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Protein

Vomeronasal type-2 receptor 1

Gene

Vmn2r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-2 receptor 1
Alternative name(s):
Putative pheromone receptor V2R1
V2Rx
Gene namesi
Name:Vmn2r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3645892. Vmn2r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 623602ExtracellularSequence analysisAdd
BLAST
Transmembranei624 – 64421HelicalSequence analysisAdd
BLAST
Topological domaini645 – 65713CytoplasmicSequence analysisAdd
BLAST
Transmembranei658 – 67821HelicalSequence analysisAdd
BLAST
Topological domaini679 – 69113ExtracellularSequence analysisAdd
BLAST
Transmembranei692 – 71221HelicalSequence analysisAdd
BLAST
Topological domaini713 – 73220CytoplasmicSequence analysisAdd
BLAST
Transmembranei733 – 75321HelicalSequence analysisAdd
BLAST
Topological domaini754 – 77825ExtracellularSequence analysisAdd
BLAST
Transmembranei779 – 79921HelicalSequence analysisAdd
BLAST
Topological domaini800 – 81213CytoplasmicSequence analysisAdd
BLAST
Transmembranei813 – 83321HelicalSequence analysisAdd
BLAST
Topological domaini834 – 8407ExtracellularSequence analysis
Transmembranei841 – 86121HelicalSequence analysisAdd
BLAST
Topological domaini862 – 91251CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell cortex Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 912891Vomeronasal type-2 receptor 1PRO_0000246126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO70410.
PRIDEiO70410.

PTM databases

PhosphoSiteiO70410.

Expressioni

Tissue specificityi

Expressed at the sensory surface of the vomeronasal organ.1 Publication

Gene expression databases

CleanExiMM_VMN2R1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029406.

Structurei

3D structure databases

ProteinModelPortaliO70410.
SMRiO70410. Positions 50-509, 611-874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
HOGENOMiHOG000232092.
HOVERGENiHBG052876.
InParanoidiO70410.
KOiK04613.
PhylomeDBiO70410.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRQISLAL GFLAFLWAVL GAQNKTEEVQ CRLMAKFNLS GYVDAKNHSL
60 70 80 90 100
VIAGLFPIHS RIIPVDEAIL EPVSPMCEGF NFRGFRWMKT MIHTIKEINE
110 120 130 140 150
RKDILPNHTL GYQIFDSCYT ISKAMESSLV FLTGQEEFKP NFRNSTGSTL
160 170 180 190 200
AALVGSGGSS LSVAASRILG LYYMPQVGYT SSCSILSDKF QFPSYLRVLP
210 220 230 240 250
SDNLQSEAIV NLIKHFGWVW VGAIAADDDY GKYGVKTFKE KMESANLCVA
260 270 280 290 300
FSETIPKVYS NEKMQKAVKA VKTSTAKVIV LYTSDIDLSL FVLEMIHHNI
310 320 330 340 350
TDRTWIATEA WITSALIAKP EYFPYFGGTI GFATPRSVIP GLKEFLYDVH
360 370 380 390 400
PNKDPNDVLT IEFWQTAFNC TWPNSSVPYN VDHRVNMTGK EDRLYDMSDQ
410 420 430 440 450
LCTGEEKLED LKNTYLDTSQ LRITKQCKQA VYAIAHGLDH LSRCQEGQGP
460 470 480 490 500
FGSNQQCAYI PTFDFWQLMY YMKEIKFKSH EDKWVILDDN GDLKNGHYDV
510 520 530 540 550
LNWHLDDEGE ISFVTVGRFN FRSTNFELVI PTNSTIFWNT ESSRRPDSFC
560 570 580 590 600
TQVCPPGTRK GIRQGQPICC FDCIPCADGY VSEKSGQREC DPCGEDDWSN
610 620 630 640 650
AGKSKCVPKL VEFLAYGEAL GFTLVILSIF GALVVLAVTV VYVIHRHTPL
660 670 680 690 700
VKANDRELSF LIQMSLVITV LSSLLFIGKP CNWSCMARQI TLALGFCLCL
710 720 730 740 750
SSILGKTISL FFAYRISVSK TRLISMHPIF RKLIVLVCVV GEIGVCAAYL
760 770 780 790 800
VLEPPRMFKN IEIQNVKIIF ECNEGSVEFL CSIFGFDVLR ALLCFLTTFV
810 820 830 840 850
ARQLPDNYYE GKCITFGMLV FFIVWISFVP AYLSTKGKFK VAVEIFAILA
860 870 880 890 900
SSYGLLGCLF LPKCFIILLR PKRNTDETVG GRVPTVDRSI QLTSASVSSE
910
LNSTTVSTVL DE
Length:912
Mass (Da):102,349
Last modified:August 1, 1998 - v1
Checksum:i2C54FAB6DFBFA48D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 176FLAFLW → AEAAEH in BAF02665 (Ref. 2) Curated
Sequence conflicti12 – 176FLAFLW → AEAAEH (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053986 mRNA. Translation: AAC08413.1.
AB267725 mRNA. Translation: BAF02665.1.
CCDSiCCDS17384.1.
RefSeqiNP_064302.2. NM_019918.2.
UniGeneiMm.57069.

Genome annotation databases

GeneIDi56544.
KEGGimmu:56544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053986 mRNA. Translation: AAC08413.1.
AB267725 mRNA. Translation: BAF02665.1.
CCDSiCCDS17384.1.
RefSeqiNP_064302.2. NM_019918.2.
UniGeneiMm.57069.

3D structure databases

ProteinModelPortaliO70410.
SMRiO70410. Positions 50-509, 611-874.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029406.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO70410.

Proteomic databases

PaxDbiO70410.
PRIDEiO70410.

Protocols and materials databases

DNASUi56544.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56544.
KEGGimmu:56544.

Organism-specific databases

CTDi56544.
MGIiMGI:3645892. Vmn2r1.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
HOGENOMiHOG000232092.
HOVERGENiHBG052876.
InParanoidiO70410.
KOiK04613.
PhylomeDBiO70410.

Miscellaneous databases

PROiO70410.
SOURCEiSearch...

Gene expression databases

CleanExiMM_VMN2R1.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A new multigene family of putative pheromone receptors."
    Ryba N.J.P., Tirindelli R.
    Neuron 19:371-379(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Vomeronasal sensory neuron.
  2. "Molecular cloning and characterisation of mouse V2Rx pheromone receptor."
    Kannan S., Krishnan M.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Kannan S.
    Submitted (MAY-2006) to UniProtKB
    Cited for: PARTIAL PROTEIN SEQUENCE, BINDING TO SEX PHEROMONE.
  4. "Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ."
    Martini S., Silvotti L., Shirazi A., Ryba N.J.P., Tirindelli R.
    J. Neurosci. 21:843-848(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiV2R1_MOUSE
AccessioniPrimary (citable) accession number: O70410
Secondary accession number(s): Q0WXF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The variant protein sequence (Ref. 3) is capable of binding the sex pheromone, 2-octanamine (2-1, methyl heptyl) via aa 11-17.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.