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O70344 (KCNQ1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily KQT member 1
Alternative name(s):
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
KQT-like 1
Voltage-gated potassium channel subunit Kv7.1
Gene names
Name:KCNQ1
Synonyms:KVLQT1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length169 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current By similarity.

Subunit structure

Heterotetramer with KCNE1 (MinK) or KCNE3 (MiRP2). Interacts with CALM By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›169›169Potassium voltage-gated channel subfamily KQT member 1
PRO_0000054021

Regions

Transmembrane‹1 – 15›15Helical; Name=Segment S2; Potential
Topological domain16 – 4328Cytoplasmic Potential
Transmembrane44 – 6421Helical; Name=Segment S3; Potential
Topological domain65 – 728Extracellular Potential
Transmembrane73 – 9523Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain96 – 10813Cytoplasmic Potential
Transmembrane109 – 12921Helical; Name=Segment S5; Potential
Topological domain130 – 14617Extracellular Potential
Intramembrane147 – 16721Pore-forming; Name=Segment H5; Potential
Topological domain168 – ›169›2Extracellular Potential
Motif159 – 1646Selectivity filter By similarity

Amino acid modifications

Glycosylation1361N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict821S → I in BAA88579. Ref.2
Non-terminal residue11
Non-terminal residue1691

Sequences

Sequence LengthMass (Da)Tools
O70344 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 97310C773D931A4F

FASTA16918,982
        10         20         30         40         50         60 
GTLFWMEIVL VVFFGTEYVV RLWSAGCRSK YVGIWGRLRF ARKPISIIDL IVVVASMVVL 

        70         80         90        100        110        120 
CVGSKGQVFA TSAIRGIRFL QSLRMLHVDR QGGTWRLLGS VVFIHRQELI TTLYIGFLGL 

       130        140        150        160 
IFSSYFVYLA EKDAVNESGR VEFGSYADAL WWGVVTVTTI GYGDKVPQT

« Hide

References

[1]"Guinea pig cardiac KvLQT1 potassium channel mRNA."
Shi H., Wang Z.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-99.
Tissue: Heart.
[2]"Guinea-pig potassium channel (KvLQT1)."
Ohya S., Imaizumi Y., Watanabe M.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-169.
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF049341 mRNA. Translation: AAC05498.1.
AB032574 mRNA. Translation: BAA88579.1.

3D structure databases

ProteinModelPortalO70344.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1226.
InParanoidO70344.
OrthoDBEOG4Q58PW.

Family and domain databases

InterProIPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR005827. K_chnl_volt-dep_KCQN1.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF9. PTHR11537:SF9. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetSearch...

Other

ChEMBLCHEMBL5135.

Entry information

Entry nameKCNQ1_CAVPO
AccessionPrimary (citable) accession number: O70344
Secondary accession number(s): Q9QYG3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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