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O70374 (MTG8R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CBFA2T2
Alternative name(s):
MTG8-like protein
MTG8-related protein 1
Gene names
Name:Cbfa2t2
Synonyms:Cbfa2t2h, Mtgr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a transcriptional corepressor. Ref.2

Subunit structure

Homooligomer and heterooligomer with MTG8. Heterodimer with CBFA2T3 By similarity.

Subcellular location

Nucleus By similarity.

Miscellaneous

Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

Sequence similarities

Belongs to the CBFA2T family.

Contains 1 MYND-type zinc finger.

Contains 1 TAFH (NHR1) domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O70374-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O70374-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Protein CBFA2T2
PRO_0000218302

Regions

Domain104 – 19996TAFH
Zinc finger498 – 53437MYND-type
Coiled coil442 – 48241 Potential
Compositional bias36 – 8853Pro-rich

Amino acid modifications

Modified residue4001Phosphoserine By similarity

Natural variations

Alternative sequence1 – 2020Missing in isoform 2.
VSP_030517

Experimental info

Sequence conflict4131Missing in BAC30586. Ref.1
Sequence conflict4131Missing in ABB02690. Ref.2
Sequence conflict4131Missing in CAM13556. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 3.
Checksum: FCE4A6A0AFD66377

FASTA59465,904
        10         20         30         40         50         60 
MVGVPGAAAF QLGCEKRVPA MPGSPVEVKI QSRSSPPIMP PLPPINPGGP RPVSFTPTAL 

        70         80         90        100        110        120 
SNGINHSPPT LNGAPSPPQR FSNGPASSTS SALTNQQLPA TCGARQLSKL KRFLTTLQQF 

       130        140        150        160        170        180 
GNDISPEIGE KVRTLVLALV NSTVTIEEFH CKLQEATNFP LRPFVIPFLK ANLPLLQREL 

       190        200        210        220        230        240 
LHCARAAKQT PSQYLAQHEH LLLNTSIASP ADSSELLMEV HGNGKRPSPE RRDENNFERD 

       250        260        270        280        290        300 
TVPPEPPAKR VCTISPAPRH SPALTVPLMN PGGQFHPTPP PLQHYTLEDI ATSHLYREPN 

       310        320        330        340        350        360 
KMLEHREVRE RHHNLSLNGG YQDELVDHRL TEREWADEWK HLDHALNCIM EMVEKTRRSM 

       370        380        390        400        410        420 
AVLRRCQESD REELNYWKRR FNENTELRKT GTELVSRQHS PGSTDSLSND SQREFTSRPA 

       430        440        450        460        470        480 
TGYVPVEFWK KTEEAVNKVK IQAMSEVQKA VAEAEQKAFE VIATERARME QTIADVKRQA 

       490        500        510        520        530        540 
AEDAFLVINE QEESTENCWN CGRKASETCS GCNIARYCGS FCQHKDWERH HRLCGQSLHG 

       550        560        570        580        590 
HSPHSQSRPL LPGGRGSARS ADCSVPSPAL DKTSATTSRS STPASVTAID ANGL 

« Hide

Isoform 2 [UniParc].

Checksum: 5385BD7F7D8A224E
Show »

FASTA57463,921

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
[2]"Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine."
Amann J.M., Chyla B.J., Ellis T.C., Martinez A., Moore A.C., Franklin J.L., McGhee L., Meyers S., Ohm J.E., Luce K.S., Ouelette A.J., Washington M.K., Thompson M.A., King D., Gautam S., Coffey R.J., Whitehead R.H., Hiebert S.W.
Mol. Cell. Biol. 25:9576-9585(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
Strain: C57BL/6 X DBA/2.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[5]"CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."
Calabi F., Cilli V.
Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-140.
Strain: 129.
[6]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 469-477, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK049206 mRNA. Translation: BAC33609.1.
AK040403 mRNA. Translation: BAC30586.1.
AK153602 mRNA. Translation: BAE32114.1.
DQ213025 mRNA. Translation: ABB02690.1.
AL772292 Genomic DNA. Translation: CAM13555.1.
AL772292 Genomic DNA. Translation: CAM13556.1.
BC064679 mRNA. Translation: AAH64679.1.
BC138410 mRNA. Translation: AAI38411.1.
BC145679 mRNA. Translation: AAI45680.1.
AF052219 Genomic DNA. Translation: AAC64697.1.
CCDSCCDS16932.1. [O70374-1]
RefSeqNP_033953.1. NM_009823.1.
NP_766448.1. NM_172860.2. [O70374-1]
XP_006498703.1. XM_006498640.1. [O70374-2]
UniGeneMm.29914.

3D structure databases

ProteinModelPortalO70374.
SMRO70374. Positions 103-200, 327-383, 420-450, 488-534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO70374. 1 interaction.
MINTMINT-2568187.

PTM databases

PhosphoSiteO70374.

Proteomic databases

PRIDEO70374.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045270; ENSMUSP00000043087; ENSMUSG00000038533. [O70374-1]
ENSMUST00000109725; ENSMUSP00000105347; ENSMUSG00000038533.
GeneID12396.
KEGGmmu:12396.
UCSCuc008njf.2. mouse. [O70374-1]

Organism-specific databases

CTD9139.
MGIMGI:1333833. Cbfa2t2.

Phylogenomic databases

eggNOGNOG79810.
GeneTreeENSGT00390000013479.
HOGENOMHOG000049245.
HOVERGENHBG000169.
InParanoidB2RRH8.
OMAHHRICGQ.
OrthoDBEOG70W3D2.
PhylomeDBO70374.
TreeFamTF106303.

Gene expression databases

BgeeO70374.
GenevestigatorO70374.

Family and domain databases

InterProIPR013289. ETO.
IPR013291. MTGR1.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PfamPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSPR01875. ETOFAMILY.
PR01877. MTGR1PROTEIN.
SMARTSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCBFA2T2. mouse.
NextBio281148.
PROO70374.
SOURCESearch...

Entry information

Entry nameMTG8R_MOUSE
AccessionPrimary (citable) accession number: O70374
Secondary accession number(s): B2RRH8, Q30BK8, Q6P288
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot