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Protein
Submitted name:

Calpain isoform Lp85

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain isoform Lp85Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliO70376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 349Calpain catalyticInterPro annotationAdd BLAST300
Domaini537 – 571EF-handInterPro annotationAdd BLAST35
Domaini608 – 634EF-handInterPro annotationAdd BLAST27
Domaini638 – 673EF-handInterPro annotationAdd BLAST36
Domaini703 – 737EF-handInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000232035.
HOVERGENiHBG012645.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029531. CAPN3.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF320. PTHR10183:SF320. 2 hits.
PfamiPF01067. Calpain_III. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLLPGFFC DRVIRERDRR NGEGTVSQPL KFEGQDFVVL KQRCLAQKCL
60 70 80 90 100
FEDRVFPAGT QALGSHELSQ KAKMKAITWK RPKEICENPR FIIGGANRTD
110 120 130 140 150
ICQGDLGDCW FLAAIACLTL NERLLFRVIP HDQSFTENYA GIFHFQFWRY
160 170 180 190 200
GDWVDVVIDD CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK
210 220 230 240 250
GGNTTEAMED FTGGVTEFFE IKDAPSDMYK IMRKAIERGS LMGCSIDTIV
260 270 280 290 300
PVQYETRMAC GLVKGHAYSV TGLEEALFKG EKVKLVRLRN PWGQVEWNGS
310 320 330 340 350
WSDGWKDWSF VDKDEKARLQ HQVTEDGEFW MSYDDFVYHF TKLEICNLTA
360 370 380 390 400
DALESDKLQT WTVSVNEGRW VRGCSAGGCR NFPDTFWTNP QYRLKLLEED
410 420 430 440 450
DDPDDSEVIC SFLVALMQKN RRKDRKLGAN LFTIGFAIYE VPKEMHGNKQ
460 470 480 490 500
HLQKDFFLYN ASKARSKTYI NMREVSQRFR LPPSEYVIVP STYEPHQEGE
510 520 530 540 550
FILRVFSEKR NLSEEAENTI SVDRPVPRPG HTDQESEEQQ QFRNIFRQIA
560 570 580 590 600
GDDMEICADE LKNVLNTVVN KRERLAPDVG DGQGPQLSES SSSPFSIPPD
610 620 630 640 650
KDLKTQGFTL ESCRSMIALM DTDGSGRLNL QEFHHLWKKI KAWQKIFKHY
660 670 680 690 700
DTDHSGTINS YEMRNAVNDA GFHLNSQLYD IITMRYADKH MNIDFDSFIC
710 720 730
CFVRLEGMFR AFHAFDKDGD GIIKLNVLEW LQLTMYA
Length:737
Mass (Da):85,130
Last modified:August 1, 1998 - v1
Checksum:iEE21E55E723B828B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052540 mRNA. Translation: AAC15423.1.
UniGeneiRn.9726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052540 mRNA. Translation: AAC15423.1.
UniGeneiRn.9726.

3D structure databases

ProteinModelPortaliO70376.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000232035.
HOVERGENiHBG012645.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029531. CAPN3.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF320. PTHR10183:SF320. 2 hits.
PfamiPF01067. Calpain_III. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO70376_RAT
AccessioniPrimary (citable) accession number: O70376
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.