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O70394

- I27RA_MOUSE

UniProt

O70394 - I27RA_MOUSE

Protein

Interleukin-27 receptor subunit alpha

Gene

Il27ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

    GO - Molecular functioni

    1. interleukin-27 receptor activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. defense response to Gram-positive bacterium Source: MGI
    2. interleukin-27-mediated signaling pathway Source: GOC
    3. negative regulation of type 2 immune response Source: MGI
    4. positive regulation of interferon-gamma production Source: MGI
    5. positive regulation of T-helper 1 type immune response Source: MGI
    6. regulation of isotype switching to IgG isotypes Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-27 receptor subunit alpha
    Short name:
    IL-27 receptor subunit alpha
    Short name:
    IL-27R subunit alpha
    Short name:
    IL-27R-alpha
    Short name:
    IL-27RA
    Alternative name(s):
    Type I T-cell cytokine receptor
    Short name:
    TCCR
    WSX-1
    Gene namesi
    Name:Il27ra
    Synonyms:Tccr, Wsx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1355318. Il27ra.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 623599Interleukin-27 receptor subunit alphaPRO_0000010877Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO70394.

    PTM databases

    PhosphoSiteiO70394.

    Expressioni

    Tissue specificityi

    Expressed in CD4+ and CD8+ T-cells, B-cells, natural killer cells and macrophages. Highest levels in CD4+ T-cells and natural killer cells. Expression highest in Th0 cells.1 Publication

    Inductioni

    Down-regulated on differentiation of CD4+ T-cells in both Th1 and TH2 cells.

    Gene expression databases

    BgeeiO70394.
    CleanExiMM_IL27RA.
    GenevestigatoriO70394.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000005601.

    Structurei

    3D structure databases

    ProteinModelPortaliO70394.
    SMRiO70394. Positions 120-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 510486ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini532 – 62392CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei511 – 53121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 12495Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini125 – 225101Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini316 – 41297Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini413 – 50593Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi211 – 2155WSXWS motif
    Motifi552 – 5609Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44355.
    GeneTreeiENSGT00700000104610.
    HOGENOMiHOG000036880.
    HOVERGENiHBG052068.
    InParanoidiO70394.
    OMAiPCELWVT.
    OrthoDBiEOG7SBNND.
    TreeFamiTF338122.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O70394-1 [UniParc]FASTAAdd to Basket

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    MNRLRVARLT PLELLLSLMS LLLGTRPHGS PGPLQCYSVG PLGILNCSWE    50
    PLGDLETPPV LYHQSQKYHP NRVWEVKVPS KQSWVTIPRE QFTMADKLLI 100
    WGTQKGRPLW SSVSVNLETQ MKPDTPQIFS QVDISEEATL EATVQWAPPV 150
    WPPQKVLICQ FRYKECQAET WTRLEPQLKT DGLTPVEMQN LEPGTCYQVS 200
    GRCQVENGYP WGEWSSPLSF QTPFLDPEDV WVSGTVCETS GKRAALLVWK 250
    DPRPCVQVTY TVWFGAGDIT TTQEEVPCCK SPVPAWMEWA VVSPGNSTSW 300
    VPPTNLSLVC LAPESAPCDV GVSSADGSPG IKVTWKQGTR KPLEYVVDWA 350
    QDGDSLDKLN WTRLPPGNLS TLLPGEFKGG VPYRITVTAV YSGGLAAAPS 400
    VWGFREELVP LAGPAVWRLP DDPPGTPVVA WGEVPRHQLR GQATHYTFCI 450
    QSRGLSTVCR NVSSQTQTAT LPNLHLGSFK LWVTVSTVAG QGPPGPNLSL 500
    HLPDNRIRWK ALPWFLSLWG LLLMGCGLSL ASTRCLQARC LHWRHKLLPQ 550
    WIWERVPDPA NSNSGQPYIK EVSLPQPPKD GPILEVEEVE LQPVVESPKA 600
    SAPIYSGYEK HFLPTPEELG LLV 623
    Length:623
    Mass (Da):69,093
    Last modified:July 27, 2011 - v2
    Checksum:iD683D282480242F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1583VLI → ALT in AAC40121. (PubMed:9600072)Curated
    Sequence conflicti156 – 1583VLI → ALT in AAG27298. (PubMed:11057672)Curated
    Sequence conflicti156 – 1583VLI → ALT in AAH32878. (PubMed:15489334)Curated
    Sequence conflicti170 – 1701T → A in AAC40121. (PubMed:9600072)Curated
    Sequence conflicti170 – 1701T → A in AAG27298. (PubMed:11057672)Curated
    Sequence conflicti170 – 1701T → A in AAH32878. (PubMed:15489334)Curated
    Sequence conflicti476 – 4761L → S in AAC40121. (PubMed:9600072)Curated
    Sequence conflicti476 – 4761L → S in AAG27298. (PubMed:11057672)Curated
    Sequence conflicti476 – 4761L → S in AAH32878. (PubMed:15489334)Curated
    Sequence conflicti497 – 4971N → D in AAC40121. (PubMed:9600072)Curated
    Sequence conflicti497 – 4971N → D in AAG27298. (PubMed:11057672)Curated
    Sequence conflicti497 – 4971N → D in AAH32878. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053005 mRNA. Translation: AAC40121.1.
    AF265243 mRNA. Translation: AAG27298.1.
    AC156028 Genomic DNA. No translation available.
    BC032878 mRNA. Translation: AAH32878.1.
    CCDSiCCDS22465.1.
    RefSeqiNP_057880.2. NM_016671.3.
    UniGeneiMm.38386.

    Genome annotation databases

    EnsembliENSMUST00000005601; ENSMUSP00000005601; ENSMUSG00000005465.
    GeneIDi50931.
    KEGGimmu:50931.
    UCSCiuc009mlr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053005 mRNA. Translation: AAC40121.1 .
    AF265243 mRNA. Translation: AAG27298.1 .
    AC156028 Genomic DNA. No translation available.
    BC032878 mRNA. Translation: AAH32878.1 .
    CCDSi CCDS22465.1.
    RefSeqi NP_057880.2. NM_016671.3.
    UniGenei Mm.38386.

    3D structure databases

    ProteinModelPortali O70394.
    SMRi O70394. Positions 120-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000005601.

    PTM databases

    PhosphoSitei O70394.

    Proteomic databases

    PRIDEi O70394.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005601 ; ENSMUSP00000005601 ; ENSMUSG00000005465 .
    GeneIDi 50931.
    KEGGi mmu:50931.
    UCSCi uc009mlr.2. mouse.

    Organism-specific databases

    CTDi 9466.
    MGIi MGI:1355318. Il27ra.

    Phylogenomic databases

    eggNOGi NOG44355.
    GeneTreei ENSGT00700000104610.
    HOGENOMi HOG000036880.
    HOVERGENi HBG052068.
    InParanoidi O70394.
    OMAi PCELWVT.
    OrthoDBi EOG7SBNND.
    TreeFami TF338122.

    Miscellaneous databases

    NextBioi 307955.
    PROi O70394.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70394.
    CleanExi MM_IL27RA.
    Genevestigatori O70394.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "Development of Th1-type immune responses requires the type I cytokine receptor TCCR."
      Chen Q., Ghilardi N., Wang H., Baker T., Xie M.-H., Gurney A., Grewal I.S., de Sauvage F.J.
      Nature 407:916-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Spleen.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiI27RA_MOUSE
    AccessioniPrimary (citable) accession number: O70394
    Secondary accession number(s): E9QNY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3