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Protein

Neuronal pentraxin-2

Gene

Nptx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi275Calcium 1By similarity1
Metal bindingi353Calcium 1By similarity1
Metal bindingi353Calcium 2PROSITE-ProRule annotation1
Metal bindingi354Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi355Calcium 1By similarity1
Metal bindingi355Calcium 2PROSITE-ProRule annotation1
Metal bindingi365Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: MGI

Keywordsi

LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-2
Short name:
NP2
Alternative name(s):
Neuronal pentraxin II
Short name:
NP-II
Gene namesi
Name:Nptx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1858209. Nptx2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000002355215 – 429Neuronal pentraxin-2Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi251 ↔ 311PROSITE-ProRule annotation
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO70340.
PaxDbiO70340.
PRIDEiO70340.

PTM databases

iPTMnetiO70340.
PhosphoSitePlusiO70340.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059991.
CleanExiMM_NPTX2.
GenevisibleiO70340. MM.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071687.

Structurei

3D structure databases

ProteinModelPortaliO70340.
SMRiO70340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 422Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiO70340.
OMAiCSTNMAG.
OrthoDBiEOG091G0AHP.
PhylomeDBiO70340.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLTVGVA LAVAAGRAQD SPIPGSRFVC TALPPEAARA GCPLPAMPMQ
60 70 80 90 100
GGALSPEEEL RAAVLQLRET VVQQKETLGA QREAIRELTG KLARCEGLAG
110 120 130 140 150
GKARGTGKDT MGDLPRDPGH VVEQLSRSLQ TLKDRLESLE LQLRTNVSNA
160 170 180 190 200
GLPSDFREVL QRRLGELERQ LLRKVAELED EKSLLHNETS AHRQKTESTL
210 220 230 240 250
NALLQRVTEL ERGNSAFKSP DAFKVSLPLR TNYLYGKIKK TLPELYAFTI
260 270 280 290 300
CLWLRSSASP GIGTPFSYAV PGQANEIVLI EWGNNPIELL INDKVAQLPL
310 320 330 340 350
FVSDGKWHHI CITWTTRDGM WEAFQDGEKL GTGENLAPWH PIKPGGVLIL
360 370 380 390 400
GQEQDTVGGR FDATQAFVGE LSQFNIWDRV LRAQEIINIA NCSTNMPGNI
410 420
IPWVDNNVDV FGGASKWPVE TCEERLLDL
Length:429
Mass (Da):47,137
Last modified:August 1, 1998 - v1
Checksum:i638EED14C4CECA28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049124 mRNA. Translation: AAC05131.1.
AF318618 Genomic DNA. Translation: AAK06745.1.
BC026054 mRNA. Translation: AAH26054.1.
CCDSiCCDS19849.1.
RefSeqiNP_058069.1. NM_016789.3.
UniGeneiMm.10099.

Genome annotation databases

EnsembliENSMUST00000071782; ENSMUSP00000071687; ENSMUSG00000059991.
GeneIDi53324.
KEGGimmu:53324.
UCSCiuc012egq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049124 mRNA. Translation: AAC05131.1.
AF318618 Genomic DNA. Translation: AAK06745.1.
BC026054 mRNA. Translation: AAH26054.1.
CCDSiCCDS19849.1.
RefSeqiNP_058069.1. NM_016789.3.
UniGeneiMm.10099.

3D structure databases

ProteinModelPortaliO70340.
SMRiO70340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071687.

PTM databases

iPTMnetiO70340.
PhosphoSitePlusiO70340.

Proteomic databases

MaxQBiO70340.
PaxDbiO70340.
PRIDEiO70340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071782; ENSMUSP00000071687; ENSMUSG00000059991.
GeneIDi53324.
KEGGimmu:53324.
UCSCiuc012egq.1. mouse.

Organism-specific databases

CTDi4885.
MGIiMGI:1858209. Nptx2.

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiO70340.
OMAiCSTNMAG.
OrthoDBiEOG091G0AHP.
PhylomeDBiO70340.
TreeFamiTF330208.

Miscellaneous databases

PROiPR:O70340.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059991.
CleanExiMM_NPTX2.
GenevisibleiO70340. MM.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX2_MOUSE
AccessioniPrimary (citable) accession number: O70340
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 1, 1998
Last modified: March 15, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.