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Protein

Synaptosomal-associated protein 23

Gene

Snap23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: FlyBase
  • syntaxin binding Source: RGD

GO - Biological processi

  • exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: SynGO
  • exocytosis Source: RGD
  • histamine secretion by mast cell Source: RGD
  • membrane fusion Source: RGD
  • protein complex assembly Source: RGD
  • protein transport Source: RGD
  • regulation of exocytosis Source: RGD
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • synaptic vesicle priming Source: GO_Central
  • vesicle-mediated transport Source: RGD

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 23
Short name:
SNAP-23
Alternative name(s):
Vesicle-membrane fusion protein SNAP-23
Gene namesi
Name:Snap23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620221. Snap23.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136001 – 210Synaptosomal-associated protein 23Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Lipidationi79S-palmitoyl cysteineBy similarity1
Lipidationi80S-palmitoyl cysteineBy similarity1
Lipidationi83S-palmitoyl cysteineBy similarity1
Lipidationi85S-palmitoyl cysteineBy similarity1
Lipidationi87S-palmitoyl cysteineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei160PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiO70377.

PTM databases

iPTMnetiO70377.
PhosphoSitePlusiO70377.

Interactioni

Subunit structurei

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (By similarity). Found in a complex with VAMP8 and STX1A (By similarity). Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (PubMed:14993220). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IkbkbQ9QY782EBI-1573765,EBI-1812464

GO - Molecular functioni

  • SNAP receptor activity Source: FlyBase
  • syntaxin binding Source: RGD

Protein-protein interaction databases

BioGridi249168. 2 interactors.
CORUMiO70377.
IntActiO70377. 7 interactors.
MINTiMINT-96124.

Structurei

3D structure databases

ProteinModelPortaliO70377.
SMRiO70377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 76t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST63
Domaini145 – 207t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 76By similarityAdd BLAST54

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG056971.
InParanoidiO70377.
KOiK08508.
PhylomeDBiO70377.

Family and domain databases

InterProiView protein in InterPro
IPR000928. SNAP-25.
IPR000727. T_SNARE_dom.
PfamiView protein in Pfam
PF00835. SNAP-25. 1 hit.
SMARTiView protein in SMART
SM00397. t_SNARE. 2 hits.
PROSITEiView protein in PROSITE
PS50192. T_SNARE. 2 hits.

Sequencei

Sequence statusi: Complete.

O70377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLSPEEIQ LRAHQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE
60 70 80 90 100
QLNRIEEGMD QINKDMREAE KTLTELNKCC GLCVCPCNRT KNFESGKNYK
110 120 130 140 150
ATWGDGGDSS PSNVVSKQPS RITNGQPQQT TGAASGGYIK RITNDAREDE
160 170 180 190 200
MEENLTQVGS ILGNLKNMAL DMGNEIDAQN QQIQKITEKA DTNKNRIDIA
210
NTRAKKLIDS
Length:210
Mass (Da):23,235
Last modified:August 1, 1998 - v1
Checksum:i0D63E3A6F9FE3BA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052596 mRNA. Translation: AAC06031.1.
BC127494 mRNA. Translation: AAI27495.1.
RefSeqiNP_073180.1. NM_022689.2.
UniGeneiRn.14789.

Genome annotation databases

GeneIDi64630.
KEGGirno:64630.
UCSCiRGD:620221. rat.

Similar proteinsi

Entry informationi

Entry nameiSNP23_RAT
AccessioniPrimary (citable) accession number: O70377
Secondary accession number(s): A0JPL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: August 1, 1998
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families