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O70421

- FZD1_MOUSE

UniProt

O70421 - FZD1_MOUSE

Protein

Frizzled-1

Gene

Fzd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. autocrine signaling Source: Ensembl
    2. axonogenesis Source: RefGenome
    3. brain development Source: RefGenome
    4. canonical Wnt signaling pathway Source: MGI
    5. canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: Ensembl
    6. canonical Wnt signaling pathway involved in osteoblast differentiation Source: Ensembl
    7. cell-cell signaling Source: MGI
    8. epithelial cell differentiation Source: MGI
    9. gonad development Source: RefGenome
    10. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
    11. hard palate development Source: MGI
    12. lung alveolus development Source: RefGenome
    13. membranous septum morphogenesis Source: MGI
    14. muscular septum morphogenesis Source: MGI
    15. negative regulation of BMP signaling pathway Source: MGI
    16. negative regulation of canonical Wnt signaling pathway Source: MGI
    17. negative regulation of catenin import into nucleus Source: MGI
    18. negative regulation of transcription, DNA-templated Source: MGI
    19. outflow tract morphogenesis Source: MGI
    20. planar cell polarity pathway involved in neural tube closure Source: MGI
    21. positive regulation of protein phosphorylation Source: MGI
    22. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    23. positive regulation of transcription, DNA-templated Source: Ensembl
    24. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    25. response to drug Source: Ensembl
    26. vasculature development Source: RefGenome
    27. ventricular septum morphogenesis Source: MGI
    28. Wnt signaling pathway Source: MGI
    29. Wnt signaling pathway, calcium modulating pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
    REACT_214043. PCP/CE pathway.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-1
    Short name:
    Fz-1
    Short name:
    mFz1
    Gene namesi
    Name:Fzd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1196625. Fzd1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: RefGenome
    2. cell surface Source: Ensembl
    3. cytoplasm Source: RefGenome
    4. integral component of membrane Source: UniProtKB-KW
    5. neuron projection membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 6868Sequence AnalysisAdd
    BLAST
    Chaini69 – 642574Frizzled-1PRO_0000012974Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi111 ↔ 172PROSITE-ProRule annotation
    Disulfide bondi119 ↔ 165PROSITE-ProRule annotation
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi156 ↔ 193PROSITE-ProRule annotation
    Disulfide bondi182 ↔ 222PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 210PROSITE-ProRule annotation
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiO70421.

    PTM databases

    PhosphoSiteiO70421.

    Expressioni

    Tissue specificityi

    Expressed in chondrocytes.

    Gene expression databases

    BgeeiO70421.
    CleanExiMM_FZD1.
    GenevestigatoriO70421.

    Interactioni

    Subunit structurei

    Interacts with MYOC.By similarity

    Protein-protein interaction databases

    BioGridi199775. 3 interactions.
    IntActiO70421. 4 interactions.
    MINTiMINT-1779162.
    STRINGi10090.ENSMUSP00000058629.

    Structurei

    3D structure databases

    ProteinModelPortaliO70421.
    SMRiO70421. Positions 111-217, 291-633.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini69 – 317249ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini339 – 34911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini371 – 39727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini419 – 44022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini462 – 48423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini506 – 53126CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini553 – 59341ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini615 – 64228CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei318 – 33821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei441 – 46121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei532 – 55221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei594 – 61421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini106 – 225120FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi620 – 6256Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi640 – 6423PDZ-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi85 – 906Poly-Pro

