Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein CBFA2T2

Gene

Cbfa2t2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional corepressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri498 – 53437MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. transcription corepressor activity Source: MGI

GO - Biological processi

  1. epithelial cell differentiation Source: MGI
  2. negative regulation of neuron projection development Source: UniProtKB
  3. negative regulation of transcription, DNA-templated Source: MGI
  4. positive regulation of neuron projection development Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T2
Alternative name(s):
MTG8-like protein
MTG8-related protein 1
Gene namesi
Name:Cbfa2t2
Synonyms:Cbfa2t2h, Mtgr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1333833. Cbfa2t2.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Protein CBFA2T2PRO_0000218302Add
BLAST

Proteomic databases

MaxQBiO70374.
PRIDEiO70374.

PTM databases

PhosphoSiteiO70374.

Expressioni

Gene expression databases

BgeeiO70374.
ExpressionAtlasiO70374. baseline and differential.
GenevestigatoriO70374.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with MTG8. Heterodimer with CBFA2T3 (By similarity).By similarity

Protein-protein interaction databases

IntActiO70374. 1 interaction.
MINTiMINT-2568187.

Structurei

3D structure databases

ProteinModelPortaliO70374.
SMRiO70374. Positions 103-200, 327-383, 420-450, 488-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 19996TAFHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili442 – 48241Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 8853Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CBFA2T family.Curated
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
Contains 1 TAFH (NHR1) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri498 – 53437MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG79810.
GeneTreeiENSGT00390000013479.
HOGENOMiHOG000049245.
HOVERGENiHBG000169.
InParanoidiO70374.
OMAiHHRICGQ.
OrthoDBiEOG70W3D2.
PhylomeDBiO70374.
TreeFamiTF106303.

Family and domain databases

InterProiIPR013289. ETO.
IPR013291. MTGR1.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01877. MTGR1PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O70374-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGVPGAAAF QLGCEKRVPA MPGSPVEVKI QSRSSPPIMP PLPPINPGGP
60 70 80 90 100
RPVSFTPTAL SNGINHSPPT LNGAPSPPQR FSNGPASSTS SALTNQQLPA
110 120 130 140 150
TCGARQLSKL KRFLTTLQQF GNDISPEIGE KVRTLVLALV NSTVTIEEFH
160 170 180 190 200
CKLQEATNFP LRPFVIPFLK ANLPLLQREL LHCARAAKQT PSQYLAQHEH
210 220 230 240 250
LLLNTSIASP ADSSELLMEV HGNGKRPSPE RRDENNFERD TVPPEPPAKR
260 270 280 290 300
VCTISPAPRH SPALTVPLMN PGGQFHPTPP PLQHYTLEDI ATSHLYREPN
310 320 330 340 350
KMLEHREVRE RHHNLSLNGG YQDELVDHRL TEREWADEWK HLDHALNCIM
360 370 380 390 400
EMVEKTRRSM AVLRRCQESD REELNYWKRR FNENTELRKT GTELVSRQHS
410 420 430 440 450
PGSTDSLSND SQREFTSRPA TGYVPVEFWK KTEEAVNKVK IQAMSEVQKA
460 470 480 490 500
VAEAEQKAFE VIATERARME QTIADVKRQA AEDAFLVINE QEESTENCWN
510 520 530 540 550
CGRKASETCS GCNIARYCGS FCQHKDWERH HRLCGQSLHG HSPHSQSRPL
560 570 580 590
LPGGRGSARS ADCSVPSPAL DKTSATTSRS STPASVTAID ANGL
Length:594
Mass (Da):65,904
Last modified:January 15, 2008 - v3
Checksum:iFCE4A6A0AFD66377
GO
Isoform 2 (identifier: O70374-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:574
Mass (Da):63,921
Checksum:i5385BD7F7D8A224E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti413 – 4131Missing in BAC30586 (PubMed:16141072).Curated
Sequence conflicti413 – 4131Missing in ABB02690 (PubMed:16227606).Curated
Sequence conflicti413 – 4131Missing in CAM13556 (PubMed:19468303).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 2. 1 PublicationVSP_030517Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049206 mRNA. Translation: BAC33609.1.
AK040403 mRNA. Translation: BAC30586.1.
AK153602 mRNA. Translation: BAE32114.1.
DQ213025 mRNA. Translation: ABB02690.1.
AL772292 Genomic DNA. Translation: CAM13555.1.
AL772292 Genomic DNA. Translation: CAM13556.1.
BC064679 mRNA. Translation: AAH64679.1.
BC138410 mRNA. Translation: AAI38411.1.
BC145679 mRNA. Translation: AAI45680.1.
AF052219 Genomic DNA. Translation: AAC64697.1.
CCDSiCCDS16932.1. [O70374-1]
RefSeqiNP_033953.1. NM_009823.1.
NP_766448.1. NM_172860.2. [O70374-1]
XP_006498703.1. XM_006498640.1. [O70374-2]
UniGeneiMm.29914.

