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O70337

- BIK_MOUSE

UniProt

O70337 - BIK_MOUSE

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Protein
Bcl-2-interacting killer
Gene
Bik, Biklk, Blk, Nbk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei143 – 1442Cleavage; by RHBDL4/RHBDD1 By similarity

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. apoptotic mitochondrial changes Source: MGI
  2. male gonad development Source: MGI
  3. positive regulation of protein homooligomerization Source: Ensembl
  4. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  5. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-interacting killer
Alternative name(s):
Apoptosis inducer NBK
Bik-like killer protein
Gene namesi
Name:Bik
Synonyms:Biklk, Blk, Nbk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1206591. Bik.

Subcellular locationi

Endomembrane system; Single-pass membrane protein By similarity. Mitochondrion membrane; Single-pass membrane protein
Note: Around the nuclear envelope, and in cytoplasmic membranes By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endomembrane system Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial envelope Source: MGI
  4. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Bcl-2-interacting killer
PRO_0000419202Add
BLAST

Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism By similarity.

Expressioni

Tissue specificityi

Expressed in testis, kidney, liver, lung and heart.1 Publication

Gene expression databases

ArrayExpressiO70337.
BgeeiO70337.
GenevestigatoriO70337.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016902.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14822Leucine-zipper Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6515BH3 By similarity
Add
BLAST

Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family By similarity.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39366.
GeneTreeiENSGT00530000064453.
HOVERGENiHBG001515.
InParanoidiO70337.
OMAiLECMEGS.
OrthoDBiEOG7NKKN5.
TreeFamiTF338339.

Family and domain databases

InterProiIPR024579. Bcl2-int_killer.
[Graphical view]
PANTHERiPTHR15018. PTHR15018. 1 hit.
PfamiPF12201. bcl-2I13. 1 hit.
[Graphical view]
ProDomiPD032623. PD032623. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O70337-1 [UniParc]FASTAAdd to Basket

« Hide

MSEARLMARD VIKTVPHDQV PQPPVASETP SMKEPVRDVD LMECVEGRNQ    50
VALRLACIGD EMDLCLRSPR LVQLPGIAIH RLAVTYSRTG VRGIFRSLIR 100
SLTNLRENIW SWRVLTPGAW VSPDQDPGQL FPMVLLVFLL LGGAWYLQLQ 150
Length:150
Mass (Da):16,901
Last modified:August 1, 1998 - v1
Checksum:i120CB6BAA4612788
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF048838 mRNA. Translation: AAC40079.1.
AL583889 Genomic DNA. No translation available.
CH467427 Genomic DNA. Translation: EDL01409.1.
CCDSiCCDS27703.1.
RefSeqiNP_031572.1. NM_007546.2.
XP_006520418.1. XM_006520355.1.
XP_006520419.1. XM_006520356.1.
XP_006520420.1. XM_006520357.1.
UniGeneiMm.267006.

Genome annotation databases

EnsembliENSMUST00000016902; ENSMUSP00000016902; ENSMUSG00000016758.
GeneIDi12124.
KEGGimmu:12124.
UCSCiuc007xbd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF048838 mRNA. Translation: AAC40079.1 .
AL583889 Genomic DNA. No translation available.
CH467427 Genomic DNA. Translation: EDL01409.1 .
CCDSi CCDS27703.1.
RefSeqi NP_031572.1. NM_007546.2.
XP_006520418.1. XM_006520355.1.
XP_006520419.1. XM_006520356.1.
XP_006520420.1. XM_006520357.1.
UniGenei Mm.267006.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000016902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016902 ; ENSMUSP00000016902 ; ENSMUSG00000016758 .
GeneIDi 12124.
KEGGi mmu:12124.
UCSCi uc007xbd.1. mouse.

Organism-specific databases

CTDi 638.
MGIi MGI:1206591. Bik.

Phylogenomic databases

eggNOGi NOG39366.
GeneTreei ENSGT00530000064453.
HOVERGENi HBG001515.
InParanoidi O70337.
OMAi LECMEGS.
OrthoDBi EOG7NKKN5.
TreeFami TF338339.

Miscellaneous databases

ChiTaRSi BIK. mouse.
NextBioi 280447.
PROi O70337.
SOURCEi Search...

Gene expression databases

ArrayExpressi O70337.
Bgeei O70337.
Genevestigatori O70337.

Family and domain databases

InterProi IPR024579. Bcl2-int_killer.
[Graphical view ]
PANTHERi PTHR15018. PTHR15018. 1 hit.
Pfami PF12201. bcl-2I13. 1 hit.
[Graphical view ]
ProDomi PD032623. PD032623. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist."
    Hegde R., Srinivasula S.M., Ahmad M., Fernandes-Alnemri T., Alnemri E.S.
    J. Biol. Chem. 273:7783-7786(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN APOPTOSIS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBIK_MOUSE
AccessioniPrimary (citable) accession number: O70337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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