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Protein

PDZ and LIM domain protein 1

Gene

Pdlim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Zinc 1By similarity
Metal bindingi261 – 2611Zinc 1By similarity
Metal bindingi278 – 2781Zinc 1By similarity
Metal bindingi281 – 2811Zinc 1By similarity
Metal bindingi284 – 2841Zinc 2By similarity
Metal bindingi287 – 2871Zinc 2By similarity
Metal bindingi305 – 3051Zinc 2By similarity
Metal bindingi308 – 3081Zinc 2By similarity

GO - Molecular functioni

  • transcription coactivator activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • regulation of transcription, DNA-templated Source: MGI
  • response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 1
Alternative name(s):
C-terminal LIM domain protein 1
Elfin
LIM domain protein CLP-36
Gene namesi
Name:Pdlim1
Synonyms:Clim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1860611. Pdlim1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • focal adhesion Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 327326PDZ and LIM domain protein 1PRO_0000075860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei90 – 901PhosphoserineCombined sources
Modified residuei130 – 1301PhosphoserineCombined sources
Modified residuei142 – 1421PhosphotyrosineBy similarity
Modified residuei314 – 3141PhosphothreonineBy similarity
Modified residuei319 – 3191PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70400.
MaxQBiO70400.
PaxDbiO70400.
PeptideAtlasiO70400.
PRIDEiO70400.

PTM databases

iPTMnetiO70400.
PhosphoSiteiO70400.
SwissPalmiO70400.

Expressioni

Tissue specificityi

Expressed in heart, lung, spleen, testis and skeletal muscle.1 Publication

Developmental stagei

Detected throughout the developing heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000055044.
CleanExiMM_PDLIM1.
ExpressionAtlasiO70400. baseline and differential.
GenevisibleiO70400. MM.

Interactioni

Subunit structurei

Interacts with alpha-actinins 1, 2 and 4.By similarity

Protein-protein interaction databases

BioGridi207571. 1 interaction.
IntActiO70400. 2 interactions.
MINTiMINT-1869633.
STRINGi10090.ENSMUSP00000064545.

Structurei

3D structure databases

ProteinModelPortaliO70400.
SMRiO70400. Positions 1-87, 249-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8583PDZPROSITE-ProRule annotationAdd
BLAST
Domaini256 – 31560LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
GeneTreeiENSGT00590000082980.
HOGENOMiHOG000290704.
HOVERGENiHBG061371.
InParanoidiO70400.
OMAiATANLCI.
OrthoDBiEOG091G0A6C.
PhylomeDBiO70400.
TreeFamiTF106408.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR031847. DUF4749.
IPR001478. PDZ.
IPR006643. ZASP.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF15936. DUF4749. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
SM00735. ZM. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQQIVLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA IANLCIGDLI
60 70 80 90 100
TAIDGEDTSS MTHLEAQNKI KGCADNMTLT VSRSEQKIWS PLVTEEGKRH
110 120 130 140 150
PYKMNLASEP QEVLHIGSAH NRSAMPFTAS PAPSTRVITN QYNSPTGLYS
160 170 180 190 200
SENISNFNNA VESKTSASGE EANSRPVVQP HPSGSLIIDK DSEVYKMLQE
210 220 230 240 250
KQELNEPPKQ STSFLVLQEI LESDGKGDPN KPSGFRSVKA PVTKVAASVG
260 270 280 290 300
NAQKLPICDK CGTGIVGVFV KLRDHHRHPE CYVCTDCGIN LKQKGHFFVE
310 320
DQIYCEKHAR ERVTPPEGYD VVTVFRE
Length:327
Mass (Da):35,774
Last modified:January 23, 2007 - v4
Checksum:i8A5EDA47F2E90C03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211Missing in AAC08436 (PubMed:11596114).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053367 mRNA. Translation: AAC08436.1.
AK076285 mRNA. Translation: BAC36288.1.
AK088089 mRNA. Translation: BAC40138.1.
AK146225 mRNA. Translation: BAE26993.1.
BC004809 mRNA. Translation: AAH04809.1.
CCDSiCCDS37977.1.
RefSeqiNP_058557.2. NM_016861.4.
UniGeneiMm.5567.

Genome annotation databases

EnsembliENSMUST00000068439; ENSMUSP00000064545; ENSMUSG00000055044.
GeneIDi54132.
KEGGimmu:54132.
UCSCiuc008hkk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053367 mRNA. Translation: AAC08436.1.
AK076285 mRNA. Translation: BAC36288.1.
AK088089 mRNA. Translation: BAC40138.1.
AK146225 mRNA. Translation: BAE26993.1.
BC004809 mRNA. Translation: AAH04809.1.
CCDSiCCDS37977.1.
RefSeqiNP_058557.2. NM_016861.4.
UniGeneiMm.5567.

3D structure databases

ProteinModelPortaliO70400.
SMRiO70400. Positions 1-87, 249-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207571. 1 interaction.
IntActiO70400. 2 interactions.
MINTiMINT-1869633.
STRINGi10090.ENSMUSP00000064545.

PTM databases

iPTMnetiO70400.
PhosphoSiteiO70400.
SwissPalmiO70400.

Proteomic databases

EPDiO70400.
MaxQBiO70400.
PaxDbiO70400.
PeptideAtlasiO70400.
PRIDEiO70400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068439; ENSMUSP00000064545; ENSMUSG00000055044.
GeneIDi54132.
KEGGimmu:54132.
UCSCiuc008hkk.2. mouse.

Organism-specific databases

CTDi9124.
MGIiMGI:1860611. Pdlim1.

Phylogenomic databases

eggNOGiKOG1703. Eukaryota.
ENOG410XRD4. LUCA.
GeneTreeiENSGT00590000082980.
HOGENOMiHOG000290704.
HOVERGENiHBG061371.
InParanoidiO70400.
OMAiATANLCI.
OrthoDBiEOG091G0A6C.
PhylomeDBiO70400.
TreeFamiTF106408.

Miscellaneous databases

PROiO70400.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055044.
CleanExiMM_PDLIM1.
ExpressionAtlasiO70400. baseline and differential.
GenevisibleiO70400. MM.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR031847. DUF4749.
IPR001478. PDZ.
IPR006643. ZASP.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF15936. DUF4749. 1 hit.
PF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
SM00735. ZM. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDLI1_MOUSE
AccessioniPrimary (citable) accession number: O70400
Secondary accession number(s): Q99K93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.