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Protein

Neuronal pentraxin-2

Gene

Nptx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi275 – 2751Calcium 1By similarity
Metal bindingi353 – 3531Calcium 1By similarity
Metal bindingi353 – 3531Calcium 2By similarity
Metal bindingi354 – 3541Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi355 – 3551Calcium 1By similarity
Metal bindingi355 – 3551Calcium 2By similarity
Metal bindingi365 – 3651Calcium 2By similarity

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-2
Short name:
NP2
Alternative name(s):
Neuronal pentraxin II
Short name:
NP-II
Gene namesi
Name:Nptx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1858209. Nptx2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414Sequence analysisAdd
BLAST
Chaini15 – 429415Neuronal pentraxin-2PRO_0000023552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO70340.
PaxDbiO70340.
PRIDEiO70340.

PTM databases

iPTMnetiO70340.
PhosphoSiteiO70340.

Expressioni

Gene expression databases

BgeeiO70340.
CleanExiMM_NPTX2.
GenevisibleiO70340. MM.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071687.

Structurei

3D structure databases

ProteinModelPortaliO70340.
SMRiO70340. Positions 231-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 429205PentaxinAdd
BLAST

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiO70340.
OMAiCSTNMAG.
OrthoDBiEOG74XS6F.
PhylomeDBiO70340.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLTVGVA LAVAAGRAQD SPIPGSRFVC TALPPEAARA GCPLPAMPMQ
60 70 80 90 100
GGALSPEEEL RAAVLQLRET VVQQKETLGA QREAIRELTG KLARCEGLAG
110 120 130 140 150
GKARGTGKDT MGDLPRDPGH VVEQLSRSLQ TLKDRLESLE LQLRTNVSNA
160 170 180 190 200
GLPSDFREVL QRRLGELERQ LLRKVAELED EKSLLHNETS AHRQKTESTL
210 220 230 240 250
NALLQRVTEL ERGNSAFKSP DAFKVSLPLR TNYLYGKIKK TLPELYAFTI
260 270 280 290 300
CLWLRSSASP GIGTPFSYAV PGQANEIVLI EWGNNPIELL INDKVAQLPL
310 320 330 340 350
FVSDGKWHHI CITWTTRDGM WEAFQDGEKL GTGENLAPWH PIKPGGVLIL
360 370 380 390 400
GQEQDTVGGR FDATQAFVGE LSQFNIWDRV LRAQEIINIA NCSTNMPGNI
410 420
IPWVDNNVDV FGGASKWPVE TCEERLLDL
Length:429
Mass (Da):47,137
Last modified:August 1, 1998 - v1
Checksum:i638EED14C4CECA28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049124 mRNA. Translation: AAC05131.1.
AF318618 Genomic DNA. Translation: AAK06745.1.
BC026054 mRNA. Translation: AAH26054.1.
CCDSiCCDS19849.1.
RefSeqiNP_058069.1. NM_016789.3.
UniGeneiMm.10099.

Genome annotation databases

EnsembliENSMUST00000071782; ENSMUSP00000071687; ENSMUSG00000059991.
GeneIDi53324.
KEGGimmu:53324.
UCSCiuc012egq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049124 mRNA. Translation: AAC05131.1.
AF318618 Genomic DNA. Translation: AAK06745.1.
BC026054 mRNA. Translation: AAH26054.1.
CCDSiCCDS19849.1.
RefSeqiNP_058069.1. NM_016789.3.
UniGeneiMm.10099.

3D structure databases

ProteinModelPortaliO70340.
SMRiO70340. Positions 231-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071687.

PTM databases

iPTMnetiO70340.
PhosphoSiteiO70340.

Proteomic databases

MaxQBiO70340.
PaxDbiO70340.
PRIDEiO70340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071782; ENSMUSP00000071687; ENSMUSG00000059991.
GeneIDi53324.
KEGGimmu:53324.
UCSCiuc012egq.1. mouse.

Organism-specific databases

CTDi4885.
MGIiMGI:1858209. Nptx2.

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiO70340.
OMAiCSTNMAG.
OrthoDBiEOG74XS6F.
PhylomeDBiO70340.
TreeFamiTF330208.

Miscellaneous databases

PROiO70340.
SOURCEiSearch...

Gene expression databases

BgeeiO70340.
CleanExiMM_NPTX2.
GenevisibleiO70340. MM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse neuronal pentraxin 2 gene."
    Perin M.S.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiNPTX2_MOUSE
AccessioniPrimary (citable) accession number: O70340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.