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O70374

- MTG8R_MOUSE

UniProt

O70374 - MTG8R_MOUSE

Protein

Protein CBFA2T2

Gene

Cbfa2t2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    May be a transcriptional corepressor.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri498 – 53437MYND-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. transcription corepressor activity Source: MGI

    GO - Biological processi

    1. epithelial cell differentiation Source: MGI
    2. negative regulation of neuron projection development Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: MGI
    4. positive regulation of neuron projection development Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CBFA2T2
    Alternative name(s):
    MTG8-like protein
    MTG8-related protein 1
    Gene namesi
    Name:Cbfa2t2
    Synonyms:Cbfa2t2h, Mtgr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1333833. Cbfa2t2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Protein CBFA2T2PRO_0000218302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei400 – 4001PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO70374.

    PTM databases

    PhosphoSiteiO70374.

    Expressioni

    Gene expression databases

    BgeeiO70374.
    GenevestigatoriO70374.

    Interactioni

    Subunit structurei

    Homooligomer and heterooligomer with MTG8. Heterodimer with CBFA2T3 By similarity.By similarity

    Protein-protein interaction databases

    IntActiO70374. 1 interaction.
    MINTiMINT-2568187.

    Structurei

    3D structure databases

    ProteinModelPortaliO70374.
    SMRiO70374. Positions 103-200, 327-383, 420-450, 488-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 19996TAFHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili442 – 48241Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 8853Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CBFA2T family.Curated
    Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
    Contains 1 TAFH (NHR1) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri498 – 53437MYND-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG79810.
    GeneTreeiENSGT00390000013479.
    HOGENOMiHOG000049245.
    HOVERGENiHBG000169.
    InParanoidiB2RRH8.
    OMAiHHRICGQ.
    OrthoDBiEOG70W3D2.
    PhylomeDBiO70374.
    TreeFamiTF106303.

    Family and domain databases

    InterProiIPR013289. ETO.
    IPR013291. MTGR1.
    IPR014896. NHR2.
    IPR003894. TAFH_NHR1.
    IPR002893. Znf_MYND.
    [Graphical view]
    PfamiPF08788. NHR2. 1 hit.
    PF07531. TAFH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view]
    PRINTSiPR01875. ETOFAMILY.
    PR01877. MTGR1PROTEIN.
    SMARTiSM00549. TAFH. 1 hit.
    [Graphical view]
    PROSITEiPS51119. TAFH. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O70374-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVGVPGAAAF QLGCEKRVPA MPGSPVEVKI QSRSSPPIMP PLPPINPGGP    50
    RPVSFTPTAL SNGINHSPPT LNGAPSPPQR FSNGPASSTS SALTNQQLPA 100
    TCGARQLSKL KRFLTTLQQF GNDISPEIGE KVRTLVLALV NSTVTIEEFH 150
    CKLQEATNFP LRPFVIPFLK ANLPLLQREL LHCARAAKQT PSQYLAQHEH 200
    LLLNTSIASP ADSSELLMEV HGNGKRPSPE RRDENNFERD TVPPEPPAKR 250
    VCTISPAPRH SPALTVPLMN PGGQFHPTPP PLQHYTLEDI ATSHLYREPN 300
    KMLEHREVRE RHHNLSLNGG YQDELVDHRL TEREWADEWK HLDHALNCIM 350
    EMVEKTRRSM AVLRRCQESD REELNYWKRR FNENTELRKT GTELVSRQHS 400
    PGSTDSLSND SQREFTSRPA TGYVPVEFWK KTEEAVNKVK IQAMSEVQKA 450
    VAEAEQKAFE VIATERARME QTIADVKRQA AEDAFLVINE QEESTENCWN 500
    CGRKASETCS GCNIARYCGS FCQHKDWERH HRLCGQSLHG HSPHSQSRPL 550
    LPGGRGSARS ADCSVPSPAL DKTSATTSRS STPASVTAID ANGL 594
    Length:594
    Mass (Da):65,904
    Last modified:January 15, 2008 - v3
    Checksum:iFCE4A6A0AFD66377
    GO
    Isoform 2 (identifier: O70374-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: Missing.

