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Protein

Bcl-2-interacting killer

Gene

Bik

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity.1 Publication

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI
  • male gonad development Source: MGI
  • positive regulation of protein homooligomerization Source: MGI
  • positive regulation of release of cytochrome c from mitochondria Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-interacting killer
Alternative name(s):
Apoptosis inducer NBK
Bik-like killer protein
Gene namesi
Name:Bik
Synonyms:Biklk, Blk, Nbk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1206591. Bik.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004192021 – 150Bcl-2-interacting killerAdd BLAST150

Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143 – 144Cleavage; by RHBDL4/RHBDD1By similarity2

Proteomic databases

PaxDbiO70337.
PRIDEiO70337.

PTM databases

iPTMnetiO70337.
PhosphoSitePlusiO70337.

Expressioni

Tissue specificityi

Expressed in testis, kidney, liver, lung and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000016758.
GenevisibleiO70337. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016902.

Structurei

3D structure databases

ProteinModelPortaliO70337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 148Leucine-zipperSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 65BH3By similarityAdd BLAST15

Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JHX0. Eukaryota.
ENOG41116I0. LUCA.
GeneTreeiENSGT00530000064453.
HOVERGENiHBG001515.
InParanoidiO70337.
KOiK18452.
OrthoDBiEOG091G0VGV.
TreeFamiTF338339.

Family and domain databases

InterProiIPR024579. Bcl2-int_killer.
[Graphical view]
PANTHERiPTHR15018. PTHR15018. 1 hit.
PfamiPF12201. bcl-2I13. 1 hit.
[Graphical view]
ProDomiPD032623. PD032623. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O70337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEARLMARD VIKTVPHDQV PQPPVASETP SMKEPVRDVD LMECVEGRNQ
60 70 80 90 100
VALRLACIGD EMDLCLRSPR LVQLPGIAIH RLAVTYSRTG VRGIFRSLIR
110 120 130 140 150
SLTNLRENIW SWRVLTPGAW VSPDQDPGQL FPMVLLVFLL LGGAWYLQLQ
Length:150
Mass (Da):16,901
Last modified:August 1, 1998 - v1
Checksum:i120CB6BAA4612788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048838 mRNA. Translation: AAC40079.1.
AL583889 Genomic DNA. No translation available.
CH467427 Genomic DNA. Translation: EDL01409.1.
CCDSiCCDS27703.1.
RefSeqiNP_031572.1. NM_007546.2.
XP_006520418.1. XM_006520355.3.
XP_006520419.1. XM_006520356.2.
XP_006520420.1. XM_006520357.3.
UniGeneiMm.267006.

Genome annotation databases

EnsembliENSMUST00000016902; ENSMUSP00000016902; ENSMUSG00000016758.
GeneIDi12124.
KEGGimmu:12124.
UCSCiuc007xbd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048838 mRNA. Translation: AAC40079.1.
AL583889 Genomic DNA. No translation available.
CH467427 Genomic DNA. Translation: EDL01409.1.
CCDSiCCDS27703.1.
RefSeqiNP_031572.1. NM_007546.2.
XP_006520418.1. XM_006520355.3.
XP_006520419.1. XM_006520356.2.
XP_006520420.1. XM_006520357.3.
UniGeneiMm.267006.

3D structure databases

ProteinModelPortaliO70337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016902.

PTM databases

iPTMnetiO70337.
PhosphoSitePlusiO70337.

Proteomic databases

PaxDbiO70337.
PRIDEiO70337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016902; ENSMUSP00000016902; ENSMUSG00000016758.
GeneIDi12124.
KEGGimmu:12124.
UCSCiuc007xbd.1. mouse.

Organism-specific databases

CTDi638.
MGIiMGI:1206591. Bik.

Phylogenomic databases

eggNOGiENOG410JHX0. Eukaryota.
ENOG41116I0. LUCA.
GeneTreeiENSGT00530000064453.
HOVERGENiHBG001515.
InParanoidiO70337.
KOiK18452.
OrthoDBiEOG091G0VGV.
TreeFamiTF338339.

Miscellaneous databases

ChiTaRSiBik. mouse.
PROiO70337.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016758.
GenevisibleiO70337. MM.

Family and domain databases

InterProiIPR024579. Bcl2-int_killer.
[Graphical view]
PANTHERiPTHR15018. PTHR15018. 1 hit.
PfamiPF12201. bcl-2I13. 1 hit.
[Graphical view]
ProDomiPD032623. PD032623. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiBIK_MOUSE
AccessioniPrimary (citable) accession number: O70337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.