Frizzled-1 precursor - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot O70421 (FZD1_MOUSE)

Last modified January 19, 2010. Version 78. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Frizzled-1
      Short name=Fz-1
      Short name=mFz1

Gene names

Name:

Fzd1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	642 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in chondrocytes.
Domain	Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity. The FZ domain is involved in binding with Wnt ligands By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain.

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Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW Wnt receptor signaling pathway Inferred from genetic interaction. Source: MGI cell-cell signaling Inferred from direct assay. Source: MGI epithelial cell differentiation Inferred from direct assay. Source: MGI negative regulation of transcription Inferred from mutant phenotype. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW non-G-protein coupled 7TM receptor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 68

Potential

Chain

69 – 642

574

Frizzled-1

PRO_0000012974

Regions

Topological domain

69 – 317

249

Extracellular Potential

Transmembrane

318 – 338

1 Potential

Topological domain

339 – 349

Cytoplasmic Potential

Transmembrane

350 – 370

2 Potential

Topological domain

371 – 397

Extracellular Potential

Transmembrane

398 – 418

3 Potential

Topological domain

419 – 440

Cytoplasmic Potential

Transmembrane

441 – 461

4 Potential

Topological domain

462 – 484

Extracellular Potential

Transmembrane

485 – 505

5 Potential

Topological domain

506 – 531

Cytoplasmic Potential

Transmembrane

532 – 552

6 Potential

Topological domain

553 – 593

Extracellular Potential

Transmembrane

594 – 614

7 Potential

Topological domain

615 – 642

Cytoplasmic Potential

Domain

106 – 225

120

Motif

620 – 625

Lys-Thr-X-X-X-Trp motif

Motif

640 – 642

PDZ-binding

Compositional bias

85 – 90

Poly-Pro

Amino acid modifications

Glycosylation

125

N-linked (GlcNAc...) Potential

Glycosylation

226

N-linked (GlcNAc...) Potential

Disulfide bond

111 ↔ 172

By similarity

Disulfide bond

119 ↔ 165

By similarity

Disulfide bond

156 ↔ 193

By similarity

Disulfide bond

182 ↔ 222

By similarity

Disulfide bond

186 ↔ 210

By similarity

Experimental info

Sequence conflict

341

P → R in AAC01952. Ref.2

Sequence conflict

352

S → F in AAC01952. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

O70421-1 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: 0AAD0C0DC820B6CE
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FASTA

642

70,956

        10         20         30         40         50         60 
MAEEAAPSES RAAGRLSLEL CAEALPGRRE EVGHEDTASH RRPRADPRRW ASGLLLLLWL 

        70         80         90        100        110        120 
LEAPLLLGVR AQAAGQVSGP GQQAPPPPQP QQSGQQYNGE RGISIPDHGY CQPISIPLCT 

       130        140        150        160        170        180 
DMAYNQTIMP NLLGHTNQED AGLEVHQFYP LVKVQCSAEL KFFLCSMYAP VCTVLEQALP 

       190        200        210        220        230        240 
PCRSLCERAR QGCEALMNKF GFQWPDTLKC EKFPVHGAGE LCVGQNTSDK GTPTPSLLPE 

       250        260        270        280        290        300 
FWTSNGQHGG GGYRGGYPGG AGTVERGKFS CPRALRVPSY LNYHFLGEKD CGAPCEPTKV 

       310        320        330        340        350        360 
YGLMYFGPEE LRFSRTWIGI WSVLCCASTL FTVLTYLVDM PRFSYPERPI ISLSGCYTAV 

       370        380        390        400        410        420 
AVAYIAGFLL EDRVVCNDKF AEDGARTVAQ GTNKEGCTIL FMMLYFFSMA SSIWWVILSL 

       430        440        450        460        470        480 
TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP AIKTITILAL GQVDGDVLSG VCFLGLNNVD 

       490        500        510        520        530        540 
ALRGFVLAPL FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLEKLMV RIGVFSVLYT 

       550        560        570        580        590        600 
VPATIVIACY FYEQAFRDQW ERSWVAQSCK SYAIPCPHLQ GGGGVPPHPP MSPDFTVFMI 

       610        620        630        640 
KYLMTLIVGI TSGFRIWSGK TLNSWRKFYT RLTNSKQGET TV

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References

[1]	"Expression of frizzled genes in mouse costochondral chondrocytes." Xu L., Tan L., Goldring M.B., Olsen B.R., Li Y. Matrix Biol. 20:147-151(2001) [PubMed: 11334716] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Embryo.
[2]	Johnson M.A., Greenberg N.M. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-376. Tissue: Prostate.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AF054623 mRNA. Translation: AAC12873.2. AF005202 mRNA. Translation: AAC01952.1.
IPI	IPI00118170.
UniGene	Mm.246003
3D structure databases
SMR	O70421. Positions 109-226.
ModBase	Search...
Protein-protein interaction databases
STRING	O70421.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O70421.
Proteomic databases
PRIDE	O70421.
Genome annotation databases
Ensembl	ENSMUST00000054294; ENSMUSP00000058629; ENSMUSG00000044674; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:1196625. Fzd1.
Phylogenomic databases
eggNOG	roNOG11987.
HOGENOM	HBG447413.
HOVERGEN	O70421.
InParanoid	O70421.
Gene expression databases
ArrayExpress	O70421.
Bgee	O70421.
CleanEx	MM_FZD1.
Genevestigator	O70421.
GermOnline	ENSMUSG00000044674. Mus musculus.
Family and domain databases
InterPro	IPR000539. Frizzled. IPR020067. Frizzled-like_dom. IPR000024. Frizzled_Cys-rich. IPR020068. Frizzled_dom_subgr. IPR015526. Frizzled_related. IPR017981. GPCR_2-like. [Graphical view]
Gene3D	G3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHER	PTHR11309. Fz_related. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

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Entry information

Entry name

FZD1_MOUSE

Accession

Primary (citable) accession number: O70421
Secondary accession number(s): O08974

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	May 1, 2000
Last modified:	January 19, 2010
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents