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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

KCNJ15

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir1.3
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:KCNJ15
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363CytoplasmicBy similarityAdd
BLAST
Transmembranei64 – 8825Helical; Name=M1By similarityAdd
BLAST
Topological domaini89 – 11325ExtracellularBy similarityAdd
BLAST
Intramembranei114 – 12512Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei126 – 1327Pore-formingBy similarity
Topological domaini133 – 1419ExtracellularBy similarity
Transmembranei142 – 16322Helical; Name=M2By similarityAdd
BLAST
Topological domaini164 – 375212CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375ATP-sensitive inward rectifier potassium channel 15PRO_0000154971Add
BLAST

Interactioni

Subunit structurei

Interacts with INADL.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020472.

Structurei

3D structure databases

ProteinModelPortaliO70339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1326Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO70339.
OMAiCPLAIFT.
OrthoDBiEOG7GFB4Z.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O70339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTIHMSVTR PPPEKHMAGP GLKTHRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPSEA
110 120 130 140 150
ISNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVITKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSSDCT FYCADSEKQK
360 370
LEEKYRQEDQ RERELRTLLL HQSNV
Length:375
Mass (Da):42,829
Last modified:August 1, 1998 - v1
Checksum:i1ACC85D34B77CFC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049076 Genomic DNA. Translation: AAC34748.1.
RefSeqiXP_013001561.1. XM_013146107.1.
XP_013001562.1. XM_013146108.1.
XP_013001563.1. XM_013146109.1.
XP_013001564.1. XM_013146110.1.
XP_013001565.1. XM_013146111.1.
XP_013001566.1. XM_013146112.1.
XP_013001567.1. XM_013146113.1.
XP_013001568.1. XM_013146114.1.

Genome annotation databases

EnsembliENSCPOT00000027947; ENSCPOP00000020472; ENSCPOG00000019502.
GeneIDi100713999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049076 Genomic DNA. Translation: AAC34748.1.
RefSeqiXP_013001561.1. XM_013146107.1.
XP_013001562.1. XM_013146108.1.
XP_013001563.1. XM_013146109.1.
XP_013001564.1. XM_013146110.1.
XP_013001565.1. XM_013146111.1.
XP_013001566.1. XM_013146112.1.
XP_013001567.1. XM_013146113.1.
XP_013001568.1. XM_013146114.1.

3D structure databases

ProteinModelPortaliO70339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020472.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000027947; ENSCPOP00000020472; ENSCPOG00000019502.
GeneIDi100713999.

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO70339.
OMAiCPLAIFT.
OrthoDBiEOG7GFB4Z.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels."
    Derst C., Wischmeyer E., Preisig-Mueller R., Spauschus A., Konrad M., Hensen P., Jeck N., Seyberth H.W., Daut J., Karschin A.
    J. Biol. Chem. 273:23884-23891(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKCJ15_CAVPO
AccessioniPrimary (citable) accession number: O70339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.