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O70421

- FZD1_MOUSE

UniProt

O70421 - FZD1_MOUSE

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Protein

Frizzled-1

Gene
Fzd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: MGI

GO - Biological processi

  1. autocrine signaling Source: Ensembl
  2. axonogenesis Source: RefGenome
  3. brain development Source: RefGenome
  4. canonical Wnt signaling pathway Source: MGI
  5. canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: Ensembl
  6. canonical Wnt signaling pathway involved in osteoblast differentiation Source: Ensembl
  7. cell-cell signaling Source: MGI
  8. epithelial cell differentiation Source: MGI
  9. gonad development Source: RefGenome
  10. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  11. hard palate development Source: MGI
  12. lung alveolus development Source: RefGenome
  13. membranous septum morphogenesis Source: MGI
  14. muscular septum morphogenesis Source: MGI
  15. negative regulation of BMP signaling pathway Source: MGI
  16. negative regulation of canonical Wnt signaling pathway Source: MGI
  17. negative regulation of catenin import into nucleus Source: MGI
  18. negative regulation of transcription, DNA-templated Source: MGI
  19. outflow tract morphogenesis Source: MGI
  20. planar cell polarity pathway involved in neural tube closure Source: MGI
  21. positive regulation of protein phosphorylation Source: MGI
  22. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  23. positive regulation of transcription, DNA-templated Source: Ensembl
  24. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  25. response to drug Source: Ensembl
  26. vasculature development Source: RefGenome
  27. ventricular septum morphogenesis Source: MGI
  28. Wnt signaling pathway Source: MGI
  29. Wnt signaling pathway, calcium modulating pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
REACT_214043. PCP/CE pathway.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-1
Short name:
Fz-1
Short name:
mFz1
Gene namesi
Name:Fzd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1196625. Fzd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini69 – 317249Extracellular Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini339 – 34911Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei350 – 37021Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini371 – 39727Extracellular Reviewed predictionAdd
BLAST
Transmembranei398 – 41821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini419 – 44022Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei441 – 46121Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini462 – 48423Extracellular Reviewed predictionAdd
BLAST
Transmembranei485 – 50521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini506 – 53126Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei532 – 55221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini553 – 59341Extracellular Reviewed predictionAdd
BLAST
Transmembranei594 – 61421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini615 – 64228Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. cell surface Source: Ensembl
  3. cytoplasm Source: RefGenome
  4. integral component of membrane Source: UniProtKB-KW
  5. neuron projection membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 6868 Reviewed predictionAdd
BLAST
Chaini69 – 642574Frizzled-1PRO_0000012974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi111 ↔ 172 By similarity
Disulfide bondi119 ↔ 165 By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi156 ↔ 193 By similarity
Disulfide bondi182 ↔ 222 By similarity
Disulfide bondi186 ↔ 210 By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiO70421.

PTM databases

PhosphoSiteiO70421.

Expressioni

Tissue specificityi

Expressed in chondrocytes.

Gene expression databases

BgeeiO70421.
CleanExiMM_FZD1.
GenevestigatoriO70421.

Interactioni

Subunit structurei

Interacts with MYOC By similarity.

Protein-protein interaction databases

BioGridi199775. 3 interactions.
IntActiO70421. 4 interactions.
MINTiMINT-1779162.
STRINGi10090.ENSMUSP00000058629.

Structurei

3D structure databases

ProteinModelPortaliO70421.
SMRiO70421. Positions 111-217, 291-633.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 225120FZAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi620 – 6256Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi640 – 6423PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi85 – 906Poly-Pro

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
GeneTreeiENSGT00740000114899.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ7TS82.
KOiK02432.
OMAiHGAGELC.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70421-1 [UniParc]FASTAAdd to Basket