    Show »
    Length:574
    Mass (Da):63,921
    Checksum:i5385BD7F7D8A224E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti413 – 4131Missing in BAC30586. (PubMed:16141072)Curated
    Sequence conflicti413 – 4131Missing in ABB02690. (PubMed:16227606)Curated
    Sequence conflicti413 – 4131Missing in CAM13556. (PubMed:19468303)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020Missing in isoform 2. 1 PublicationVSP_030517Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049206 mRNA. Translation: BAC33609.1.
    AK040403 mRNA. Translation: BAC30586.1.
    AK153602 mRNA. Translation: BAE32114.1.
    DQ213025 mRNA. Translation: ABB02690.1.
    AL772292 Genomic DNA. Translation: CAM13555.1.
    AL772292 Genomic DNA. Translation: CAM13556.1.
    BC064679 mRNA. Translation: AAH64679.1.
    BC138410 mRNA. Translation: AAI38411.1.
    BC145679 mRNA. Translation: AAI45680.1.
    AF052219 Genomic DNA. Translation: AAC64697.1.
    CCDSiCCDS16932.1. [O70374-1]
    RefSeqiNP_033953.1. NM_009823.1.
    NP_766448.1. NM_172860.2. [O70374-1]
    XP_006498703.1. XM_006498640.1. [O70374-2]
    UniGeneiMm.29914.

    Genome annotation databases

    EnsembliENSMUST00000045270; ENSMUSP00000043087; ENSMUSG00000038533. [O70374-1]
    ENSMUST00000109725; ENSMUSP00000105347; ENSMUSG00000038533.
    GeneIDi12396.
    KEGGimmu:12396.
    UCSCiuc008njf.2. mouse. [O70374-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049206 mRNA. Translation: BAC33609.1 .
    AK040403 mRNA. Translation: BAC30586.1 .
    AK153602 mRNA. Translation: BAE32114.1 .
    DQ213025 mRNA. Translation: ABB02690.1 .
    AL772292 Genomic DNA. Translation: CAM13555.1 .
    AL772292 Genomic DNA. Translation: CAM13556.1 .
    BC064679 mRNA. Translation: AAH64679.1 .
    BC138410 mRNA. Translation: AAI38411.1 .
    BC145679 mRNA. Translation: AAI45680.1 .
    AF052219 Genomic DNA. Translation: AAC64697.1 .
    CCDSi CCDS16932.1. [O70374-1 ]
    RefSeqi NP_033953.1. NM_009823.1.
    NP_766448.1. NM_172860.2. [O70374-1 ]
    XP_006498703.1. XM_006498640.1. [O70374-2 ]
    UniGenei Mm.29914.

    3D structure databases

    ProteinModelPortali O70374.
    SMRi O70374. Positions 103-200, 327-383, 420-450, 488-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O70374. 1 interaction.
    MINTi MINT-2568187.

    PTM databases

    PhosphoSitei O70374.

    Proteomic databases

    PRIDEi O70374.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045270 ; ENSMUSP00000043087 ; ENSMUSG00000038533 . [O70374-1 ]
    ENSMUST00000109725 ; ENSMUSP00000105347 ; ENSMUSG00000038533 .
    GeneIDi 12396.
    KEGGi mmu:12396.
    UCSCi uc008njf.2. mouse. [O70374-1 ]

    Organism-specific databases

    CTDi 9139.
    MGIi MGI:1333833. Cbfa2t2.

    Phylogenomic databases

    eggNOGi NOG79810.
    GeneTreei ENSGT00390000013479.
    HOGENOMi HOG000049245.
    HOVERGENi HBG000169.
    InParanoidi B2RRH8.
    OMAi HHRICGQ.
    OrthoDBi EOG70W3D2.
    PhylomeDBi O70374.
    TreeFami TF106303.

    Miscellaneous databases

    ChiTaRSi CBFA2T2. mouse.
    NextBioi 281148.
    PROi O70374.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70374.
    Genevestigatori O70374.

    Family and domain databases

    InterProi IPR013289. ETO.
    IPR013291. MTGR1.
    IPR014896. NHR2.
    IPR003894. TAFH_NHR1.
    IPR002893. Znf_MYND.
    [Graphical view ]
    Pfami PF08788. NHR2. 1 hit.
    PF07531. TAFH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view ]
    PRINTSi PR01875. ETOFAMILY.
    PR01877. MTGR1PROTEIN.
    SMARTi SM00549. TAFH. 1 hit.
    [Graphical view ]
    PROSITEi PS51119. TAFH. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
    2. "Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine."
      Amann J.M., Chyla B.J., Ellis T.C., Martinez A., Moore A.C., Franklin J.L., McGhee L., Meyers S., Ohm J.E., Luce K.S., Ouelette A.J., Washington M.K., Thompson M.A., King D., Gautam S., Coffey R.J., Whitehead R.H., Hiebert S.W.
      Mol. Cell. Biol. 25:9576-9585(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
      Strain: C57BL/6 X DBA/2.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    5. "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."
      Calabi F., Cilli V.
      Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-140.
      Strain: 129.
    6. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 469-477, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiMTG8R_MOUSE
    AccessioniPrimary (citable) accession number: O70374
    Secondary accession number(s): B2RRH8, Q30BK8, Q6P288
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3