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    GeneTreeiENSGT00740000114899.
    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    InParanoidiQ7TS82.
    KOiK02432.
    OMAiHGAGELC.
    OrthoDBiEOG7M3J01.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026548. FZD1.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF81. PTHR11309:SF81. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70421-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEEAAPSES RAAGRLSLEL CAEALPGRRE EVGHEDTASH RRPRADPRRW    50
    ASGLLLLLWL LEAPLLLGVR AQAAGQVSGP GQQAPPPPQP QQSGQQYNGE 100
    RGISIPDHGY CQPISIPLCT DIAYNQTIMP NLLGHTNQED AGLEVHQFYP 150
    LVKVQCSAEL KFFLCSMYAP VCTVLEQALP PCRSLCERAR QGCEALMNKF 200
    GFQWPDTLKC EKFPVHGAGE LCVGQNTSDK GTPTPSLLPE FWTSNPQHGG 250
    GGYRGGYPGG AGTVERGKFS CPRALRVPSY LNYHFLGEKD CGAPCEPTKV 300
    YGLMYFGPEE LRFSRTWIGI WSVLCCASTL FTVLTYLVDM RRFSYPERPI 350
    IFLSGCYTAV AVAYIAGFLL EDRVVCNDKF AEDGARTVAQ GTKKEGCTIL 400
    FMMLYFFSMA SSIWWVILSL TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP 450
    AIKTITILAL GQVDGDVLSG VCFVGLNNVD ALRGFVLAPL FVYLFIGTSF 500
    LLAGFVSLFR IRTIMKHDGT KTEKLEKLMV RIGVFSVLYT VPATIVIACY 550
    FYEQAFRDQW ERSWVAQSCK SYAIPCPHLQ GGGGVPPHPP MSPDFTVFMI 600
    KYLMTLIVGI TSGFWIWSGK TLNSWRKFYT RLTNSKQGET TV 642
    Length:642
    Mass (Da):71,127
    Last modified:July 27, 2011 - v3
    Checksum:i7674583F819014E2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221I → M in AAC12873. (PubMed:11334716)Curated
    Sequence conflicti246 – 2461P → G in AAC12873. (PubMed:11334716)Curated
    Sequence conflicti341 – 3411R → P in AAC12873. (PubMed:11334716)Curated
    Sequence conflicti352 – 3521F → S in AAC12873. (PubMed:11334716)Curated
    Sequence conflicti393 – 3931K → N in AAC12873. (PubMed:11334716)Curated
    Sequence conflicti474 – 4741V → L in AAC12873. (PubMed:11334716)Curated
    Sequence conflicti615 – 6151W → R in AAC12873. (PubMed:11334716)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054623 mRNA. Translation: AAC12873.2.
    AK143101 mRNA. Translation: BAE25269.1.
    CH466600 Genomic DNA. Translation: EDL14633.1.
    BC053010 mRNA. Translation: AAH53010.1.
    AF005202 mRNA. Translation: AAC01952.1.
    CCDSiCCDS19072.1.
    RefSeqiNP_067432.2. NM_021457.3.
    UniGeneiMm.246003.

    Genome annotation databases

    EnsembliENSMUST00000054294; ENSMUSP00000058629; ENSMUSG00000044674.
    GeneIDi14362.
    KEGGimmu:14362.
    UCSCiuc008wig.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054623 mRNA. Translation: AAC12873.2 .
    AK143101 mRNA. Translation: BAE25269.1 .
    CH466600 Genomic DNA. Translation: EDL14633.1 .
    BC053010 mRNA. Translation: AAH53010.1 .
    AF005202 mRNA. Translation: AAC01952.1 .
    CCDSi CCDS19072.1.
    RefSeqi NP_067432.2. NM_021457.3.
    UniGenei Mm.246003.

    3D structure databases

    ProteinModelPortali O70421.
    SMRi O70421. Positions 111-217, 291-633.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199775. 3 interactions.
    IntActi O70421. 4 interactions.
    MINTi MINT-1779162.
    STRINGi 10090.ENSMUSP00000058629.

    Chemistry

    GuidetoPHARMACOLOGYi 229.

    Protein family/group databases

    MEROPSi I93.001.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei O70421.

    Proteomic databases

    PRIDEi O70421.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054294 ; ENSMUSP00000058629 ; ENSMUSG00000044674 .
    GeneIDi 14362.
    KEGGi mmu:14362.
    UCSCi uc008wig.2. mouse.

    Organism-specific databases

    CTDi 8321.
    MGIi MGI:1196625. Fzd1.

    Phylogenomic databases

    eggNOGi NOG257258.
    GeneTreei ENSGT00740000114899.
    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    InParanoidi Q7TS82.
    KOi K02432.
    OMAi HGAGELC.
    OrthoDBi EOG7M3J01.
    TreeFami TF317907.

    Enzyme and pathway databases

    Reactomei REACT_207044. TCF dependent signaling in response to WNT.
    REACT_214043. PCP/CE pathway.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Miscellaneous databases

    NextBioi 285827.
    PROi O70421.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70421.
    CleanExi MM_FZD1.
    Genevestigatori O70421.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026548. FZD1.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF81. PTHR11309:SF81. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of frizzled genes in mouse costochondral chondrocytes."
      Xu L., Tan L., Goldring M.B., Olsen B.R., Li Y.
      Matrix Biol. 20:147-151(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Embryo.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. Johnson M.A., Greenberg N.M.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-376.
      Tissue: Prostate.

    Entry informationi

    Entry nameiFZD1_MOUSE
    AccessioniPrimary (citable) accession number: O70421
    Secondary accession number(s): O08974, Q7TS82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3