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O70370 (CATS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin S

EC=3.4.22.27
Gene names
Name:Ctss
Synonyms:Cats
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Catalytic activity

Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

Subcellular location

Lysosome.

Tissue specificity

Widely expressed with highest expression found in non-skeletal tissues. Relatively high levels found in skeletal tissues. Ref.4

Sequence similarities

Belongs to the peptidase C1 family.

Sequence caution

The sequence CAA05360.1 differs from that shown. Reason: Frameshift at position 30.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 122105Activation peptide Potential
PRO_0000026315
Chain123 – 340218Cathepsin S
PRO_0000026316

Sites

Active site1471 By similarity
Active site2871 By similarity
Active site3071 By similarity

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Disulfide bond134 ↔ 233 By similarity
Disulfide bond144 ↔ 189 By similarity
Disulfide bond178 ↔ 222 By similarity
Disulfide bond281 ↔ 329 By similarity

Experimental info

Sequence conflict341Y → H in CAA05360. Ref.2
Sequence conflict971L → S in AAB94925. Ref.1
Sequence conflict971L → S in AAC05781. Ref.1
Sequence conflict1061P → S in AAB94925. Ref.1
Sequence conflict1061P → S in AAC05781. Ref.1
Sequence conflict1461A → S in CAA77184. Ref.3
Sequence conflict2181T → M in AAB94925. Ref.1
Sequence conflict2181T → M in CAA05360. Ref.2

Secondary structure

....................................... 340
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O70370 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 10550C5106318C47

FASTA34038,475
        10         20         30         40         50         60 
MRAPGHAAIR WLFWMPLVCS VAMEQLQRDP TLDYHWDLWK KTHEKEYKDK NEEEVRRLIW 

        70         80         90        100        110        120 
EKNLKFIMIH NLEYSMGMHT YQVGMNDMGD MTNEEILCRM GALRIPRQSP KTVTFRSYSN 

       130        140        150        160        170        180 
RTLPDTVDWR EKGCVTEVKY QGSCGACWAF SAVGALEGQL KLKTGKLISL SAQNLVDCSN 

       190        200        210        220        230        240 
EEKYGNKGCG GGYMTEAFQY IIDNGGIEAD ASYPYKATDE KCHYNSKNRA ATCSRYIQLP 

       250        260        270        280        290        300 
FGDEDALKEA VATKGPVSVG IDASHSSFFF YKSGVYDDPS CTGNVNHGVL VVGYGTLDGK 

       310        320        330        340 
DYWLVKNSWG LNFGDQGYIR MARNNKNHCG IASYCSYPEI 

« Hide

References

« Hide 'large scale' references
[1]Doh-ura K.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Sv and BALB/c.
Tissue: Brain.
[2]Rommerskirch W.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"Cathepsin expression during skeletal development."
Soederstroem M., Salminen H., Glumoff V., Kirschke H., Aro H., Vuorio E.
Biochim. Biophys. Acta 1446:35-46(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-306, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Cartilage.
[5]"Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts."
Dandoy-Dron F., Guillo F., Benboudjema L., Deslys J.-P., Lasmesas C., Dormont D., Tovey M.G., Dron M.
J. Biol. Chem. 273:7691-7697(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 296-340.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF051732 expand/collapse EMBL AC list , AF051727, AF051728, AF051729, AF051726, AF051730, AF051731 Genomic DNA. Translation: AAC05781.1.
AF038546 mRNA. Translation: AAB94925.1.
AJ002386 mRNA. Translation: CAA05360.1. Frameshift.
AC092203 Genomic DNA. No translation available.
Y18466 mRNA. Translation: CAA77184.1.
AJ223208 mRNA. Translation: CAA11182.1.
RefSeqNP_067256.4. NM_021281.3.
UniGeneMm.3619.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1M0Hmodel-A1-340[»]
4BS5X-ray1.25A116-340[»]
4BSQX-ray1.96A116-340[»]
ProteinModelPortalO70370.
SMRO70370. Positions 26-340.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBO70370.
ChEMBLCHEMBL4098.

Protein family/group databases

MEROPSC01.034.

PTM databases

PhosphoSiteO70370.

Proteomic databases

PaxDbO70370.
PRIDEO70370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000116304; ENSMUSP00000112006; ENSMUSG00000038642.
GeneID13040.
KEGGmmu:13040.
UCSCuc008qjz.2. mouse.

Organism-specific databases

CTD1520.
MGIMGI:107341. Ctss.

Phylogenomic databases

eggNOGCOG4870.
GeneTreeENSGT00740000115447.
HOVERGENHBG011513.
KOK01368.

Enzyme and pathway databases

BRENDA3.4.22.27. 3474.
ReactomeREACT_102124. Immune System.

Gene expression databases

ArrayExpressO70370.
BgeeO70370.
CleanExMM_CTSS.
GenevestigatorO70370.

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCTSS. mouse.
NextBio282932.
PROO70370.
SOURCESearch...

Entry information

Entry nameCATS_MOUSE
AccessionPrimary (citable) accession number: O70370
Secondary accession number(s): E9QK18, O54973
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot