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Protein

RING finger protein 112

Gene

Rnf112

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 9842RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: InterPro
  • zinc ion binding Source: RGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 112
Alternative name(s):
Brain finger protein
Zinc finger protein 179
Gene namesi
Name:Rnf112
Synonyms:Bfp, Zfp179, Znf179
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3986. Rnf112.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei547 – 56721HelicalSequence analysisAdd
BLAST
Transmembranei580 – 60021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631RING finger protein 112PRO_0000056302Add
BLAST

Proteomic databases

PaxDbiO70418.
PRIDEiO70418.

PTM databases

PhosphoSiteiO70418.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiENSRNOG00000002364.
ExpressionAtlasiO70418. baseline and differential.
GenevisibleiO70418. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003228.

Structurei

3D structure databases

ProteinModelPortaliO70418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 397232GB1/RHD3-type GAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 9842RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
KOG2177. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000139175.
HOVERGENiHBG056662.
InParanoidiO70418.
OrthoDBiEOG091G0GYC.
PhylomeDBiO70418.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPVLSVTA FCHRLGKRES KRSFMGNSSN SWSHASFPKL ELGLGQRPSP
60 70 80 90 100
PRESPTCSIC LERLREPISL DCGHDFCIRC FSTHRIPGCE LPCCPECRKI
110 120 130 140 150
CKQKKGLRSL GERMKLLPQR PLPPALQETC AVRAERLLLV RINASGGLIL
160 170 180 190 200
RMGAINRCLK HPLARDTPVC LLAVLGEQHS GKSFLLDHLL RGLPGLESGD
210 220 230 240 250
STRPRAEGSL PGIRWGANGL TRGIWMWSHP FLLGKEGKKV AVFLVDTGDV
260 270 280 290 300
MSPELSRETR VKLCALTMML SSYQILNTSQ ELKDTDLGYL EMFVHVAEVM
310 320 330 340 350
GKHYGMVPIQ HLDLLVRDSS HHNKSGQGHV GDILQKLSGK YPKVQELLLG
360 370 380 390 400
KRARCYLLPA PERQWVNKGQ ASPGGNTEDD FSHHFRAYIS DVLSTAPQHA
410 420 430 440 450
KSRCQGYWSE GRAMARGDRR LLTGQQLAQE IKNLSGWMGK SGPSFSSPDE
460 470 480 490 500
MAAQLHDLRK VEAAKKEFEE YVRQQDIATK RIFSALRVLP DTMRNLLSTQ
510 520 530 540 550
KDAILARHGV ALLCKEREQT LEALEAELQA EAKAFMDSYT MRFCGHLAAV
560 570 580 590 600
GGAVGAGLMG LAGGVVGAGM AAAALAAEAG MVAAGAAVGA TGAAVVGGGV
610 620 630
GAGLAATVGC MEKEEDERVQ GGDREPLLQE E
Length:631
Mass (Da):68,646
Last modified:August 1, 1998 - v1
Checksum:i6C997B8890CAB564
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054586 mRNA. Translation: AAC08583.1.
PIRiJC5803.
RefSeqiNP_619516.1. NM_138613.1.
UniGeneiRn.7544.

Genome annotation databases

EnsembliENSRNOT00000085011; ENSRNOP00000075698; ENSRNOG00000002364.
GeneIDi24916.
KEGGirno:24916.
UCSCiRGD:3986. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054586 mRNA. Translation: AAC08583.1.
PIRiJC5803.
RefSeqiNP_619516.1. NM_138613.1.
UniGeneiRn.7544.

3D structure databases

ProteinModelPortaliO70418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003228.

PTM databases

PhosphoSiteiO70418.

Proteomic databases

PaxDbiO70418.
PRIDEiO70418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085011; ENSRNOP00000075698; ENSRNOG00000002364.
GeneIDi24916.
KEGGirno:24916.
UCSCiRGD:3986. rat.

Organism-specific databases

CTDi7732.
RGDi3986. Rnf112.

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
KOG2177. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000139175.
HOVERGENiHBG056662.
InParanoidiO70418.
OrthoDBiEOG091G0GYC.
PhylomeDBiO70418.

Miscellaneous databases

PROiO70418.

Gene expression databases

BgeeiENSRNOG00000002364.
ExpressionAtlasiO70418. baseline and differential.
GenevisibleiO70418. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN112_RAT
AccessioniPrimary (citable) accession number: O70418
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.