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Protein

Neuropeptide Y receptor type 5

Gene

Npy5r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: MGI
  • pancreatic polypeptide receptor activity Source: MGI
  • peptide YY receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 5
Short name:
NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name:
NPYY5-R
Short name:
Y5 receptor
Gene namesi
Name:Npy5r
Synonyms:Npy5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:108082. Npy5r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363ExtracellularSequence analysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini85 – 9814CytoplasmicSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini120 – 13819ExtracellularSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini160 – 17718CytoplasmicSequence analysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini199 – 22931ExtracellularSequence analysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini251 – 389139CytoplasmicSequence analysisAdd
BLAST
Transmembranei390 – 41021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini411 – 42717ExtracellularSequence analysisAdd
BLAST
Transmembranei428 – 44821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini449 – 46618CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • neuron projection Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Neuropeptide Y receptor type 5PRO_0000069940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi135 ↔ 219PROSITE-ProRule annotation
Lipidationi462 – 4621S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO70342.
PRIDEiO70342.

Expressioni

Gene expression databases

BgeeiO70342.
CleanExiMM_NPY5R.
ExpressionAtlasiO70342. baseline and differential.
GenevisibleiO70342. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065157.

Chemistry

BindingDBiO70342.

Structurei

3D structure databases

ProteinModelPortaliO70342.
SMRiO70342. Positions 21-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiO70342.
KOiK04207.
OMAiCIEKAWH.
OrthoDBiEOG7S7SDH.
PhylomeDBiO70342.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKLEEHFN KTFVTENNTA ASQNTASPAW EDYRGTENNT SAARNTAFPV
60 70 80 90 100
WEDYRGSVDD LQYFLIGLYT FVSLLGFMGN LLILMAVMKK RNQKTTVNFL
110 120 130 140 150
IGNLAFSDIL VVLFCSPFTL TSVLLDQWMF GKAMCHIMPF LQCVSVLVST
160 170 180 190 200
LILISIAIVR YHMIKHPISN NLTANHGYFL IATVWTLGFA ICSPLPVFHS
210 220 230 240 250
LVELKETFGS ALLSSKYLCV ESWPSDSYRI AFTISLLLVQ YILPLVCLTV
260 270 280 290 300
SHTSVCRSIS CGLSHKENRL EENEMINLTL HPSKKSRDQA KPPSTQKWSY
310 320 330 340 350
SFIRKHRRRY SKKTACVLPA PAGPSQEKHL TVPENPGSVR SQLSPSSKVI
360 370 380 390 400
PGVPICFEVK PEESSDAQEM RVKRSLTRIK KRSRSVFYRL TILILVFAVS
410 420 430 440 450
WMPLHVFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL NPILYGFLNN
460
GIKADLRALI HCLHMS
Length:466
Mass (Da):52,785
Last modified:February 21, 2001 - v2
Checksum:iB157F236EF2D4385
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951L → F in AAC17839 (PubMed:9802393).Curated
Sequence conflicti284 – 2841K → Q in BAA89538 (PubMed:9315606).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049329 mRNA. Translation: AAC17839.1.
AF022948 Genomic DNA. Translation: AAB81829.1.
AB001346 mRNA. Translation: BAA89538.1.
CCDSiCCDS22335.1.
RefSeqiNP_057917.2. NM_016708.3.
XP_006509661.1. XM_006509598.2.
XP_006509662.1. XM_006509599.2.
UniGeneiMm.10685.

Genome annotation databases

EnsembliENSMUST00000070810; ENSMUSP00000065157; ENSMUSG00000044014.
GeneIDi18168.
KEGGimmu:18168.
UCSCiuc009lvr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049329 mRNA. Translation: AAC17839.1.
AF022948 Genomic DNA. Translation: AAB81829.1.
AB001346 mRNA. Translation: BAA89538.1.
CCDSiCCDS22335.1.
RefSeqiNP_057917.2. NM_016708.3.
XP_006509661.1. XM_006509598.2.
XP_006509662.1. XM_006509599.2.
UniGeneiMm.10685.

3D structure databases

ProteinModelPortaliO70342.
SMRiO70342. Positions 21-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065157.

Chemistry

BindingDBiO70342.
ChEMBLiCHEMBL3802.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO70342.
PRIDEiO70342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070810; ENSMUSP00000065157; ENSMUSG00000044014.
GeneIDi18168.
KEGGimmu:18168.
UCSCiuc009lvr.2. mouse.

Organism-specific databases

CTDi4889.
MGIiMGI:108082. Npy5r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiO70342.
KOiK04207.
OMAiCIEKAWH.
OrthoDBiEOG7S7SDH.
PhylomeDBiO70342.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi293458.
PROiO70342.
SOURCEiSearch...

Gene expression databases

BgeeiO70342.
CleanExiMM_NPY5R.
ExpressionAtlasiO70342. baseline and differential.
GenevisibleiO70342. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs."
    Borowsky B., Walker M.W., Bard J., Weinshank R.L., Laz T.M., Vaysse P., Branchek T.A., Gerald C.
    Regul. Pept. 75:45-53(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse neuropeptide Y Y5 receptor characterized by repeat sequence in extracellular domain."
    Chen H., Adams S., McWhinnie E., Bayne M., Gadski R., Zastawny R.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
    Tissue: Brain.
  3. "Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor."
    Nakamura M., Yokoyama M., Watanabe H., Matsumoto T.
    Biochim. Biophys. Acta 1328:83-89(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNPY5R_MOUSE
AccessioniPrimary (citable) accession number: O70342
Secondary accession number(s): O35380, Q9JMK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 21, 2001
Last modified: May 11, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.