Reviewed, UniProtKB/Swiss-Prot O70342 (NPY5R_MOUSE)

Names and origin

Protein names

Recommended name:
    Neuropeptide Y receptor type 5
      Short name=NPY5-R
Alternative name(s):
    NPY-Y5 receptor
      Short name=Y5 receptor

Gene names

Name:	Npy5r
Synonyms:	Npy5

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from mutant phenotype. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	pancreatic polypeptide receptor activity Ref.1 Inferred from direct assay. Source: MGI peptide YY receptor activity Ref.1 Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Neuropeptide Y receptor type 5		PRO_0000069940
Regions
	Topological domain	1 – 63	63	Extracellular Potential
	Transmembrane	64 – 84	21	1 Potential
	Topological domain	85 – 98	14	Cytoplasmic Potential
	Transmembrane	99 – 119	21	2 Potential
	Topological domain	120 – 138	19	Extracellular Potential
	Transmembrane	139 – 159	21	3 Potential
	Topological domain	160 – 177	18	Cytoplasmic Potential
	Transmembrane	178 – 198	21	4 Potential
	Topological domain	199 – 229	31	Extracellular Potential
	Transmembrane	230 – 250	21	5 Potential
	Topological domain	251 – 389	139	Cytoplasmic Potential
	Transmembrane	390 – 410	21	6 Potential
	Topological domain	411 – 427	17	Extracellular Potential
	Transmembrane	428 – 448	21	7 Potential
	Topological domain	449 – 466	18	Cytoplasmic Potential
Amino acid modifications
	Lipidation	462	1	S-palmitoyl cysteine Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Disulfide bond	135 ↔ 219		By similarity
Experimental info
	Sequence conflict	195	1	L → F in AAC17839. Ref.1
	Sequence conflict	284	1	K → Q in BAA89538. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O70342-1 [UniParc]. Last modified February 21, 2001. Version 2. Checksum: B157F236EF2D4385	FASTA	466	52,785
	10 20 30 40 50 60 MEVKLEEHFN KTFVTENNTA ASQNTASPAW EDYRGTENNT SAARNTAFPV WEDYRGSVDD 70 80 90 100 110 120 LQYFLIGLYT FVSLLGFMGN LLILMAVMKK RNQKTTVNFL IGNLAFSDIL VVLFCSPFTL 130 140 150 160 170 180 TSVLLDQWMF GKAMCHIMPF LQCVSVLVST LILISIAIVR YHMIKHPISN NLTANHGYFL 190 200 210 220 230 240 IATVWTLGFA ICSPLPVFHS LVELKETFGS ALLSSKYLCV ESWPSDSYRI AFTISLLLVQ 250 260 270 280 290 300 YILPLVCLTV SHTSVCRSIS CGLSHKENRL EENEMINLTL HPSKKSRDQA KPPSTQKWSY 310 320 330 340 350 360 SFIRKHRRRY SKKTACVLPA PAGPSQEKHL TVPENPGSVR SQLSPSSKVI PGVPICFEVK 370 380 390 400 410 420 PEESSDAQEM RVKRSLTRIK KRSRSVFYRL TILILVFAVS WMPLHVFHVV TDFNDNLISN 430 440 450 460 RHFKLVYCIC HLLGMMSCCL NPILYGFLNN GIKADLRALI HCLHMS

References

[1]	"Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs." Borowsky B., Walker M.W., Bard J., Weinshank R.L., Laz T.M., Vaysse P., Branchek T.A., Gerald C. Regul. Pept. 75:45-53(1998) [PubMed: 9802393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Mouse neuropeptide Y Y5 receptor characterized by repeat sequence in extracellular domain." Chen H., Adams S., McWhinnie E., Bayne M., Gadski R., Zastawny R. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv. Tissue: Brain.
[3]	"Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor." Nakamura M., Yokoyama M., Watanabe H., Matsumoto T. Biochim. Biophys. Acta 1328:83-89(1997) [PubMed: 9315606] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF049329 mRNA. Translation: AAC17839.1. AF022948 Genomic DNA. Translation: AAB81829.1. AB001346 mRNA. Translation: BAA89538.1.
IPI	IPI00309496.
RefSeq	NP_057917.2.
UniGene	Mm.10685
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUSG00000044014. Mus musculus. [Contig view]
GeneID	18168.
KEGG	mmu:18168.
Organism-specific databases
MGI	MGI:108082. Npy5r.
Phylogenomic databases
HOGENOM	O70342.
HOVERGEN	O70342.
OMA	O70342. IKADLMS.
Gene expression databases
ArrayExpress	O70342.
Bgee	O70342.
CleanEx	MM_NPY5R.
GermOnline	ENSMUSG00000044014. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000393. NPY5_rcpt. IPR000611. NPY_rcpt. [Graphical view]
PANTHER	PTHR19264:SF262. NPY5_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01016. NRPEPTIDEY5R. PR01012. NRPEPTIDEYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	293458.
SOURCE	Search...

Entry information

Entry name

NPY5R_MOUSE

Accession

Primary (citable) accession number: O70342
Secondary accession number(s): O35380, Q9JMK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 21, 2001
Last modified:	June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)