« Hide

MAEEAAPSES RAAGRLSLEL CAEALPGRRE EVGHEDTASH RRPRADPRRW    50
ASGLLLLLWL LEAPLLLGVR AQAAGQVSGP GQQAPPPPQP QQSGQQYNGE 100
RGISIPDHGY CQPISIPLCT DIAYNQTIMP NLLGHTNQED AGLEVHQFYP 150
LVKVQCSAEL KFFLCSMYAP VCTVLEQALP PCRSLCERAR QGCEALMNKF 200
GFQWPDTLKC EKFPVHGAGE LCVGQNTSDK GTPTPSLLPE FWTSNPQHGG 250
GGYRGGYPGG AGTVERGKFS CPRALRVPSY LNYHFLGEKD CGAPCEPTKV 300
YGLMYFGPEE LRFSRTWIGI WSVLCCASTL FTVLTYLVDM RRFSYPERPI 350
IFLSGCYTAV AVAYIAGFLL EDRVVCNDKF AEDGARTVAQ GTKKEGCTIL 400
FMMLYFFSMA SSIWWVILSL TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP 450
AIKTITILAL GQVDGDVLSG VCFVGLNNVD ALRGFVLAPL FVYLFIGTSF 500
LLAGFVSLFR IRTIMKHDGT KTEKLEKLMV RIGVFSVLYT VPATIVIACY 550
FYEQAFRDQW ERSWVAQSCK SYAIPCPHLQ GGGGVPPHPP MSPDFTVFMI 600
KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV 642
Length:642
Mass (Da):71,127
Last modified:July 27, 2011 - v3
Checksum:i7674583F819014E2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221I → M in AAC12873. 1 Publication
Sequence conflicti246 – 2461P → G in AAC12873. 1 Publication
Sequence conflicti341 – 3411R → P in AAC12873. 1 Publication
Sequence conflicti352 – 3521F → S in AAC12873. 1 Publication
Sequence conflicti393 – 3931K → N in AAC12873. 1 Publication
Sequence conflicti474 – 4741V → L in AAC12873. 1 Publication
Sequence conflicti615 – 6151W → R in AAC12873. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054623 mRNA. Translation: AAC12873.2.
AK143101 mRNA. Translation: BAE25269.1.
CH466600 Genomic DNA. Translation: EDL14633.1.
BC053010 mRNA. Translation: AAH53010.1.
AF005202 mRNA. Translation: AAC01952.1.
CCDSiCCDS19072.1.
RefSeqiNP_067432.2. NM_021457.3.
UniGeneiMm.246003.

Genome annotation databases

EnsembliENSMUST00000054294; ENSMUSP00000058629; ENSMUSG00000044674.
GeneIDi14362.
KEGGimmu:14362.
UCSCiuc008wig.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054623 mRNA. Translation: AAC12873.2 .
AK143101 mRNA. Translation: BAE25269.1 .
CH466600 Genomic DNA. Translation: EDL14633.1 .
BC053010 mRNA. Translation: AAH53010.1 .
AF005202 mRNA. Translation: AAC01952.1 .
CCDSi CCDS19072.1.
RefSeqi NP_067432.2. NM_021457.3.
UniGenei Mm.246003.

3D structure databases

ProteinModelPortali O70421.
SMRi O70421. Positions 111-217, 291-633.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199775. 3 interactions.
IntActi O70421. 4 interactions.
MINTi MINT-1779162.
STRINGi 10090.ENSMUSP00000058629.

Chemistry

GuidetoPHARMACOLOGYi 229.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

PTM databases

PhosphoSitei O70421.

Proteomic databases

PRIDEi O70421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054294 ; ENSMUSP00000058629 ; ENSMUSG00000044674 .
GeneIDi 14362.
KEGGi mmu:14362.
UCSCi uc008wig.2. mouse.

Organism-specific databases

CTDi 8321.
MGIi MGI:1196625. Fzd1.

Phylogenomic databases

eggNOGi NOG257258.
GeneTreei ENSGT00740000114899.
HOGENOMi HOG000233236.
HOVERGENi HBG006977.
InParanoidi Q7TS82.
KOi K02432.
OMAi HGAGELC.
OrthoDBi EOG7M3J01.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_207044. TCF dependent signaling in response to WNT.
REACT_214043. PCP/CE pathway.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

NextBioi 285827.
PROi O70421.
SOURCEi Search...

Gene expression databases

Bgeei O70421.
CleanExi MM_FZD1.
Genevestigatori O70421.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026548. FZD1.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF81. PTHR11309:SF81. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of frizzled genes in mouse costochondral chondrocytes."
    Xu L., Tan L., Goldring M.B., Olsen B.R., Li Y.
    Matrix Biol. 20:147-151(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. Johnson M.A., Greenberg N.M.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-376.
    Tissue: Prostate.

Entry informationi

Entry nameiFZD1_MOUSE
AccessioniPrimary (citable) accession number: O70421
Secondary accession number(s): O08974, Q7TS82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi