Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CD82 antigen

Gene

Cd82

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CD82 antigen
Alternative name(s):
Metastasis suppressor Kangai-1 homolog
CD_antigen: CD82
Gene namesi
Name:Cd82
Synonyms:Kai1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69070 Cd82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 53ExtracellularSequence analysisAdd BLAST21
Transmembranei54 – 72HelicalSequence analysisAdd BLAST19
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 110HelicalSequence analysisAdd BLAST27
Topological domaini111 – 227ExtracellularSequence analysisAdd BLAST117
Transmembranei228 – 249HelicalSequence analysisAdd BLAST22
Topological domaini250 – 266CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192281 – 266CD82 antigenAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagine; alternateSequence analysis1
Glycosylationi157N-linked (HexNAc...) asparagine; alternateCombined sources1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO70352
PRIDEiO70352

PTM databases

iPTMnetiO70352
PhosphoSitePlusiO70352
UniCarbKBiO70352

Interactioni

Subunit structurei

Interacts directly with IGSF8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000052

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiO70352
PhylomeDBiO70352

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 2 hits
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

O70352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKSS FISVLQTSSS
60 70 80 90 100
SLQVGAYVFI GVGAITMLMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV
110 120 130 140 150
TVEVLFYFNA NKLKQEMGNT VMDIIQNYSV NASSSREEAW DYVQAQVKCC
160 170 180 190 200
GWVSPSNWTR NPVLKNSTKT TYPCSCEKTK EEDNQLIVKK GFCESDNSTA
210 220 230 240 250
SENSPEDWPV HPEGCMEKAQ AWLQENFGIL LGVCAGVAVI ELLGLFLSIC
260
LCRYIHSEDY SKVPKY
Length:266
Mass (Da):29,487
Last modified:August 1, 1998 - v1
Checksum:iD6E10AB5AA348474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049882 mRNA Translation: AAC05159.1
UniGeneiRn.3022

Genome annotation databases

UCSCiRGD:69070 rat

Similar proteinsi

Entry informationi

Entry nameiCD82_RAT
AccessioniPrimary (citable) accession number: O70352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health