Genome annotation databases

EnsembliENSMUST00000045270; ENSMUSP00000043087; ENSMUSG00000038533. [O70374-1]
GeneIDi12396.
KEGGimmu:12396.
UCSCiuc008njf.2. mouse. [O70374-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049206 mRNA. Translation: BAC33609.1.
AK040403 mRNA. Translation: BAC30586.1.
AK153602 mRNA. Translation: BAE32114.1.
DQ213025 mRNA. Translation: ABB02690.1.
AL772292 Genomic DNA. Translation: CAM13555.1.
AL772292 Genomic DNA. Translation: CAM13556.1.
BC064679 mRNA. Translation: AAH64679.1.
BC138410 mRNA. Translation: AAI38411.1.
BC145679 mRNA. Translation: AAI45680.1.
AF052219 Genomic DNA. Translation: AAC64697.1.
CCDSiCCDS16932.1. [O70374-1]
RefSeqiNP_033953.1. NM_009823.1.
NP_766448.1. NM_172860.2. [O70374-1]
XP_006498703.1. XM_006498640.1. [O70374-2]
UniGeneiMm.29914.

3D structure databases

ProteinModelPortaliO70374.
SMRiO70374. Positions 103-200, 327-383, 420-450, 488-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70374. 1 interaction.
MINTiMINT-2568187.

PTM databases

PhosphoSiteiO70374.

Proteomic databases

MaxQBiO70374.
PRIDEiO70374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045270; ENSMUSP00000043087; ENSMUSG00000038533. [O70374-1]
GeneIDi12396.
KEGGimmu:12396.
UCSCiuc008njf.2. mouse. [O70374-1]

Organism-specific databases

CTDi9139.
MGIiMGI:1333833. Cbfa2t2.

Phylogenomic databases

eggNOGiNOG79810.
GeneTreeiENSGT00390000013479.
HOGENOMiHOG000049245.
HOVERGENiHBG000169.
InParanoidiO70374.
OMAiHHRICGQ.
OrthoDBiEOG70W3D2.
PhylomeDBiO70374.
TreeFamiTF106303.

Miscellaneous databases

ChiTaRSiCbfa2t2. mouse.
NextBioi281148.
PROiO70374.
SOURCEiSearch...

Gene expression databases

BgeeiO70374.
ExpressionAtlasiO70374. baseline and differential.
GenevestigatoriO70374.

Family and domain databases

InterProiIPR013289. ETO.
IPR013291. MTGR1.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01877. MTGR1PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
  2. "Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine."
    Amann J.M., Chyla B.J., Ellis T.C., Martinez A., Moore A.C., Franklin J.L., McGhee L., Meyers S., Ohm J.E., Luce K.S., Ouelette A.J., Washington M.K., Thompson M.A., King D., Gautam S., Coffey R.J., Whitehead R.H., Hiebert S.W.
    Mol. Cell. Biol. 25:9576-9585(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Strain: C57BL/6 X DBA/2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  5. "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."
    Calabi F., Cilli V.
    Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-140.
    Strain: 129.
  6. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 469-477, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiMTG8R_MOUSE
AccessioniPrimary (citable) accession number: O70374
Secondary accession number(s): B2RRH8, Q30BK8, Q6P288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 15, 2008
Last modified: March 4, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.