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Protein
Submitted name:

Calpain isoform Lp85

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109PROSITE-ProRule annotation1
Active sitei266PROSITE-ProRule annotation1
Active sitei290PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi621 – 632PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi651 – 662PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain isoform Lp85Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Structurei

3D structure databases

ProteinModelPortaliO70376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 349Calpain catalyticInterPro annotationAdd BLAST300
Domaini537 – 571EF-handInterPro annotationAdd BLAST35
Domaini608 – 634EF-handInterPro annotationAdd BLAST27
Domaini638 – 673EF-handInterPro annotationAdd BLAST36
Domaini703 – 737EF-handInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000232035.
HOVERGENiHBG012645.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR036213. Calpain_III_sf.
IPR029531. CAPN3.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF329. PTHR10183:SF329. 3 hits.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

O70376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLLPGFFC DRVIRERDRR NGEGTVSQPL KFEGQDFVVL KQRCLAQKCL
60 70 80 90 100
FEDRVFPAGT QALGSHELSQ KAKMKAITWK RPKEICENPR FIIGGANRTD
110 120 130 140 150
ICQGDLGDCW FLAAIACLTL NERLLFRVIP HDQSFTENYA GIFHFQFWRY
160 170 180 190 200
GDWVDVVIDD CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK
210 220 230 240 250
GGNTTEAMED FTGGVTEFFE IKDAPSDMYK IMRKAIERGS LMGCSIDTIV
260 270 280 290 300
PVQYETRMAC GLVKGHAYSV TGLEEALFKG EKVKLVRLRN PWGQVEWNGS
310 320 330 340 350
WSDGWKDWSF VDKDEKARLQ HQVTEDGEFW MSYDDFVYHF TKLEICNLTA
360 370 380 390 400
DALESDKLQT WTVSVNEGRW VRGCSAGGCR NFPDTFWTNP QYRLKLLEED
410 420 430 440 450
DDPDDSEVIC SFLVALMQKN RRKDRKLGAN LFTIGFAIYE VPKEMHGNKQ
460 470 480 490 500
HLQKDFFLYN ASKARSKTYI NMREVSQRFR LPPSEYVIVP STYEPHQEGE
510 520 530 540 550
FILRVFSEKR NLSEEAENTI SVDRPVPRPG HTDQESEEQQ QFRNIFRQIA
560 570 580 590 600
GDDMEICADE LKNVLNTVVN KRERLAPDVG DGQGPQLSES SSSPFSIPPD
610 620 630 640 650
KDLKTQGFTL ESCRSMIALM DTDGSGRLNL QEFHHLWKKI KAWQKIFKHY
660 670 680 690 700
DTDHSGTINS YEMRNAVNDA GFHLNSQLYD IITMRYADKH MNIDFDSFIC
710 720 730
CFVRLEGMFR AFHAFDKDGD GIIKLNVLEW LQLTMYA
Length:737
Mass (Da):85,130
Last modified:August 1, 1998 - v1
Checksum:iEE21E55E723B828B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052540 mRNA. Translation: AAC15423.1.
UniGeneiRn.9726.

Entry informationi

Entry nameiO70376_RAT
AccessioniPrimary (citable) accession number: O70376
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation