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O70400 (PDLI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PDZ and LIM domain protein 1
Alternative name(s):
C-terminal LIM domain protein 1
Elfin
LIM domain protein CLP-36
Gene names
Name:Pdlim1
Synonyms:Clim1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton By similarity.

Subunit structure

Interacts with alpha-actinins 1, 2 and 4 By similarity.

Subcellular location

Cytoplasmcytoskeleton. Note: Associates with the actin stress fibers. Ref.1

Tissue specificity

Expressed in heart, lung, spleen, testis and skeletal muscle. Ref.1

Developmental stage

Detected throughout the developing heart. Ref.1

Sequence similarities

Contains 1 LIM zinc-binding domain.

Contains 1 PDZ (DHR) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 327326PDZ and LIM domain protein 1
PRO_0000075860

Regions

Domain3 – 8583PDZ
Domain256 – 31560LIM zinc-binding

Sites

Metal binding2581Zinc 1 By similarity
Metal binding2611Zinc 1 By similarity
Metal binding2781Zinc 1 By similarity
Metal binding2811Zinc 1 By similarity
Metal binding2841Zinc 2 By similarity
Metal binding2871Zinc 2 By similarity
Metal binding3051Zinc 2 By similarity
Metal binding3081Zinc 2 By similarity

Amino acid modifications

Modified residue21N-acetylthreonine By similarity
Modified residue901Phosphoserine By similarity
Modified residue1301Phosphoserine By similarity
Modified residue1421Phosphotyrosine By similarity
Modified residue3191Phosphotyrosine By similarity

Experimental info

Sequence conflict211Missing in AAC08436. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O70400 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 8A5EDA47F2E90C03

FASTA32735,774
        10         20         30         40         50         60 
MTTQQIVLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA IANLCIGDLI TAIDGEDTSS 

        70         80         90        100        110        120 
MTHLEAQNKI KGCADNMTLT VSRSEQKIWS PLVTEEGKRH PYKMNLASEP QEVLHIGSAH 

       130        140        150        160        170        180 
NRSAMPFTAS PAPSTRVITN QYNSPTGLYS SENISNFNNA VESKTSASGE EANSRPVVQP 

       190        200        210        220        230        240 
HPSGSLIIDK DSEVYKMLQE KQELNEPPKQ STSFLVLQEI LESDGKGDPN KPSGFRSVKA 

       250        260        270        280        290        300 
PVTKVAASVG NAQKLPICDK CGTGIVGVFV KLRDHHRHPE CYVCTDCGIN LKQKGHFFVE 

       310        320 
DQIYCEKHAR ERVTPPEGYD VVTVFRE 

« Hide

References

« Hide 'large scale' references
[1]"Elfin is expressed during early heart development."
Kotaka M., Lau Y.-M., Cheung K.-K., Lee S.M.Y., Li H.-Y., Chan W.-Y., Fung K.-P., Lee C.-Y., Waye M.M.Y., Tsui S.K.W.
J. Cell. Biochem. 83:463-472(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c, C57BL/6J and NOD.
Tissue: Skin and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF053367 mRNA. Translation: AAC08436.1.
AK076285 mRNA. Translation: BAC36288.1.
AK088089 mRNA. Translation: BAC40138.1.
AK146225 mRNA. Translation: BAE26993.1.
BC004809 mRNA. Translation: AAH04809.1.
RefSeqNP_058557.2. NM_016861.4.
UniGeneMm.5567.

3D structure databases

ProteinModelPortalO70400.
SMRO70400. Positions 1-87, 249-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO70400. 2 interactions.
MINTMINT-1869633.

PTM databases

PhosphoSiteO70400.

Proteomic databases

PaxDbO70400.
PRIDEO70400.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068439; ENSMUSP00000064545; ENSMUSG00000055044.
GeneID54132.
KEGGmmu:54132.
UCSCuc008hkk.2. mouse.

Organism-specific databases

CTD9124.
MGIMGI:1860611. Pdlim1.

Phylogenomic databases

eggNOGNOG250485.
GeneTreeENSGT00590000082980.
HOGENOMHOG000290704.
HOVERGENHBG061371.
InParanoidO70400.
OMANLCIGDI.
OrthoDBEOG77DJ69.
PhylomeDBO70400.
TreeFamTF106408.

Gene expression databases

BgeeO70400.
CleanExMM_PDLIM1.
GenevestigatorO70400.

Family and domain databases

Gene3D2.10.110.10. 1 hit.
2.30.42.10. 1 hit.
InterProIPR028537. PDLIM1.
IPR001478. PDZ.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERPTHR24214:SF11. PTHR24214:SF11. 1 hit.
PfamPF00412. LIM. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310941.
PROO70400.
SOURCESearch...

Entry information

Entry namePDLI1_MOUSE
AccessionPrimary (citable) accession number: O70400
Secondary accession number(s): Q99K93
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot