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Protein

CD82 antigen

Gene

Cd82

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD82 antigen
Alternative name(s):
Metastasis suppressor Kangai-1 homolog
CD_antigen: CD82
Gene namesi
Name:Cd82
Synonyms:Kai1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69070. Cd82.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 5321ExtracellularSequence analysisAdd
BLAST
Transmembranei54 – 7219HelicalSequence analysisAdd
BLAST
Topological domaini73 – 8311CytoplasmicSequence analysisAdd
BLAST
Transmembranei84 – 11027HelicalSequence analysisAdd
BLAST
Topological domaini111 – 227117ExtracellularSequence analysisAdd
BLAST
Transmembranei228 – 24922HelicalSequence analysisAdd
BLAST
Topological domaini250 – 26617CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266CD82 antigenPRO_0000219228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO70352.
PRIDEiO70352.

PTM databases

iPTMnetiO70352.
PhosphoSiteiO70352.
UniCarbKBiO70352.

Interactioni

Subunit structurei

Interacts directly with IGSF8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000052.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO70352.
PhylomeDBiO70352.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKSS FISVLQTSSS
60 70 80 90 100
SLQVGAYVFI GVGAITMLMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV
110 120 130 140 150
TVEVLFYFNA NKLKQEMGNT VMDIIQNYSV NASSSREEAW DYVQAQVKCC
160 170 180 190 200
GWVSPSNWTR NPVLKNSTKT TYPCSCEKTK EEDNQLIVKK GFCESDNSTA
210 220 230 240 250
SENSPEDWPV HPEGCMEKAQ AWLQENFGIL LGVCAGVAVI ELLGLFLSIC
260
LCRYIHSEDY SKVPKY
Length:266
Mass (Da):29,487
Last modified:August 1, 1998 - v1
Checksum:iD6E10AB5AA348474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049882 mRNA. Translation: AAC05159.1.
UniGeneiRn.3022.

Genome annotation databases

UCSCiRGD:69070. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049882 mRNA. Translation: AAC05159.1.
UniGeneiRn.3022.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000052.

PTM databases

iPTMnetiO70352.
PhosphoSiteiO70352.
UniCarbKBiO70352.

Proteomic databases

PaxDbiO70352.
PRIDEiO70352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:69070. rat.

Organism-specific databases

RGDi69070. Cd82.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO70352.
PhylomeDBiO70352.

Miscellaneous databases

PROiO70352.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD82_RAT
AccessioniPrimary (citable) accession number: O70352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.