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Protein

Frizzled-1

Gene

Fzd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins (PubMed:15923619). Activated by WNT7B (PubMed:15923619). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:15923619). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).By similarityCurated1 Publication

Caution

Activation by specific Wnt family members may depend on the cells used for the experiment. Contradictory results have been reported for activation by WNT7B in human and mouse.Curated

GO - Molecular functioni

GO - Biological processi

  • autocrine signaling Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: MGI
  • canonical Wnt signaling pathway involved in osteoblast differentiation Source: MGI
  • cell-cell signaling Source: MGI
  • epithelial cell differentiation Source: MGI
  • hard palate development Source: MGI
  • membranous septum morphogenesis Source: MGI
  • muscular septum morphogenesis Source: MGI
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of catenin import into nucleus Source: MGI
  • negative regulation of oxidative stress-induced neuron death Source: ParkinsonsUK-UCL
  • negative regulation of transcription, DNA-templated Source: MGI
  • outflow tract morphogenesis Source: MGI
  • planar cell polarity pathway involved in neural tube closure Source: MGI
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • response to drug Source: MGI
  • ventricular septum morphogenesis Source: MGI
  • Wnt signaling pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-4086400 PCP/CE pathway
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-1
Short name:
Fz-1
Short name:
mFz1
Gene namesi
Name:Fzd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1196625 Fzd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini69 – 317ExtracellularSequence analysisAdd BLAST249
Transmembranei318 – 338Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini339 – 349CytoplasmicSequence analysisAdd BLAST11
Transmembranei350 – 370Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini371 – 397ExtracellularSequence analysisAdd BLAST27
Transmembranei398 – 418Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini419 – 440CytoplasmicSequence analysisAdd BLAST22
Transmembranei441 – 461Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini462 – 484ExtracellularSequence analysisAdd BLAST23
Transmembranei485 – 505Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini506 – 531CytoplasmicSequence analysisAdd BLAST26
Transmembranei532 – 552Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini553 – 593ExtracellularSequence analysisAdd BLAST41
Transmembranei594 – 614Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini615 – 642CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 68Sequence analysisAdd BLAST68
ChainiPRO_000001297469 – 642Frizzled-1Add BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi111 ↔ 172PROSITE-ProRule annotation
Disulfide bondi119 ↔ 165PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 193PROSITE-ProRule annotation
Disulfide bondi182 ↔ 222PROSITE-ProRule annotation
Disulfide bondi186 ↔ 210PROSITE-ProRule annotation
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiO70421
PaxDbiO70421
PeptideAtlasiO70421
PRIDEiO70421

PTM databases

iPTMnetiO70421
PhosphoSitePlusiO70421

Expressioni

Tissue specificityi

Expressed in chondrocytes.

Gene expression databases

BgeeiENSMUSG00000044674
CleanExiMM_FZD1
GenevisibleiO70421 MM

Interactioni

Subunit structurei

Interacts with MYOC (By similarity). Interacts with WNT7B (PubMed:15923619).By similarity1 Publication

GO - Molecular functioni

  • frizzled binding Source: MGI
  • PDZ domain binding Source: MGI
  • receptor binding Source: MGI
  • Wnt-protein binding Source: MGI

Protein-protein interaction databases

BioGridi1997753 interactors.
IntActiO70421 4 interactors.
MINTiO70421
STRINGi10090.ENSMUSP00000058629

Structurei

3D structure databases

ProteinModelPortaliO70421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 225FZPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi620 – 625Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi640 – 642PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 90Poly-Pro6

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
HOGENOMiHOG000233236
HOVERGENiHBG006977
InParanoidiO70421
KOiK02432
OMAiKFPVHGA
OrthoDBiEOG091G0N5M
TreeFamiTF317907

Family and domain databases

Gene3Di1.10.2000.101 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026548 FZD1
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF81 PTHR11309:SF81, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEAAPSES RAAGRLSLEL CAEALPGRRE EVGHEDTASH RRPRADPRRW
60 70 80 90 100
ASGLLLLLWL LEAPLLLGVR AQAAGQVSGP GQQAPPPPQP QQSGQQYNGE
110 120 130 140 150
RGISIPDHGY CQPISIPLCT DIAYNQTIMP NLLGHTNQED AGLEVHQFYP
160 170 180 190 200
LVKVQCSAEL KFFLCSMYAP VCTVLEQALP PCRSLCERAR QGCEALMNKF
210 220 230 240 250
GFQWPDTLKC EKFPVHGAGE LCVGQNTSDK GTPTPSLLPE FWTSNPQHGG
260 270 280 290 300
GGYRGGYPGG AGTVERGKFS CPRALRVPSY LNYHFLGEKD CGAPCEPTKV
310 320 330 340 350
YGLMYFGPEE LRFSRTWIGI WSVLCCASTL FTVLTYLVDM RRFSYPERPI
360 370 380 390 400
IFLSGCYTAV AVAYIAGFLL EDRVVCNDKF AEDGARTVAQ GTKKEGCTIL
410 420 430 440 450
FMMLYFFSMA SSIWWVILSL TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP
460 470 480 490 500
AIKTITILAL GQVDGDVLSG VCFVGLNNVD ALRGFVLAPL FVYLFIGTSF
510 520 530 540 550
LLAGFVSLFR IRTIMKHDGT KTEKLEKLMV RIGVFSVLYT VPATIVIACY
560 570 580 590 600
FYEQAFRDQW ERSWVAQSCK SYAIPCPHLQ GGGGVPPHPP MSPDFTVFMI
610 620 630 640
KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV
Length:642
Mass (Da):71,127
Last modified:July 27, 2011 - v3
Checksum:i7674583F819014E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122I → M in AAC12873 (PubMed:11334716).Curated1
Sequence conflicti246P → G in AAC12873 (PubMed:11334716).Curated1
Sequence conflicti341R → P in AAC12873 (PubMed:11334716).Curated1
Sequence conflicti352F → S in AAC12873 (PubMed:11334716).Curated1
Sequence conflicti393K → N in AAC12873 (PubMed:11334716).Curated1
Sequence conflicti474V → L in AAC12873 (PubMed:11334716).Curated1
Sequence conflicti615W → R in AAC12873 (PubMed:11334716).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054623 mRNA Translation: AAC12873.2
AK143101 mRNA Translation: BAE25269.1
CH466600 Genomic DNA Translation: EDL14633.1
BC053010 mRNA Translation: AAH53010.1
AF005202 mRNA Translation: AAC01952.1
CCDSiCCDS19072.1
RefSeqiNP_067432.2, NM_021457.3
UniGeneiMm.246003

Genome annotation databases

EnsembliENSMUST00000054294; ENSMUSP00000058629; ENSMUSG00000044674
GeneIDi14362
KEGGimmu:14362
UCSCiuc008wig.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFZD1_MOUSE
AccessioniPrimary (citable) accession number: O70421
Secondary accession number(s): O08974, Q7TS82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome