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O70337

- BIK_MOUSE

UniProt

O70337 - BIK_MOUSE

Protein

Bcl-2-interacting killer

Gene

Bik

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1442Cleavage; by RHBDL4/RHBDD1By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. apoptotic mitochondrial changes Source: MGI
    2. male gonad development Source: MGI
    3. positive regulation of protein homooligomerization Source: Ensembl
    4. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
    5. spermatogenesis Source: MGI

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl-2-interacting killer
    Alternative name(s):
    Apoptosis inducer NBK
    Bik-like killer protein
    Gene namesi
    Name:Bik
    Synonyms:Biklk, Blk, Nbk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1206591. Bik.

    Subcellular locationi

    Endomembrane system By similarity; Single-pass membrane protein By similarity. Mitochondrion membrane 1 Publication; Single-pass membrane protein 1 Publication
    Note: Around the nuclear envelope, and in cytoplasmic membranes.By similarity

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial envelope Source: MGI
    4. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Bcl-2-interacting killerPRO_0000419202Add
    BLAST

    Post-translational modificationi

    Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism By similarity.By similarity

    Expressioni

    Tissue specificityi

    Expressed in testis, kidney, liver, lung and heart.1 Publication

    Gene expression databases

    ArrayExpressiO70337.
    BgeeiO70337.
    GenevestigatoriO70337.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000016902.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 14822Leucine-zipperSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 6515BH3By similarityAdd
    BLAST

    Domaini

    Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.By similarity

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39366.
    GeneTreeiENSGT00530000064453.
    HOVERGENiHBG001515.
    InParanoidiO70337.
    OMAiLECMEGS.
    OrthoDBiEOG7NKKN5.
    TreeFamiTF338339.

    Family and domain databases

    InterProiIPR024579. Bcl2-int_killer.
    [Graphical view]
    PANTHERiPTHR15018. PTHR15018. 1 hit.
    PfamiPF12201. bcl-2I13. 1 hit.
    [Graphical view]
    ProDomiPD032623. PD032623. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    O70337-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEARLMARD VIKTVPHDQV PQPPVASETP SMKEPVRDVD LMECVEGRNQ    50
    VALRLACIGD EMDLCLRSPR LVQLPGIAIH RLAVTYSRTG VRGIFRSLIR 100
    SLTNLRENIW SWRVLTPGAW VSPDQDPGQL FPMVLLVFLL LGGAWYLQLQ 150
    Length:150
    Mass (Da):16,901
    Last modified:August 1, 1998 - v1
    Checksum:i120CB6BAA4612788
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF048838 mRNA. Translation: AAC40079.1.
    AL583889 Genomic DNA. No translation available.
    CH467427 Genomic DNA. Translation: EDL01409.1.
    CCDSiCCDS27703.1.
    RefSeqiNP_031572.1. NM_007546.2.
    XP_006520418.1. XM_006520355.1.
    XP_006520419.1. XM_006520356.1.
    XP_006520420.1. XM_006520357.1.
    UniGeneiMm.267006.

    Genome annotation databases

    EnsembliENSMUST00000016902; ENSMUSP00000016902; ENSMUSG00000016758.
    GeneIDi12124.
    KEGGimmu:12124.
    UCSCiuc007xbd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF048838 mRNA. Translation: AAC40079.1 .
    AL583889 Genomic DNA. No translation available.
    CH467427 Genomic DNA. Translation: EDL01409.1 .
    CCDSi CCDS27703.1.
    RefSeqi NP_031572.1. NM_007546.2.
    XP_006520418.1. XM_006520355.1.
    XP_006520419.1. XM_006520356.1.
    XP_006520420.1. XM_006520357.1.
    UniGenei Mm.267006.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000016902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016902 ; ENSMUSP00000016902 ; ENSMUSG00000016758 .
    GeneIDi 12124.
    KEGGi mmu:12124.
    UCSCi uc007xbd.1. mouse.

    Organism-specific databases

    CTDi 638.
    MGIi MGI:1206591. Bik.

    Phylogenomic databases

    eggNOGi NOG39366.
    GeneTreei ENSGT00530000064453.
    HOVERGENi HBG001515.
    InParanoidi O70337.
    OMAi LECMEGS.
    OrthoDBi EOG7NKKN5.
    TreeFami TF338339.

    Miscellaneous databases

    ChiTaRSi BIK. mouse.
    NextBioi 280447.
    PROi O70337.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70337.
    Bgeei O70337.
    Genevestigatori O70337.

    Family and domain databases

    InterProi IPR024579. Bcl2-int_killer.
    [Graphical view ]
    PANTHERi PTHR15018. PTHR15018. 1 hit.
    Pfami PF12201. bcl-2I13. 1 hit.
    [Graphical view ]
    ProDomi PD032623. PD032623. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist."
      Hegde R., Srinivasula S.M., Ahmad M., Fernandes-Alnemri T., Alnemri E.S.
      J. Biol. Chem. 273:7783-7786(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN APOPTOSIS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiBIK_MOUSE
    AccessioniPrimary (citable) accession number: O70337
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3