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O70374

- MTG8R_MOUSE

UniProt

O70374 - MTG8R_MOUSE

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Protein

Protein CBFA2T2

Gene
Cbfa2t2, Cbfa2t2h, Mtgr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be a transcriptional corepressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri498 – 53437MYND-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. transcription corepressor activity Source: MGI

GO - Biological processi

  1. epithelial cell differentiation Source: MGI
  2. negative regulation of neuron projection development Source: UniProtKB
  3. negative regulation of transcription, DNA-templated Source: MGI
  4. positive regulation of neuron projection development Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T2
Alternative name(s):
MTG8-like protein
MTG8-related protein 1
Gene namesi
Name:Cbfa2t2
Synonyms:Cbfa2t2h, Mtgr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1333833. Cbfa2t2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Protein CBFA2T2PRO_0000218302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei400 – 4001Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO70374.

PTM databases

PhosphoSiteiO70374.

Expressioni

Gene expression databases

BgeeiO70374.
GenevestigatoriO70374.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with MTG8. Heterodimer with CBFA2T3 By similarity.

Protein-protein interaction databases

IntActiO70374. 1 interaction.
MINTiMINT-2568187.

Structurei

3D structure databases

ProteinModelPortaliO70374.
SMRiO70374. Positions 103-200, 327-383, 420-450, 488-534.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 19996TAFHAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili442 – 48241 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 8853Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CBFA2T family.
Contains 1 TAFH (NHR1) domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri498 – 53437MYND-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG79810.
GeneTreeiENSGT00390000013479.
HOGENOMiHOG000049245.
HOVERGENiHBG000169.
InParanoidiB2RRH8.
OMAiHHRICGQ.
OrthoDBiEOG70W3D2.
PhylomeDBiO70374.
TreeFamiTF106303.

Family and domain databases

InterProiIPR013289. ETO.
IPR013291. MTGR1.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01877. MTGR1PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O70374-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVGVPGAAAF QLGCEKRVPA MPGSPVEVKI QSRSSPPIMP PLPPINPGGP    50
RPVSFTPTAL SNGINHSPPT LNGAPSPPQR FSNGPASSTS SALTNQQLPA 100
TCGARQLSKL KRFLTTLQQF GNDISPEIGE KVRTLVLALV NSTVTIEEFH 150
CKLQEATNFP LRPFVIPFLK ANLPLLQREL LHCARAAKQT PSQYLAQHEH 200
LLLNTSIASP ADSSELLMEV HGNGKRPSPE RRDENNFERD TVPPEPPAKR 250
VCTISPAPRH SPALTVPLMN PGGQFHPTPP PLQHYTLEDI ATSHLYREPN 300
KMLEHREVRE RHHNLSLNGG YQDELVDHRL TEREWADEWK HLDHALNCIM 350
EMVEKTRRSM AVLRRCQESD REELNYWKRR FNENTELRKT GTELVSRQHS 400
PGSTDSLSND SQREFTSRPA TGYVPVEFWK KTEEAVNKVK IQAMSEVQKA 450
VAEAEQKAFE VIATERARME QTIADVKRQA AEDAFLVINE QEESTENCWN 500
CGRKASETCS GCNIARYCGS FCQHKDWERH HRLCGQSLHG HSPHSQSRPL 550
LPGGRGSARS ADCSVPSPAL DKTSATTSRS STPASVTAID ANGL 594
Length:594
Mass (Da):65,904
Last modified:January 15, 2008 - v3
Checksum:iFCE4A6A0AFD66377
GO
Isoform 2 (identifier: O70374-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:574
Mass (Da):63,921
Checksum:i5385BD7F7D8A224E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 2. VSP_030517Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti413 – 4131Missing in BAC30586. 1 Publication
Sequence conflicti413 – 4131Missing in ABB02690. 1 Publication
Sequence conflicti413 – 4131Missing in CAM13556. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049206 mRNA. Translation: BAC33609.1.
AK040403 mRNA. Translation: BAC30586.1.
AK153602 mRNA. Translation: BAE32114.1.
DQ213025 mRNA. Translation: ABB02690.1.
AL772292 Genomic DNA. Translation: CAM13555.1.
AL772292 Genomic DNA. Translation: CAM13556.1.
BC064679 mRNA. Translation: AAH64679.1.
BC138410 mRNA. Translation: AAI38411.1.
BC145679 mRNA. Translation: AAI45680.1.
AF052219 Genomic DNA. Translation: AAC64697.1.
CCDSiCCDS16932.1. [O70374-1]
RefSeqiNP_033953.1. NM_009823.1.
NP_766448.1. NM_172860.2. [O70374-1]
XP_006498703.1. XM_006498640.1. [O70374-2]
UniGeneiMm.29914.

