneiMm.10182.

    Genome annotation databases

    EnsembliENSMUST00000001565; ENSMUSP00000001565; ENSMUSG00000001524.
    ENSMUST00000160734; ENSMUSP00000124335; ENSMUSG00000001524.
    GeneIDi14885.
    KEGGimmu:14885.
    UCSCiuc008cig.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054823 mRNA. Translation: AAC08594.1 .
    BC012638 mRNA. Translation: AAH12638.1 .
    CCDSi CCDS28702.1.
    RefSeqi NP_034494.1. NM_010364.3.
    XP_006523731.1. XM_006523668.1.
    XP_006523732.1. XM_006523669.1.
    XP_006536584.1. XM_006536521.1.
    XP_006537317.1. XM_006537254.1.
    UniGenei Mm.10182.

    3D structure databases

    ProteinModelPortali O70422.
    SMRi O70422. Positions 383-458.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O70422. 2 interactions.
    MINTi MINT-4137470.

    PTM databases

    PhosphoSitei O70422.

    Proteomic databases

    PaxDbi O70422.
    PRIDEi O70422.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001565 ; ENSMUSP00000001565 ; ENSMUSG00000001524 .
    ENSMUST00000160734 ; ENSMUSP00000124335 ; ENSMUSG00000001524 .
    GeneIDi 14885.
    KEGGi mmu:14885.
    UCSCi uc008cig.1. mouse.

    Organism-specific databases

    CTDi 2968.
    MGIi MGI:1338799. Gtf2h4.

    Phylogenomic databases

    eggNOGi COG5144.
    HOGENOMi HOG000170529.
    HOVERGENi HBG054205.
    InParanoidi O70422.
    KOi K03144.
    OMAi PHAQLWE.
    OrthoDBi EOG71VSST.
    PhylomeDBi O70422.
    TreeFami TF300879.

    Enzyme and pathway databases

    Reactomei REACT_203462. Formation of the Early Elongation Complex.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Miscellaneous databases

    NextBioi 287167.
    PROi O70422.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70422.
    Bgeei O70422.
    CleanExi MM_GTF2H4.
    Genevestigatori O70422.

    Family and domain databases

    InterProi IPR004598. TFIIH_p52/Tfb2.
    [Graphical view ]
    PANTHERi PTHR13152. PTHR13152. 1 hit.
    Pfami PF03849. Tfb2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00625. tfb2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H-2 complex: cloning and sequence polymorphism."
      Lanning D., Lafuse W.P.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: T-cell lymphoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiTF2H4_MOUSE
    AccessioniPrimary (citable) accession number: O70422
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3