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Protein

Vomeronasal type-2 receptor 1

Gene

Vmn2r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-2 receptor 1
Alternative name(s):
Putative pheromone receptor V2R1
V2Rx
Gene namesi
Name:Vmn2r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3645892. Vmn2r1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 623ExtracellularSequence analysisAdd BLAST602
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Topological domaini645 – 657CytoplasmicSequence analysisAdd BLAST13
Transmembranei658 – 678HelicalSequence analysisAdd BLAST21
Topological domaini679 – 691ExtracellularSequence analysisAdd BLAST13
Transmembranei692 – 712HelicalSequence analysisAdd BLAST21
Topological domaini713 – 732CytoplasmicSequence analysisAdd BLAST20
Transmembranei733 – 753HelicalSequence analysisAdd BLAST21
Topological domaini754 – 778ExtracellularSequence analysisAdd BLAST25
Transmembranei779 – 799HelicalSequence analysisAdd BLAST21
Topological domaini800 – 812CytoplasmicSequence analysisAdd BLAST13
Transmembranei813 – 833HelicalSequence analysisAdd BLAST21
Topological domaini834 – 840ExtracellularSequence analysis7
Transmembranei841 – 861HelicalSequence analysisAdd BLAST21
Topological domaini862 – 912CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • cell cortex Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000024612622 – 912Vomeronasal type-2 receptor 1Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO70410.
PRIDEiO70410.

PTM databases

PhosphoSitePlusiO70410.

Expressioni

Tissue specificityi

Expressed at the sensory surface of the vomeronasal organ.1 Publication

Gene expression databases

CleanExiMM_VMN2R1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029406.

Structurei

3D structure databases

ProteinModelPortaliO70410.
SMRiO70410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
HOGENOMiHOG000232092.
HOVERGENiHBG052876.
InParanoidiO70410.
KOiK04613.
PhylomeDBiO70410.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRQISLAL GFLAFLWAVL GAQNKTEEVQ CRLMAKFNLS GYVDAKNHSL
60 70 80 90 100
VIAGLFPIHS RIIPVDEAIL EPVSPMCEGF NFRGFRWMKT MIHTIKEINE
110 120 130 140 150
RKDILPNHTL GYQIFDSCYT ISKAMESSLV FLTGQEEFKP NFRNSTGSTL
160 170 180 190 200
AALVGSGGSS LSVAASRILG LYYMPQVGYT SSCSILSDKF QFPSYLRVLP
210 220 230 240 250
SDNLQSEAIV NLIKHFGWVW VGAIAADDDY GKYGVKTFKE KMESANLCVA
260 270 280 290 300
FSETIPKVYS NEKMQKAVKA VKTSTAKVIV LYTSDIDLSL FVLEMIHHNI
310 320 330 340 350
TDRTWIATEA WITSALIAKP EYFPYFGGTI GFATPRSVIP GLKEFLYDVH
360 370 380 390 400
PNKDPNDVLT IEFWQTAFNC TWPNSSVPYN VDHRVNMTGK EDRLYDMSDQ
410 420 430 440 450
LCTGEEKLED LKNTYLDTSQ LRITKQCKQA VYAIAHGLDH LSRCQEGQGP
460 470 480 490 500
FGSNQQCAYI PTFDFWQLMY YMKEIKFKSH EDKWVILDDN GDLKNGHYDV
510 520 530 540 550
LNWHLDDEGE ISFVTVGRFN FRSTNFELVI PTNSTIFWNT ESSRRPDSFC
560 570 580 590 600
TQVCPPGTRK GIRQGQPICC FDCIPCADGY VSEKSGQREC DPCGEDDWSN
610 620 630 640 650
AGKSKCVPKL VEFLAYGEAL GFTLVILSIF GALVVLAVTV VYVIHRHTPL
660 670 680 690 700
VKANDRELSF LIQMSLVITV LSSLLFIGKP CNWSCMARQI TLALGFCLCL
710 720 730 740 750
SSILGKTISL FFAYRISVSK TRLISMHPIF RKLIVLVCVV GEIGVCAAYL
760 770 780 790 800
VLEPPRMFKN IEIQNVKIIF ECNEGSVEFL CSIFGFDVLR ALLCFLTTFV
810 820 830 840 850
ARQLPDNYYE GKCITFGMLV FFIVWISFVP AYLSTKGKFK VAVEIFAILA
860 870 880 890 900
SSYGLLGCLF LPKCFIILLR PKRNTDETVG GRVPTVDRSI QLTSASVSSE
910
LNSTTVSTVL DE
Length:912
Mass (Da):102,349
Last modified:August 1, 1998 - v1
Checksum:i2C54FAB6DFBFA48D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 17FLAFLW → AEAAEH in BAF02665 (Ref. 2) Curated6
Sequence conflicti12 – 17FLAFLW → AEAAEH (Ref. 3) Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053986 mRNA. Translation: AAC08413.1.
AB267725 mRNA. Translation: BAF02665.1.
CCDSiCCDS17384.1.
RefSeqiNP_064302.2. NM_019918.2.
UniGeneiMm.57069.

Genome annotation databases

GeneIDi56544.
KEGGimmu:56544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053986 mRNA. Translation: AAC08413.1.
AB267725 mRNA. Translation: BAF02665.1.
CCDSiCCDS17384.1.
RefSeqiNP_064302.2. NM_019918.2.
UniGeneiMm.57069.

3D structure databases

ProteinModelPortaliO70410.
SMRiO70410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029406.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO70410.

Proteomic databases

PaxDbiO70410.
PRIDEiO70410.

Protocols and materials databases

DNASUi56544.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56544.
KEGGimmu:56544.

Organism-specific databases

CTDi56544.
MGIiMGI:3645892. Vmn2r1.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
HOGENOMiHOG000232092.
HOVERGENiHBG052876.
InParanoidiO70410.
KOiK04613.
PhylomeDBiO70410.

Miscellaneous databases

PROiO70410.
SOURCEiSearch...

Gene expression databases

CleanExiMM_VMN2R1.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV2R1_MOUSE
AccessioniPrimary (citable) accession number: O70410
Secondary accession number(s): Q0WXF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The variant protein sequence (Ref. 3) is capable of binding the sex pheromone, 2-octanamine (2-1, methyl heptyl) via aa 11-17.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.