Genome annotation databases

EnsembliENSMUST00000045270; ENSMUSP00000043087; ENSMUSG00000038533. [O70374-1]
ENSMUST00000109725; ENSMUSP00000105347; ENSMUSG00000038533.
GeneIDi12396.
KEGGimmu:12396.
UCSCiuc008njf.2. mouse. [O70374-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK049206 mRNA. Translation: BAC33609.1 .
AK040403 mRNA. Translation: BAC30586.1 .
AK153602 mRNA. Translation: BAE32114.1 .
DQ213025 mRNA. Translation: ABB02690.1 .
AL772292 Genomic DNA. Translation: CAM13555.1 .
AL772292 Genomic DNA. Translation: CAM13556.1 .
BC064679 mRNA. Translation: AAH64679.1 .
BC138410 mRNA. Translation: AAI38411.1 .
BC145679 mRNA. Translation: AAI45680.1 .
AF052219 Genomic DNA. Translation: AAC64697.1 .
CCDSi CCDS16932.1. [O70374-1 ]
RefSeqi NP_033953.1. NM_009823.1.
NP_766448.1. NM_172860.2. [O70374-1 ]
XP_006498703.1. XM_006498640.1. [O70374-2 ]
UniGenei Mm.29914.

3D structure databases

ProteinModelPortali O70374.
SMRi O70374. Positions 103-200, 327-383, 420-450, 488-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O70374. 1 interaction.
MINTi MINT-2568187.

PTM databases

PhosphoSitei O70374.

Proteomic databases

PRIDEi O70374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045270 ; ENSMUSP00000043087 ; ENSMUSG00000038533 . [O70374-1 ]
ENSMUST00000109725 ; ENSMUSP00000105347 ; ENSMUSG00000038533 .
GeneIDi 12396.
KEGGi mmu:12396.
UCSCi uc008njf.2. mouse. [O70374-1 ]

Organism-specific databases

CTDi 9139.
MGIi MGI:1333833. Cbfa2t2.

Phylogenomic databases

eggNOGi NOG79810.
GeneTreei ENSGT00390000013479.
HOGENOMi HOG000049245.
HOVERGENi HBG000169.
InParanoidi B2RRH8.
OMAi HHRICGQ.
OrthoDBi EOG70W3D2.
PhylomeDBi O70374.
TreeFami TF106303.

Miscellaneous databases

ChiTaRSi CBFA2T2. mouse.
NextBioi 281148.
PROi O70374.
SOURCEi Search...

Gene expression databases

Bgeei O70374.
Genevestigatori O70374.

Family and domain databases

InterProi IPR013289. ETO.
IPR013291. MTGR1.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PRINTSi PR01875. ETOFAMILY.
PR01877. MTGR1PROTEIN.
SMARTi SM00549. TAFH. 1 hit.
[Graphical view ]
PROSITEi PS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
  2. "Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine."
    Amann J.M., Chyla B.J., Ellis T.C., Martinez A., Moore A.C., Franklin J.L., McGhee L., Meyers S., Ohm J.E., Luce K.S., Ouelette A.J., Washington M.K., Thompson M.A., King D., Gautam S., Coffey R.J., Whitehead R.H., Hiebert S.W.
    Mol. Cell. Biol. 25:9576-9585(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Strain: C57BL/6 X DBA/2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  5. "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."
    Calabi F., Cilli V.
    Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-140.
    Strain: 129.
  6. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 469-477, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiMTG8R_MOUSE
AccessioniPrimary (citable) accession number: O70374
Secondary accession number(s): B2RRH8, Q30BK8, Q6P288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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