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Protein

Neuronal pentraxin-2

Gene

Nptx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi275Calcium 1By similarity1
Metal bindingi353Calcium 1By similarity1
Metal bindingi353Calcium 2PROSITE-ProRule annotation1
Metal bindingi354Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi355Calcium 1By similarity1
Metal bindingi355Calcium 2PROSITE-ProRule annotation1
Metal bindingi365Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: MGI

Keywordsi

LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-2
Short name:
NP2
Alternative name(s):
Neuronal pentraxin II
Short name:
NP-II
Gene namesi
Name:Nptx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1858209 Nptx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000002355215 – 429Neuronal pentraxin-2Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 311PROSITE-ProRule annotation
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO70340
PaxDbiO70340
PRIDEiO70340

PTM databases

iPTMnetiO70340
PhosphoSitePlusiO70340

Expressioni

Gene expression databases

BgeeiENSMUSG00000059991
CleanExiMM_NPTX2
GenevisibleiO70340 MM

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071687

Structurei

3D structure databases

ProteinModelPortaliO70340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 422Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiO70340
OMAiDNLAPWH
OrthoDBiEOG091G0AHP
PhylomeDBiO70340
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLTVGVA LAVAAGRAQD SPIPGSRFVC TALPPEAARA GCPLPAMPMQ
60 70 80 90 100
GGALSPEEEL RAAVLQLRET VVQQKETLGA QREAIRELTG KLARCEGLAG
110 120 130 140 150
GKARGTGKDT MGDLPRDPGH VVEQLSRSLQ TLKDRLESLE LQLRTNVSNA
160 170 180 190 200
GLPSDFREVL QRRLGELERQ LLRKVAELED EKSLLHNETS AHRQKTESTL
210 220 230 240 250
NALLQRVTEL ERGNSAFKSP DAFKVSLPLR TNYLYGKIKK TLPELYAFTI
260 270 280 290 300
CLWLRSSASP GIGTPFSYAV PGQANEIVLI EWGNNPIELL INDKVAQLPL
310 320 330 340 350
FVSDGKWHHI CITWTTRDGM WEAFQDGEKL GTGENLAPWH PIKPGGVLIL
360 370 380 390 400
GQEQDTVGGR FDATQAFVGE LSQFNIWDRV LRAQEIINIA NCSTNMPGNI
410 420
IPWVDNNVDV FGGASKWPVE TCEERLLDL
Length:429
Mass (Da):47,137
Last modified:August 1, 1998 - v1
Checksum:i638EED14C4CECA28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049124 mRNA Translation: AAC05131.1
AF318618 Genomic DNA Translation: AAK06745.1
BC026054 mRNA Translation: AAH26054.1
CCDSiCCDS19849.1
RefSeqiNP_058069.1, NM_016789.3
UniGeneiMm.10099

Genome annotation databases

EnsembliENSMUST00000071782; ENSMUSP00000071687; ENSMUSG00000059991
GeneIDi53324
KEGGimmu:53324
UCSCiuc012egq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNPTX2_MOUSE
AccessioniPrimary (citable) accession number: O70340
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health